Amino acid dipepetide frequency for Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.096AlaAla: 15.096 ± 0.119	0.962AlaCys: 0.962 ± 0.019	6.618AlaAsp: 6.618 ± 0.056	6.86AlaGlu: 6.86 ± 0.067	4.462AlaPhe: 4.462 ± 0.051	9.787AlaGly: 9.787 ± 0.075	2.042AlaHis: 2.042 ± 0.036	7.251AlaIle: 7.251 ± 0.056	4.477AlaLys: 4.477 ± 0.054	12.286AlaLeu: 12.286 ± 0.109	3.274AlaMet: 3.274 ± 0.043	3.123AlaAsn: 3.123 ± 0.052	4.61AlaPro: 4.61 ± 0.053	3.52AlaGln: 3.52 ± 0.049	7.251AlaArg: 7.251 ± 0.057	6.667AlaSer: 6.667 ± 0.055	5.934AlaThr: 5.934 ± 0.068	8.37AlaVal: 8.37 ± 0.074	1.327AlaTrp: 1.327 ± 0.029	2.617AlaTyr: 2.617 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.021	0.102CysCys: 0.102 ± 0.007	0.491CysAsp: 0.491 ± 0.016	0.404CysGlu: 0.404 ± 0.013	0.331CysPhe: 0.331 ± 0.013	0.843CysGly: 0.843 ± 0.02	0.211CysHis: 0.211 ± 0.011	0.413CysIle: 0.413 ± 0.014	0.206CysLys: 0.206 ± 0.01	0.788CysLeu: 0.788 ± 0.021	0.165CysMet: 0.165 ± 0.01	0.222CysAsn: 0.222 ± 0.012	0.376CysPro: 0.376 ± 0.015	0.221CysGln: 0.221 ± 0.01	0.529CysArg: 0.529 ± 0.016	0.486CysSer: 0.486 ± 0.016	0.36CysThr: 0.36 ± 0.014	0.569CysVal: 0.569 ± 0.016	0.112CysTrp: 0.112 ± 0.008	0.198CysTyr: 0.198 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.32AspAla: 6.32 ± 0.054	0.463AspCys: 0.463 ± 0.017	3.034AspAsp: 3.034 ± 0.044	3.334AspGlu: 3.334 ± 0.041	2.338AspPhe: 2.338 ± 0.035	5.011AspGly: 5.011 ± 0.052	1.304AspHis: 1.304 ± 0.028	3.66AspIle: 3.66 ± 0.043	1.982AspLys: 1.982 ± 0.032	5.74AspLeu: 5.74 ± 0.051	1.375AspMet: 1.375 ± 0.029	1.535AspAsn: 1.535 ± 0.028	3.253AspPro: 3.253 ± 0.046	1.77AspGln: 1.77 ± 0.035	4.042AspArg: 4.042 ± 0.055	2.291AspSer: 2.291 ± 0.039	2.611AspThr: 2.611 ± 0.042	4.176AspVal: 4.176 ± 0.053	0.95AspTrp: 0.95 ± 0.023	1.55AspTyr: 1.55 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.808GluAla: 6.808 ± 0.067	0.326GluCys: 0.326 ± 0.013	2.665GluAsp: 2.665 ± 0.042	3.203GluGlu: 3.203 ± 0.048	1.854GluPhe: 1.854 ± 0.032	3.855GluGly: 3.855 ± 0.052	1.188GluHis: 1.188 ± 0.026	3.727GluIle: 3.727 ± 0.044	2.535GluLys: 2.535 ± 0.038	5.234GluLeu: 5.234 ± 0.061	1.466GluMet: 1.466 ± 0.027	1.767GluAsn: 1.767 ± 0.029	2.539GluPro: 2.539 ± 0.038	2.069GluGln: 2.069 ± 0.036	4.532GluArg: 4.532 ± 0.055	2.336GluSer: 2.336 ± 0.036	3.525GluThr: 3.525 ± 0.042	3.549GluVal: 3.549 ± 0.04	0.674GluTrp: 0.674 ± 0.015	1.013GluTyr: 1.013 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.53PheAla: 4.53 ± 0.047	0.379PheCys: 0.379 ± 0.014	2.781PheAsp: 2.781 ± 0.034	2.15PheGlu: 2.15 ± 0.037	1.621PhePhe: 1.621 ± 0.031	3.807PheGly: 3.807 ± 0.047	0.815PheHis: 0.815 ± 0.021	2.004PheIle: 2.004 ± 0.032	1.204PheLys: 1.204 ± 0.023	3.619PheLeu: 3.619 ± 0.054	0.878PheMet: 0.878 ± 0.021	1.186PheAsn: 1.186 ± 0.027	1.68PhePro: 1.68 ± 0.031	1.14PheGln: 1.14 ± 0.023	2.264PheArg: 2.264 ± 0.034	2.638PheSer: 2.638 ± 0.035	2.056PheThr: 2.056 ± 0.035	3.006PheVal: 3.006 ± 0.04	0.538PheTrp: 0.538 ± 0.015	1.005PheTyr: 1.005 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	8.248GlyAla: 8.248 ± 0.078	0.763GlyCys: 0.763 ± 0.022	4.254GlyAsp: 4.254 ± 0.052	4.4GlyGlu: 4.4 ± 0.043	3.695GlyPhe: 3.695 ± 0.042	6.783GlyGly: 6.783 ± 0.075	1.862GlyHis: 1.862 ± 0.033	5.228GlyIle: 5.228 ± 0.055	3.781GlyLys: 3.781 ± 0.045	8.698GlyLeu: 8.698 ± 0.057	2.207GlyMet: 2.207 ± 0.038	2.476GlyAsn: 2.476 ± 0.045	3.088GlyPro: 3.088 ± 0.041	2.852GlyGln: 2.852 ± 0.04	5.483GlyArg: 5.483 ± 0.059	4.931GlySer: 4.931 ± 0.058	4.495GlyThr: 4.495 ± 0.054	5.763GlyVal: 5.763 ± 0.058	1.28GlyTrp: 1.28 ± 0.024	2.448GlyTyr: 2.448 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.156HisAla: 2.156 ± 0.033	0.196HisCys: 0.196 ± 0.01	1.28HisAsp: 1.28 ± 0.028	1.079HisGlu: 1.079 ± 0.023	0.911HisPhe: 0.911 ± 0.022	1.895HisGly: 1.895 ± 0.033	0.623HisHis: 0.623 ± 0.024	1.141HisIle: 1.141 ± 0.025	0.537HisLys: 0.537 ± 0.016	2.098HisLeu: 2.098 ± 0.033	0.547HisMet: 0.547 ± 0.016	0.478HisAsn: 0.478 ± 0.015	1.285HisPro: 1.285 ± 0.027	0.607HisGln: 0.607 ± 0.018	1.389HisArg: 1.389 ± 0.03	1.076HisSer: 1.076 ± 0.024	0.848HisThr: 0.848 ± 0.02	1.513HisVal: 1.513 ± 0.029	0.329HisTrp: 0.329 ± 0.013	0.593HisTyr: 0.593 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	8.121IleAla: 8.121 ± 0.09	0.578IleCys: 0.578 ± 0.016	3.95IleAsp: 3.95 ± 0.042	3.75IleGlu: 3.75 ± 0.046	2.166IlePhe: 2.166 ± 0.031	5.667IleGly: 5.667 ± 0.057	1.046IleHis: 1.046 ± 0.021	2.987IleIle: 2.987 ± 0.042	1.788IleLys: 1.788 ± 0.034	5.252IleLeu: 5.252 ± 0.065	1.181IleMet: 1.181 ± 0.024	1.727IleAsn: 1.727 ± 0.03	2.622IlePro: 2.622 ± 0.036	1.403IleGln: 1.403 ± 0.028	3.492IleArg: 3.492 ± 0.036	3.754IleSer: 3.754 ± 0.042	2.982IleThr: 2.982 ± 0.04	4.865IleVal: 4.865 ± 0.051	0.666IleTrp: 0.666 ± 0.019	1.293IleTyr: 1.293 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.675LysAla: 4.675 ± 0.054	0.17LysCys: 0.17 ± 0.01	2.044LysAsp: 2.044 ± 0.036	1.775LysGlu: 1.775 ± 0.033	1.058LysPhe: 1.058 ± 0.023	2.91LysGly: 2.91 ± 0.045	0.699LysHis: 0.699 ± 0.018	2.167LysIle: 2.167 ± 0.031	1.469LysLys: 1.469 ± 0.032	3.79LysLeu: 3.79 ± 0.045	0.911LysMet: 0.911 ± 0.024	1.08LysAsn: 1.08 ± 0.022	2.208LysPro: 2.208 ± 0.034	1.228LysGln: 1.228 ± 0.026	2.468LysArg: 2.468 ± 0.039	2.296LysSer: 2.296 ± 0.034	2.339LysThr: 2.339 ± 0.036	2.755LysVal: 2.755 ± 0.043	0.422LysTrp: 0.422 ± 0.012	0.717LysTyr: 0.717 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	12.584LeuAla: 12.584 ± 0.094	0.874LeuCys: 0.874 ± 0.021	5.812LeuAsp: 5.812 ± 0.064	5.102LeuGlu: 5.102 ± 0.048	3.799LeuPhe: 3.799 ± 0.05	7.927LeuGly: 7.927 ± 0.068	1.892LeuHis: 1.892 ± 0.034	5.501LeuIle: 5.501 ± 0.055	4.105LeuLys: 4.105 ± 0.044	9.557LeuLeu: 9.557 ± 0.095	2.416LeuMet: 2.416 ± 0.037	2.914LeuAsn: 2.914 ± 0.036	5.363LeuPro: 5.363 ± 0.058	2.943LeuGln: 2.943 ± 0.042	6.184LeuArg: 6.184 ± 0.06	7.284LeuSer: 7.284 ± 0.092	5.816LeuThr: 5.816 ± 0.064	7.18LeuVal: 7.18 ± 0.06	1.099LeuTrp: 1.099 ± 0.025	2.159LeuTyr: 2.159 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.931MetAla: 2.931 ± 0.037	0.136MetCys: 0.136 ± 0.008	1.163MetAsp: 1.163 ± 0.022	1.188MetGlu: 1.188 ± 0.023	0.744MetPhe: 0.744 ± 0.019	1.729MetGly: 1.729 ± 0.029	0.475MetHis: 0.475 ± 0.014	1.591MetIle: 1.591 ± 0.029	1.054MetLys: 1.054 ± 0.022	2.56MetLeu: 2.56 ± 0.039	0.693MetMet: 0.693 ± 0.018	0.867MetAsn: 0.867 ± 0.021	1.445MetPro: 1.445 ± 0.025	0.871MetGln: 0.871 ± 0.022	1.762MetArg: 1.762 ± 0.031	1.777MetSer: 1.777 ± 0.028	1.972MetThr: 1.972 ± 0.03	1.731MetVal: 1.731 ± 0.03	0.196MetTrp: 0.196 ± 0.011	0.326MetTyr: 0.326 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.362AsnAla: 3.362 ± 0.051	0.235AsnCys: 0.235 ± 0.011	1.604AsnAsp: 1.604 ± 0.032	1.39AsnGlu: 1.39 ± 0.025	1.19AsnPhe: 1.19 ± 0.023	2.832AsnGly: 2.832 ± 0.045	0.585AsnHis: 0.585 ± 0.018	1.687AsnIle: 1.687 ± 0.027	0.876AsnLys: 0.876 ± 0.02	2.859AsnLeu: 2.859 ± 0.039	0.687AsnMet: 0.687 ± 0.018	0.872AsnAsn: 0.872 ± 0.023	1.917AsnPro: 1.917 ± 0.031	0.895AsnGln: 0.895 ± 0.023	1.872AsnArg: 1.872 ± 0.034	1.626AsnSer: 1.626 ± 0.033	1.423AsnThr: 1.423 ± 0.025	2.155AsnVal: 2.155 ± 0.035	0.478AsnTrp: 0.478 ± 0.015	0.783AsnTyr: 0.783 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.421ProAla: 5.421 ± 0.059	0.273ProCys: 0.273 ± 0.01	3.32ProAsp: 3.32 ± 0.048	3.329ProGlu: 3.329 ± 0.046	1.975ProPhe: 1.975 ± 0.028	3.899ProGly: 3.899 ± 0.045	1.047ProHis: 1.047 ± 0.023	2.572ProIle: 2.572 ± 0.035	1.811ProLys: 1.811 ± 0.031	4.633ProLeu: 4.633 ± 0.045	1.186ProMet: 1.186 ± 0.019	1.471ProAsn: 1.471 ± 0.029	2.12ProPro: 2.12 ± 0.041	1.705ProGln: 1.705 ± 0.032	2.518ProArg: 2.518 ± 0.038	2.904ProSer: 2.904 ± 0.032	2.542ProThr: 2.542 ± 0.033	3.969ProVal: 3.969 ± 0.049	0.639ProTrp: 0.639 ± 0.021	1.273ProTyr: 1.273 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.938GlnAla: 3.938 ± 0.052	0.2GlnCys: 0.2 ± 0.011	1.484GlnAsp: 1.484 ± 0.029	1.514GlnGlu: 1.514 ± 0.026	1.117GlnPhe: 1.117 ± 0.022	2.254GlnGly: 2.254 ± 0.036	0.663GlnHis: 0.663 ± 0.016	2.025GlnIle: 2.025 ± 0.059	1.309GlnLys: 1.309 ± 0.027	3.006GlnLeu: 3.006 ± 0.041	0.945GlnMet: 0.945 ± 0.019	0.975GlnAsn: 0.975 ± 0.023	1.777GlnPro: 1.777 ± 0.036	1.421GlnGln: 1.421 ± 0.036	2.27GlnArg: 2.27 ± 0.036	2.036GlnSer: 2.036 ± 0.036	1.848GlnThr: 1.848 ± 0.032	2.124GlnVal: 2.124 ± 0.041	0.415GlnTrp: 0.415 ± 0.012	0.678GlnTyr: 0.678 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.492ArgAla: 6.492 ± 0.054	0.448ArgCys: 0.448 ± 0.014	3.771ArgAsp: 3.771 ± 0.047	3.654ArgGlu: 3.654 ± 0.048	2.803ArgPhe: 2.803 ± 0.043	4.227ArgGly: 4.227 ± 0.049	1.621ArgHis: 1.621 ± 0.028	4.129ArgIle: 4.129 ± 0.04	2.481ArgLys: 2.481 ± 0.036	7.217ArgLeu: 7.217 ± 0.071	1.796ArgMet: 1.796 ± 0.028	2.052ArgAsn: 2.052 ± 0.029	3.068ArgPro: 3.068 ± 0.043	2.598ArgGln: 2.598 ± 0.034	5.0ArgArg: 5.0 ± 0.064	3.828ArgSer: 3.828 ± 0.042	3.123ArgThr: 3.123 ± 0.038	4.211ArgVal: 4.211 ± 0.049	0.883ArgTrp: 0.883 ± 0.019	1.731ArgTyr: 1.731 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.432SerAla: 6.432 ± 0.063	0.412SerCys: 0.412 ± 0.013	3.296SerAsp: 3.296 ± 0.045	2.987SerGlu: 2.987 ± 0.038	2.643SerPhe: 2.643 ± 0.034	5.962SerGly: 5.962 ± 0.06	1.242SerHis: 1.242 ± 0.025	3.49SerIle: 3.49 ± 0.043	1.967SerLys: 1.967 ± 0.035	6.125SerLeu: 6.125 ± 0.06	1.482SerMet: 1.482 ± 0.025	1.756SerAsn: 1.756 ± 0.031	2.86SerPro: 2.86 ± 0.041	1.838SerGln: 1.838 ± 0.033	3.74SerArg: 3.74 ± 0.05	3.757SerSer: 3.757 ± 0.061	3.229SerThr: 3.229 ± 0.069	4.387SerVal: 4.387 ± 0.054	0.844SerTrp: 0.844 ± 0.024	1.478SerTyr: 1.478 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.334ThrAla: 6.334 ± 0.08	0.375ThrCys: 0.375 ± 0.014	2.939ThrAsp: 2.939 ± 0.04	2.7ThrGlu: 2.7 ± 0.035	2.146ThrPhe: 2.146 ± 0.038	4.818ThrGly: 4.818 ± 0.055	1.08ThrHis: 1.08 ± 0.025	3.502ThrIle: 3.502 ± 0.044	1.788ThrLys: 1.788 ± 0.031	5.807ThrLeu: 5.807 ± 0.053	1.341ThrMet: 1.341 ± 0.026	1.511ThrAsn: 1.511 ± 0.035	3.034ThrPro: 3.034 ± 0.039	1.522ThrGln: 1.522 ± 0.036	3.091ThrArg: 3.091 ± 0.039	3.252ThrSer: 3.252 ± 0.053	3.159ThrThr: 3.159 ± 0.064	4.473ThrVal: 4.473 ± 0.047	0.62ThrTrp: 0.62 ± 0.018	1.28ThrTyr: 1.28 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	8.644ValAla: 8.644 ± 0.074	0.595ValCys: 0.595 ± 0.018	4.093ValAsp: 4.093 ± 0.044	4.239ValGlu: 4.239 ± 0.052	2.862ValPhe: 2.862 ± 0.039	5.489ValGly: 5.489 ± 0.061	1.349ValHis: 1.349 ± 0.028	4.426ValIle: 4.426 ± 0.053	2.551ValLys: 2.551 ± 0.038	7.25ValLeu: 7.25 ± 0.063	1.841ValMet: 1.841 ± 0.028	2.1ValAsn: 2.1 ± 0.038	3.529ValPro: 3.529 ± 0.044	2.018ValGln: 2.018 ± 0.03	4.507ValArg: 4.507 ± 0.048	4.786ValSer: 4.786 ± 0.047	4.598ValThr: 4.598 ± 0.044	5.651ValVal: 5.651 ± 0.059	0.839ValTrp: 0.839 ± 0.02	1.529ValTyr: 1.529 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.122TrpAla: 1.122 ± 0.029	0.13TrpCys: 0.13 ± 0.008	0.612TrpAsp: 0.612 ± 0.019	0.558TrpGlu: 0.558 ± 0.019	0.552TrpPhe: 0.552 ± 0.015	0.863TrpGly: 0.863 ± 0.021	0.333TrpHis: 0.333 ± 0.015	0.691TrpIle: 0.691 ± 0.019	0.52TrpLys: 0.52 ± 0.017	1.608TrpLeu: 1.608 ± 0.031	0.355TrpMet: 0.355 ± 0.012	0.496TrpAsn: 0.496 ± 0.016	0.648TrpPro: 0.648 ± 0.018	0.585TrpGln: 0.585 ± 0.019	0.997TrpArg: 0.997 ± 0.023	0.86TrpSer: 0.86 ± 0.02	0.719TrpThr: 0.719 ± 0.018	0.744TrpVal: 0.744 ± 0.02	0.214TrpTrp: 0.214 ± 0.01	0.301TrpTyr: 0.301 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.035	0.236TyrCys: 0.236 ± 0.011	1.527TyrAsp: 1.527 ± 0.032	1.251TyrGlu: 1.251 ± 0.025	1.033TyrPhe: 1.033 ± 0.024	2.175TyrGly: 2.175 ± 0.039	0.504TyrHis: 0.504 ± 0.017	1.096TyrIle: 1.096 ± 0.023	0.74TyrLys: 0.74 ± 0.018	2.384TyrLeu: 2.384 ± 0.037	0.464TyrMet: 0.464 ± 0.015	0.72TyrAsn: 0.72 ± 0.021	1.188TyrPro: 1.188 ± 0.023	0.792TyrGln: 0.792 ± 0.018	1.742TyrArg: 1.742 ± 0.03	1.343TyrSer: 1.343 ± 0.03	1.194TyrThr: 1.194 ± 0.027	1.705TyrVal: 1.705 ± 0.026	0.381TyrTrp: 0.381 ± 0.015	0.663TyrTyr: 0.663 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6674 proteins (2107362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---