Amino acid dipepetide frequency for Salmonella phage vB_SenS_phi135

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.538AlaAla: 11.538 ± 1.566
0.98AlaCys: 0.98 ± 0.261
6.033AlaAsp: 6.033 ± 0.658
6.486AlaGlu: 6.486 ± 0.993
3.771AlaPhe: 3.771 ± 0.515
7.24AlaGly: 7.24 ± 0.682
1.961AlaHis: 1.961 ± 0.382
3.997AlaIle: 3.997 ± 0.576
5.958AlaLys: 5.958 ± 0.803
7.617AlaLeu: 7.617 ± 0.9
2.112AlaMet: 2.112 ± 0.516
3.092AlaAsn: 3.092 ± 0.503
3.62AlaPro: 3.62 ± 0.444
3.62AlaGln: 3.62 ± 0.722
3.922AlaArg: 3.922 ± 0.55
6.561AlaSer: 6.561 ± 0.947
5.581AlaThr: 5.581 ± 0.701
7.24AlaVal: 7.24 ± 0.859
1.131AlaTrp: 1.131 ± 0.246
3.318AlaTyr: 3.318 ± 0.496
0.0AlaXaa: 0.0 ± 0.0
Cys
0.905CysAla: 0.905 ± 0.233
0.226CysCys: 0.226 ± 0.13
0.754CysAsp: 0.754 ± 0.2
1.131CysGlu: 1.131 ± 0.451
0.226CysPhe: 0.226 ± 0.126
0.754CysGly: 0.754 ± 0.225
0.151CysHis: 0.151 ± 0.112
0.151CysIle: 0.151 ± 0.095
0.754CysLys: 0.754 ± 0.219
0.754CysLeu: 0.754 ± 0.274
0.075CysMet: 0.075 ± 0.103
0.302CysAsn: 0.302 ± 0.201
0.377CysPro: 0.377 ± 0.173
0.151CysGln: 0.151 ± 0.104
0.905CysArg: 0.905 ± 0.285
0.302CysSer: 0.302 ± 0.149
0.452CysThr: 0.452 ± 0.125
0.603CysVal: 0.603 ± 0.194
0.302CysTrp: 0.302 ± 0.143
0.302CysTyr: 0.302 ± 0.125
0.0CysXaa: 0.0 ± 0.0
Asp
6.863AspAla: 6.863 ± 0.673
0.528AspCys: 0.528 ± 0.218
3.544AspAsp: 3.544 ± 0.459
3.846AspGlu: 3.846 ± 0.572
3.469AspPhe: 3.469 ± 0.499
5.958AspGly: 5.958 ± 0.742
0.603AspHis: 0.603 ± 0.202
3.544AspIle: 3.544 ± 0.395
3.771AspLys: 3.771 ± 0.529
4.449AspLeu: 4.449 ± 0.554
1.433AspMet: 1.433 ± 0.224
2.64AspAsn: 2.64 ± 0.461
1.885AspPro: 1.885 ± 0.386
0.377AspGln: 0.377 ± 0.165
2.866AspArg: 2.866 ± 0.352
3.318AspSer: 3.318 ± 0.485
4.525AspThr: 4.525 ± 0.484
4.072AspVal: 4.072 ± 0.342
0.905AspTrp: 0.905 ± 0.304
1.735AspTyr: 1.735 ± 0.345
0.0AspXaa: 0.0 ± 0.0
Glu
5.807GluAla: 5.807 ± 0.803
0.452GluCys: 0.452 ± 0.204
3.922GluAsp: 3.922 ± 0.493
4.676GluGlu: 4.676 ± 0.999
3.243GluPhe: 3.243 ± 0.695
4.827GluGly: 4.827 ± 0.702
1.282GluHis: 1.282 ± 0.308
3.469GluIle: 3.469 ± 0.494
4.072GluLys: 4.072 ± 0.779
6.109GluLeu: 6.109 ± 0.795
2.413GluMet: 2.413 ± 0.452
2.338GluAsn: 2.338 ± 0.35
1.885GluPro: 1.885 ± 0.483
3.243GluGln: 3.243 ± 0.569
3.695GluArg: 3.695 ± 0.609
3.846GluSer: 3.846 ± 0.54
3.771GluThr: 3.771 ± 0.529
4.299GluVal: 4.299 ± 0.54
0.98GluTrp: 0.98 ± 0.31
1.961GluTyr: 1.961 ± 0.404
0.0GluXaa: 0.0 ± 0.0
Phe
2.715PheAla: 2.715 ± 0.564
0.603PheCys: 0.603 ± 0.176
3.243PheAsp: 3.243 ± 0.508
2.941PheGlu: 2.941 ± 0.438
0.83PhePhe: 0.83 ± 0.232
3.167PheGly: 3.167 ± 0.366
0.679PheHis: 0.679 ± 0.175
2.489PheIle: 2.489 ± 0.473
1.659PheLys: 1.659 ± 0.359
2.112PheLeu: 2.112 ± 0.384
0.679PheMet: 0.679 ± 0.188
1.659PheAsn: 1.659 ± 0.343
1.584PhePro: 1.584 ± 0.389
1.282PheGln: 1.282 ± 0.315
2.187PheArg: 2.187 ± 0.312
2.79PheSer: 2.79 ± 0.554
3.469PheThr: 3.469 ± 0.641
2.564PheVal: 2.564 ± 0.37
0.83PheTrp: 0.83 ± 0.252
0.83PheTyr: 0.83 ± 0.258
0.0PheXaa: 0.0 ± 0.0
Gly
6.863GlyAla: 6.863 ± 0.669
0.905GlyCys: 0.905 ± 0.288
4.223GlyAsp: 4.223 ± 0.653
5.656GlyGlu: 5.656 ± 0.772
3.092GlyPhe: 3.092 ± 0.567
6.486GlyGly: 6.486 ± 0.82
1.659GlyHis: 1.659 ± 0.431
3.695GlyIle: 3.695 ± 0.435
4.977GlyLys: 4.977 ± 0.589
5.807GlyLeu: 5.807 ± 0.545
2.262GlyMet: 2.262 ± 0.539
3.771GlyAsn: 3.771 ± 0.578
1.885GlyPro: 1.885 ± 0.399
3.092GlyGln: 3.092 ± 0.492
5.053GlyArg: 5.053 ± 0.688
5.204GlySer: 5.204 ± 0.691
3.771GlyThr: 3.771 ± 0.561
5.505GlyVal: 5.505 ± 0.642
1.282GlyTrp: 1.282 ± 0.276
2.941GlyTyr: 2.941 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
0.98HisAla: 0.98 ± 0.303
0.302HisCys: 0.302 ± 0.135
0.905HisAsp: 0.905 ± 0.234
0.98HisGlu: 0.98 ± 0.29
0.679HisPhe: 0.679 ± 0.246
1.207HisGly: 1.207 ± 0.394
0.528HisHis: 0.528 ± 0.196
0.905HisIle: 0.905 ± 0.215
1.131HisLys: 1.131 ± 0.271
1.282HisLeu: 1.282 ± 0.367
0.603HisMet: 0.603 ± 0.181
0.679HisAsn: 0.679 ± 0.206
0.905HisPro: 0.905 ± 0.297
0.905HisGln: 0.905 ± 0.23
0.905HisArg: 0.905 ± 0.247
1.207HisSer: 1.207 ± 0.279
0.679HisThr: 0.679 ± 0.274
0.83HisVal: 0.83 ± 0.272
0.151HisTrp: 0.151 ± 0.116
1.056HisTyr: 1.056 ± 0.315
0.0HisXaa: 0.0 ± 0.0
Ile
4.827IleAla: 4.827 ± 0.626
0.528IleCys: 0.528 ± 0.195
3.771IleAsp: 3.771 ± 0.499
2.941IleGlu: 2.941 ± 0.432
1.282IlePhe: 1.282 ± 0.344
2.866IleGly: 2.866 ± 0.383
0.754IleHis: 0.754 ± 0.222
2.489IleIle: 2.489 ± 0.4
2.64IleLys: 2.64 ± 0.55
3.394IleLeu: 3.394 ± 0.441
1.207IleMet: 1.207 ± 0.299
2.036IleAsn: 2.036 ± 0.383
2.715IlePro: 2.715 ± 0.411
1.81IleGln: 1.81 ± 0.328
2.564IleArg: 2.564 ± 0.386
3.318IleSer: 3.318 ± 0.514
4.299IleThr: 4.299 ± 0.582
3.318IleVal: 3.318 ± 0.49
0.679IleTrp: 0.679 ± 0.23
1.207IleTyr: 1.207 ± 0.326
0.0IleXaa: 0.0 ± 0.0
Lys
5.204LysAla: 5.204 ± 0.742
0.905LysCys: 0.905 ± 0.285
3.62LysAsp: 3.62 ± 0.562
4.6LysGlu: 4.6 ± 0.637
2.112LysPhe: 2.112 ± 0.338
3.771LysGly: 3.771 ± 0.359
1.282LysHis: 1.282 ± 0.269
1.81LysIle: 1.81 ± 0.366
3.092LysLys: 3.092 ± 0.512
5.053LysLeu: 5.053 ± 0.508
2.64LysMet: 2.64 ± 0.465
2.262LysAsn: 2.262 ± 0.336
2.564LysPro: 2.564 ± 0.52
2.262LysGln: 2.262 ± 0.486
3.997LysArg: 3.997 ± 0.576
2.715LysSer: 2.715 ± 0.486
4.072LysThr: 4.072 ± 0.454
3.469LysVal: 3.469 ± 0.546
0.754LysTrp: 0.754 ± 0.24
2.413LysTyr: 2.413 ± 0.403
0.0LysXaa: 0.0 ± 0.0
Leu
7.315LeuAla: 7.315 ± 0.678
0.603LeuCys: 0.603 ± 0.259
3.922LeuAsp: 3.922 ± 0.642
4.6LeuGlu: 4.6 ± 0.862
2.036LeuPhe: 2.036 ± 0.381
4.902LeuGly: 4.902 ± 0.504
1.056LeuHis: 1.056 ± 0.29
4.525LeuIle: 4.525 ± 0.559
5.505LeuLys: 5.505 ± 0.684
6.033LeuLeu: 6.033 ± 0.784
2.262LeuMet: 2.262 ± 0.398
4.977LeuAsn: 4.977 ± 0.742
4.148LeuPro: 4.148 ± 0.575
2.564LeuGln: 2.564 ± 0.375
5.128LeuArg: 5.128 ± 0.569
4.525LeuSer: 4.525 ± 0.555
5.053LeuThr: 5.053 ± 0.401
6.184LeuVal: 6.184 ± 0.608
0.98LeuTrp: 0.98 ± 0.288
2.338LeuTyr: 2.338 ± 0.426
0.0LeuXaa: 0.0 ± 0.0
Met
2.64MetAla: 2.64 ± 0.339
0.302MetCys: 0.302 ± 0.155
0.98MetAsp: 0.98 ± 0.298
1.282MetGlu: 1.282 ± 0.253
1.131MetPhe: 1.131 ± 0.282
1.885MetGly: 1.885 ± 0.322
0.302MetHis: 0.302 ± 0.171
0.98MetIle: 0.98 ± 0.283
1.357MetLys: 1.357 ± 0.336
1.81MetLeu: 1.81 ± 0.349
0.679MetMet: 0.679 ± 0.276
1.131MetAsn: 1.131 ± 0.298
1.282MetPro: 1.282 ± 0.359
1.056MetGln: 1.056 ± 0.251
1.433MetArg: 1.433 ± 0.296
2.262MetSer: 2.262 ± 0.338
1.81MetThr: 1.81 ± 0.34
2.036MetVal: 2.036 ± 0.462
0.528MetTrp: 0.528 ± 0.154
0.528MetTyr: 0.528 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
3.997AsnAla: 3.997 ± 0.538
0.452AsnCys: 0.452 ± 0.203
2.79AsnAsp: 2.79 ± 0.385
2.64AsnGlu: 2.64 ± 0.45
1.508AsnPhe: 1.508 ± 0.246
4.148AsnGly: 4.148 ± 0.508
0.528AsnHis: 0.528 ± 0.186
2.64AsnIle: 2.64 ± 0.339
1.885AsnLys: 1.885 ± 0.413
3.997AsnLeu: 3.997 ± 0.404
0.603AsnMet: 0.603 ± 0.284
2.262AsnAsn: 2.262 ± 0.531
1.659AsnPro: 1.659 ± 0.327
1.357AsnGln: 1.357 ± 0.332
2.262AsnArg: 2.262 ± 0.262
2.489AsnSer: 2.489 ± 0.302
2.187AsnThr: 2.187 ± 0.402
3.771AsnVal: 3.771 ± 0.487
0.83AsnTrp: 0.83 ± 0.25
1.357AsnTyr: 1.357 ± 0.324
0.0AsnXaa: 0.0 ± 0.0
Pro
2.79ProAla: 2.79 ± 0.519
0.226ProCys: 0.226 ± 0.137
3.017ProAsp: 3.017 ± 0.412
3.469ProGlu: 3.469 ± 0.464
1.659ProPhe: 1.659 ± 0.326
3.167ProGly: 3.167 ± 0.545
0.528ProHis: 0.528 ± 0.142
1.584ProIle: 1.584 ± 0.296
2.79ProLys: 2.79 ± 0.472
3.544ProLeu: 3.544 ± 0.461
0.679ProMet: 0.679 ± 0.235
1.433ProAsn: 1.433 ± 0.505
1.357ProPro: 1.357 ± 0.298
1.282ProGln: 1.282 ± 0.293
2.262ProArg: 2.262 ± 0.381
2.413ProSer: 2.413 ± 0.388
1.584ProThr: 1.584 ± 0.31
3.997ProVal: 3.997 ± 0.45
0.452ProTrp: 0.452 ± 0.229
1.508ProTyr: 1.508 ± 0.386
0.0ProXaa: 0.0 ± 0.0
Gln
4.148GlnAla: 4.148 ± 0.675
0.226GlnCys: 0.226 ± 0.126
1.433GlnAsp: 1.433 ± 0.299
2.338GlnGlu: 2.338 ± 0.519
1.433GlnPhe: 1.433 ± 0.391
2.187GlnGly: 2.187 ± 0.502
0.679GlnHis: 0.679 ± 0.238
1.735GlnIle: 1.735 ± 0.335
2.036GlnLys: 2.036 ± 0.329
3.092GlnLeu: 3.092 ± 0.503
1.131GlnMet: 1.131 ± 0.32
1.81GlnAsn: 1.81 ± 0.337
2.036GlnPro: 2.036 ± 0.324
2.112GlnGln: 2.112 ± 0.46
1.961GlnArg: 1.961 ± 0.369
1.961GlnSer: 1.961 ± 0.346
1.584GlnThr: 1.584 ± 0.294
2.715GlnVal: 2.715 ± 0.496
0.452GlnTrp: 0.452 ± 0.165
1.433GlnTyr: 1.433 ± 0.305
0.0GlnXaa: 0.0 ± 0.0
Arg
4.676ArgAla: 4.676 ± 0.501
0.377ArgCys: 0.377 ± 0.132
3.394ArgAsp: 3.394 ± 0.338
3.394ArgGlu: 3.394 ± 0.523
2.036ArgPhe: 2.036 ± 0.402
4.299ArgGly: 4.299 ± 0.553
0.98ArgHis: 0.98 ± 0.265
2.79ArgIle: 2.79 ± 0.508
3.771ArgLys: 3.771 ± 0.572
4.525ArgLeu: 4.525 ± 0.637
1.961ArgMet: 1.961 ± 0.349
3.167ArgAsn: 3.167 ± 0.448
1.81ArgPro: 1.81 ± 0.329
3.017ArgGln: 3.017 ± 0.483
4.449ArgArg: 4.449 ± 0.64
2.338ArgSer: 2.338 ± 0.397
2.715ArgThr: 2.715 ± 0.521
4.374ArgVal: 4.374 ± 0.527
1.056ArgTrp: 1.056 ± 0.263
1.584ArgTyr: 1.584 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
6.938SerAla: 6.938 ± 1.013
0.075SerCys: 0.075 ± 0.075
3.469SerAsp: 3.469 ± 0.522
3.167SerGlu: 3.167 ± 0.655
2.489SerPhe: 2.489 ± 0.353
7.315SerGly: 7.315 ± 0.812
1.056SerHis: 1.056 ± 0.233
2.564SerIle: 2.564 ± 0.445
2.564SerLys: 2.564 ± 0.429
5.128SerLeu: 5.128 ± 0.585
0.905SerMet: 0.905 ± 0.246
2.564SerAsn: 2.564 ± 0.344
1.961SerPro: 1.961 ± 0.452
2.036SerGln: 2.036 ± 0.377
3.318SerArg: 3.318 ± 0.476
3.092SerSer: 3.092 ± 0.488
4.6SerThr: 4.6 ± 0.748
5.505SerVal: 5.505 ± 0.678
0.905SerTrp: 0.905 ± 0.197
2.262SerTyr: 2.262 ± 0.466
0.0SerXaa: 0.0 ± 0.0
Thr
6.863ThrAla: 6.863 ± 0.682
0.452ThrCys: 0.452 ± 0.164
4.072ThrAsp: 4.072 ± 0.508
2.941ThrGlu: 2.941 ± 0.416
2.941ThrPhe: 2.941 ± 0.449
6.033ThrGly: 6.033 ± 0.812
1.433ThrHis: 1.433 ± 0.357
2.79ThrIle: 2.79 ± 0.471
2.866ThrLys: 2.866 ± 0.43
5.354ThrLeu: 5.354 ± 0.607
1.056ThrMet: 1.056 ± 0.324
1.81ThrAsn: 1.81 ± 0.308
3.922ThrPro: 3.922 ± 0.517
1.885ThrGln: 1.885 ± 0.304
2.941ThrArg: 2.941 ± 0.445
4.827ThrSer: 4.827 ± 0.518
3.544ThrThr: 3.544 ± 0.376
4.525ThrVal: 4.525 ± 0.7
0.905ThrTrp: 0.905 ± 0.266
2.187ThrTyr: 2.187 ± 0.48
0.0ThrXaa: 0.0 ± 0.0
Val
6.637ValAla: 6.637 ± 0.769
0.83ValCys: 0.83 ± 0.245
4.148ValAsp: 4.148 ± 0.527
6.109ValGlu: 6.109 ± 0.695
2.338ValPhe: 2.338 ± 0.384
4.223ValGly: 4.223 ± 0.406
0.754ValHis: 0.754 ± 0.165
4.223ValIle: 4.223 ± 0.534
4.751ValLys: 4.751 ± 0.669
4.525ValLeu: 4.525 ± 0.598
1.357ValMet: 1.357 ± 0.277
3.394ValAsn: 3.394 ± 0.48
2.489ValPro: 2.489 ± 0.601
2.413ValGln: 2.413 ± 0.421
3.62ValArg: 3.62 ± 0.477
6.109ValSer: 6.109 ± 0.784
6.486ValThr: 6.486 ± 0.776
5.732ValVal: 5.732 ± 0.89
1.056ValTrp: 1.056 ± 0.261
2.79ValTyr: 2.79 ± 0.443
0.0ValXaa: 0.0 ± 0.0
Trp
1.207TrpAla: 1.207 ± 0.473
0.075TrpCys: 0.075 ± 0.08
1.056TrpAsp: 1.056 ± 0.283
0.377TrpGlu: 0.377 ± 0.159
0.754TrpPhe: 0.754 ± 0.241
0.98TrpGly: 0.98 ± 0.213
0.302TrpHis: 0.302 ± 0.178
0.679TrpIle: 0.679 ± 0.203
0.679TrpLys: 0.679 ± 0.292
1.885TrpLeu: 1.885 ± 0.374
0.528TrpMet: 0.528 ± 0.219
0.679TrpAsn: 0.679 ± 0.195
0.377TrpPro: 0.377 ± 0.22
0.679TrpGln: 0.679 ± 0.203
1.056TrpArg: 1.056 ± 0.364
0.679TrpSer: 0.679 ± 0.201
0.754TrpThr: 0.754 ± 0.204
1.207TrpVal: 1.207 ± 0.237
0.151TrpTrp: 0.151 ± 0.102
0.302TrpTyr: 0.302 ± 0.174
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.866TyrAla: 2.866 ± 0.454
0.603TyrCys: 0.603 ± 0.21
2.036TyrAsp: 2.036 ± 0.474
2.715TyrGlu: 2.715 ± 0.506
1.282TyrPhe: 1.282 ± 0.379
2.715TyrGly: 2.715 ± 0.396
0.302TyrHis: 0.302 ± 0.127
1.584TyrIle: 1.584 ± 0.279
2.338TyrLys: 2.338 ± 0.46
2.187TyrLeu: 2.187 ± 0.425
0.754TyrMet: 0.754 ± 0.212
1.357TyrAsn: 1.357 ± 0.321
1.282TyrPro: 1.282 ± 0.385
1.357TyrGln: 1.357 ± 0.276
2.187TyrArg: 2.187 ± 0.51
1.961TyrSer: 1.961 ± 0.466
2.413TyrThr: 2.413 ± 0.345
2.036TyrVal: 2.036 ± 0.339
0.075TyrTrp: 0.075 ± 0.08
1.433TyrTyr: 1.433 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (13261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski