Amino acid dipepetide frequency for Neolecta irregularis (strain DAH-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.142AlaAla: 6.142 ± 0.073	1.039AlaCys: 1.039 ± 0.024	3.417AlaAsp: 3.417 ± 0.04	4.238AlaGlu: 4.238 ± 0.045	2.988AlaPhe: 2.988 ± 0.039	4.051AlaGly: 4.051 ± 0.05	1.549AlaHis: 1.549 ± 0.029	4.605AlaIle: 4.605 ± 0.05	4.052AlaLys: 4.052 ± 0.051	7.153AlaLeu: 7.153 ± 0.066	1.643AlaMet: 1.643 ± 0.028	2.758AlaAsn: 2.758 ± 0.035	3.119AlaPro: 3.119 ± 0.049	2.85AlaGln: 2.85 ± 0.037	4.106AlaArg: 4.106 ± 0.04	5.775AlaSer: 5.775 ± 0.058	3.867AlaThr: 3.867 ± 0.046	4.377AlaVal: 4.377 ± 0.049	0.829AlaTrp: 0.829 ± 0.019	1.922AlaTyr: 1.922 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.021	0.244CysCys: 0.244 ± 0.013	0.708CysAsp: 0.708 ± 0.02	0.732CysGlu: 0.732 ± 0.017	0.638CysPhe: 0.638 ± 0.017	0.982CysGly: 0.982 ± 0.023	0.394CysHis: 0.394 ± 0.014	0.93CysIle: 0.93 ± 0.021	0.716CysLys: 0.716 ± 0.022	1.546CysLeu: 1.546 ± 0.027	0.279CysMet: 0.279 ± 0.012	0.529CysAsn: 0.529 ± 0.018	0.735CysPro: 0.735 ± 0.02	0.534CysGln: 0.534 ± 0.017	0.819CysArg: 0.819 ± 0.019	1.19CysSer: 1.19 ± 0.022	0.774CysThr: 0.774 ± 0.017	0.836CysVal: 0.836 ± 0.018	0.178CysTrp: 0.178 ± 0.008	0.41CysTyr: 0.41 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.597AspAla: 3.597 ± 0.041	0.735AspCys: 0.735 ± 0.022	3.807AspAsp: 3.807 ± 0.055	4.158AspGlu: 4.158 ± 0.051	2.479AspPhe: 2.479 ± 0.036	3.239AspGly: 3.239 ± 0.035	1.356AspHis: 1.356 ± 0.023	4.126AspIle: 4.126 ± 0.047	2.653AspLys: 2.653 ± 0.041	5.649AspLeu: 5.649 ± 0.053	1.18AspMet: 1.18 ± 0.025	2.039AspAsn: 2.039 ± 0.027	2.932AspPro: 2.932 ± 0.037	2.111AspGln: 2.111 ± 0.031	3.0AspArg: 3.0 ± 0.041	4.356AspSer: 4.356 ± 0.052	2.778AspThr: 2.778 ± 0.033	3.45AspVal: 3.45 ± 0.041	0.749AspTrp: 0.749 ± 0.019	1.676AspTyr: 1.676 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.213GluAla: 4.213 ± 0.047	0.745GluCys: 0.745 ± 0.02	3.866GluAsp: 3.866 ± 0.045	5.137GluGlu: 5.137 ± 0.074	2.49GluPhe: 2.49 ± 0.032	3.096GluGly: 3.096 ± 0.038	1.349GluHis: 1.349 ± 0.025	4.516GluIle: 4.516 ± 0.049	4.446GluLys: 4.446 ± 0.05	5.679GluLeu: 5.679 ± 0.056	1.65GluMet: 1.65 ± 0.028	3.004GluAsn: 3.004 ± 0.04	2.228GluPro: 2.228 ± 0.033	2.588GluGln: 2.588 ± 0.038	3.824GluArg: 3.824 ± 0.05	4.682GluSer: 4.682 ± 0.052	3.572GluThr: 3.572 ± 0.044	3.118GluVal: 3.118 ± 0.038	0.802GluTrp: 0.802 ± 0.017	1.955GluTyr: 1.955 ± 0.032	0.001GluXaa: 0.001 ± 0.001
Phe	3.02PheAla: 3.02 ± 0.036	0.679PheCys: 0.679 ± 0.017	2.569PheAsp: 2.569 ± 0.039	2.71PheGlu: 2.71 ± 0.032	1.72PhePhe: 1.72 ± 0.028	2.679PheGly: 2.679 ± 0.04	1.03PheHis: 1.03 ± 0.019	2.398PheIle: 2.398 ± 0.038	1.987PheLys: 1.987 ± 0.031	3.999PheLeu: 3.999 ± 0.048	0.83PheMet: 0.83 ± 0.019	1.7PheAsn: 1.7 ± 0.024	2.05PhePro: 2.05 ± 0.032	1.652PheGln: 1.652 ± 0.025	2.176PheArg: 2.176 ± 0.035	3.592PheSer: 3.592 ± 0.044	2.285PheThr: 2.285 ± 0.035	2.596PheVal: 2.596 ± 0.038	0.584PheTrp: 0.584 ± 0.018	1.255PheTyr: 1.255 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	3.377GlyAla: 3.377 ± 0.044	0.886GlyCys: 0.886 ± 0.021	3.036GlyAsp: 3.036 ± 0.039	3.094GlyGlu: 3.094 ± 0.045	2.589GlyPhe: 2.589 ± 0.036	3.739GlyGly: 3.739 ± 0.065	1.433GlyHis: 1.433 ± 0.027	3.904GlyIle: 3.904 ± 0.048	3.573GlyLys: 3.573 ± 0.041	5.339GlyLeu: 5.339 ± 0.047	1.349GlyMet: 1.349 ± 0.026	2.427GlyAsn: 2.427 ± 0.036	2.227GlyPro: 2.227 ± 0.033	2.114GlyGln: 2.114 ± 0.031	3.303GlyArg: 3.303 ± 0.042	4.557GlySer: 4.557 ± 0.054	3.141GlyThr: 3.141 ± 0.044	3.391GlyVal: 3.391 ± 0.049	0.783GlyTrp: 0.783 ± 0.019	1.941GlyTyr: 1.941 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	1.587HisAla: 1.587 ± 0.03	0.366HisCys: 0.366 ± 0.012	1.291HisAsp: 1.291 ± 0.024	1.332HisGlu: 1.332 ± 0.024	1.067HisPhe: 1.067 ± 0.021	1.375HisGly: 1.375 ± 0.026	0.81HisHis: 0.81 ± 0.021	1.624HisIle: 1.624 ± 0.027	1.157HisLys: 1.157 ± 0.023	2.598HisLeu: 2.598 ± 0.035	0.466HisMet: 0.466 ± 0.013	0.914HisAsn: 0.914 ± 0.021	1.629HisPro: 1.629 ± 0.032	1.042HisGln: 1.042 ± 0.021	1.5HisArg: 1.5 ± 0.029	2.09HisSer: 2.09 ± 0.035	1.272HisThr: 1.272 ± 0.024	1.41HisVal: 1.41 ± 0.023	0.292HisTrp: 0.292 ± 0.012	0.726HisTyr: 0.726 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.689IleAla: 4.689 ± 0.045	1.003IleCys: 1.003 ± 0.025	3.755IleAsp: 3.755 ± 0.043	3.959IleGlu: 3.959 ± 0.042	2.614IlePhe: 2.614 ± 0.04	3.398IleGly: 3.398 ± 0.044	1.603IleHis: 1.603 ± 0.03	3.648IleIle: 3.648 ± 0.048	3.359IleLys: 3.359 ± 0.047	6.197IleLeu: 6.197 ± 0.059	1.213IleMet: 1.213 ± 0.023	2.498IleAsn: 2.498 ± 0.035	3.624IlePro: 3.624 ± 0.041	2.615IleGln: 2.615 ± 0.034	3.514IleArg: 3.514 ± 0.039	5.594IleSer: 5.594 ± 0.061	3.462IleThr: 3.462 ± 0.04	3.815IleVal: 3.815 ± 0.045	0.799IleTrp: 0.799 ± 0.021	1.892IleTyr: 1.892 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.085LysAla: 4.085 ± 0.042	0.737LysCys: 0.737 ± 0.019	3.2LysAsp: 3.2 ± 0.039	3.905LysGlu: 3.905 ± 0.047	2.128LysPhe: 2.128 ± 0.03	2.839LysGly: 2.839 ± 0.04	1.355LysHis: 1.355 ± 0.025	3.778LysIle: 3.778 ± 0.045	4.117LysLys: 4.117 ± 0.061	5.144LysLeu: 5.144 ± 0.05	1.245LysMet: 1.245 ± 0.023	2.489LysAsn: 2.489 ± 0.036	2.669LysPro: 2.669 ± 0.036	2.171LysGln: 2.171 ± 0.032	3.828LysArg: 3.828 ± 0.047	4.726LysSer: 4.726 ± 0.047	3.377LysThr: 3.377 ± 0.046	3.309LysVal: 3.309 ± 0.04	0.683LysTrp: 0.683 ± 0.018	1.749LysTyr: 1.749 ± 0.025	0.001LysXaa: 0.001 ± 0.001
Leu	7.263LeuAla: 7.263 ± 0.064	1.49LeuCys: 1.49 ± 0.025	5.682LeuAsp: 5.682 ± 0.052	6.437LeuGlu: 6.437 ± 0.074	3.907LeuPhe: 3.907 ± 0.05	5.476LeuGly: 5.476 ± 0.05	2.524LeuHis: 2.524 ± 0.035	4.998LeuIle: 4.998 ± 0.049	5.652LeuLys: 5.652 ± 0.049	9.555LeuLeu: 9.555 ± 0.092	1.739LeuMet: 1.739 ± 0.029	3.927LeuAsn: 3.927 ± 0.042	5.216LeuPro: 5.216 ± 0.053	4.383LeuGln: 4.383 ± 0.05	5.8LeuArg: 5.8 ± 0.061	8.471LeuSer: 8.471 ± 0.069	4.826LeuThr: 4.826 ± 0.04	5.827LeuVal: 5.827 ± 0.059	1.093LeuTrp: 1.093 ± 0.021	2.681LeuTyr: 2.681 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.629MetAla: 1.629 ± 0.025	0.241MetCys: 0.241 ± 0.009	1.248MetAsp: 1.248 ± 0.025	1.275MetGlu: 1.275 ± 0.023	0.83MetPhe: 0.83 ± 0.022	1.212MetGly: 1.212 ± 0.026	0.448MetHis: 0.448 ± 0.013	1.272MetIle: 1.272 ± 0.023	1.31MetLys: 1.31 ± 0.028	1.907MetLeu: 1.907 ± 0.028	0.552MetMet: 0.552 ± 0.017	1.008MetAsn: 1.008 ± 0.019	1.066MetPro: 1.066 ± 0.023	0.853MetGln: 0.853 ± 0.017	1.11MetArg: 1.11 ± 0.022	1.905MetSer: 1.905 ± 0.029	1.327MetThr: 1.327 ± 0.024	1.156MetVal: 1.156 ± 0.025	0.214MetTrp: 0.214 ± 0.01	0.522MetTyr: 0.522 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.922AsnAla: 2.922 ± 0.038	0.566AsnCys: 0.566 ± 0.018	2.256AsnAsp: 2.256 ± 0.033	2.522AsnGlu: 2.522 ± 0.033	1.642AsnPhe: 1.642 ± 0.026	2.562AsnGly: 2.562 ± 0.039	1.052AsnHis: 1.052 ± 0.022	2.976AsnIle: 2.976 ± 0.04	2.015AsnLys: 2.015 ± 0.033	4.196AsnLeu: 4.196 ± 0.053	0.882AsnMet: 0.882 ± 0.019	1.667AsnAsn: 1.667 ± 0.03	2.517AsnPro: 2.517 ± 0.031	1.629AsnGln: 1.629 ± 0.027	2.22AsnArg: 2.22 ± 0.034	3.346AsnSer: 3.346 ± 0.044	2.397AsnThr: 2.397 ± 0.039	2.52AsnVal: 2.52 ± 0.034	0.511AsnTrp: 0.511 ± 0.015	1.214AsnTyr: 1.214 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	3.617ProAla: 3.617 ± 0.049	0.606ProCys: 0.606 ± 0.019	2.78ProAsp: 2.78 ± 0.039	3.363ProGlu: 3.363 ± 0.043	2.131ProPhe: 2.131 ± 0.03	2.703ProGly: 2.703 ± 0.038	1.261ProHis: 1.261 ± 0.026	2.845ProIle: 2.845 ± 0.035	2.716ProLys: 2.716 ± 0.039	4.8ProLeu: 4.8 ± 0.051	0.877ProMet: 0.877 ± 0.021	2.097ProAsn: 2.097 ± 0.031	3.971ProPro: 3.971 ± 0.07	2.268ProGln: 2.268 ± 0.034	2.985ProArg: 2.985 ± 0.041	5.183ProSer: 5.183 ± 0.064	3.132ProThr: 3.132 ± 0.036	3.202ProVal: 3.202 ± 0.047	0.504ProTrp: 0.504 ± 0.016	1.349ProTyr: 1.349 ± 0.025	0.001ProXaa: 0.001 ± 0.001
Gln	2.813GlnAla: 2.813 ± 0.039	0.504GlnCys: 0.504 ± 0.016	2.251GlnAsp: 2.251 ± 0.037	2.478GlnGlu: 2.478 ± 0.038	1.57GlnPhe: 1.57 ± 0.028	2.041GlnGly: 2.041 ± 0.031	1.055GlnHis: 1.055 ± 0.023	2.755GlnIle: 2.755 ± 0.033	2.567GlnLys: 2.567 ± 0.032	3.835GlnLeu: 3.835 ± 0.04	0.907GlnMet: 0.907 ± 0.021	1.919GlnAsn: 1.919 ± 0.029	1.946GlnPro: 1.946 ± 0.034	2.174GlnGln: 2.174 ± 0.06	2.447GlnArg: 2.447 ± 0.039	3.407GlnSer: 3.407 ± 0.045	2.446GlnThr: 2.446 ± 0.033	2.42GlnVal: 2.42 ± 0.03	0.466GlnTrp: 0.466 ± 0.013	1.224GlnTyr: 1.224 ± 0.021	0.001GlnXaa: 0.001 ± 0.001
Arg	3.781ArgAla: 3.781 ± 0.047	0.744ArgCys: 0.744 ± 0.018	3.173ArgAsp: 3.173 ± 0.039	3.703ArgGlu: 3.703 ± 0.051	2.311ArgPhe: 2.311 ± 0.037	3.017ArgGly: 3.017 ± 0.044	1.51ArgHis: 1.51 ± 0.026	3.666ArgIle: 3.666 ± 0.035	4.115ArgLys: 4.115 ± 0.051	5.688ArgLeu: 5.688 ± 0.05	1.281ArgMet: 1.281 ± 0.023	2.662ArgAsn: 2.662 ± 0.036	2.928ArgPro: 2.928 ± 0.04	2.485ArgGln: 2.485 ± 0.035	4.299ArgArg: 4.299 ± 0.063	4.488ArgSer: 4.488 ± 0.059	3.062ArgThr: 3.062 ± 0.041	3.196ArgVal: 3.196 ± 0.036	0.699ArgTrp: 0.699 ± 0.018	1.768ArgTyr: 1.768 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.645SerAla: 5.645 ± 0.053	1.099SerCys: 1.099 ± 0.024	4.266SerAsp: 4.266 ± 0.047	4.543SerGlu: 4.543 ± 0.051	3.573SerPhe: 3.573 ± 0.042	4.708SerGly: 4.708 ± 0.054	2.136SerHis: 2.136 ± 0.036	5.149SerIle: 5.149 ± 0.052	4.649SerLys: 4.649 ± 0.053	8.378SerLeu: 8.378 ± 0.063	1.677SerMet: 1.677 ± 0.028	3.552SerAsn: 3.552 ± 0.039	5.144SerPro: 5.144 ± 0.075	3.55SerGln: 3.55 ± 0.045	5.076SerArg: 5.076 ± 0.05	8.921SerSer: 8.921 ± 0.089	5.415SerThr: 5.415 ± 0.063	4.619SerVal: 4.619 ± 0.048	0.985SerTrp: 0.985 ± 0.023	2.214SerTyr: 2.214 ± 0.036	0.001SerXaa: 0.001 ± 0.001
Thr	4.155ThrAla: 4.155 ± 0.046	0.885ThrCys: 0.885 ± 0.025	2.75ThrAsp: 2.75 ± 0.034	3.158ThrGlu: 3.158 ± 0.038	2.477ThrPhe: 2.477 ± 0.028	3.398ThrGly: 3.398 ± 0.041	1.268ThrHis: 1.268 ± 0.022	3.674ThrIle: 3.674 ± 0.045	2.931ThrLys: 2.931 ± 0.033	5.428ThrLeu: 5.428 ± 0.051	1.151ThrMet: 1.151 ± 0.024	2.234ThrAsn: 2.234 ± 0.033	3.566ThrPro: 3.566 ± 0.046	2.088ThrGln: 2.088 ± 0.03	3.017ThrArg: 3.017 ± 0.033	4.92ThrSer: 4.92 ± 0.06	3.607ThrThr: 3.607 ± 0.047	3.376ThrVal: 3.376 ± 0.043	0.652ThrTrp: 0.652 ± 0.017	1.421ThrTyr: 1.421 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	4.25ValAla: 4.25 ± 0.047	0.911ValCys: 0.911 ± 0.021	3.557ValAsp: 3.557 ± 0.039	3.846ValGlu: 3.846 ± 0.041	2.526ValPhe: 2.526 ± 0.035	3.265ValGly: 3.265 ± 0.049	1.361ValHis: 1.361 ± 0.024	3.673ValIle: 3.673 ± 0.043	3.274ValLys: 3.274 ± 0.038	5.763ValLeu: 5.763 ± 0.057	1.252ValMet: 1.252 ± 0.026	2.312ValAsn: 2.312 ± 0.032	2.951ValPro: 2.951 ± 0.036	2.457ValGln: 2.457 ± 0.038	3.142ValArg: 3.142 ± 0.042	4.802ValSer: 4.802 ± 0.049	3.052ValThr: 3.052 ± 0.042	3.977ValVal: 3.977 ± 0.052	0.733ValTrp: 0.733 ± 0.02	1.769ValTyr: 1.769 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.817TrpAla: 0.817 ± 0.023	0.163TrpCys: 0.163 ± 0.008	0.78TrpAsp: 0.78 ± 0.021	0.717TrpGlu: 0.717 ± 0.017	0.481TrpPhe: 0.481 ± 0.015	0.645TrpGly: 0.645 ± 0.016	0.277TrpHis: 0.277 ± 0.01	0.856TrpIle: 0.856 ± 0.021	0.859TrpLys: 0.859 ± 0.019	1.087TrpLeu: 1.087 ± 0.024	0.311TrpMet: 0.311 ± 0.012	0.66TrpAsn: 0.66 ± 0.019	0.412TrpPro: 0.412 ± 0.013	0.438TrpGln: 0.438 ± 0.014	0.74TrpArg: 0.74 ± 0.019	0.944TrpSer: 0.944 ± 0.019	0.732TrpThr: 0.732 ± 0.018	0.688TrpVal: 0.688 ± 0.017	0.193TrpTrp: 0.193 ± 0.011	0.337TrpTyr: 0.337 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.948TyrAla: 1.948 ± 0.032	0.467TyrCys: 0.467 ± 0.015	1.68TyrAsp: 1.68 ± 0.026	1.652TyrGlu: 1.652 ± 0.025	1.35TyrPhe: 1.35 ± 0.027	1.781TyrGly: 1.781 ± 0.031	0.776TyrHis: 0.776 ± 0.019	1.857TyrIle: 1.857 ± 0.026	1.386TyrLys: 1.386 ± 0.028	3.004TyrLeu: 3.004 ± 0.038	0.6TyrMet: 0.6 ± 0.02	1.215TyrAsn: 1.215 ± 0.023	1.46TyrPro: 1.46 ± 0.025	1.222TyrGln: 1.222 ± 0.022	1.671TyrArg: 1.671 ± 0.03	2.348TyrSer: 2.348 ± 0.034	1.631TyrThr: 1.631 ± 0.032	1.589TyrVal: 1.589 ± 0.027	0.386TyrTrp: 0.386 ± 0.013	0.963TyrTyr: 0.963 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.028XaaXaa: 0.028 ± 0.007

Statistics based on 5551 proteins (2315541 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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