Amino acid dipepetide frequency for Roseibium hamelinense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.149AlaAla: 14.149 ± 0.14
1.064AlaCys: 1.064 ± 0.027
6.647AlaAsp: 6.647 ± 0.084
7.243AlaGlu: 7.243 ± 0.08
4.651AlaPhe: 4.651 ± 0.058
9.62AlaGly: 9.62 ± 0.093
2.111AlaHis: 2.111 ± 0.044
5.929AlaIle: 5.929 ± 0.074
4.278AlaLys: 4.278 ± 0.068
11.977AlaLeu: 11.977 ± 0.116
3.122AlaMet: 3.122 ± 0.049
3.171AlaAsn: 3.171 ± 0.051
4.86AlaPro: 4.86 ± 0.063
3.818AlaGln: 3.818 ± 0.047
6.76AlaArg: 6.76 ± 0.079
6.469AlaSer: 6.469 ± 0.078
5.263AlaThr: 5.263 ± 0.069
8.037AlaVal: 8.037 ± 0.092
1.213AlaTrp: 1.213 ± 0.033
2.612AlaTyr: 2.612 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.995CysAla: 0.995 ± 0.028
0.128CysCys: 0.128 ± 0.011
0.579CysAsp: 0.579 ± 0.022
0.446CysGlu: 0.446 ± 0.02
0.378CysPhe: 0.378 ± 0.018
0.918CysGly: 0.918 ± 0.027
0.235CysHis: 0.235 ± 0.013
0.412CysIle: 0.412 ± 0.015
0.26CysLys: 0.26 ± 0.013
0.94CysLeu: 0.94 ± 0.029
0.189CysMet: 0.189 ± 0.012
0.229CysAsn: 0.229 ± 0.013
0.436CysPro: 0.436 ± 0.018
0.271CysGln: 0.271 ± 0.014
0.57CysArg: 0.57 ± 0.021
0.528CysSer: 0.528 ± 0.021
0.408CysThr: 0.408 ± 0.018
0.642CysVal: 0.642 ± 0.025
0.114CysTrp: 0.114 ± 0.01
0.208CysTyr: 0.208 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.399AspAla: 6.399 ± 0.073
0.495AspCys: 0.495 ± 0.02
3.299AspAsp: 3.299 ± 0.063
3.593AspGlu: 3.593 ± 0.06
2.379AspPhe: 2.379 ± 0.043
5.38AspGly: 5.38 ± 0.091
1.298AspHis: 1.298 ± 0.031
3.548AspIle: 3.548 ± 0.045
2.107AspLys: 2.107 ± 0.042
6.602AspLeu: 6.602 ± 0.074
1.564AspMet: 1.564 ± 0.031
1.564AspAsn: 1.564 ± 0.04
3.448AspPro: 3.448 ± 0.059
2.083AspGln: 2.083 ± 0.046
4.089AspArg: 4.089 ± 0.056
2.312AspSer: 2.312 ± 0.046
3.204AspThr: 3.204 ± 0.062
4.294AspVal: 4.294 ± 0.057
0.94AspTrp: 0.94 ± 0.028
1.57AspTyr: 1.57 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.259GluAla: 7.259 ± 0.086
0.34GluCys: 0.34 ± 0.016
3.574GluAsp: 3.574 ± 0.055
3.538GluGlu: 3.538 ± 0.054
2.025GluPhe: 2.025 ± 0.038
4.09GluGly: 4.09 ± 0.06
1.247GluHis: 1.247 ± 0.031
3.845GluIle: 3.845 ± 0.057
2.824GluLys: 2.824 ± 0.055
5.683GluLeu: 5.683 ± 0.076
1.538GluMet: 1.538 ± 0.036
2.254GluAsn: 2.254 ± 0.046
2.685GluPro: 2.685 ± 0.051
2.304GluGln: 2.304 ± 0.049
4.336GluArg: 4.336 ± 0.064
2.429GluSer: 2.429 ± 0.04
4.34GluThr: 4.34 ± 0.055
4.018GluVal: 4.018 ± 0.055
0.622GluTrp: 0.622 ± 0.024
1.078GluTyr: 1.078 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.475PheAla: 4.475 ± 0.066
0.454PheCys: 0.454 ± 0.017
2.825PheAsp: 2.825 ± 0.048
2.612PheGlu: 2.612 ± 0.046
1.673PhePhe: 1.673 ± 0.038
3.78PheGly: 3.78 ± 0.061
0.746PheHis: 0.746 ± 0.024
1.797PheIle: 1.797 ± 0.039
1.478PheLys: 1.478 ± 0.037
3.838PheLeu: 3.838 ± 0.059
0.943PheMet: 0.943 ± 0.026
1.24PheAsn: 1.24 ± 0.031
1.625PhePro: 1.625 ± 0.034
1.276PheGln: 1.276 ± 0.032
2.074PheArg: 2.074 ± 0.039
2.66PheSer: 2.66 ± 0.047
2.049PheThr: 2.049 ± 0.04
3.013PheVal: 3.013 ± 0.051
0.591PheTrp: 0.591 ± 0.021
1.002PheTyr: 1.002 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.481GlyAla: 8.481 ± 0.086
0.878GlyCys: 0.878 ± 0.028
4.426GlyAsp: 4.426 ± 0.068
4.558GlyGlu: 4.558 ± 0.063
3.779GlyPhe: 3.779 ± 0.057
6.816GlyGly: 6.816 ± 0.115
1.932GlyHis: 1.932 ± 0.041
4.54GlyIle: 4.54 ± 0.064
3.414GlyLys: 3.414 ± 0.053
8.853GlyLeu: 8.853 ± 0.089
2.208GlyMet: 2.208 ± 0.046
2.47GlyAsn: 2.47 ± 0.057
3.3GlyPro: 3.3 ± 0.059
2.951GlyGln: 2.951 ± 0.055
4.959GlyArg: 4.959 ± 0.063
4.901GlySer: 4.901 ± 0.073
4.812GlyThr: 4.812 ± 0.074
5.826GlyVal: 5.826 ± 0.063
1.25GlyTrp: 1.25 ± 0.03
2.366GlyTyr: 2.366 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.113HisAla: 2.113 ± 0.04
0.236HisCys: 0.236 ± 0.014
1.195HisAsp: 1.195 ± 0.031
1.076HisGlu: 1.076 ± 0.027
0.895HisPhe: 0.895 ± 0.026
1.837HisGly: 1.837 ± 0.035
0.578HisHis: 0.578 ± 0.026
1.015HisIle: 1.015 ± 0.029
0.678HisLys: 0.678 ± 0.025
2.054HisLeu: 2.054 ± 0.04
0.517HisMet: 0.517 ± 0.02
0.519HisAsn: 0.519 ± 0.019
1.252HisPro: 1.252 ± 0.033
0.724HisGln: 0.724 ± 0.024
1.225HisArg: 1.225 ± 0.032
0.975HisSer: 0.975 ± 0.029
0.943HisThr: 0.943 ± 0.027
1.44HisVal: 1.44 ± 0.032
0.281HisTrp: 0.281 ± 0.014
0.515HisTyr: 0.515 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.753IleAla: 6.753 ± 0.075
0.604IleCys: 0.604 ± 0.021
3.731IleAsp: 3.731 ± 0.057
3.66IleGlu: 3.66 ± 0.056
1.829IlePhe: 1.829 ± 0.039
5.057IleGly: 5.057 ± 0.063
0.903IleHis: 0.903 ± 0.029
2.358IleIle: 2.358 ± 0.044
1.817IleLys: 1.817 ± 0.041
4.956IleLeu: 4.956 ± 0.074
1.116IleMet: 1.116 ± 0.032
1.63IleAsn: 1.63 ± 0.037
2.392IlePro: 2.392 ± 0.041
1.497IleGln: 1.497 ± 0.034
3.124IleArg: 3.124 ± 0.04
3.568IleSer: 3.568 ± 0.054
2.847IleThr: 2.847 ± 0.058
4.103IleVal: 4.103 ± 0.056
0.686IleTrp: 0.686 ± 0.023
1.24IleTyr: 1.24 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.639LysAla: 4.639 ± 0.066
0.234LysCys: 0.234 ± 0.012
2.31LysAsp: 2.31 ± 0.044
1.954LysGlu: 1.954 ± 0.041
1.103LysPhe: 1.103 ± 0.03
2.704LysGly: 2.704 ± 0.046
0.805LysHis: 0.805 ± 0.026
2.226LysIle: 2.226 ± 0.04
1.773LysLys: 1.773 ± 0.048
3.755LysLeu: 3.755 ± 0.059
0.903LysMet: 0.903 ± 0.028
1.32LysAsn: 1.32 ± 0.035
2.203LysPro: 2.203 ± 0.043
1.343LysGln: 1.343 ± 0.03
2.648LysArg: 2.648 ± 0.047
2.444LysSer: 2.444 ± 0.046
2.67LysThr: 2.67 ± 0.046
2.764LysVal: 2.764 ± 0.054
0.397LysTrp: 0.397 ± 0.016
0.776LysTyr: 0.776 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
11.738LeuAla: 11.738 ± 0.114
0.95LeuCys: 0.95 ± 0.027
6.071LeuAsp: 6.071 ± 0.072
6.151LeuGlu: 6.151 ± 0.075
3.838LeuPhe: 3.838 ± 0.066
7.833LeuGly: 7.833 ± 0.079
1.711LeuHis: 1.711 ± 0.036
5.283LeuIle: 5.283 ± 0.067
4.531LeuLys: 4.531 ± 0.057
8.962LeuLeu: 8.962 ± 0.116
2.301LeuMet: 2.301 ± 0.045
3.202LeuAsn: 3.202 ± 0.049
5.285LeuPro: 5.285 ± 0.07
3.095LeuGln: 3.095 ± 0.047
5.701LeuArg: 5.701 ± 0.074
7.344LeuSer: 7.344 ± 0.09
5.679LeuThr: 5.679 ± 0.069
7.193LeuVal: 7.193 ± 0.093
1.028LeuTrp: 1.028 ± 0.028
2.17LeuTyr: 2.17 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.881MetAla: 2.881 ± 0.045
0.184MetCys: 0.184 ± 0.012
1.272MetAsp: 1.272 ± 0.033
1.2MetGlu: 1.2 ± 0.036
0.752MetPhe: 0.752 ± 0.024
1.782MetGly: 1.782 ± 0.04
0.438MetHis: 0.438 ± 0.018
1.436MetIle: 1.436 ± 0.034
1.056MetLys: 1.056 ± 0.029
2.344MetLeu: 2.344 ± 0.044
0.682MetMet: 0.682 ± 0.025
0.853MetAsn: 0.853 ± 0.028
1.474MetPro: 1.474 ± 0.034
0.844MetGln: 0.844 ± 0.024
1.63MetArg: 1.63 ± 0.034
1.817MetSer: 1.817 ± 0.038
1.896MetThr: 1.896 ± 0.04
1.7MetVal: 1.7 ± 0.038
0.214MetTrp: 0.214 ± 0.013
0.336MetTyr: 0.336 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.468AsnAla: 3.468 ± 0.055
0.259AsnCys: 0.259 ± 0.014
1.802AsnAsp: 1.802 ± 0.04
1.663AsnGlu: 1.663 ± 0.04
1.078AsnPhe: 1.078 ± 0.026
2.801AsnGly: 2.801 ± 0.05
0.58AsnHis: 0.58 ± 0.023
1.617AsnIle: 1.617 ± 0.032
1.023AsnLys: 1.023 ± 0.03
2.859AsnLeu: 2.859 ± 0.044
0.783AsnMet: 0.783 ± 0.026
0.933AsnAsn: 0.933 ± 0.031
1.952AsnPro: 1.952 ± 0.034
1.064AsnGln: 1.064 ± 0.027
1.955AsnArg: 1.955 ± 0.042
1.586AsnSer: 1.586 ± 0.04
1.731AsnThr: 1.731 ± 0.039
2.151AsnVal: 2.151 ± 0.043
0.468AsnTrp: 0.468 ± 0.019
0.772AsnTyr: 0.772 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.347ProAla: 5.347 ± 0.064
0.299ProCys: 0.299 ± 0.016
3.896ProAsp: 3.896 ± 0.056
3.808ProGlu: 3.808 ± 0.055
2.076ProPhe: 2.076 ± 0.044
4.063ProGly: 4.063 ± 0.057
1.001ProHis: 1.001 ± 0.027
2.327ProIle: 2.327 ± 0.041
1.926ProLys: 1.926 ± 0.04
4.371ProLeu: 4.371 ± 0.057
1.093ProMet: 1.093 ± 0.031
1.528ProAsn: 1.528 ± 0.034
2.108ProPro: 2.108 ± 0.054
1.635ProGln: 1.635 ± 0.037
2.309ProArg: 2.309 ± 0.044
2.747ProSer: 2.747 ± 0.039
2.187ProThr: 2.187 ± 0.037
4.278ProVal: 4.278 ± 0.061
0.572ProTrp: 0.572 ± 0.021
1.173ProTyr: 1.173 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.916GlnAla: 3.916 ± 0.06
0.201GlnCys: 0.201 ± 0.012
1.912GlnAsp: 1.912 ± 0.038
1.818GlnGlu: 1.818 ± 0.034
1.193GlnPhe: 1.193 ± 0.03
2.32GlnGly: 2.32 ± 0.041
0.67GlnHis: 0.67 ± 0.023
2.155GlnIle: 2.155 ± 0.041
1.495GlnLys: 1.495 ± 0.036
3.043GlnLeu: 3.043 ± 0.051
0.963GlnMet: 0.963 ± 0.025
1.245GlnAsn: 1.245 ± 0.028
1.654GlnPro: 1.654 ± 0.04
1.344GlnGln: 1.344 ± 0.041
2.252GlnArg: 2.252 ± 0.049
2.187GlnSer: 2.187 ± 0.041
2.27GlnThr: 2.27 ± 0.044
2.351GlnVal: 2.351 ± 0.038
0.328GlnTrp: 0.328 ± 0.016
0.632GlnTyr: 0.632 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.2ArgAla: 6.2 ± 0.075
0.469ArgCys: 0.469 ± 0.019
3.491ArgAsp: 3.491 ± 0.06
3.617ArgGlu: 3.617 ± 0.048
2.748ArgPhe: 2.748 ± 0.046
4.018ArgGly: 4.018 ± 0.061
1.395ArgHis: 1.395 ± 0.034
3.608ArgIle: 3.608 ± 0.048
2.563ArgLys: 2.563 ± 0.043
6.886ArgLeu: 6.886 ± 0.09
1.622ArgMet: 1.622 ± 0.036
1.784ArgAsn: 1.784 ± 0.038
2.988ArgPro: 2.988 ± 0.054
2.443ArgGln: 2.443 ± 0.046
4.203ArgArg: 4.203 ± 0.064
3.589ArgSer: 3.589 ± 0.053
3.064ArgThr: 3.064 ± 0.05
4.02ArgVal: 4.02 ± 0.059
0.758ArgTrp: 0.758 ± 0.025
1.483ArgTyr: 1.483 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.711SerAla: 6.711 ± 0.09
0.496SerCys: 0.496 ± 0.021
3.711SerAsp: 3.711 ± 0.061
3.622SerGlu: 3.622 ± 0.062
2.574SerPhe: 2.574 ± 0.04
6.048SerGly: 6.048 ± 0.083
1.16SerHis: 1.16 ± 0.031
3.03SerIle: 3.03 ± 0.055
2.233SerLys: 2.233 ± 0.047
5.772SerLeu: 5.772 ± 0.064
1.411SerMet: 1.411 ± 0.032
1.813SerAsn: 1.813 ± 0.041
2.579SerPro: 2.579 ± 0.041
1.964SerGln: 1.964 ± 0.041
3.336SerArg: 3.336 ± 0.05
3.566SerSer: 3.566 ± 0.066
2.876SerThr: 2.876 ± 0.055
4.49SerVal: 4.49 ± 0.054
0.821SerTrp: 0.821 ± 0.027
1.366SerTyr: 1.366 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.177ThrAla: 6.177 ± 0.073
0.487ThrCys: 0.487 ± 0.018
3.178ThrAsp: 3.178 ± 0.062
3.071ThrGlu: 3.071 ± 0.051
2.212ThrPhe: 2.212 ± 0.04
5.509ThrGly: 5.509 ± 0.071
1.067ThrHis: 1.067 ± 0.029
2.957ThrIle: 2.957 ± 0.048
1.787ThrLys: 1.787 ± 0.034
5.753ThrLeu: 5.753 ± 0.06
1.164ThrMet: 1.164 ± 0.031
1.607ThrAsn: 1.607 ± 0.039
3.069ThrPro: 3.069 ± 0.051
1.634ThrGln: 1.634 ± 0.035
3.083ThrArg: 3.083 ± 0.045
3.188ThrSer: 3.188 ± 0.05
2.854ThrThr: 2.854 ± 0.047
4.459ThrVal: 4.459 ± 0.069
0.684ThrTrp: 0.684 ± 0.023
1.373ThrTyr: 1.373 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
7.768ValAla: 7.768 ± 0.092
0.691ValCys: 0.691 ± 0.025
4.106ValAsp: 4.106 ± 0.054
4.444ValGlu: 4.444 ± 0.053
3.354ValPhe: 3.354 ± 0.053
5.2ValGly: 5.2 ± 0.069
1.371ValHis: 1.371 ± 0.034
4.103ValIle: 4.103 ± 0.058
2.498ValLys: 2.498 ± 0.049
7.639ValLeu: 7.639 ± 0.087
1.844ValMet: 1.844 ± 0.039
2.102ValAsn: 2.102 ± 0.043
3.666ValPro: 3.666 ± 0.055
2.192ValGln: 2.192 ± 0.044
4.201ValArg: 4.201 ± 0.06
5.116ValSer: 5.116 ± 0.067
4.312ValThr: 4.312 ± 0.068
5.507ValVal: 5.507 ± 0.084
0.858ValTrp: 0.858 ± 0.026
1.627ValTyr: 1.627 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.13TrpAla: 1.13 ± 0.03
0.149TrpCys: 0.149 ± 0.011
0.642TrpAsp: 0.642 ± 0.022
0.54TrpGlu: 0.54 ± 0.02
0.563TrpPhe: 0.563 ± 0.021
0.84TrpGly: 0.84 ± 0.024
0.306TrpHis: 0.306 ± 0.015
0.658TrpIle: 0.658 ± 0.023
0.443TrpLys: 0.443 ± 0.019
1.416TrpLeu: 1.416 ± 0.036
0.336TrpMet: 0.336 ± 0.017
0.431TrpAsn: 0.431 ± 0.018
0.642TrpPro: 0.642 ± 0.022
0.595TrpGln: 0.595 ± 0.022
0.903TrpArg: 0.903 ± 0.027
0.811TrpSer: 0.811 ± 0.026
0.744TrpThr: 0.744 ± 0.021
0.757TrpVal: 0.757 ± 0.026
0.197TrpTrp: 0.197 ± 0.012
0.286TrpTyr: 0.286 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.048
0.269TyrCys: 0.269 ± 0.014
1.5TyrAsp: 1.5 ± 0.033
1.415TyrGlu: 1.415 ± 0.039
1.05TyrPhe: 1.05 ± 0.03
2.102TyrGly: 2.102 ± 0.044
0.515TyrHis: 0.515 ± 0.021
1.025TyrIle: 1.025 ± 0.028
0.786TyrLys: 0.786 ± 0.025
2.364TyrLeu: 2.364 ± 0.045
0.492TyrMet: 0.492 ± 0.017
0.653TyrAsn: 0.653 ± 0.025
1.128TyrPro: 1.128 ± 0.03
0.87TyrGln: 0.87 ± 0.024
1.592TyrArg: 1.592 ± 0.033
1.343TyrSer: 1.343 ± 0.03
1.165TyrThr: 1.165 ± 0.029
1.556TyrVal: 1.556 ± 0.041
0.368TyrTrp: 0.368 ± 0.017
0.633TyrTyr: 0.633 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4355 proteins (1400321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski