Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)

Taxonomy: cellular organisms; Bacteria; Terrabacteria group; Actinobacteria; Actinomycetia; Propionibacteriales; Propionibacteriaceae; Cutibacterium; Cutibacterium acnes

Average proteome isoelectric point is 6.38

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 2294 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q6A6M5|RS10_CUTAK 30S ribosomal protein S10 OS=Cutibacterium acnes (strain DSM 16379 / KPA171202) OX=267747 GN=rpsJ PE=3 SV=1
MM1 pKa = 7.79KK2 pKa = 10.47FIDD5 pKa = 3.7WFADD9 pKa = 3.62GSVYY13 pKa = 10.83VVDD16 pKa = 5.88LALACCGVEE25 pKa = 4.06SGAAVLANAPVRR37 pKa = 11.84EE38 pKa = 4.67EE39 pKa = 4.38IPDD42 pKa = 3.79GAPIVVLVSGTVTTGLAPVVSDD64 pKa = 3.72TVHH67 pKa = 5.43EE68 pKa = 4.52LKK70 pKa = 10.53RR71 pKa = 11.84NHH73 pKa = 6.59PVDD76 pKa = 3.75VVAFGACACAGGPYY90 pKa = 8.74WDD92 pKa = 3.92SAGVVAGLPDD102 pKa = 3.92AGVDD106 pKa = 3.43ADD108 pKa = 4.36HH109 pKa = 7.77WIPGCPPGPEE119 pKa = 4.12TLTGLLASSRR129 pKa = 11.84EE130 pKa = 4.14AAA132 pKa = 3.83

Molecular weight: 13.31 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q6A5B6|Q6A5B6_CUTAK Uncharacterized protein OS=Cutibacterium acnes (strain DSM 16379 / KPA171202) OX=267747 GN=PPA2369 PE=4 SV=1
MM1 pKa = 7.45KK2 pKa = 9.61RR3 pKa = 11.84TFQPSNRR10 pKa = 11.84RR11 pKa = 11.84RR12 pKa = 11.84ARR14 pKa = 11.84NHH16 pKa = 5.31GFRR19 pKa = 11.84SRR21 pKa = 11.84MSTRR25 pKa = 11.84AGRR28 pKa = 11.84SILAARR34 pKa = 11.84RR35 pKa = 11.84RR36 pKa = 11.84KK37 pKa = 10.31GRR39 pKa = 11.84VNLSAA44 pKa = 4.92

Molecular weight: 5.17 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

2294

0

2294

760875

33

2117

331.7

35.91

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

11.043 ± 0.052

1.092 ± 0.017

6.214 ± 0.048

5.244 ± 0.046

2.909 ± 0.036

8.517 ± 0.045

2.53 ± 0.023

4.979 ± 0.039

2.927 ± 0.042

9.323 ± 0.051

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.471 ± 0.023

2.54 ± 0.027

5.3 ± 0.036

3.057 ± 0.027

6.828 ± 0.051

6.208 ± 0.038

6.328 ± 0.043

8.856 ± 0.045

1.633 ± 0.025

2.002 ± 0.025
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski