Amino acid dipepetide frequency for Verticillium longisporum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.952AlaAla: 11.952 ± 0.059	1.159AlaCys: 1.159 ± 0.014	5.065AlaAsp: 5.065 ± 0.026	5.658AlaGlu: 5.658 ± 0.036	3.27AlaPhe: 3.27 ± 0.02	6.848AlaGly: 6.848 ± 0.033	2.091AlaHis: 2.091 ± 0.014	4.139AlaIle: 4.139 ± 0.024	4.229AlaLys: 4.229 ± 0.026	8.418AlaLeu: 8.418 ± 0.039	2.176AlaMet: 2.176 ± 0.017	3.094AlaAsn: 3.094 ± 0.021	5.934AlaPro: 5.934 ± 0.037	3.773AlaGln: 3.773 ± 0.025	5.893AlaArg: 5.893 ± 0.032	7.94AlaSer: 7.94 ± 0.036	5.793AlaThr: 5.793 ± 0.027	6.19AlaVal: 6.19 ± 0.026	1.294AlaTrp: 1.294 ± 0.017	2.176AlaTyr: 2.176 ± 0.018	0.02AlaXaa: 0.02 ± 0.002
Cys	1.008CysAla: 1.008 ± 0.012	0.245CysCys: 0.245 ± 0.007	0.675CysAsp: 0.675 ± 0.011	0.584CysGlu: 0.584 ± 0.01	0.501CysPhe: 0.501 ± 0.009	0.957CysGly: 0.957 ± 0.017	0.34CysHis: 0.34 ± 0.008	0.635CysIle: 0.635 ± 0.011	0.463CysLys: 0.463 ± 0.011	1.206CysLeu: 1.206 ± 0.013	0.247CysMet: 0.247 ± 0.005	0.421CysAsn: 0.421 ± 0.008	0.682CysPro: 0.682 ± 0.01	0.443CysGln: 0.443 ± 0.008	0.823CysArg: 0.823 ± 0.012	0.858CysSer: 0.858 ± 0.012	0.675CysThr: 0.675 ± 0.011	0.794CysVal: 0.794 ± 0.015	0.19CysTrp: 0.19 ± 0.005	0.326CysTyr: 0.326 ± 0.006	0.002CysXaa: 0.002 ± 0.0
Asp	5.705AspAla: 5.705 ± 0.028	0.621AspCys: 0.621 ± 0.009	4.969AspAsp: 4.969 ± 0.039	4.657AspGlu: 4.657 ± 0.027	2.193AspPhe: 2.193 ± 0.017	4.542AspGly: 4.542 ± 0.027	1.299AspHis: 1.299 ± 0.013	2.738AspIle: 2.738 ± 0.02	2.43AspLys: 2.43 ± 0.02	5.08AspLeu: 5.08 ± 0.027	1.343AspMet: 1.343 ± 0.013	1.83AspAsn: 1.83 ± 0.015	3.304AspPro: 3.304 ± 0.021	1.85AspGln: 1.85 ± 0.014	3.216AspArg: 3.216 ± 0.024	3.84AspSer: 3.84 ± 0.027	2.927AspThr: 2.927 ± 0.022	3.992AspVal: 3.992 ± 0.024	0.889AspTrp: 0.889 ± 0.011	1.497AspTyr: 1.497 ± 0.015	0.009AspXaa: 0.009 ± 0.001
Glu	6.088GluAla: 6.088 ± 0.035	0.567GluCys: 0.567 ± 0.009	4.201GluAsp: 4.201 ± 0.027	4.962GluGlu: 4.962 ± 0.037	1.774GluPhe: 1.774 ± 0.015	3.856GluGly: 3.856 ± 0.023	1.38GluHis: 1.38 ± 0.012	2.557GluIle: 2.557 ± 0.017	3.294GluLys: 3.294 ± 0.022	4.971GluLeu: 4.971 ± 0.029	1.382GluMet: 1.382 ± 0.013	1.934GluAsn: 1.934 ± 0.015	2.99GluPro: 2.99 ± 0.03	2.37GluGln: 2.37 ± 0.019	3.892GluArg: 3.892 ± 0.025	3.83GluSer: 3.83 ± 0.027	3.491GluThr: 3.491 ± 0.022	3.579GluVal: 3.579 ± 0.023	0.791GluTrp: 0.791 ± 0.01	1.492GluTyr: 1.492 ± 0.014	0.012GluXaa: 0.012 ± 0.001
Phe	3.269PheAla: 3.269 ± 0.022	0.546PheCys: 0.546 ± 0.009	2.309PheAsp: 2.309 ± 0.019	2.064PheGlu: 2.064 ± 0.017	1.589PhePhe: 1.589 ± 0.017	2.852PheGly: 2.852 ± 0.022	0.86PheHis: 0.86 ± 0.01	1.613PheIle: 1.613 ± 0.017	1.377PheLys: 1.377 ± 0.014	3.249PheLeu: 3.249 ± 0.023	0.752PheMet: 0.752 ± 0.011	1.347PheAsn: 1.347 ± 0.012	1.821PhePro: 1.821 ± 0.016	1.305PheGln: 1.305 ± 0.012	1.938PheArg: 1.938 ± 0.015	2.703PheSer: 2.703 ± 0.021	2.049PheThr: 2.049 ± 0.017	2.414PheVal: 2.414 ± 0.019	0.621PheTrp: 0.621 ± 0.009	0.993PheTyr: 0.993 ± 0.012	0.006PheXaa: 0.006 ± 0.001
Gly	6.302GlyAla: 6.302 ± 0.031	0.884GlyCys: 0.884 ± 0.012	3.982GlyAsp: 3.982 ± 0.024	3.708GlyGlu: 3.708 ± 0.022	2.79GlyPhe: 2.79 ± 0.019	6.588GlyGly: 6.588 ± 0.047	1.854GlyHis: 1.854 ± 0.02	3.264GlyIle: 3.264 ± 0.022	3.27GlyLys: 3.27 ± 0.023	6.261GlyLeu: 6.261 ± 0.027	1.602GlyMet: 1.602 ± 0.016	2.534GlyAsn: 2.534 ± 0.024	3.74GlyPro: 3.74 ± 0.029	2.746GlyGln: 2.746 ± 0.024	4.684GlyArg: 4.684 ± 0.025	5.676GlySer: 5.676 ± 0.035	4.079GlyThr: 4.079 ± 0.021	4.63GlyVal: 4.63 ± 0.028	1.167GlyTrp: 1.167 ± 0.014	1.977GlyTyr: 1.977 ± 0.018	0.015GlyXaa: 0.015 ± 0.001
His	2.173HisAla: 2.173 ± 0.019	0.335HisCys: 0.335 ± 0.007	1.486HisAsp: 1.486 ± 0.014	1.35HisGlu: 1.35 ± 0.013	0.894HisPhe: 0.894 ± 0.01	1.911HisGly: 1.911 ± 0.019	0.948HisHis: 0.948 ± 0.012	1.128HisIle: 1.128 ± 0.011	0.871HisLys: 0.871 ± 0.009	2.262HisLeu: 2.262 ± 0.019	0.521HisMet: 0.521 ± 0.007	0.819HisAsn: 0.819 ± 0.009	1.675HisPro: 1.675 ± 0.015	1.058HisGln: 1.058 ± 0.014	1.662HisArg: 1.662 ± 0.017	1.683HisSer: 1.683 ± 0.015	1.251HisThr: 1.251 ± 0.013	1.593HisVal: 1.593 ± 0.017	0.339HisTrp: 0.339 ± 0.006	0.656HisTyr: 0.656 ± 0.009	0.004HisXaa: 0.004 ± 0.001
Ile	4.067IleAla: 4.067 ± 0.023	0.657IleCys: 0.657 ± 0.01	2.701IleAsp: 2.701 ± 0.018	2.585IleGlu: 2.585 ± 0.017	1.763IlePhe: 1.763 ± 0.017	2.919IleGly: 2.919 ± 0.02	1.088IleHis: 1.088 ± 0.012	2.217IleIle: 2.217 ± 0.016	1.93IleLys: 1.93 ± 0.017	4.018IleLeu: 4.018 ± 0.028	1.031IleMet: 1.031 ± 0.011	1.619IleAsn: 1.619 ± 0.013	2.652IlePro: 2.652 ± 0.019	1.614IleGln: 1.614 ± 0.014	2.604IleArg: 2.604 ± 0.019	3.257IleSer: 3.257 ± 0.022	2.584IleThr: 2.584 ± 0.016	3.043IleVal: 3.043 ± 0.022	0.666IleTrp: 0.666 ± 0.008	1.181IleTyr: 1.181 ± 0.013	0.007IleXaa: 0.007 ± 0.001
Lys	4.439LysAla: 4.439 ± 0.031	0.46LysCys: 0.46 ± 0.01	2.609LysAsp: 2.609 ± 0.018	2.931LysGlu: 2.931 ± 0.021	1.324LysPhe: 1.324 ± 0.012	2.855LysGly: 2.855 ± 0.022	1.058LysHis: 1.058 ± 0.012	1.944LysIle: 1.944 ± 0.015	3.227LysLys: 3.227 ± 0.037	3.746LysLeu: 3.746 ± 0.026	0.969LysMet: 0.969 ± 0.012	1.556LysAsn: 1.556 ± 0.015	2.658LysPro: 2.658 ± 0.021	1.717LysGln: 1.717 ± 0.015	3.213LysArg: 3.213 ± 0.019	3.094LysSer: 3.094 ± 0.021	2.846LysThr: 2.846 ± 0.018	2.683LysVal: 2.683 ± 0.018	0.613LysTrp: 0.613 ± 0.008	1.192LysTyr: 1.192 ± 0.012	0.008LysXaa: 0.008 ± 0.001
Leu	8.638LeuAla: 8.638 ± 0.035	1.141LeuCys: 1.141 ± 0.013	5.205LeuAsp: 5.205 ± 0.033	5.225LeuGlu: 5.225 ± 0.029	3.153LeuPhe: 3.153 ± 0.024	6.082LeuGly: 6.082 ± 0.028	2.215LeuHis: 2.215 ± 0.016	3.519LeuIle: 3.519 ± 0.026	3.783LeuLys: 3.783 ± 0.026	8.172LeuLeu: 8.172 ± 0.05	1.701LeuMet: 1.701 ± 0.014	2.877LeuAsn: 2.877 ± 0.02	5.614LeuPro: 5.614 ± 0.029	3.63LeuGln: 3.63 ± 0.027	5.944LeuArg: 5.944 ± 0.031	6.72LeuSer: 6.72 ± 0.033	4.855LeuThr: 4.855 ± 0.026	5.586LeuVal: 5.586 ± 0.028	1.161LeuTrp: 1.161 ± 0.012	2.155LeuTyr: 2.155 ± 0.018	0.015LeuXaa: 0.015 ± 0.001
Met	2.456MetAla: 2.456 ± 0.017	0.232MetCys: 0.232 ± 0.005	1.244MetAsp: 1.244 ± 0.012	1.166MetGlu: 1.166 ± 0.013	0.724MetPhe: 0.724 ± 0.009	1.505MetGly: 1.505 ± 0.015	0.481MetHis: 0.481 ± 0.008	0.916MetIle: 0.916 ± 0.01	0.951MetLys: 0.951 ± 0.01	1.824MetLeu: 1.824 ± 0.015	0.58MetMet: 0.58 ± 0.011	0.753MetAsn: 0.753 ± 0.009	1.333MetPro: 1.333 ± 0.015	0.822MetGln: 0.822 ± 0.011	1.331MetArg: 1.331 ± 0.012	1.813MetSer: 1.813 ± 0.014	1.359MetThr: 1.359 ± 0.012	1.328MetVal: 1.328 ± 0.011	0.263MetTrp: 0.263 ± 0.006	0.512MetTyr: 0.512 ± 0.007	0.004MetXaa: 0.004 ± 0.001
Asn	3.101AsnAla: 3.101 ± 0.02	0.417AsnCys: 0.417 ± 0.007	1.926AsnAsp: 1.926 ± 0.016	1.826AsnGlu: 1.826 ± 0.016	1.274AsnPhe: 1.274 ± 0.015	2.928AsnGly: 2.928 ± 0.024	0.8AsnHis: 0.8 ± 0.009	1.756AsnIle: 1.756 ± 0.013	1.454AsnLys: 1.454 ± 0.014	3.017AsnLeu: 3.017 ± 0.021	0.832AsnMet: 0.832 ± 0.011	1.371AsnAsn: 1.371 ± 0.015	2.285AsnPro: 2.285 ± 0.019	1.178AsnGln: 1.178 ± 0.012	1.852AsnArg: 1.852 ± 0.015	2.365AsnSer: 2.365 ± 0.019	2.031AsnThr: 2.031 ± 0.015	2.234AsnVal: 2.234 ± 0.017	0.518AsnTrp: 0.518 ± 0.007	0.931AsnTyr: 0.931 ± 0.01	0.006AsnXaa: 0.006 ± 0.001
Pro	6.43ProAla: 6.43 ± 0.038	0.569ProCys: 0.569 ± 0.011	3.302ProAsp: 3.302 ± 0.022	3.819ProGlu: 3.819 ± 0.03	2.043ProPhe: 2.043 ± 0.016	4.317ProGly: 4.317 ± 0.032	1.395ProHis: 1.395 ± 0.015	2.318ProIle: 2.318 ± 0.016	2.54ProLys: 2.54 ± 0.021	4.863ProLeu: 4.863 ± 0.026	1.119ProMet: 1.119 ± 0.012	2.026ProAsn: 2.026 ± 0.017	5.575ProPro: 5.575 ± 0.059	2.539ProGln: 2.539 ± 0.023	3.883ProArg: 3.883 ± 0.031	6.02ProSer: 6.02 ± 0.039	4.134ProThr: 4.134 ± 0.03	3.84ProVal: 3.84 ± 0.026	0.765ProTrp: 0.765 ± 0.009	1.416ProTyr: 1.416 ± 0.013	0.016ProXaa: 0.016 ± 0.001
Gln	3.774GlnAla: 3.774 ± 0.027	0.439GlnCys: 0.439 ± 0.008	2.106GlnAsp: 2.106 ± 0.016	2.165GlnGlu: 2.165 ± 0.015	1.165GlnPhe: 1.165 ± 0.012	2.588GlnGly: 2.588 ± 0.022	1.186GlnHis: 1.186 ± 0.013	1.661GlnIle: 1.661 ± 0.016	1.788GlnLys: 1.788 ± 0.015	3.34GlnLeu: 3.34 ± 0.023	0.872GlnMet: 0.872 ± 0.009	1.356GlnAsn: 1.356 ± 0.013	2.688GlnPro: 2.688 ± 0.028	2.843GlnGln: 2.843 ± 0.039	2.717GlnArg: 2.717 ± 0.02	2.874GlnSer: 2.874 ± 0.02	2.329GlnThr: 2.329 ± 0.017	2.209GlnVal: 2.209 ± 0.015	0.548GlnTrp: 0.548 ± 0.008	1.077GlnTyr: 1.077 ± 0.012	0.006GlnXaa: 0.006 ± 0.001
Arg	5.522ArgAla: 5.522 ± 0.025	0.756ArgCys: 0.756 ± 0.012	3.683ArgAsp: 3.683 ± 0.026	3.799ArgGlu: 3.799 ± 0.029	2.132ArgPhe: 2.132 ± 0.016	4.133ArgGly: 4.133 ± 0.024	1.872ArgHis: 1.872 ± 0.018	2.726ArgIle: 2.726 ± 0.019	3.247ArgLys: 3.247 ± 0.023	5.657ArgLeu: 5.657 ± 0.031	1.319ArgMet: 1.319 ± 0.012	2.163ArgAsn: 2.163 ± 0.016	4.029ArgPro: 4.029 ± 0.024	2.877ArgGln: 2.877 ± 0.018	5.853ArgArg: 5.853 ± 0.038	4.788ArgSer: 4.788 ± 0.032	3.454ArgThr: 3.454 ± 0.025	3.538ArgVal: 3.538 ± 0.021	0.975ArgTrp: 0.975 ± 0.014	1.582ArgTyr: 1.582 ± 0.015	0.014ArgXaa: 0.014 ± 0.001
Ser	6.967SerAla: 6.967 ± 0.035	0.855SerCys: 0.855 ± 0.01	4.083SerAsp: 4.083 ± 0.025	3.749SerGlu: 3.749 ± 0.025	2.846SerPhe: 2.846 ± 0.019	5.472SerGly: 5.472 ± 0.033	1.902SerHis: 1.902 ± 0.017	3.535SerIle: 3.535 ± 0.02	3.287SerLys: 3.287 ± 0.027	6.736SerLeu: 6.736 ± 0.031	1.646SerMet: 1.646 ± 0.015	2.711SerAsn: 2.711 ± 0.018	5.464SerPro: 5.464 ± 0.044	3.023SerGln: 3.023 ± 0.022	5.039SerArg: 5.039 ± 0.026	8.214SerSer: 8.214 ± 0.055	5.274SerThr: 5.274 ± 0.034	4.447SerVal: 4.447 ± 0.026	1.086SerTrp: 1.086 ± 0.011	1.849SerTyr: 1.849 ± 0.018	0.014SerXaa: 0.014 ± 0.001
Thr	5.777ThrAla: 5.777 ± 0.026	0.773ThrCys: 0.773 ± 0.018	2.886ThrAsp: 2.886 ± 0.02	2.987ThrGlu: 2.987 ± 0.02	2.139ThrPhe: 2.139 ± 0.016	4.2ThrGly: 4.2 ± 0.024	1.304ThrHis: 1.304 ± 0.013	2.889ThrIle: 2.889 ± 0.018	2.514ThrLys: 2.514 ± 0.019	5.133ThrLeu: 5.133 ± 0.025	1.277ThrMet: 1.277 ± 0.012	1.996ThrAsn: 1.996 ± 0.015	4.578ThrPro: 4.578 ± 0.031	2.084ThrGln: 2.084 ± 0.016	3.332ThrArg: 3.332 ± 0.019	5.198ThrSer: 5.198 ± 0.031	4.485ThrThr: 4.485 ± 0.035	3.744ThrVal: 3.744 ± 0.025	0.875ThrTrp: 0.875 ± 0.01	1.488ThrTyr: 1.488 ± 0.013	0.009ThrXaa: 0.009 ± 0.001
Val	6.062ValAla: 6.062 ± 0.027	0.842ValCys: 0.842 ± 0.016	3.966ValAsp: 3.966 ± 0.022	3.943ValGlu: 3.943 ± 0.023	2.455ValPhe: 2.455 ± 0.019	4.254ValGly: 4.254 ± 0.025	1.44ValHis: 1.44 ± 0.014	2.749ValIle: 2.749 ± 0.019	2.792ValLys: 2.792 ± 0.022	5.731ValLeu: 5.731 ± 0.031	1.313ValMet: 1.313 ± 0.013	2.126ValAsn: 2.126 ± 0.018	3.856ValPro: 3.856 ± 0.026	2.313ValGln: 2.313 ± 0.019	3.689ValArg: 3.689 ± 0.02	4.541ValSer: 4.541 ± 0.027	3.672ValThr: 3.672 ± 0.022	4.567ValVal: 4.567 ± 0.028	0.895ValTrp: 0.895 ± 0.011	1.627ValTyr: 1.627 ± 0.016	0.009ValXaa: 0.009 ± 0.001
Trp	1.216TrpAla: 1.216 ± 0.014	0.195TrpCys: 0.195 ± 0.005	0.905TrpAsp: 0.905 ± 0.011	0.793TrpGlu: 0.793 ± 0.01	0.547TrpPhe: 0.547 ± 0.008	0.944TrpGly: 0.944 ± 0.011	0.386TrpHis: 0.386 ± 0.008	0.684TrpIle: 0.684 ± 0.009	0.714TrpLys: 0.714 ± 0.009	1.316TrpLeu: 1.316 ± 0.014	0.35TrpMet: 0.35 ± 0.006	0.588TrpAsn: 0.588 ± 0.009	0.663TrpPro: 0.663 ± 0.01	0.582TrpGln: 0.582 ± 0.009	0.98TrpArg: 0.98 ± 0.013	1.021TrpSer: 1.021 ± 0.011	0.926TrpThr: 0.926 ± 0.011	0.868TrpVal: 0.868 ± 0.011	0.274TrpTrp: 0.274 ± 0.007	0.401TrpTyr: 0.401 ± 0.008	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.149TyrAla: 2.149 ± 0.018	0.376TyrCys: 0.376 ± 0.007	1.621TyrAsp: 1.621 ± 0.013	1.436TyrGlu: 1.436 ± 0.012	1.092TyrPhe: 1.092 ± 0.013	1.985TyrGly: 1.985 ± 0.019	0.712TyrHis: 0.712 ± 0.009	1.206TyrIle: 1.206 ± 0.013	0.982TyrLys: 0.982 ± 0.01	2.375TyrLeu: 2.375 ± 0.02	0.558TyrMet: 0.558 ± 0.008	0.974TyrAsn: 0.974 ± 0.01	1.374TyrPro: 1.374 ± 0.015	0.96TyrGln: 0.96 ± 0.01	1.558TyrArg: 1.558 ± 0.014	1.752TyrSer: 1.752 ± 0.016	1.446TyrThr: 1.446 ± 0.015	1.551TyrVal: 1.551 ± 0.016	0.425TyrTrp: 0.425 ± 0.007	0.809TyrTyr: 0.809 ± 0.012	0.003TyrXaa: 0.003 ± 0.001
Xaa	0.016XaaAla: 0.016 ± 0.001	0.003XaaCys: 0.003 ± 0.001	0.009XaaAsp: 0.009 ± 0.001	0.008XaaGlu: 0.008 ± 0.001	0.005XaaPhe: 0.005 ± 0.001	0.017XaaGly: 0.017 ± 0.001	0.005XaaHis: 0.005 ± 0.001	0.006XaaIle: 0.006 ± 0.001	0.006XaaLys: 0.006 ± 0.001	0.015XaaLeu: 0.015 ± 0.001	0.007XaaMet: 0.007 ± 0.001	0.006XaaAsn: 0.006 ± 0.001	0.015XaaPro: 0.015 ± 0.001	0.006XaaGln: 0.006 ± 0.001	0.016XaaArg: 0.016 ± 0.001	0.012XaaSer: 0.012 ± 0.001	0.01XaaThr: 0.01 ± 0.001	0.011XaaVal: 0.011 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.004XaaTyr: 0.004 ± 0.001	0.624XaaXaa: 0.624 ± 0.062

Statistics based on 20580 proteins (9306748 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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