Amino acid dipepetide frequency for Flavobacterium indicum (strain DSM 17447 / CIP 109464 / GPTSA100-9)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.109AlaAla: 4.109 ± 0.097	0.617AlaCys: 0.617 ± 0.034	2.892AlaAsp: 2.892 ± 0.072	3.734AlaGlu: 3.734 ± 0.086	3.244AlaPhe: 3.244 ± 0.065	4.108AlaGly: 4.108 ± 0.111	1.002AlaHis: 1.002 ± 0.039	5.341AlaIle: 5.341 ± 0.081	4.761AlaLys: 4.761 ± 0.095	6.028AlaLeu: 6.028 ± 0.098	1.391AlaMet: 1.391 ± 0.04	3.745AlaAsn: 3.745 ± 0.074	1.894AlaPro: 1.894 ± 0.053	2.568AlaGln: 2.568 ± 0.063	1.688AlaArg: 1.688 ± 0.05	4.049AlaSer: 4.049 ± 0.091	4.377AlaThr: 4.377 ± 0.14	3.879AlaVal: 3.879 ± 0.07	0.573AlaTrp: 0.573 ± 0.027	2.363AlaTyr: 2.363 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.489CysAla: 0.489 ± 0.029	0.118CysCys: 0.118 ± 0.013	0.448CysAsp: 0.448 ± 0.026	0.472CysGlu: 0.472 ± 0.028	0.474CysPhe: 0.474 ± 0.026	0.71CysGly: 0.71 ± 0.047	0.195CysHis: 0.195 ± 0.019	0.612CysIle: 0.612 ± 0.026	0.529CysLys: 0.529 ± 0.024	0.644CysLeu: 0.644 ± 0.026	0.167CysMet: 0.167 ± 0.014	0.557CysAsn: 0.557 ± 0.027	0.373CysPro: 0.373 ± 0.024	0.275CysGln: 0.275 ± 0.019	0.193CysArg: 0.193 ± 0.014	0.686CysSer: 0.686 ± 0.035	0.532CysThr: 0.532 ± 0.036	0.477CysVal: 0.477 ± 0.024	0.072CysTrp: 0.072 ± 0.009	0.326CysTyr: 0.326 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.453AspAla: 3.453 ± 0.079	0.436AspCys: 0.436 ± 0.022	2.193AspAsp: 2.193 ± 0.058	3.437AspGlu: 3.437 ± 0.068	3.517AspPhe: 3.517 ± 0.065	3.171AspGly: 3.171 ± 0.07	0.727AspHis: 0.727 ± 0.032	3.738AspIle: 3.738 ± 0.069	4.175AspLys: 4.175 ± 0.086	4.804AspLeu: 4.804 ± 0.086	0.897AspMet: 0.897 ± 0.036	2.922AspAsn: 2.922 ± 0.059	1.259AspPro: 1.259 ± 0.044	1.282AspGln: 1.282 ± 0.04	1.523AspArg: 1.523 ± 0.042	2.809AspSer: 2.809 ± 0.067	2.554AspThr: 2.554 ± 0.062	3.433AspVal: 3.433 ± 0.068	0.647AspTrp: 0.647 ± 0.025	2.732AspTyr: 2.732 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.977GluAla: 3.977 ± 0.085	0.359GluCys: 0.359 ± 0.023	3.12GluAsp: 3.12 ± 0.066	4.832GluGlu: 4.832 ± 0.1	3.106GluPhe: 3.106 ± 0.062	3.361GluGly: 3.361 ± 0.059	1.059GluHis: 1.059 ± 0.041	5.929GluIle: 5.929 ± 0.105	6.661GluLys: 6.661 ± 0.115	6.218GluLeu: 6.218 ± 0.096	1.552GluMet: 1.552 ± 0.043	5.076GluAsn: 5.076 ± 0.086	1.428GluPro: 1.428 ± 0.044	2.339GluGln: 2.339 ± 0.063	2.162GluArg: 2.162 ± 0.056	3.014GluSer: 3.014 ± 0.063	3.46GluThr: 3.46 ± 0.065	4.4GluVal: 4.4 ± 0.079	0.554GluTrp: 0.554 ± 0.024	2.393GluTyr: 2.393 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.123PheAla: 3.123 ± 0.06	0.519PheCys: 0.519 ± 0.023	3.296PheAsp: 3.296 ± 0.064	3.747PheGlu: 3.747 ± 0.071	3.079PhePhe: 3.079 ± 0.077	3.606PheGly: 3.606 ± 0.072	0.905PheHis: 0.905 ± 0.035	4.304PheIle: 4.304 ± 0.091	4.081PheLys: 4.081 ± 0.074	4.921PheLeu: 4.921 ± 0.1	1.087PheMet: 1.087 ± 0.04	3.699PheAsn: 3.699 ± 0.078	1.734PhePro: 1.734 ± 0.043	1.738PheGln: 1.738 ± 0.05	1.479PheArg: 1.479 ± 0.045	4.056PheSer: 4.056 ± 0.086	3.443PheThr: 3.443 ± 0.076	3.357PheVal: 3.357 ± 0.066	0.556PheTrp: 0.556 ± 0.028	2.475PheTyr: 2.475 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	4.175GlyAla: 4.175 ± 0.096	0.663GlyCys: 0.663 ± 0.04	2.741GlyAsp: 2.741 ± 0.06	3.172GlyGlu: 3.172 ± 0.055	3.566GlyPhe: 3.566 ± 0.068	4.39GlyGly: 4.39 ± 0.117	1.074GlyHis: 1.074 ± 0.034	5.256GlyIle: 5.256 ± 0.087	4.895GlyLys: 4.895 ± 0.075	5.364GlyLeu: 5.364 ± 0.089	1.542GlyMet: 1.542 ± 0.045	3.781GlyAsn: 3.781 ± 0.103	1.24GlyPro: 1.24 ± 0.047	1.976GlyGln: 1.976 ± 0.057	1.775GlyArg: 1.775 ± 0.053	3.943GlySer: 3.943 ± 0.103	4.52GlyThr: 4.52 ± 0.144	4.104GlyVal: 4.104 ± 0.086	0.672GlyTrp: 0.672 ± 0.034	2.724GlyTyr: 2.724 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.918HisAla: 0.918 ± 0.034	0.179HisCys: 0.179 ± 0.014	0.78HisAsp: 0.78 ± 0.029	0.956HisGlu: 0.956 ± 0.032	1.194HisPhe: 1.194 ± 0.04	0.988HisGly: 0.988 ± 0.037	0.429HisHis: 0.429 ± 0.022	1.337HisIle: 1.337 ± 0.042	1.077HisLys: 1.077 ± 0.04	1.658HisLeu: 1.658 ± 0.046	0.28HisMet: 0.28 ± 0.017	0.94HisAsn: 0.94 ± 0.032	0.78HisPro: 0.78 ± 0.031	0.762HisGln: 0.762 ± 0.037	0.602HisArg: 0.602 ± 0.026	1.033HisSer: 1.033 ± 0.036	0.884HisThr: 0.884 ± 0.031	0.981HisVal: 0.981 ± 0.036	0.175HisTrp: 0.175 ± 0.015	0.819HisTyr: 0.819 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.674IleAla: 5.674 ± 0.089	0.709IleCys: 0.709 ± 0.031	4.699IleAsp: 4.699 ± 0.08	5.936IleGlu: 5.936 ± 0.095	3.864IlePhe: 3.864 ± 0.088	4.959IleGly: 4.959 ± 0.085	1.449IleHis: 1.449 ± 0.042	6.482IleIle: 6.482 ± 0.119	6.25IleLys: 6.25 ± 0.089	7.05IleLeu: 7.05 ± 0.119	1.361IleMet: 1.361 ± 0.041	5.28IleAsn: 5.28 ± 0.09	3.148IlePro: 3.148 ± 0.058	3.236IleGln: 3.236 ± 0.067	2.33IleArg: 2.33 ± 0.058	5.683IleSer: 5.683 ± 0.081	4.942IleThr: 4.942 ± 0.085	5.062IleVal: 5.062 ± 0.085	0.684IleTrp: 0.684 ± 0.029	3.038IleTyr: 3.038 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	4.782LysAla: 4.782 ± 0.098	0.409LysCys: 0.409 ± 0.021	4.246LysAsp: 4.246 ± 0.076	6.544LysGlu: 6.544 ± 0.113	3.4LysPhe: 3.4 ± 0.067	4.375LysGly: 4.375 ± 0.087	1.252LysHis: 1.252 ± 0.039	7.358LysIle: 7.358 ± 0.119	7.636LysLys: 7.636 ± 0.128	6.917LysLeu: 6.917 ± 0.102	2.284LysMet: 2.284 ± 0.05	6.281LysAsn: 6.281 ± 0.115	2.464LysPro: 2.464 ± 0.057	2.888LysGln: 2.888 ± 0.06	2.523LysArg: 2.523 ± 0.06	4.566LysSer: 4.566 ± 0.075	4.663LysThr: 4.663 ± 0.082	4.97LysVal: 4.97 ± 0.099	0.759LysTrp: 0.759 ± 0.031	3.442LysTyr: 3.442 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	5.739LeuAla: 5.739 ± 0.091	0.603LeuCys: 0.603 ± 0.03	4.546LeuAsp: 4.546 ± 0.073	5.925LeuGlu: 5.925 ± 0.09	5.2LeuPhe: 5.2 ± 0.107	5.406LeuGly: 5.406 ± 0.09	1.6LeuHis: 1.6 ± 0.053	7.112LeuIle: 7.112 ± 0.104	7.883LeuLys: 7.883 ± 0.119	8.529LeuLeu: 8.529 ± 0.154	1.892LeuMet: 1.892 ± 0.047	6.33LeuAsn: 6.33 ± 0.102	3.37LeuPro: 3.37 ± 0.068	3.215LeuGln: 3.215 ± 0.069	2.688LeuArg: 2.688 ± 0.055	6.214LeuSer: 6.214 ± 0.099	5.196LeuThr: 5.196 ± 0.088	5.542LeuVal: 5.542 ± 0.086	0.672LeuTrp: 0.672 ± 0.037	3.205LeuTyr: 3.205 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.434MetAla: 1.434 ± 0.049	0.163MetCys: 0.163 ± 0.013	0.956MetAsp: 0.956 ± 0.03	1.288MetGlu: 1.288 ± 0.041	0.868MetPhe: 0.868 ± 0.033	1.345MetGly: 1.345 ± 0.039	0.392MetHis: 0.392 ± 0.019	1.503MetIle: 1.503 ± 0.043	2.253MetLys: 2.253 ± 0.052	1.772MetLeu: 1.772 ± 0.05	0.562MetMet: 0.562 ± 0.028	1.412MetAsn: 1.412 ± 0.039	0.793MetPro: 0.793 ± 0.028	0.858MetGln: 0.858 ± 0.031	0.749MetArg: 0.749 ± 0.028	1.342MetSer: 1.342 ± 0.04	1.133MetThr: 1.133 ± 0.038	1.186MetVal: 1.186 ± 0.04	0.16MetTrp: 0.16 ± 0.012	0.721MetTyr: 0.721 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.009AsnAla: 4.009 ± 0.084	0.646AsnCys: 0.646 ± 0.032	3.211AsnAsp: 3.211 ± 0.064	4.436AsnGlu: 4.436 ± 0.079	3.827AsnPhe: 3.827 ± 0.078	4.532AsnGly: 4.532 ± 0.112	1.185AsnHis: 1.185 ± 0.038	4.806AsnIle: 4.806 ± 0.084	5.214AsnLys: 5.214 ± 0.104	6.087AsnLeu: 6.087 ± 0.094	1.336AsnMet: 1.336 ± 0.037	4.673AsnAsn: 4.673 ± 0.116	2.886AsnPro: 2.886 ± 0.065	2.891AsnGln: 2.891 ± 0.066	1.911AsnArg: 1.911 ± 0.054	4.314AsnSer: 4.314 ± 0.097	3.962AsnThr: 3.962 ± 0.094	3.876AsnVal: 3.876 ± 0.079	0.893AsnTrp: 0.893 ± 0.035	3.475AsnTyr: 3.475 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	2.012ProAla: 2.012 ± 0.068	0.221ProCys: 0.221 ± 0.016	1.622ProAsp: 1.622 ± 0.046	2.419ProGlu: 2.419 ± 0.051	1.867ProPhe: 1.867 ± 0.044	1.794ProGly: 1.794 ± 0.06	0.543ProHis: 0.543 ± 0.026	2.815ProIle: 2.815 ± 0.055	2.552ProLys: 2.552 ± 0.063	2.66ProLeu: 2.66 ± 0.067	0.675ProMet: 0.675 ± 0.026	2.453ProAsn: 2.453 ± 0.056	0.691ProPro: 0.691 ± 0.033	1.072ProGln: 1.072 ± 0.039	0.78ProArg: 0.78 ± 0.045	2.069ProSer: 2.069 ± 0.053	2.355ProThr: 2.355 ± 0.071	2.295ProVal: 2.295 ± 0.052	0.29ProTrp: 0.29 ± 0.02	1.375ProTyr: 1.375 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.151GlnAla: 2.151 ± 0.061	0.217GlnCys: 0.217 ± 0.017	1.607GlnAsp: 1.607 ± 0.041	2.289GlnGlu: 2.289 ± 0.055	2.023GlnPhe: 2.023 ± 0.059	1.715GlnGly: 1.715 ± 0.042	0.601GlnHis: 0.601 ± 0.029	3.007GlnIle: 3.007 ± 0.062	3.077GlnLys: 3.077 ± 0.071	3.818GlnLeu: 3.818 ± 0.078	0.794GlnMet: 0.794 ± 0.033	2.641GlnAsn: 2.641 ± 0.073	1.157GlnPro: 1.157 ± 0.041	1.418GlnGln: 1.418 ± 0.041	1.028GlnArg: 1.028 ± 0.031	2.066GlnSer: 2.066 ± 0.052	2.096GlnThr: 2.096 ± 0.054	2.25GlnVal: 2.25 ± 0.051	0.332GlnTrp: 0.332 ± 0.018	1.357GlnTyr: 1.357 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.743ArgAla: 1.743 ± 0.054	0.185ArgCys: 0.185 ± 0.015	1.324ArgAsp: 1.324 ± 0.045	1.914ArgGlu: 1.914 ± 0.054	1.635ArgPhe: 1.635 ± 0.042	1.6ArgGly: 1.6 ± 0.05	0.5ArgHis: 0.5 ± 0.023	2.696ArgIle: 2.696 ± 0.056	2.588ArgLys: 2.588 ± 0.061	2.679ArgLeu: 2.679 ± 0.054	0.814ArgMet: 0.814 ± 0.03	1.966ArgAsn: 1.966 ± 0.055	0.906ArgPro: 0.906 ± 0.035	0.918ArgGln: 0.918 ± 0.037	1.03ArgArg: 1.03 ± 0.035	1.552ArgSer: 1.552 ± 0.048	1.637ArgThr: 1.637 ± 0.041	1.892ArgVal: 1.892 ± 0.049	0.299ArgTrp: 0.299 ± 0.018	1.216ArgTyr: 1.216 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.554SerAla: 3.554 ± 0.09	0.753SerCys: 0.753 ± 0.038	3.122SerAsp: 3.122 ± 0.067	3.693SerGlu: 3.693 ± 0.074	3.947SerPhe: 3.947 ± 0.077	4.387SerGly: 4.387 ± 0.102	0.954SerHis: 0.954 ± 0.03	5.526SerIle: 5.526 ± 0.091	5.166SerLys: 5.166 ± 0.095	5.547SerLeu: 5.547 ± 0.089	1.163SerMet: 1.163 ± 0.037	4.704SerAsn: 4.704 ± 0.112	1.869SerPro: 1.869 ± 0.053	2.08SerGln: 2.08 ± 0.048	1.686SerArg: 1.686 ± 0.047	4.376SerSer: 4.376 ± 0.111	4.048SerThr: 4.048 ± 0.111	3.816SerVal: 3.816 ± 0.081	0.684SerTrp: 0.684 ± 0.026	2.671SerTyr: 2.671 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	3.922ThrAla: 3.922 ± 0.128	0.529ThrCys: 0.529 ± 0.038	2.883ThrAsp: 2.883 ± 0.067	3.236ThrGlu: 3.236 ± 0.062	3.439ThrPhe: 3.439 ± 0.077	4.23ThrGly: 4.23 ± 0.131	1.001ThrHis: 1.001 ± 0.035	5.525ThrIle: 5.525 ± 0.113	4.253ThrLys: 4.253 ± 0.073	5.359ThrLeu: 5.359 ± 0.089	0.914ThrMet: 0.914 ± 0.028	4.041ThrAsn: 4.041 ± 0.1	2.761ThrPro: 2.761 ± 0.087	1.999ThrGln: 1.999 ± 0.052	1.511ThrArg: 1.511 ± 0.041	4.357ThrSer: 4.357 ± 0.104	4.55ThrThr: 4.55 ± 0.176	3.968ThrVal: 3.968 ± 0.125	0.614ThrTrp: 0.614 ± 0.037	2.601ThrTyr: 2.601 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	4.247ValAla: 4.247 ± 0.085	0.541ValCys: 0.541 ± 0.025	3.302ValAsp: 3.302 ± 0.061	3.989ValGlu: 3.989 ± 0.084	3.484ValPhe: 3.484 ± 0.068	3.837ValGly: 3.837 ± 0.086	0.933ValHis: 0.933 ± 0.033	4.808ValIle: 4.808 ± 0.087	4.743ValLys: 4.743 ± 0.084	6.06ValLeu: 6.06 ± 0.107	1.209ValMet: 1.209 ± 0.037	3.965ValAsn: 3.965 ± 0.077	2.195ValPro: 2.195 ± 0.056	1.969ValGln: 1.969 ± 0.049	1.828ValArg: 1.828 ± 0.048	4.231ValSer: 4.231 ± 0.077	4.03ValThr: 4.03 ± 0.111	4.515ValVal: 4.515 ± 0.08	0.568ValTrp: 0.568 ± 0.028	2.523ValTyr: 2.523 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.545TrpAla: 0.545 ± 0.027	0.101TrpCys: 0.101 ± 0.011	0.498TrpAsp: 0.498 ± 0.025	0.587TrpGlu: 0.587 ± 0.026	0.549TrpPhe: 0.549 ± 0.025	0.578TrpGly: 0.578 ± 0.035	0.185TrpHis: 0.185 ± 0.016	0.726TrpIle: 0.726 ± 0.032	0.804TrpLys: 0.804 ± 0.033	0.895TrpLeu: 0.895 ± 0.044	0.249TrpMet: 0.249 ± 0.017	0.791TrpAsn: 0.791 ± 0.031	0.179TrpPro: 0.179 ± 0.016	0.42TrpGln: 0.42 ± 0.025	0.302TrpArg: 0.302 ± 0.018	0.599TrpSer: 0.599 ± 0.03	0.634TrpThr: 0.634 ± 0.042	0.599TrpVal: 0.599 ± 0.026	0.124TrpTrp: 0.124 ± 0.013	0.437TrpTyr: 0.437 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.055	0.383TyrCys: 0.383 ± 0.02	2.223TyrAsp: 2.223 ± 0.061	2.393TyrGlu: 2.393 ± 0.059	2.92TyrPhe: 2.92 ± 0.065	2.479TyrGly: 2.479 ± 0.059	0.784TyrHis: 0.784 ± 0.032	2.955TyrIle: 2.955 ± 0.061	3.161TyrLys: 3.161 ± 0.068	3.855TyrLeu: 3.855 ± 0.076	0.721TyrMet: 0.721 ± 0.031	2.914TyrAsn: 2.914 ± 0.066	1.432TyrPro: 1.432 ± 0.043	1.741TyrGln: 1.741 ± 0.057	1.307TyrArg: 1.307 ± 0.04	2.786TyrSer: 2.786 ± 0.062	2.68TyrThr: 2.68 ± 0.089	2.376TyrVal: 2.376 ± 0.062	0.474TyrTrp: 0.474 ± 0.024	2.1TyrTyr: 2.1 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2649 proteins (890273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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