Amino acid dipepetide frequency for Klebsiella phage ST13-OXA48phi12.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.132AlaAla: 10.132 ± 1.152
1.144AlaCys: 1.144 ± 0.396
7.027AlaAsp: 7.027 ± 0.728
6.21AlaGlu: 6.21 ± 0.727
3.023AlaPhe: 3.023 ± 0.584
7.272AlaGly: 7.272 ± 1.105
1.553AlaHis: 1.553 ± 0.389
4.331AlaIle: 4.331 ± 0.505
5.556AlaLys: 5.556 ± 0.797
9.397AlaLeu: 9.397 ± 1.017
3.269AlaMet: 3.269 ± 0.552
2.451AlaAsn: 2.451 ± 0.416
3.023AlaPro: 3.023 ± 0.533
3.677AlaGln: 3.677 ± 0.696
6.128AlaArg: 6.128 ± 0.871
6.946AlaSer: 6.946 ± 0.835
4.739AlaThr: 4.739 ± 0.555
7.027AlaVal: 7.027 ± 0.745
1.144AlaTrp: 1.144 ± 0.26
3.105AlaTyr: 3.105 ± 0.506
0.0AlaXaa: 0.0 ± 0.0
Cys
0.572CysAla: 0.572 ± 0.328
0.245CysCys: 0.245 ± 0.184
0.409CysAsp: 0.409 ± 0.214
0.572CysGlu: 0.572 ± 0.239
0.409CysPhe: 0.409 ± 0.171
0.735CysGly: 0.735 ± 0.283
0.245CysHis: 0.245 ± 0.161
0.327CysIle: 0.327 ± 0.193
0.49CysLys: 0.49 ± 0.189
1.226CysLeu: 1.226 ± 0.413
0.163CysMet: 0.163 ± 0.123
0.245CysAsn: 0.245 ± 0.142
0.654CysPro: 0.654 ± 0.254
0.654CysGln: 0.654 ± 0.284
0.735CysArg: 0.735 ± 0.322
0.327CysSer: 0.327 ± 0.171
0.572CysThr: 0.572 ± 0.184
0.735CysVal: 0.735 ± 0.202
0.327CysTrp: 0.327 ± 0.155
0.49CysTyr: 0.49 ± 0.19
0.0CysXaa: 0.0 ± 0.0
Asp
6.292AspAla: 6.292 ± 0.754
0.327AspCys: 0.327 ± 0.143
4.331AspAsp: 4.331 ± 0.707
4.004AspGlu: 4.004 ± 0.605
2.615AspPhe: 2.615 ± 0.517
5.802AspGly: 5.802 ± 0.538
0.817AspHis: 0.817 ± 0.259
3.759AspIle: 3.759 ± 0.515
3.023AspLys: 3.023 ± 0.393
4.984AspLeu: 4.984 ± 0.679
1.471AspMet: 1.471 ± 0.381
2.942AspAsn: 2.942 ± 0.513
2.533AspPro: 2.533 ± 0.454
2.533AspGln: 2.533 ± 0.446
2.942AspArg: 2.942 ± 0.4
3.187AspSer: 3.187 ± 0.478
3.187AspThr: 3.187 ± 0.567
4.412AspVal: 4.412 ± 0.743
0.49AspTrp: 0.49 ± 0.197
1.553AspTyr: 1.553 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
5.802GluAla: 5.802 ± 0.751
0.572GluCys: 0.572 ± 0.222
3.432GluAsp: 3.432 ± 0.926
3.759GluGlu: 3.759 ± 0.725
2.37GluPhe: 2.37 ± 0.395
3.269GluGly: 3.269 ± 0.516
0.817GluHis: 0.817 ± 0.311
2.86GluIle: 2.86 ± 0.475
4.086GluLys: 4.086 ± 0.533
8.498GluLeu: 8.498 ± 0.922
2.043GluMet: 2.043 ± 0.457
3.105GluAsn: 3.105 ± 0.514
2.533GluPro: 2.533 ± 0.466
3.35GluGln: 3.35 ± 0.582
3.759GluArg: 3.759 ± 0.471
3.187GluSer: 3.187 ± 0.567
4.903GluThr: 4.903 ± 0.794
3.595GluVal: 3.595 ± 0.678
0.981GluTrp: 0.981 ± 0.309
2.043GluTyr: 2.043 ± 0.507
0.0GluXaa: 0.0 ± 0.0
Phe
3.514PheAla: 3.514 ± 0.506
0.49PheCys: 0.49 ± 0.177
1.961PheAsp: 1.961 ± 0.486
1.961PheGlu: 1.961 ± 0.371
1.062PhePhe: 1.062 ± 0.355
1.798PheGly: 1.798 ± 0.409
0.981PheHis: 0.981 ± 0.317
1.879PheIle: 1.879 ± 0.411
1.389PheLys: 1.389 ± 0.3
2.451PheLeu: 2.451 ± 0.441
1.226PheMet: 1.226 ± 0.337
2.043PheAsn: 2.043 ± 0.464
1.471PhePro: 1.471 ± 0.381
1.144PheGln: 1.144 ± 0.344
2.942PheArg: 2.942 ± 0.516
3.105PheSer: 3.105 ± 0.554
2.37PheThr: 2.37 ± 0.492
1.553PheVal: 1.553 ± 0.28
1.062PheTrp: 1.062 ± 0.285
0.735PheTyr: 0.735 ± 0.234
0.0PheXaa: 0.0 ± 0.0
Gly
6.047GlyAla: 6.047 ± 0.731
0.654GlyCys: 0.654 ± 0.219
3.514GlyAsp: 3.514 ± 0.469
5.148GlyGlu: 5.148 ± 0.788
3.187GlyPhe: 3.187 ± 0.485
6.128GlyGly: 6.128 ± 1.142
0.899GlyHis: 0.899 ± 0.322
4.412GlyIle: 4.412 ± 0.711
4.086GlyLys: 4.086 ± 0.7
5.556GlyLeu: 5.556 ± 0.824
2.125GlyMet: 2.125 ± 0.396
4.086GlyAsn: 4.086 ± 0.638
1.879GlyPro: 1.879 ± 0.405
2.37GlyGln: 2.37 ± 0.52
4.167GlyArg: 4.167 ± 0.704
4.086GlySer: 4.086 ± 0.607
3.269GlyThr: 3.269 ± 0.446
4.739GlyVal: 4.739 ± 0.661
0.981GlyTrp: 0.981 ± 0.294
1.798GlyTyr: 1.798 ± 0.371
0.0GlyXaa: 0.0 ± 0.0
His
1.389HisAla: 1.389 ± 0.302
0.327HisCys: 0.327 ± 0.16
0.654HisAsp: 0.654 ± 0.296
0.49HisGlu: 0.49 ± 0.205
0.654HisPhe: 0.654 ± 0.31
0.981HisGly: 0.981 ± 0.307
0.654HisHis: 0.654 ± 0.296
0.735HisIle: 0.735 ± 0.234
1.307HisLys: 1.307 ± 0.357
1.307HisLeu: 1.307 ± 0.292
0.899HisMet: 0.899 ± 0.255
0.572HisAsn: 0.572 ± 0.221
0.899HisPro: 0.899 ± 0.239
0.735HisGln: 0.735 ± 0.244
1.062HisArg: 1.062 ± 0.392
0.899HisSer: 0.899 ± 0.389
1.471HisThr: 1.471 ± 0.343
0.817HisVal: 0.817 ± 0.232
0.409HisTrp: 0.409 ± 0.178
0.735HisTyr: 0.735 ± 0.277
0.0HisXaa: 0.0 ± 0.0
Ile
5.23IleAla: 5.23 ± 0.518
0.49IleCys: 0.49 ± 0.208
4.167IleAsp: 4.167 ± 0.584
3.677IleGlu: 3.677 ± 0.648
1.307IlePhe: 1.307 ± 0.426
3.432IleGly: 3.432 ± 0.596
0.654IleHis: 0.654 ± 0.235
2.206IleIle: 2.206 ± 0.32
2.942IleLys: 2.942 ± 0.529
3.105IleLeu: 3.105 ± 0.454
1.879IleMet: 1.879 ± 0.407
3.105IleAsn: 3.105 ± 0.583
1.961IlePro: 1.961 ± 0.464
1.716IleGln: 1.716 ± 0.416
3.677IleArg: 3.677 ± 0.456
3.187IleSer: 3.187 ± 0.459
4.167IleThr: 4.167 ± 0.489
2.942IleVal: 2.942 ± 0.61
0.572IleTrp: 0.572 ± 0.197
1.553IleTyr: 1.553 ± 0.354
0.0IleXaa: 0.0 ± 0.0
Lys
4.821LysAla: 4.821 ± 0.584
0.327LysCys: 0.327 ± 0.155
2.451LysAsp: 2.451 ± 0.582
2.533LysGlu: 2.533 ± 0.454
1.716LysPhe: 1.716 ± 0.388
3.84LysGly: 3.84 ± 0.523
1.144LysHis: 1.144 ± 0.345
2.778LysIle: 2.778 ± 0.677
4.004LysLys: 4.004 ± 0.652
4.903LysLeu: 4.903 ± 0.816
1.226LysMet: 1.226 ± 0.274
2.043LysAsn: 2.043 ± 0.437
2.206LysPro: 2.206 ± 0.417
2.86LysGln: 2.86 ± 0.445
4.331LysArg: 4.331 ± 0.703
2.778LysSer: 2.778 ± 0.442
3.35LysThr: 3.35 ± 0.554
1.634LysVal: 1.634 ± 0.402
1.226LysTrp: 1.226 ± 0.326
1.307LysTyr: 1.307 ± 0.329
0.0LysXaa: 0.0 ± 0.0
Leu
10.296LeuAla: 10.296 ± 0.923
1.062LeuCys: 1.062 ± 0.314
5.802LeuAsp: 5.802 ± 0.677
5.556LeuGlu: 5.556 ± 0.704
3.432LeuPhe: 3.432 ± 0.556
5.72LeuGly: 5.72 ± 0.824
1.307LeuHis: 1.307 ± 0.283
5.066LeuIle: 5.066 ± 0.6
4.331LeuLys: 4.331 ± 0.594
8.171LeuLeu: 8.171 ± 0.786
2.37LeuMet: 2.37 ± 0.456
4.821LeuAsn: 4.821 ± 0.556
4.412LeuPro: 4.412 ± 0.578
4.412LeuGln: 4.412 ± 0.537
6.7LeuArg: 6.7 ± 0.975
5.556LeuSer: 5.556 ± 0.917
6.21LeuThr: 6.21 ± 0.66
5.148LeuVal: 5.148 ± 0.607
0.817LeuTrp: 0.817 ± 0.245
2.533LeuTyr: 2.533 ± 0.427
0.0LeuXaa: 0.0 ± 0.0
Met
3.759MetAla: 3.759 ± 0.595
0.409MetCys: 0.409 ± 0.143
1.471MetAsp: 1.471 ± 0.315
1.798MetGlu: 1.798 ± 0.332
0.654MetPhe: 0.654 ± 0.278
1.553MetGly: 1.553 ± 0.404
0.327MetHis: 0.327 ± 0.146
1.144MetIle: 1.144 ± 0.318
0.981MetLys: 0.981 ± 0.247
2.615MetLeu: 2.615 ± 0.35
1.471MetMet: 1.471 ± 0.54
1.389MetAsn: 1.389 ± 0.343
1.553MetPro: 1.553 ± 0.344
0.899MetGln: 0.899 ± 0.258
1.634MetArg: 1.634 ± 0.374
2.206MetSer: 2.206 ± 0.435
2.288MetThr: 2.288 ± 0.433
1.307MetVal: 1.307 ± 0.291
0.409MetTrp: 0.409 ± 0.173
0.735MetTyr: 0.735 ± 0.266
0.0MetXaa: 0.0 ± 0.0
Asn
4.086AsnAla: 4.086 ± 0.461
0.49AsnCys: 0.49 ± 0.243
2.125AsnAsp: 2.125 ± 0.425
3.35AsnGlu: 3.35 ± 0.529
1.307AsnPhe: 1.307 ± 0.313
3.759AsnGly: 3.759 ± 0.667
0.817AsnHis: 0.817 ± 0.321
2.451AsnIle: 2.451 ± 0.473
2.37AsnLys: 2.37 ± 0.348
3.84AsnLeu: 3.84 ± 0.532
1.062AsnMet: 1.062 ± 0.313
1.389AsnAsn: 1.389 ± 0.378
3.187AsnPro: 3.187 ± 0.577
2.125AsnGln: 2.125 ± 0.305
2.533AsnArg: 2.533 ± 0.522
2.451AsnSer: 2.451 ± 0.551
1.226AsnThr: 1.226 ± 0.276
2.697AsnVal: 2.697 ± 0.531
0.735AsnTrp: 0.735 ± 0.281
1.144AsnTyr: 1.144 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
4.249ProAla: 4.249 ± 0.555
0.409ProCys: 0.409 ± 0.175
3.514ProAsp: 3.514 ± 0.595
2.778ProGlu: 2.778 ± 0.436
1.471ProPhe: 1.471 ± 0.348
3.023ProGly: 3.023 ± 0.543
0.735ProHis: 0.735 ± 0.296
1.471ProIle: 1.471 ± 0.307
1.961ProLys: 1.961 ± 0.327
4.249ProLeu: 4.249 ± 0.574
0.654ProMet: 0.654 ± 0.281
1.307ProAsn: 1.307 ± 0.355
1.961ProPro: 1.961 ± 0.423
1.553ProGln: 1.553 ± 0.347
2.288ProArg: 2.288 ± 0.41
2.206ProSer: 2.206 ± 0.4
1.634ProThr: 1.634 ± 0.31
3.677ProVal: 3.677 ± 0.568
0.735ProTrp: 0.735 ± 0.193
1.226ProTyr: 1.226 ± 0.321
0.0ProXaa: 0.0 ± 0.0
Gln
5.148GlnAla: 5.148 ± 0.724
0.654GlnCys: 0.654 ± 0.246
1.798GlnAsp: 1.798 ± 0.341
2.942GlnGlu: 2.942 ± 0.62
1.471GlnPhe: 1.471 ± 0.313
2.942GlnGly: 2.942 ± 0.442
0.082GlnHis: 0.082 ± 0.104
1.716GlnIle: 1.716 ± 0.535
1.307GlnLys: 1.307 ± 0.399
5.638GlnLeu: 5.638 ± 0.68
1.716GlnMet: 1.716 ± 0.403
1.471GlnAsn: 1.471 ± 0.298
1.471GlnPro: 1.471 ± 0.337
1.961GlnGln: 1.961 ± 0.499
3.84GlnArg: 3.84 ± 0.673
2.86GlnSer: 2.86 ± 0.527
2.288GlnThr: 2.288 ± 0.486
3.105GlnVal: 3.105 ± 0.417
0.572GlnTrp: 0.572 ± 0.267
1.307GlnTyr: 1.307 ± 0.305
0.0GlnXaa: 0.0 ± 0.0
Arg
6.21ArgAla: 6.21 ± 0.588
0.409ArgCys: 0.409 ± 0.183
3.595ArgAsp: 3.595 ± 0.546
4.903ArgGlu: 4.903 ± 0.895
2.451ArgPhe: 2.451 ± 0.505
3.187ArgGly: 3.187 ± 0.514
1.961ArgHis: 1.961 ± 0.388
4.004ArgIle: 4.004 ± 0.509
3.35ArgLys: 3.35 ± 0.883
6.374ArgLeu: 6.374 ± 0.731
1.307ArgMet: 1.307 ± 0.361
2.288ArgAsn: 2.288 ± 0.503
2.043ArgPro: 2.043 ± 0.447
4.412ArgGln: 4.412 ± 0.691
5.883ArgArg: 5.883 ± 0.765
4.004ArgSer: 4.004 ± 0.596
2.778ArgThr: 2.778 ± 0.421
5.393ArgVal: 5.393 ± 0.757
1.307ArgTrp: 1.307 ± 0.371
1.634ArgTyr: 1.634 ± 0.349
0.0ArgXaa: 0.0 ± 0.0
Ser
5.72SerAla: 5.72 ± 0.655
0.572SerCys: 0.572 ± 0.196
3.595SerAsp: 3.595 ± 0.438
3.84SerGlu: 3.84 ± 0.612
1.634SerPhe: 1.634 ± 0.277
4.412SerGly: 4.412 ± 0.573
1.634SerHis: 1.634 ± 0.513
2.697SerIle: 2.697 ± 0.522
3.35SerLys: 3.35 ± 0.602
5.556SerLeu: 5.556 ± 0.82
2.125SerMet: 2.125 ± 0.457
2.697SerAsn: 2.697 ± 0.512
2.451SerPro: 2.451 ± 0.431
2.533SerGln: 2.533 ± 0.478
3.514SerArg: 3.514 ± 0.472
2.942SerSer: 2.942 ± 0.457
3.84SerThr: 3.84 ± 0.673
4.004SerVal: 4.004 ± 0.704
0.735SerTrp: 0.735 ± 0.271
1.471SerTyr: 1.471 ± 0.404
0.0SerXaa: 0.0 ± 0.0
Thr
5.311ThrAla: 5.311 ± 0.658
0.327ThrCys: 0.327 ± 0.157
4.739ThrAsp: 4.739 ± 0.592
4.167ThrGlu: 4.167 ± 0.587
1.879ThrPhe: 1.879 ± 0.347
5.475ThrGly: 5.475 ± 0.782
0.817ThrHis: 0.817 ± 0.22
3.269ThrIle: 3.269 ± 0.494
1.634ThrLys: 1.634 ± 0.388
5.475ThrLeu: 5.475 ± 0.51
1.062ThrMet: 1.062 ± 0.356
2.125ThrAsn: 2.125 ± 0.403
2.37ThrPro: 2.37 ± 0.5
2.533ThrGln: 2.533 ± 0.428
4.331ThrArg: 4.331 ± 0.576
2.942ThrSer: 2.942 ± 0.527
4.412ThrThr: 4.412 ± 0.626
4.004ThrVal: 4.004 ± 0.518
0.409ThrTrp: 0.409 ± 0.188
1.879ThrTyr: 1.879 ± 0.482
0.0ThrXaa: 0.0 ± 0.0
Val
5.72ValAla: 5.72 ± 0.685
0.572ValCys: 0.572 ± 0.18
3.759ValAsp: 3.759 ± 0.558
3.922ValGlu: 3.922 ± 0.53
2.37ValPhe: 2.37 ± 0.334
3.35ValGly: 3.35 ± 0.766
0.735ValHis: 0.735 ± 0.213
4.249ValIle: 4.249 ± 0.551
3.759ValLys: 3.759 ± 0.476
5.23ValLeu: 5.23 ± 0.519
1.798ValMet: 1.798 ± 0.333
3.432ValAsn: 3.432 ± 0.57
2.778ValPro: 2.778 ± 0.406
2.615ValGln: 2.615 ± 0.546
3.35ValArg: 3.35 ± 0.476
4.658ValSer: 4.658 ± 0.674
4.086ValThr: 4.086 ± 0.585
3.595ValVal: 3.595 ± 0.563
1.062ValTrp: 1.062 ± 0.326
1.471ValTyr: 1.471 ± 0.473
0.0ValXaa: 0.0 ± 0.0
Trp
0.981TrpAla: 0.981 ± 0.263
0.245TrpCys: 0.245 ± 0.161
0.981TrpAsp: 0.981 ± 0.357
1.062TrpGlu: 1.062 ± 0.319
0.654TrpPhe: 0.654 ± 0.221
0.327TrpGly: 0.327 ± 0.16
0.327TrpHis: 0.327 ± 0.172
1.062TrpIle: 1.062 ± 0.335
0.899TrpLys: 0.899 ± 0.278
2.206TrpLeu: 2.206 ± 0.395
0.245TrpMet: 0.245 ± 0.139
0.327TrpAsn: 0.327 ± 0.173
0.572TrpPro: 0.572 ± 0.194
0.735TrpGln: 0.735 ± 0.211
1.226TrpArg: 1.226 ± 0.313
0.654TrpSer: 0.654 ± 0.217
0.49TrpThr: 0.49 ± 0.227
0.654TrpVal: 0.654 ± 0.225
0.49TrpTrp: 0.49 ± 0.178
0.572TrpTyr: 0.572 ± 0.278
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.879TyrAla: 1.879 ± 0.333
0.409TyrCys: 0.409 ± 0.188
1.879TyrAsp: 1.879 ± 0.361
2.288TyrGlu: 2.288 ± 0.405
1.471TyrPhe: 1.471 ± 0.406
2.125TyrGly: 2.125 ± 0.429
0.49TyrHis: 0.49 ± 0.212
1.553TyrIle: 1.553 ± 0.312
0.654TyrLys: 0.654 ± 0.245
2.942TyrLeu: 2.942 ± 0.585
0.49TyrMet: 0.49 ± 0.226
1.307TyrAsn: 1.307 ± 0.423
1.144TyrPro: 1.144 ± 0.277
1.471TyrGln: 1.471 ± 0.386
2.451TyrArg: 2.451 ± 0.502
1.144TyrSer: 1.144 ± 0.257
1.879TyrThr: 1.879 ± 0.428
1.471TyrVal: 1.471 ± 0.326
0.245TyrTrp: 0.245 ± 0.148
0.49TyrTyr: 0.49 ± 0.235
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (12239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski