Amino acid dipepetide frequency for Erwinia phage vB_EamM_EarlPhillipIV

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.457AlaAla: 8.457 ± 0.529
0.757AlaCys: 0.757 ± 0.112
4.867AlaAsp: 4.867 ± 0.289
4.474AlaGlu: 4.474 ± 0.25
3.352AlaPhe: 3.352 ± 0.208
5.287AlaGly: 5.287 ± 0.311
1.374AlaHis: 1.374 ± 0.146
5.091AlaIle: 5.091 ± 0.265
4.558AlaLys: 4.558 ± 0.32
7.728AlaLeu: 7.728 ± 0.334
2.665AlaMet: 2.665 ± 0.2
3.885AlaAsn: 3.885 ± 0.253
2.987AlaPro: 2.987 ± 0.216
3.198AlaGln: 3.198 ± 0.252
4.039AlaArg: 4.039 ± 0.264
4.362AlaSer: 4.362 ± 0.275
4.867AlaThr: 4.867 ± 0.36
5.68AlaVal: 5.68 ± 0.283
1.066AlaTrp: 1.066 ± 0.126
3.015AlaTyr: 3.015 ± 0.182
0.0AlaXaa: 0.0 ± 0.0
Cys
0.533CysAla: 0.533 ± 0.092
0.056CysCys: 0.056 ± 0.027
0.491CysAsp: 0.491 ± 0.07
0.533CysGlu: 0.533 ± 0.101
0.295CysPhe: 0.295 ± 0.067
0.617CysGly: 0.617 ± 0.09
0.182CysHis: 0.182 ± 0.054
0.533CysIle: 0.533 ± 0.083
0.393CysLys: 0.393 ± 0.067
0.645CysLeu: 0.645 ± 0.081
0.337CysMet: 0.337 ± 0.063
0.421CysAsn: 0.421 ± 0.099
0.379CysPro: 0.379 ± 0.081
0.351CysGln: 0.351 ± 0.076
0.477CysArg: 0.477 ± 0.072
0.729CysSer: 0.729 ± 0.229
0.519CysThr: 0.519 ± 0.09
0.575CysVal: 0.575 ± 0.087
0.126CysTrp: 0.126 ± 0.039
0.337CysTyr: 0.337 ± 0.065
0.0CysXaa: 0.0 ± 0.0
Asp
5.063AspAla: 5.063 ± 0.26
0.575AspCys: 0.575 ± 0.103
4.334AspAsp: 4.334 ± 0.31
4.418AspGlu: 4.418 ± 0.26
2.861AspPhe: 2.861 ± 0.174
5.049AspGly: 5.049 ± 0.264
1.108AspHis: 1.108 ± 0.116
4.081AspIle: 4.081 ± 0.231
3.492AspLys: 3.492 ± 0.248
5.554AspLeu: 5.554 ± 0.299
1.893AspMet: 1.893 ± 0.19
3.015AspAsn: 3.015 ± 0.215
2.945AspPro: 2.945 ± 0.206
2.118AspGln: 2.118 ± 0.183
2.763AspArg: 2.763 ± 0.204
2.917AspSer: 2.917 ± 0.141
3.604AspThr: 3.604 ± 0.244
4.951AspVal: 4.951 ± 0.309
0.856AspTrp: 0.856 ± 0.101
2.861AspTyr: 2.861 ± 0.163
0.0AspXaa: 0.0 ± 0.0
Glu
4.446GluAla: 4.446 ± 0.239
0.463GluCys: 0.463 ± 0.082
3.941GluAsp: 3.941 ± 0.241
4.067GluGlu: 4.067 ± 0.315
2.581GluPhe: 2.581 ± 0.223
3.618GluGly: 3.618 ± 0.212
1.599GluHis: 1.599 ± 0.155
3.534GluIle: 3.534 ± 0.237
2.875GluLys: 2.875 ± 0.212
6.704GluLeu: 6.704 ± 0.358
1.992GluMet: 1.992 ± 0.163
2.903GluAsn: 2.903 ± 0.2
2.02GluPro: 2.02 ± 0.159
2.524GluGln: 2.524 ± 0.207
3.52GluArg: 3.52 ± 0.254
3.464GluSer: 3.464 ± 0.228
3.338GluThr: 3.338 ± 0.17
4.46GluVal: 4.46 ± 0.276
0.982GluTrp: 0.982 ± 0.13
2.258GluTyr: 2.258 ± 0.171
0.0GluXaa: 0.0 ± 0.0
Phe
3.001PheAla: 3.001 ± 0.218
0.365PheCys: 0.365 ± 0.073
3.043PheAsp: 3.043 ± 0.219
2.37PheGlu: 2.37 ± 0.185
1.935PhePhe: 1.935 ± 0.172
2.917PheGly: 2.917 ± 0.231
0.645PheHis: 0.645 ± 0.091
2.426PheIle: 2.426 ± 0.199
2.328PheLys: 2.328 ± 0.159
2.707PheLeu: 2.707 ± 0.188
0.968PheMet: 0.968 ± 0.11
2.861PheAsn: 2.861 ± 0.195
1.753PhePro: 1.753 ± 0.152
0.996PheGln: 0.996 ± 0.104
2.188PheArg: 2.188 ± 0.132
2.51PheSer: 2.51 ± 0.196
3.057PheThr: 3.057 ± 0.22
2.819PheVal: 2.819 ± 0.215
0.477PheTrp: 0.477 ± 0.087
1.641PheTyr: 1.641 ± 0.127
0.0PheXaa: 0.0 ± 0.0
Gly
4.712GlyAla: 4.712 ± 0.351
0.631GlyCys: 0.631 ± 0.133
3.899GlyAsp: 3.899 ± 0.253
4.011GlyGlu: 4.011 ± 0.251
2.637GlyPhe: 2.637 ± 0.185
4.67GlyGly: 4.67 ± 0.446
1.024GlyHis: 1.024 ± 0.13
4.039GlyIle: 4.039 ± 0.273
4.348GlyLys: 4.348 ± 0.266
5.47GlyLeu: 5.47 ± 0.315
1.893GlyMet: 1.893 ± 0.172
3.142GlyAsn: 3.142 ± 0.233
1.781GlyPro: 1.781 ± 0.182
2.581GlyGln: 2.581 ± 0.217
3.618GlyArg: 3.618 ± 0.256
3.759GlySer: 3.759 ± 0.283
4.558GlyThr: 4.558 ± 0.319
4.67GlyVal: 4.67 ± 0.258
1.108GlyTrp: 1.108 ± 0.12
2.482GlyTyr: 2.482 ± 0.208
0.0GlyXaa: 0.0 ± 0.0
His
1.557HisAla: 1.557 ± 0.14
0.168HisCys: 0.168 ± 0.045
1.192HisAsp: 1.192 ± 0.137
1.038HisGlu: 1.038 ± 0.129
0.912HisPhe: 0.912 ± 0.124
1.164HisGly: 1.164 ± 0.136
0.561HisHis: 0.561 ± 0.087
1.136HisIle: 1.136 ± 0.126
0.771HisLys: 0.771 ± 0.123
2.02HisLeu: 2.02 ± 0.197
0.519HisMet: 0.519 ± 0.088
0.954HisAsn: 0.954 ± 0.114
1.108HisPro: 1.108 ± 0.138
0.533HisGln: 0.533 ± 0.082
1.473HisArg: 1.473 ± 0.139
0.87HisSer: 0.87 ± 0.108
1.108HisThr: 1.108 ± 0.118
1.473HisVal: 1.473 ± 0.14
0.21HisTrp: 0.21 ± 0.06
1.052HisTyr: 1.052 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
4.951IleAla: 4.951 ± 0.241
0.365IleCys: 0.365 ± 0.064
4.502IleAsp: 4.502 ± 0.23
3.562IleGlu: 3.562 ± 0.218
1.613IlePhe: 1.613 ± 0.136
2.917IleGly: 2.917 ± 0.184
1.15IleHis: 1.15 ± 0.129
2.819IleIle: 2.819 ± 0.244
3.366IleLys: 3.366 ± 0.216
4.165IleLeu: 4.165 ± 0.234
1.234IleMet: 1.234 ± 0.134
3.001IleAsn: 3.001 ± 0.197
3.268IlePro: 3.268 ± 0.223
1.921IleGln: 1.921 ± 0.179
3.394IleArg: 3.394 ± 0.224
3.184IleSer: 3.184 ± 0.213
4.011IleThr: 4.011 ± 0.214
3.675IleVal: 3.675 ± 0.234
0.617IleTrp: 0.617 ± 0.081
1.992IleTyr: 1.992 ± 0.162
0.0IleXaa: 0.0 ± 0.0
Lys
4.572LysAla: 4.572 ± 0.278
0.295LysCys: 0.295 ± 0.057
3.254LysAsp: 3.254 ± 0.229
3.773LysGlu: 3.773 ± 0.259
2.216LysPhe: 2.216 ± 0.157
3.268LysGly: 3.268 ± 0.265
1.262LysHis: 1.262 ± 0.155
2.581LysIle: 2.581 ± 0.168
2.987LysLys: 2.987 ± 0.208
5.848LysLeu: 5.848 ± 0.286
1.571LysMet: 1.571 ± 0.133
2.104LysAsn: 2.104 ± 0.178
2.314LysPro: 2.314 ± 0.187
2.048LysGln: 2.048 ± 0.182
3.029LysArg: 3.029 ± 0.256
3.057LysSer: 3.057 ± 0.182
3.534LysThr: 3.534 ± 0.222
3.703LysVal: 3.703 ± 0.228
0.589LysTrp: 0.589 ± 0.079
1.963LysTyr: 1.963 ± 0.195
0.0LysXaa: 0.0 ± 0.0
Leu
7.223LeuAla: 7.223 ± 0.316
0.645LeuCys: 0.645 ± 0.101
5.4LeuAsp: 5.4 ± 0.268
5.918LeuGlu: 5.918 ± 0.374
3.38LeuPhe: 3.38 ± 0.184
5.4LeuGly: 5.4 ± 0.279
1.711LeuHis: 1.711 ± 0.191
4.306LeuIle: 4.306 ± 0.282
5.091LeuLys: 5.091 ± 0.274
7.503LeuLeu: 7.503 ± 0.312
2.524LeuMet: 2.524 ± 0.191
4.881LeuAsn: 4.881 ± 0.291
4.179LeuPro: 4.179 ± 0.211
3.17LeuGln: 3.17 ± 0.225
5.47LeuArg: 5.47 ± 0.244
6.479LeuSer: 6.479 ± 0.369
6.578LeuThr: 6.578 ± 0.341
6.017LeuVal: 6.017 ± 0.29
0.884LeuTrp: 0.884 ± 0.103
3.352LeuTyr: 3.352 ± 0.207
0.0LeuXaa: 0.0 ± 0.0
Met
2.496MetAla: 2.496 ± 0.204
0.309MetCys: 0.309 ± 0.071
1.613MetAsp: 1.613 ± 0.144
1.445MetGlu: 1.445 ± 0.147
1.332MetPhe: 1.332 ± 0.128
1.921MetGly: 1.921 ± 0.19
0.617MetHis: 0.617 ± 0.104
1.22MetIle: 1.22 ± 0.121
1.431MetLys: 1.431 ± 0.131
2.567MetLeu: 2.567 ± 0.148
0.729MetMet: 0.729 ± 0.094
1.136MetAsn: 1.136 ± 0.142
0.982MetPro: 0.982 ± 0.093
1.178MetGln: 1.178 ± 0.154
1.697MetArg: 1.697 ± 0.159
2.412MetSer: 2.412 ± 0.168
1.823MetThr: 1.823 ± 0.146
1.992MetVal: 1.992 ± 0.16
0.196MetTrp: 0.196 ± 0.05
0.701MetTyr: 0.701 ± 0.083
0.0MetXaa: 0.0 ± 0.0
Asn
4.39AsnAla: 4.39 ± 0.248
0.505AsnCys: 0.505 ± 0.096
2.889AsnAsp: 2.889 ± 0.188
2.651AsnGlu: 2.651 ± 0.183
2.048AsnPhe: 2.048 ± 0.177
3.604AsnGly: 3.604 ± 0.237
0.827AsnHis: 0.827 ± 0.109
2.693AsnIle: 2.693 ± 0.202
2.637AsnLys: 2.637 ± 0.191
4.095AsnLeu: 4.095 ± 0.256
1.248AsnMet: 1.248 ± 0.143
2.342AsnAsn: 2.342 ± 0.185
2.833AsnPro: 2.833 ± 0.195
1.669AsnGln: 1.669 ± 0.137
2.833AsnArg: 2.833 ± 0.203
2.651AsnSer: 2.651 ± 0.215
3.212AsnThr: 3.212 ± 0.21
3.422AsnVal: 3.422 ± 0.238
0.926AsnTrp: 0.926 ± 0.113
1.767AsnTyr: 1.767 ± 0.174
0.0AsnXaa: 0.0 ± 0.0
Pro
3.618ProAla: 3.618 ± 0.275
0.182ProCys: 0.182 ± 0.042
3.226ProAsp: 3.226 ± 0.196
3.492ProGlu: 3.492 ± 0.215
1.711ProPhe: 1.711 ± 0.157
2.496ProGly: 2.496 ± 0.189
0.841ProHis: 0.841 ± 0.123
2.286ProIle: 2.286 ± 0.206
2.034ProLys: 2.034 ± 0.159
3.548ProLeu: 3.548 ± 0.232
1.066ProMet: 1.066 ± 0.131
1.992ProAsn: 1.992 ± 0.176
1.515ProPro: 1.515 ± 0.135
1.767ProGln: 1.767 ± 0.177
1.809ProArg: 1.809 ± 0.14
2.651ProSer: 2.651 ± 0.208
3.184ProThr: 3.184 ± 0.207
3.478ProVal: 3.478 ± 0.261
0.407ProTrp: 0.407 ± 0.069
1.459ProTyr: 1.459 ± 0.145
0.0ProXaa: 0.0 ± 0.0
Gln
2.987GlnAla: 2.987 ± 0.241
0.365GlnCys: 0.365 ± 0.057
1.627GlnAsp: 1.627 ± 0.145
2.062GlnGlu: 2.062 ± 0.185
1.388GlnPhe: 1.388 ± 0.131
1.992GlnGly: 1.992 ± 0.155
0.841GlnHis: 0.841 ± 0.118
1.823GlnIle: 1.823 ± 0.164
1.823GlnLys: 1.823 ± 0.179
4.278GlnLeu: 4.278 ± 0.274
1.01GlnMet: 1.01 ± 0.122
1.543GlnAsn: 1.543 ± 0.157
1.599GlnPro: 1.599 ± 0.13
1.851GlnGln: 1.851 ± 0.189
2.595GlnArg: 2.595 ± 0.209
2.244GlnSer: 2.244 ± 0.171
2.244GlnThr: 2.244 ± 0.202
2.09GlnVal: 2.09 ± 0.175
0.547GlnTrp: 0.547 ± 0.083
1.697GlnTyr: 1.697 ± 0.146
0.0GlnXaa: 0.0 ± 0.0
Arg
3.689ArgAla: 3.689 ± 0.269
0.547ArgCys: 0.547 ± 0.113
3.745ArgAsp: 3.745 ± 0.238
3.352ArgGlu: 3.352 ± 0.25
2.356ArgPhe: 2.356 ± 0.178
3.254ArgGly: 3.254 ± 0.202
1.276ArgHis: 1.276 ± 0.143
3.492ArgIle: 3.492 ± 0.222
3.029ArgLys: 3.029 ± 0.222
5.582ArgLeu: 5.582 ± 0.272
1.753ArgMet: 1.753 ± 0.16
2.889ArgAsn: 2.889 ± 0.179
1.963ArgPro: 1.963 ± 0.188
2.174ArgGln: 2.174 ± 0.215
3.324ArgArg: 3.324 ± 0.245
2.987ArgSer: 2.987 ± 0.226
2.987ArgThr: 2.987 ± 0.189
3.885ArgVal: 3.885 ± 0.246
0.912ArgTrp: 0.912 ± 0.119
2.202ArgTyr: 2.202 ± 0.185
0.0ArgXaa: 0.0 ± 0.0
Ser
4.965SerAla: 4.965 ± 0.242
0.589SerCys: 0.589 ± 0.102
3.52SerAsp: 3.52 ± 0.205
3.198SerGlu: 3.198 ± 0.23
2.272SerPhe: 2.272 ± 0.191
4.474SerGly: 4.474 ± 0.375
0.968SerHis: 0.968 ± 0.122
3.632SerIle: 3.632 ± 0.24
3.408SerLys: 3.408 ± 0.212
5.484SerLeu: 5.484 ± 0.277
1.473SerMet: 1.473 ± 0.127
2.679SerAsn: 2.679 ± 0.181
2.623SerPro: 2.623 ± 0.19
1.992SerGln: 1.992 ± 0.148
3.001SerArg: 3.001 ± 0.209
3.773SerSer: 3.773 ± 0.297
3.843SerThr: 3.843 ± 0.247
4.151SerVal: 4.151 ± 0.247
0.813SerTrp: 0.813 ± 0.107
2.118SerTyr: 2.118 ± 0.207
0.0SerXaa: 0.0 ± 0.0
Thr
5.61ThrAla: 5.61 ± 0.329
0.561ThrCys: 0.561 ± 0.097
4.264ThrAsp: 4.264 ± 0.291
3.759ThrGlu: 3.759 ± 0.25
2.847ThrPhe: 2.847 ± 0.17
4.712ThrGly: 4.712 ± 0.268
1.262ThrHis: 1.262 ± 0.134
3.226ThrIle: 3.226 ± 0.189
3.001ThrLys: 3.001 ± 0.206
5.989ThrLeu: 5.989 ± 0.308
1.655ThrMet: 1.655 ± 0.162
3.128ThrAsn: 3.128 ± 0.211
3.114ThrPro: 3.114 ± 0.199
2.118ThrGln: 2.118 ± 0.212
3.198ThrArg: 3.198 ± 0.198
3.576ThrSer: 3.576 ± 0.202
4.404ThrThr: 4.404 ± 0.273
5.245ThrVal: 5.245 ± 0.323
1.024ThrTrp: 1.024 ± 0.121
2.258ThrTyr: 2.258 ± 0.198
0.0ThrXaa: 0.0 ± 0.0
Val
5.708ValAla: 5.708 ± 0.268
0.687ValCys: 0.687 ± 0.09
5.021ValAsp: 5.021 ± 0.267
4.684ValGlu: 4.684 ± 0.294
2.805ValPhe: 2.805 ± 0.176
4.586ValGly: 4.586 ± 0.233
1.29ValHis: 1.29 ± 0.132
4.376ValIle: 4.376 ± 0.263
3.815ValLys: 3.815 ± 0.202
5.343ValLeu: 5.343 ± 0.235
2.118ValMet: 2.118 ± 0.153
3.366ValAsn: 3.366 ± 0.177
3.296ValPro: 3.296 ± 0.222
2.314ValGln: 2.314 ± 0.202
3.857ValArg: 3.857 ± 0.26
4.432ValSer: 4.432 ± 0.206
4.951ValThr: 4.951 ± 0.241
4.993ValVal: 4.993 ± 0.32
0.799ValTrp: 0.799 ± 0.092
2.693ValTyr: 2.693 ± 0.23
0.0ValXaa: 0.0 ± 0.0
Trp
0.982TrpAla: 0.982 ± 0.089
0.098TrpCys: 0.098 ± 0.036
1.108TrpAsp: 1.108 ± 0.122
0.645TrpGlu: 0.645 ± 0.081
0.715TrpPhe: 0.715 ± 0.11
0.631TrpGly: 0.631 ± 0.093
0.252TrpHis: 0.252 ± 0.057
0.687TrpIle: 0.687 ± 0.09
0.912TrpLys: 0.912 ± 0.091
1.487TrpLeu: 1.487 ± 0.138
0.295TrpMet: 0.295 ± 0.074
0.757TrpAsn: 0.757 ± 0.104
0.463TrpPro: 0.463 ± 0.086
0.505TrpGln: 0.505 ± 0.09
0.743TrpArg: 0.743 ± 0.101
0.631TrpSer: 0.631 ± 0.094
0.673TrpThr: 0.673 ± 0.114
0.982TrpVal: 0.982 ± 0.118
0.266TrpTrp: 0.266 ± 0.054
0.435TrpTyr: 0.435 ± 0.081
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.749TyrAla: 2.749 ± 0.193
0.365TyrCys: 0.365 ± 0.067
2.524TyrAsp: 2.524 ± 0.193
1.837TyrGlu: 1.837 ± 0.135
1.753TyrPhe: 1.753 ± 0.14
2.454TyrGly: 2.454 ± 0.199
1.024TyrHis: 1.024 ± 0.124
1.725TyrIle: 1.725 ± 0.153
1.683TyrLys: 1.683 ± 0.146
3.394TyrLeu: 3.394 ± 0.204
0.841TyrMet: 0.841 ± 0.097
2.244TyrAsn: 2.244 ± 0.171
1.641TyrPro: 1.641 ± 0.17
1.599TyrGln: 1.599 ± 0.153
2.37TyrArg: 2.37 ± 0.165
2.286TyrSer: 2.286 ± 0.206
2.454TyrThr: 2.454 ± 0.206
2.875TyrVal: 2.875 ± 0.207
0.463TyrTrp: 0.463 ± 0.077
1.963TyrTyr: 1.963 ± 0.182
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 241 proteins (71303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski