Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus; Human alphaherpesvirus 3

Average proteome isoelectric point is 6.75

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 70 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P09264|TEG1_VZVD Tegument protein UL46 homolog OS=Varicella-zoster virus (strain Dumas) OX=10338 GN=ORF12 PE=3 SV=1
MM1 pKa = 7.68QSGHH5 pKa = 4.86YY6 pKa = 9.77NRR8 pKa = 11.84RR9 pKa = 11.84QSRR12 pKa = 11.84RR13 pKa = 11.84QRR15 pKa = 11.84ISSNTTDD22 pKa = 3.7SPRR25 pKa = 11.84HH26 pKa = 4.12THH28 pKa = 4.18GTRR31 pKa = 11.84YY32 pKa = 10.06RR33 pKa = 11.84STNWYY38 pKa = 5.81THH40 pKa = 6.65PPQILSNSEE49 pKa = 3.81TLVAVQEE56 pKa = 4.25LLNSEE61 pKa = 4.36MDD63 pKa = 3.34QDD65 pKa = 4.13SSSDD69 pKa = 3.47ASDD72 pKa = 4.6DD73 pKa = 3.89FPGYY77 pKa = 10.4ALHH80 pKa = 6.96HH81 pKa = 5.29STYY84 pKa = 10.77NGSEE88 pKa = 4.21QNTSTSRR95 pKa = 11.84HH96 pKa = 4.88EE97 pKa = 3.85NRR99 pKa = 11.84IFKK102 pKa = 9.06LTEE105 pKa = 3.57RR106 pKa = 11.84EE107 pKa = 4.07ANEE110 pKa = 4.39EE111 pKa = 3.9ININTDD117 pKa = 3.47AIDD120 pKa = 4.23DD121 pKa = 3.88EE122 pKa = 5.47GEE124 pKa = 4.14AEE126 pKa = 4.04EE127 pKa = 5.88GEE129 pKa = 4.29AEE131 pKa = 4.11EE132 pKa = 5.78DD133 pKa = 4.16AIDD136 pKa = 4.58DD137 pKa = 3.75EE138 pKa = 5.54GEE140 pKa = 4.14AEE142 pKa = 4.04EE143 pKa = 5.88GEE145 pKa = 4.29AEE147 pKa = 4.11EE148 pKa = 5.78DD149 pKa = 4.16AIDD152 pKa = 4.58DD153 pKa = 3.75EE154 pKa = 5.54GEE156 pKa = 4.14AEE158 pKa = 4.04EE159 pKa = 5.88GEE161 pKa = 4.29AEE163 pKa = 4.11EE164 pKa = 5.78DD165 pKa = 4.16AIDD168 pKa = 4.58DD169 pKa = 3.75EE170 pKa = 5.54GEE172 pKa = 4.14AEE174 pKa = 4.03EE175 pKa = 5.47GEE177 pKa = 4.31AEE179 pKa = 4.05EE180 pKa = 5.49GEE182 pKa = 4.31AEE184 pKa = 4.04EE185 pKa = 5.9GEE187 pKa = 4.29AEE189 pKa = 4.11EE190 pKa = 5.78DD191 pKa = 4.16AIDD194 pKa = 4.58DD195 pKa = 3.87EE196 pKa = 5.74GEE198 pKa = 4.18AEE200 pKa = 3.83EE201 pKa = 5.46DD202 pKa = 3.5AAEE205 pKa = 4.25EE206 pKa = 4.65DD207 pKa = 4.49AIDD210 pKa = 4.53DD211 pKa = 3.87EE212 pKa = 5.67GEE214 pKa = 4.0AEE216 pKa = 3.85EE217 pKa = 5.97DD218 pKa = 3.95YY219 pKa = 11.25FSVSQVCSRR228 pKa = 11.84DD229 pKa = 3.05ADD231 pKa = 3.64EE232 pKa = 6.18VYY234 pKa = 8.95FTLDD238 pKa = 3.33PEE240 pKa = 4.33ISYY243 pKa = 8.34STDD246 pKa = 2.73LRR248 pKa = 11.84IAKK251 pKa = 9.77VMEE254 pKa = 4.16PAVSKK259 pKa = 10.2EE260 pKa = 3.74LNVSKK265 pKa = 10.7RR266 pKa = 11.84CVEE269 pKa = 3.96PVTLTGSMLAHH280 pKa = 6.57NGFDD284 pKa = 3.63EE285 pKa = 4.17SWFAMRR291 pKa = 11.84EE292 pKa = 4.19CTRR295 pKa = 11.84RR296 pKa = 