Amino acid dipepetide frequency for Pseudomonas bauzanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.552AlaAla: 12.552 ± 0.151	1.189AlaCys: 1.189 ± 0.037	6.355AlaAsp: 6.355 ± 0.079	7.227AlaGlu: 7.227 ± 0.094	3.477AlaPhe: 3.477 ± 0.058	9.325AlaGly: 9.325 ± 0.112	2.085AlaHis: 2.085 ± 0.042	5.218AlaIle: 5.218 ± 0.075	2.771AlaLys: 2.771 ± 0.067	12.72AlaLeu: 12.72 ± 0.116	2.985AlaMet: 2.985 ± 0.056	2.878AlaAsn: 2.878 ± 0.059	4.359AlaPro: 4.359 ± 0.069	4.534AlaGln: 4.534 ± 0.069	7.005AlaArg: 7.005 ± 0.08	5.687AlaSer: 5.687 ± 0.076	4.932AlaThr: 4.932 ± 0.069	7.531AlaVal: 7.531 ± 0.086	1.521AlaTrp: 1.521 ± 0.041	2.225AlaTyr: 2.225 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.028CysAla: 1.028 ± 0.034	0.159CysCys: 0.159 ± 0.013	0.515CysAsp: 0.515 ± 0.02	0.56CysGlu: 0.56 ± 0.022	0.361CysPhe: 0.361 ± 0.018	0.905CysGly: 0.905 ± 0.03	0.321CysHis: 0.321 ± 0.019	0.465CysIle: 0.465 ± 0.021	0.249CysLys: 0.249 ± 0.015	1.078CysLeu: 1.078 ± 0.031	0.241CysMet: 0.241 ± 0.014	0.296CysAsn: 0.296 ± 0.017	0.536CysPro: 0.536 ± 0.026	0.42CysGln: 0.42 ± 0.02	0.709CysArg: 0.709 ± 0.027	0.587CysSer: 0.587 ± 0.024	0.461CysThr: 0.461 ± 0.022	0.656CysVal: 0.656 ± 0.028	0.158CysTrp: 0.158 ± 0.012	0.248CysTyr: 0.248 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.538AspAla: 5.538 ± 0.079	0.55AspCys: 0.55 ± 0.027	3.083AspAsp: 3.083 ± 0.055	3.741AspGlu: 3.741 ± 0.06	2.094AspPhe: 2.094 ± 0.047	4.549AspGly: 4.549 ± 0.073	1.257AspHis: 1.257 ± 0.034	3.09AspIle: 3.09 ± 0.061	1.756AspLys: 1.756 ± 0.049	5.942AspLeu: 5.942 ± 0.074	1.485AspMet: 1.485 ± 0.037	1.866AspAsn: 1.866 ± 0.044	2.858AspPro: 2.858 ± 0.057	2.523AspGln: 2.523 ± 0.052	3.459AspArg: 3.459 ± 0.057	3.114AspSer: 3.114 ± 0.057	2.724AspThr: 2.724 ± 0.057	3.592AspVal: 3.592 ± 0.056	0.985AspTrp: 0.985 ± 0.03	1.73AspTyr: 1.73 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.44GluAla: 6.44 ± 0.072	0.46GluCys: 0.46 ± 0.02	2.853GluAsp: 2.853 ± 0.058	3.486GluGlu: 3.486 ± 0.072	1.915GluPhe: 1.915 ± 0.041	4.094GluGly: 4.094 ± 0.067	1.657GluHis: 1.657 ± 0.042	2.877GluIle: 2.877 ± 0.059	1.951GluLys: 1.951 ± 0.044	7.434GluLeu: 7.434 ± 0.087	1.483GluMet: 1.483 ± 0.035	1.617GluAsn: 1.617 ± 0.039	2.778GluPro: 2.778 ± 0.055	4.444GluGln: 4.444 ± 0.081	5.025GluArg: 5.025 ± 0.083	2.747GluSer: 2.747 ± 0.047	2.642GluThr: 2.642 ± 0.049	4.292GluVal: 4.292 ± 0.068	0.808GluTrp: 0.808 ± 0.027	1.338GluTyr: 1.338 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.758PheAla: 3.758 ± 0.056	0.418PheCys: 0.418 ± 0.02	2.411PheAsp: 2.411 ± 0.05	2.022PheGlu: 2.022 ± 0.041	1.423PhePhe: 1.423 ± 0.044	3.136PheGly: 3.136 ± 0.068	0.801PheHis: 0.801 ± 0.028	1.97PheIle: 1.97 ± 0.044	1.045PheLys: 1.045 ± 0.034	3.268PheLeu: 3.268 ± 0.071	0.972PheMet: 0.972 ± 0.037	1.323PheAsn: 1.323 ± 0.036	1.414PhePro: 1.414 ± 0.033	1.155PheGln: 1.155 ± 0.037	1.899PheArg: 1.899 ± 0.047	2.472PheSer: 2.472 ± 0.05	1.98PheThr: 1.98 ± 0.049	2.363PheVal: 2.363 ± 0.049	0.553PheTrp: 0.553 ± 0.024	1.04PheTyr: 1.04 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.194GlyAla: 7.194 ± 0.081	0.986GlyCys: 0.986 ± 0.036	4.111GlyAsp: 4.111 ± 0.064	4.97GlyGlu: 4.97 ± 0.062	3.198GlyPhe: 3.198 ± 0.065	5.983GlyGly: 5.983 ± 0.103	1.856GlyHis: 1.856 ± 0.039	4.439GlyIle: 4.439 ± 0.058	3.031GlyLys: 3.031 ± 0.06	9.149GlyLeu: 9.149 ± 0.105	2.518GlyMet: 2.518 ± 0.053	2.539GlyAsn: 2.539 ± 0.055	2.656GlyPro: 2.656 ± 0.053	3.578GlyGln: 3.578 ± 0.057	4.955GlyArg: 4.955 ± 0.073	4.617GlySer: 4.617 ± 0.066	3.823GlyThr: 3.823 ± 0.065	5.901GlyVal: 5.901 ± 0.083	1.331GlyTrp: 1.331 ± 0.037	2.474GlyTyr: 2.474 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.276HisAla: 2.276 ± 0.053	0.353HisCys: 0.353 ± 0.017	1.291HisAsp: 1.291 ± 0.033	1.215HisGlu: 1.215 ± 0.032	0.982HisPhe: 0.982 ± 0.032	2.001HisGly: 2.001 ± 0.047	0.641HisHis: 0.641 ± 0.028	1.185HisIle: 1.185 ± 0.033	0.58HisLys: 0.58 ± 0.021	2.426HisLeu: 2.426 ± 0.047	0.553HisMet: 0.553 ± 0.024	0.687HisAsn: 0.687 ± 0.025	1.441HisPro: 1.441 ± 0.036	1.011HisGln: 1.011 ± 0.029	1.553HisArg: 1.553 ± 0.035	1.302HisSer: 1.302 ± 0.038	1.081HisThr: 1.081 ± 0.032	1.313HisVal: 1.313 ± 0.038	0.437HisTrp: 0.437 ± 0.021	0.773HisTyr: 0.773 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.734IleAla: 5.734 ± 0.082	0.514IleCys: 0.514 ± 0.022	3.487IleAsp: 3.487 ± 0.064	3.477IleGlu: 3.477 ± 0.059	1.557IlePhe: 1.557 ± 0.045	4.504IleGly: 4.504 ± 0.067	1.116IleHis: 1.116 ± 0.035	2.602IleIle: 2.602 ± 0.06	1.667IleLys: 1.667 ± 0.04	4.576IleLeu: 4.576 ± 0.081	1.109IleMet: 1.109 ± 0.037	1.954IleAsn: 1.954 ± 0.05	2.453IlePro: 2.453 ± 0.05	1.787IleGln: 1.787 ± 0.044	3.263IleArg: 3.263 ± 0.06	3.247IleSer: 3.247 ± 0.061	2.869IleThr: 2.869 ± 0.046	3.143IleVal: 3.143 ± 0.065	0.572IleTrp: 0.572 ± 0.028	1.147IleTyr: 1.147 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.345LysAla: 3.345 ± 0.061	0.191LysCys: 0.191 ± 0.014	1.505LysAsp: 1.505 ± 0.039	1.563LysGlu: 1.563 ± 0.045	0.746LysPhe: 0.746 ± 0.031	2.307LysGly: 2.307 ± 0.05	0.687LysHis: 0.687 ± 0.024	1.442LysIle: 1.442 ± 0.043	1.118LysLys: 1.118 ± 0.046	3.311LysLeu: 3.311 ± 0.063	0.677LysMet: 0.677 ± 0.027	0.842LysAsn: 0.842 ± 0.03	1.798LysPro: 1.798 ± 0.048	1.409LysGln: 1.409 ± 0.039	2.117LysArg: 2.117 ± 0.052	1.533LysSer: 1.533 ± 0.039	1.601LysThr: 1.601 ± 0.045	2.371LysVal: 2.371 ± 0.049	0.305LysTrp: 0.305 ± 0.015	0.648LysTyr: 0.648 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.626LeuAla: 13.626 ± 0.148	1.142LeuCys: 1.142 ± 0.037	6.898LeuAsp: 6.898 ± 0.079	6.708LeuGlu: 6.708 ± 0.099	4.111LeuPhe: 4.111 ± 0.075	8.865LeuGly: 8.865 ± 0.1	2.498LeuHis: 2.498 ± 0.051	5.828LeuIle: 5.828 ± 0.089	3.485LeuLys: 3.485 ± 0.058	13.595LeuLeu: 13.595 ± 0.181	2.7LeuMet: 2.7 ± 0.053	3.413LeuAsn: 3.413 ± 0.059	6.371LeuPro: 6.371 ± 0.099	5.168LeuGln: 5.168 ± 0.092	7.502LeuArg: 7.502 ± 0.086	6.707LeuSer: 6.707 ± 0.083	5.886LeuThr: 5.886 ± 0.082	7.823LeuVal: 7.823 ± 0.107	1.429LeuTrp: 1.429 ± 0.039	2.578LeuTyr: 2.578 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.887MetAla: 2.887 ± 0.053	0.197MetCys: 0.197 ± 0.014	1.269MetAsp: 1.269 ± 0.037	1.214MetGlu: 1.214 ± 0.033	0.768MetPhe: 0.768 ± 0.027	1.895MetGly: 1.895 ± 0.04	0.586MetHis: 0.586 ± 0.026	1.256MetIle: 1.256 ± 0.036	0.885MetLys: 0.885 ± 0.028	3.071MetLeu: 3.071 ± 0.061	0.57MetMet: 0.57 ± 0.022	0.873MetAsn: 0.873 ± 0.027	1.456MetPro: 1.456 ± 0.041	1.203MetGln: 1.203 ± 0.036	1.646MetArg: 1.646 ± 0.04	1.745MetSer: 1.745 ± 0.037	1.555MetThr: 1.555 ± 0.039	1.853MetVal: 1.853 ± 0.045	0.204MetTrp: 0.204 ± 0.016	0.439MetTyr: 0.439 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.048AsnAla: 3.048 ± 0.052	0.286AsnCys: 0.286 ± 0.017	1.591AsnAsp: 1.591 ± 0.04	1.637AsnGlu: 1.637 ± 0.039	1.013AsnPhe: 1.013 ± 0.033	2.438AsnGly: 2.438 ± 0.05	0.667AsnHis: 0.667 ± 0.027	1.641AsnIle: 1.641 ± 0.038	0.894AsnLys: 0.894 ± 0.034	3.392AsnLeu: 3.392 ± 0.065	0.75AsnMet: 0.75 ± 0.027	1.034AsnAsn: 1.034 ± 0.039	2.023AsnPro: 2.023 ± 0.048	1.366AsnGln: 1.366 ± 0.04	2.045AsnArg: 2.045 ± 0.049	1.581AsnSer: 1.581 ± 0.04	1.619AsnThr: 1.619 ± 0.042	1.856AsnVal: 1.856 ± 0.047	0.462AsnTrp: 0.462 ± 0.023	0.837AsnTyr: 0.837 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.717ProAla: 5.717 ± 0.088	0.382ProCys: 0.382 ± 0.021	3.21ProAsp: 3.21 ± 0.055	3.756ProGlu: 3.756 ± 0.056	1.726ProPhe: 1.726 ± 0.036	4.152ProGly: 4.152 ± 0.067	1.028ProHis: 1.028 ± 0.029	2.049ProIle: 2.049 ± 0.045	1.19ProLys: 1.19 ± 0.038	5.519ProLeu: 5.519 ± 0.078	1.291ProMet: 1.291 ± 0.034	1.344ProAsn: 1.344 ± 0.036	2.075ProPro: 2.075 ± 0.049	2.174ProGln: 2.174 ± 0.05	2.543ProArg: 2.543 ± 0.044	2.423ProSer: 2.423 ± 0.053	2.234ProThr: 2.234 ± 0.047	4.09ProVal: 4.09 ± 0.061	0.749ProTrp: 0.749 ± 0.026	1.123ProTyr: 1.123 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.787GlnAla: 5.787 ± 0.082	0.363GlnCys: 0.363 ± 0.019	1.997GlnAsp: 1.997 ± 0.045	2.224GlnGlu: 2.224 ± 0.048	1.383GlnPhe: 1.383 ± 0.033	3.204GlnGly: 3.204 ± 0.058	1.222GlnHis: 1.222 ± 0.035	2.09GlnIle: 2.09 ± 0.043	1.059GlnLys: 1.059 ± 0.035	6.004GlnLeu: 6.004 ± 0.103	1.105GlnMet: 1.105 ± 0.03	1.132GlnAsn: 1.132 ± 0.037	2.721GlnPro: 2.721 ± 0.049	3.304GlnGln: 3.304 ± 0.08	3.861GlnArg: 3.861 ± 0.07	2.253GlnSer: 2.253 ± 0.046	2.062GlnThr: 2.062 ± 0.044	3.471GlnVal: 3.471 ± 0.062	0.722GlnTrp: 0.722 ± 0.027	0.96GlnTyr: 0.96 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.844ArgAla: 5.844 ± 0.08	0.606ArgCys: 0.606 ± 0.023	3.737ArgAsp: 3.737 ± 0.056	4.37ArgGlu: 4.37 ± 0.072	2.739ArgPhe: 2.739 ± 0.055	4.149ArgGly: 4.149 ± 0.063	1.826ArgHis: 1.826 ± 0.039	3.692ArgIle: 3.692 ± 0.064	2.076ArgLys: 2.076 ± 0.044	8.395ArgLeu: 8.395 ± 0.1	1.762ArgMet: 1.762 ± 0.036	2.071ArgAsn: 2.071 ± 0.043	2.9ArgPro: 2.9 ± 0.057	3.733ArgGln: 3.733 ± 0.072	4.737ArgArg: 4.737 ± 0.077	3.658ArgSer: 3.658 ± 0.058	2.919ArgThr: 2.919 ± 0.054	4.464ArgVal: 4.464 ± 0.061	1.098ArgTrp: 1.098 ± 0.031	2.09ArgTyr: 2.09 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.66SerAla: 5.66 ± 0.072	0.56SerCys: 0.56 ± 0.024	2.915SerAsp: 2.915 ± 0.054	3.111SerGlu: 3.111 ± 0.057	2.103SerPhe: 2.103 ± 0.048	5.103SerGly: 5.103 ± 0.068	1.327SerHis: 1.327 ± 0.039	2.874SerIle: 2.874 ± 0.057	1.605SerLys: 1.605 ± 0.046	6.613SerLeu: 6.613 ± 0.097	1.544SerMet: 1.544 ± 0.043	1.683SerAsn: 1.683 ± 0.037	2.648SerPro: 2.648 ± 0.05	2.33SerGln: 2.33 ± 0.053	3.772SerArg: 3.772 ± 0.069	3.36SerSer: 3.36 ± 0.064	2.766SerThr: 2.766 ± 0.055	3.813SerVal: 3.813 ± 0.058	0.861SerTrp: 0.861 ± 0.03	1.44SerTyr: 1.44 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.22ThrAla: 5.22 ± 0.068	0.421ThrCys: 0.421 ± 0.018	2.764ThrAsp: 2.764 ± 0.056	2.789ThrGlu: 2.789 ± 0.053	1.721ThrPhe: 1.721 ± 0.043	4.651ThrGly: 4.651 ± 0.08	1.057ThrHis: 1.057 ± 0.03	2.215ThrIle: 2.215 ± 0.045	1.043ThrLys: 1.043 ± 0.037	6.597ThrLeu: 6.597 ± 0.078	0.981ThrMet: 0.981 ± 0.033	1.288ThrAsn: 1.288 ± 0.037	3.043ThrPro: 3.043 ± 0.06	1.84ThrGln: 1.84 ± 0.049	3.232ThrArg: 3.232 ± 0.056	2.711ThrSer: 2.711 ± 0.052	2.481ThrThr: 2.481 ± 0.055	3.456ThrVal: 3.456 ± 0.055	0.652ThrTrp: 0.652 ± 0.029	1.091ThrTyr: 1.091 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.429ValAla: 7.429 ± 0.09	0.728ValCys: 0.728 ± 0.027	3.959ValAsp: 3.959 ± 0.066	4.402ValGlu: 4.402 ± 0.066	2.524ValPhe: 2.524 ± 0.053	5.095ValGly: 5.095 ± 0.071	1.471ValHis: 1.471 ± 0.038	4.102ValIle: 4.102 ± 0.066	2.088ValLys: 2.088 ± 0.056	7.919ValLeu: 7.919 ± 0.104	1.924ValMet: 1.924 ± 0.042	2.218ValAsn: 2.218 ± 0.046	3.227ValPro: 3.227 ± 0.061	2.575ValGln: 2.575 ± 0.051	4.375ValArg: 4.375 ± 0.069	4.115ValSer: 4.115 ± 0.066	3.796ValThr: 3.796 ± 0.059	5.485ValVal: 5.485 ± 0.082	0.886ValTrp: 0.886 ± 0.032	1.582ValTyr: 1.582 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.145TrpAla: 1.145 ± 0.032	0.152TrpCys: 0.152 ± 0.013	0.665TrpAsp: 0.665 ± 0.028	0.622TrpGlu: 0.622 ± 0.026	0.567TrpPhe: 0.567 ± 0.022	0.906TrpGly: 0.906 ± 0.032	0.397TrpHis: 0.397 ± 0.02	0.644TrpIle: 0.644 ± 0.026	0.354TrpLys: 0.354 ± 0.016	2.347TrpLeu: 2.347 ± 0.066	0.395TrpMet: 0.395 ± 0.02	0.431TrpAsn: 0.431 ± 0.018	0.722TrpPro: 0.722 ± 0.03	0.996TrpGln: 0.996 ± 0.036	1.084TrpArg: 1.084 ± 0.031	0.764TrpSer: 0.764 ± 0.03	0.656TrpThr: 0.656 ± 0.025	0.927TrpVal: 0.927 ± 0.033	0.232TrpTrp: 0.232 ± 0.018	0.351TrpTyr: 0.351 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.351TyrAla: 2.351 ± 0.05	0.294TyrCys: 0.294 ± 0.016	1.319TyrAsp: 1.319 ± 0.033	1.246TyrGlu: 1.246 ± 0.036	1.015TyrPhe: 1.015 ± 0.033	2.047TyrGly: 2.047 ± 0.049	0.602TyrHis: 0.602 ± 0.02	1.099TyrIle: 1.099 ± 0.034	0.667TyrLys: 0.667 ± 0.028	2.976TyrLeu: 2.976 ± 0.055	0.526TyrMet: 0.526 ± 0.021	0.691TyrAsn: 0.691 ± 0.026	1.294TyrPro: 1.294 ± 0.034	1.376TyrGln: 1.376 ± 0.035	2.085TyrArg: 2.085 ± 0.04	1.465TyrSer: 1.465 ± 0.038	1.165TyrThr: 1.165 ± 0.037	1.503TyrVal: 1.503 ± 0.04	0.392TyrTrp: 0.392 ± 0.021	0.702TyrTyr: 0.702 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3223 proteins (1068713 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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