11.84EE297 pKa = 4.12YY298 pKa = 9.93ITVQGLYY305 pKa = 10.79DD306 pKa = 5.17PIHH309 pKa = 6.65LRR311 pKa = 11.84YY312 pKa = 10.02QFDD315 pKa = 4.0TSRR318 pKa = 11.84MTPPQILRR326 pKa = 11.84TIPALPNMTLGEE338 pKa = 4.43LLLIFPIEE346 pKa = 4.47FMAQPISIEE355 pKa = 4.23RR356 pKa = 11.84ILVEE360 pKa = 5.63DD361 pKa = 3.56VFLDD365 pKa = 3.68RR366 pKa = 11.84RR367 pKa = 11.84ASSKK371 pKa = 5.67THH373 pKa = 6.45KK374 pKa = 10.58YY375 pKa = 8.36GPRR378 pKa = 11.84WNSVYY383 pKa = 10.9ALPYY387 pKa = 9.82NAGKK391 pKa = 9.69MYY393 pKa = 10.06VQHH396 pKa = 6.92IPGFYY401 pKa = 10.01DD402 pKa = 3.13VSLRR406 pKa = 11.84AVGQGTAIWHH416 pKa = 5.64HH417 pKa = 6.6MILSTAACAISNRR430 pKa = 11.84ISHH433 pKa = 6.71GDD435 pKa = 3.3GLGFLLDD442 pKa = 3.43AAIRR446 pKa = 11.84ISANCIFLGRR456 pKa = 11.84NDD458 pKa = 3.56NFGVGDD464 pKa = 3.98PCWLEE469 pKa = 3.78DD470 pKa = 4.1HH471 pKa = 6.89LAGLPRR477 pKa = 11.84EE478 pKa = 4.31AVPDD482 pKa = 3.81VLQVTQLVLPNRR494 pKa = 11.84GPTVAIMRR502 pKa = 11.84GFFGALAYY510 pKa = 9.6WPEE513 pKa = 3.68LRR515 pKa = 11.84IAISEE520 pKa = 4.18PSTSLVRR527 pKa = 11.84YY528 pKa = 7.33ATGHH532 pKa = 5.77MEE534 pKa = 3.77LAEE537 pKa = 4.01WFLFSRR543 pKa = 11.84THH545 pKa = 5.1SLKK548 pKa = 10.65PQFTPTEE555 pKa = 4.19RR556 pKa = 11.84EE557 pKa = 3.74MLASFFTLYY566 pKa = 9.1VTLGGGMLNWICRR579 pKa = 11.84ATAMYY584 pKa = 10.16LAAPYY589 pKa = 9.47HH590 pKa = 6.23SRR592 pKa = 11.84SAYY595 pKa = 9.45IAVCEE600 pKa = 4.14SLPYY604 pKa = 10.67YY605 pKa = 8.97YY606 pKa = 10.01IPVNSDD612 pKa = 3.64LLCDD616 pKa = 4.78LEE618 pKa = 4.37VLLLGEE624 pKa = 4.17VDD626 pKa = 4.74LPTVCEE632 pKa = 4.3SYY634 pKa = 10.13ATIAHH639 pKa = 6.82EE640 pKa = 4.12LTGYY644 pKa = 9.72EE645 pKa = 4.23AVRR648 pKa = 11.84TAATNFMIEE657 pKa = 3.97FADD660 pKa = 4.32CYY662 pKa = 10.81KK663 pKa = 10.78EE664 pKa = 4.58SEE666 pKa = 4.19TDD668 pKa = 3.67LMVSAYY674 pKa = 10.36LGAVLLLQRR683 pKa = 11.84VLGHH687 pKa = 7.09ANLLLLLLSGAALYY701 pKa = 9.5GGCSIYY707 pKa = 10.23IPRR710 pKa = 11.84GILDD714 pKa = 4.32AYY716 pKa = 8.47NTLMLAASPLYY727 pKa = 10.44AHH729 pKa = 6.1QTLTSFWKK737 pKa = 10.68DD738 pKa = 2.66RR739 pKa = 11.84DD740 pKa = 3.84DD741 pKa = 5.0AMQTLGIRR749 pKa = 11.84PTTDD753 pKa = 3.01VLPKK757 pKa = 9.02EE758 pKa = 4.14QDD760 pKa = 3.58RR761 pKa = 11.84IVQASPIEE769 pKa = 4.0MNFRR773 pKa = 11.84FVGLEE778 pKa = 3.7TIYY781 pKa = 10.5PRR783 pKa = 11.84EE784 pKa = 3.9QPIPSVDD791 pKa = 3.41LAEE794 pKa = 5.39NLMQYY799 pKa = 10.47RR800 pKa = 11.84NEE802 pKa = 3.92ILGLDD807 pKa = 3.64WKK809 pKa = 10.61SVAMHH814 pKa = 7.3LLRR817 pKa = 11.84KK818 pKa = 9.19YY819 pKa = 10.73

Molecular weight: 91.83 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P09289|TEG4_VZVD Tegument protein UL21 homolog OS=Varicella-zoster virus (strain Dumas) OX=10338 GN=ORF38 PE=3 SV=1
MM1 pKa = 6.78SASRR5 pKa = 11.84IRR7 pKa = 11.84AKK9 pKa = 10.37CFRR12 pKa = 11.84LGQRR16 pKa = 11.84CHH18 pKa = 5.15TRR20 pKa = 11.84FYY22 pKa = 11.56DD23 pKa = 3.84VLKK26 pKa = 10.89KK27 pKa = 10.84DD28 pKa = 2.9IDD30 pKa = 3.54NVRR33 pKa = 11.84RR34 pKa = 11.84GFADD38 pKa = 3.49AFNPRR43 pKa = 11.84LAKK46 pKa = 10.44LLSPLSHH53 pKa = 7.24VDD55 pKa = 2.88VQRR58 pKa = 11.84AVRR61 pKa = 11.84ISMSFEE67 pKa = 3.86VNLGRR72 pKa = 11.84RR73 pKa = 11.84RR74 pKa = 11.84PDD76 pKa = 3.31CVCIIQTEE84 pKa = 4.29SSGAGKK90 pKa = 7.25TVCFIVEE97 pKa = 4.42LKK99 pKa = 10.32SCRR102 pKa = 11.84FSANIHH108 pKa = 5.9TPTKK112 pKa = 9.62YY113 pKa = 10.09HH114 pKa = 5.37QFCEE118 pKa = 4.36GMRR121 pKa = 11.84QLRR124 pKa = 11.84DD125 pKa = 3.07TMALIKK131 pKa = 9.21EE132 pKa = 4.49TTPTGSDD139 pKa = 3.44EE140 pKa = 4.86IMVTPLLVFVSQRR153 pKa = 11.84GLNLLQVTRR162 pKa = 11.84LPPKK166 pKa = 9.79VIHH169 pKa = 6.65GNLVMLASHH178 pKa = 7.15LEE180 pKa = 4.06NVAEE184 pKa = 4.08YY185 pKa = 8.61TPPIRR190 pKa = 11.84SVRR193 pKa = 11.84EE194 pKa = 3.45RR195 pKa = 11.84RR196 pKa = 11.84RR197 pKa = 11.84LCKK200 pKa = 10.2KK201 pKa = 10.03KK202 pKa = 10.17IHH204 pKa = 5.83VCSLAKK210 pKa = 10.12KK211 pKa = 9.26RR212 pKa = 11.84AKK214 pKa = 9.87SCHH217 pKa = 6.0RR218 pKa = 11.84SALTKK223 pKa = 10.46FEE225 pKa = 4.52EE226 pKa = 4.34NAACGVDD233 pKa = 3.79LPLRR237 pKa = 11.84RR238 pKa = 11.84PSLGACGGILQSITGMFSHH257 pKa = 7.15GG258 pKa = 3.37

Molecular weight: 28.98 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

69

1

70

36084

71

2763

515.5

57.45

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

7.43 ± 0.196

2.148 ± 0.123

5.254 ± 0.155

5.091 ± 0.177

4.157 ± 0.167

6.03 ± 0.211

2.638 ± 0.101

5.695 ± 0.206

3.564 ± 0.154

9.708 ± 0.209

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.128 ± 0.092

4.199 ± 0.128

5.886 ± 0.251

3.553 ± 0.115

6.391 ± 0.211

7.341 ± 0.169

7.422 ± 0.204

6.862 ± 0.164

1.059 ± 0.063

3.445 ± 0.132
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski