Amino acid dipepetide frequency for Osedax japonicus RNA virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.949AlaAla: 10.949 ± 0.925
1.369AlaCys: 1.369 ± 0.268
4.714AlaAsp: 4.714 ± 0.165
4.714AlaGlu: 4.714 ± 0.408
3.345AlaPhe: 3.345 ± 0.14
4.562AlaGly: 4.562 ± 0.894
2.737AlaHis: 2.737 ± 0.292
4.562AlaIle: 4.562 ± 0.407
5.018AlaLys: 5.018 ± 0.576
9.276AlaLeu: 9.276 ± 0.976
3.802AlaMet: 3.802 ± 0.88
3.802AlaAsn: 3.802 ± 0.095
4.41AlaPro: 4.41 ± 0.484
3.345AlaGln: 3.345 ± 0.103
3.954AlaArg: 3.954 ± 0.499
8.06AlaSer: 8.06 ± 2.863
8.364AlaThr: 8.364 ± 0.015
5.779AlaVal: 5.779 ± 0.265
0.76AlaTrp: 0.76 ± 0.176
3.954AlaTyr: 3.954 ± 0.232
0.0AlaXaa: 0.0 ± 0.0
Cys
1.825CysAla: 1.825 ± 0.211
0.304CysCys: 0.304 ± 0.076
1.825CysAsp: 1.825 ± 0.211
1.369CysGlu: 1.369 ± 0.22
0.76CysPhe: 0.76 ± 0.312
1.521CysGly: 1.521 ± 0.623
0.456CysHis: 0.456 ± 0.236
0.912CysIle: 0.912 ± 0.26
0.912CysLys: 0.912 ± 0.228
0.76CysLeu: 0.76 ± 0.068
0.152CysMet: 0.152 ± 0.16
0.608CysAsn: 0.608 ± 0.395
0.0CysPro: 0.0 ± 0.0
0.152CysGln: 0.152 ± 0.084
1.217CysArg: 1.217 ± 0.06
2.889CysSer: 2.889 ± 0.132
0.456CysThr: 0.456 ± 0.008
1.217CysVal: 1.217 ± 0.428
0.152CysTrp: 0.152 ± 0.084
0.912CysTyr: 0.912 ± 0.228
0.0CysXaa: 0.0 ± 0.0
Asp
5.018AspAla: 5.018 ± 0.82
1.064AspCys: 1.064 ± 0.1
5.322AspAsp: 5.322 ± 0.257
3.345AspGlu: 3.345 ± 0.384
1.521AspPhe: 1.521 ± 0.352
4.41AspGly: 4.41 ± 0.003
1.217AspHis: 1.217 ± 0.671
3.041AspIle: 3.041 ± 0.216
2.281AspLys: 2.281 ± 1.178
2.737AspLeu: 2.737 ± 0.292
1.217AspMet: 1.217 ± 0.06
2.585AspAsn: 2.585 ± 0.452
2.585AspPro: 2.585 ± 0.208
1.064AspGln: 1.064 ± 0.387
3.193AspArg: 3.193 ± 0.3
3.802AspSer: 3.802 ± 0.095
3.041AspThr: 3.041 ± 0.515
4.866AspVal: 4.866 ± 1.457
0.304AspTrp: 0.304 ± 0.076
1.064AspTyr: 1.064 ± 0.387
0.0AspXaa: 0.0 ± 0.0
Glu
5.018GluAla: 5.018 ± 0.155
1.064GluCys: 1.064 ± 0.387
2.889GluAsp: 2.889 ± 0.111
3.954GluGlu: 3.954 ± 0.72
1.673GluPhe: 1.673 ± 0.192
3.193GluGly: 3.193 ± 0.3
1.521GluHis: 1.521 ± 0.379
2.737GluIle: 2.737 ± 0.048
3.802GluLys: 3.802 ± 0.392
3.954GluLeu: 3.954 ± 0.476
1.217GluMet: 1.217 ± 0.547
2.433GluAsn: 2.433 ± 0.612
1.369GluPro: 1.369 ± 0.268
1.977GluGln: 1.977 ± 0.116
2.433GluArg: 2.433 ± 0.612
4.714GluSer: 4.714 ± 0.896
3.041GluThr: 3.041 ± 0.027
4.41GluVal: 4.41 ± 0.484
0.912GluTrp: 0.912 ± 0.016
2.281GluTyr: 2.281 ± 0.203
0.0GluXaa: 0.0 ± 0.0
Phe
2.889PheAla: 2.889 ± 0.355
0.912PheCys: 0.912 ± 0.016
1.369PheAsp: 1.369 ± 0.024
1.673PheGlu: 1.673 ± 0.192
0.912PhePhe: 0.912 ± 0.471
2.585PheGly: 2.585 ± 0.279
0.456PheHis: 0.456 ± 0.008
1.369PheIle: 1.369 ± 0.22
1.064PheLys: 1.064 ± 0.344
1.369PheLeu: 1.369 ± 0.463
1.825PheMet: 1.825 ± 0.699
1.825PheAsn: 1.825 ± 0.032
1.064PhePro: 1.064 ± 0.1
0.152PheGln: 0.152 ± 0.16
1.825PheArg: 1.825 ± 0.943
3.041PheSer: 3.041 ± 1.191
2.129PheThr: 2.129 ± 1.018
2.737PheVal: 2.737 ± 0.048
0.304PheTrp: 0.304 ± 0.076
0.912PheTyr: 0.912 ± 0.504
0.0PheXaa: 0.0 ± 0.0
Gly
5.17GlyAla: 5.17 ± 0.315
1.064GlyCys: 1.064 ± 0.144
2.889GlyAsp: 2.889 ± 0.599
4.714GlyGlu: 4.714 ± 0.079
1.369GlyPhe: 1.369 ± 0.707
4.106GlyGly: 4.106 ± 0.073
0.76GlyHis: 0.76 ± 0.176
3.954GlyIle: 3.954 ± 0.011
4.106GlyLys: 4.106 ± 0.902
4.41GlyLeu: 4.41 ± 0.003
1.977GlyMet: 1.977 ± 0.116
2.737GlyAsn: 2.737 ± 0.683
1.673GlyPro: 1.673 ± 0.192
1.217GlyGln: 1.217 ± 0.303
2.889GlyArg: 2.889 ± 0.599
4.866GlySer: 4.866 ± 0.248
5.474GlyThr: 5.474 ± 0.878
5.474GlyVal: 5.474 ± 0.147
0.304GlyTrp: 0.304 ± 0.076
2.281GlyTyr: 2.281 ± 0.528
0.0GlyXaa: 0.0 ± 0.0
His
3.65HisAla: 3.65 ± 0.308
0.912HisCys: 0.912 ± 0.016
1.369HisAsp: 1.369 ± 0.22
1.217HisGlu: 1.217 ± 0.428
0.912HisPhe: 0.912 ± 0.228
0.912HisGly: 0.912 ± 0.504
0.76HisHis: 0.76 ± 0.068
1.673HisIle: 1.673 ± 0.679
1.977HisLys: 1.977 ± 0.847
0.76HisLeu: 0.76 ± 0.176
0.76HisMet: 0.76 ± 0.42
1.673HisAsn: 1.673 ± 0.923
1.064HisPro: 1.064 ± 0.144
0.152HisGln: 0.152 ± 0.16
1.217HisArg: 1.217 ± 0.428
1.977HisSer: 1.977 ± 0.371
0.912HisThr: 0.912 ± 0.016
2.433HisVal: 2.433 ± 0.124
0.456HisTrp: 0.456 ± 0.008
0.912HisTyr: 0.912 ± 0.471
0.0HisXaa: 0.0 ± 0.0
Ile
4.714IleAla: 4.714 ± 0.567
0.608IleCys: 0.608 ± 0.152
3.498IleAsp: 3.498 ± 0.263
2.737IleGlu: 2.737 ± 0.195
1.825IlePhe: 1.825 ± 0.032
3.193IleGly: 3.193 ± 0.056
1.977IleHis: 1.977 ± 0.116
3.954IleIle: 3.954 ± 0.499
2.585IleLys: 2.585 ± 0.208
3.041IleLeu: 3.041 ± 0.027
0.912IleMet: 0.912 ± 0.016
2.585IleAsn: 2.585 ± 0.696
2.889IlePro: 2.889 ± 1.107
1.369IleGln: 1.369 ± 0.024
2.585IleArg: 2.585 ± 0.452
6.235IleSer: 6.235 ± 0.702
5.474IleThr: 5.474 ± 0.634
4.106IleVal: 4.106 ± 0.56
0.456IleTrp: 0.456 ± 0.008
1.977IleTyr: 1.977 ± 0.128
0.0IleXaa: 0.0 ± 0.0
Lys
6.083LysAla: 6.083 ± 0.786
1.673LysCys: 1.673 ± 0.052
2.737LysAsp: 2.737 ± 0.439
3.802LysGlu: 3.802 ± 0.583
0.76LysPhe: 0.76 ± 0.312
2.433LysGly: 2.433 ± 0.119
2.129LysHis: 2.129 ± 0.044
3.193LysIle: 3.193 ± 0.187
3.345LysLys: 3.345 ± 0.103
5.474LysLeu: 5.474 ± 0.828
2.129LysMet: 2.129 ± 0.044
1.521LysAsn: 1.521 ± 0.352
1.825LysPro: 1.825 ± 0.763
0.76LysGln: 0.76 ± 0.312
3.498LysArg: 3.498 ± 0.507
4.258LysSer: 4.258 ± 0.818
3.802LysThr: 3.802 ± 0.392
2.889LysVal: 2.889 ± 0.376
0.608LysTrp: 0.608 ± 0.152
2.585LysTyr: 2.585 ± 0.523
0.0LysXaa: 0.0 ± 0.0
Leu
8.668LeuAla: 8.668 ± 1.615
1.825LeuCys: 1.825 ± 0.699
3.498LeuAsp: 3.498 ± 0.224
3.041LeuGlu: 3.041 ± 0.704
3.193LeuPhe: 3.193 ± 0.187
3.954LeuGly: 3.954 ± 0.742
1.521LeuHis: 1.521 ± 0.108
3.954LeuIle: 3.954 ± 0.232
3.65LeuLys: 3.65 ± 0.552
4.714LeuLeu: 4.714 ± 0.652
2.737LeuMet: 2.737 ± 0.439
3.041LeuAsn: 3.041 ± 0.46
3.802LeuPro: 3.802 ± 0.392
1.977LeuGln: 1.977 ± 0.604
4.258LeuArg: 4.258 ± 1.131
5.931LeuSer: 5.931 ± 1.08
5.627LeuThr: 5.627 ± 0.307
6.387LeuVal: 6.387 ± 0.131
0.912LeuTrp: 0.912 ± 0.504
2.281LeuTyr: 2.281 ± 0.447
0.0LeuXaa: 0.0 ± 0.0
Met
3.498MetAla: 3.498 ± 0.224
0.76MetCys: 0.76 ± 0.176
0.608MetAsp: 0.608 ± 0.092
1.977MetGlu: 1.977 ± 0.604
1.369MetPhe: 1.369 ± 0.22
1.825MetGly: 1.825 ± 0.455
0.912MetHis: 0.912 ± 0.016
1.977MetIle: 1.977 ± 0.371
1.825MetLys: 1.825 ± 0.032
2.585MetLeu: 2.585 ± 0.208
1.977MetMet: 1.977 ± 0.128
0.76MetAsn: 0.76 ± 0.068
2.129MetPro: 2.129 ± 0.444
1.977MetGln: 1.977 ± 0.615
2.281MetArg: 2.281 ± 0.203
1.521MetSer: 1.521 ± 0.352
2.433MetThr: 2.433 ± 0.607
2.281MetVal: 2.281 ± 0.203
0.304MetTrp: 0.304 ± 0.32
1.217MetTyr: 1.217 ± 0.303
0.0MetXaa: 0.0 ± 0.0
Asn
3.954AsnAla: 3.954 ± 0.232
0.608AsnCys: 0.608 ± 0.152
3.954AsnAsp: 3.954 ± 0.476
1.825AsnGlu: 1.825 ± 0.52
1.064AsnPhe: 1.064 ± 0.387
1.977AsnGly: 1.977 ± 0.371
0.912AsnHis: 0.912 ± 0.504
3.193AsnIle: 3.193 ± 0.544
1.521AsnLys: 1.521 ± 0.136
2.585AsnLeu: 2.585 ± 0.208
1.064AsnMet: 1.064 ± 0.344
1.977AsnAsn: 1.977 ± 0.128
1.369AsnPro: 1.369 ± 0.22
1.977AsnGln: 1.977 ± 0.371
1.673AsnArg: 1.673 ± 0.052
3.041AsnSer: 3.041 ± 0.704
2.737AsnThr: 2.737 ± 0.292
4.258AsnVal: 4.258 ± 0.4
0.152AsnTrp: 0.152 ± 0.16
2.129AsnTyr: 2.129 ± 0.531
0.0AsnXaa: 0.0 ± 0.0
Pro
4.258ProAla: 4.258 ± 0.087
0.152ProCys: 0.152 ± 0.16
1.369ProAsp: 1.369 ± 0.024
3.041ProGlu: 3.041 ± 0.704
0.912ProPhe: 0.912 ± 0.228
3.802ProGly: 3.802 ± 0.339
0.608ProHis: 0.608 ± 0.336
2.433ProIle: 2.433 ± 0.855
1.977ProLys: 1.977 ± 0.371
3.345ProLeu: 3.345 ± 0.384
1.673ProMet: 1.673 ± 0.052
0.912ProAsn: 0.912 ± 0.504
1.825ProPro: 1.825 ± 0.211
1.673ProGln: 1.673 ± 0.295
2.281ProArg: 2.281 ± 0.528
3.041ProSer: 3.041 ± 0.027
2.281ProThr: 2.281 ± 0.691
2.281ProVal: 2.281 ± 0.771
0.456ProTrp: 0.456 ± 0.008
1.521ProTyr: 1.521 ± 0.352
0.0ProXaa: 0.0 ± 0.0
Gln
2.129GlnAla: 2.129 ± 0.531
0.456GlnCys: 0.456 ± 0.008
1.977GlnAsp: 1.977 ± 0.604
1.825GlnGlu: 1.825 ± 0.455
0.912GlnPhe: 0.912 ± 0.016
2.281GlnGly: 2.281 ± 0.284
0.912GlnHis: 0.912 ± 0.016
0.912GlnIle: 0.912 ± 0.471
0.912GlnLys: 0.912 ± 0.228
1.977GlnLeu: 1.977 ± 0.371
0.608GlnMet: 0.608 ± 0.092
0.912GlnAsn: 0.912 ± 0.228
1.521GlnPro: 1.521 ± 0.108
1.521GlnGln: 1.521 ± 0.839
0.456GlnArg: 0.456 ± 0.008
1.673GlnSer: 1.673 ± 0.539
2.129GlnThr: 2.129 ± 0.287
1.977GlnVal: 1.977 ± 0.615
0.608GlnTrp: 0.608 ± 0.152
1.217GlnTyr: 1.217 ± 0.184
0.0GlnXaa: 0.0 ± 0.0
Arg
3.498ArgAla: 3.498 ± 0.263
1.217ArgCys: 1.217 ± 0.303
2.737ArgAsp: 2.737 ± 0.292
1.673ArgGlu: 1.673 ± 0.052
1.673ArgPhe: 1.673 ± 0.052
1.977ArgGly: 1.977 ± 0.615
1.369ArgHis: 1.369 ± 0.755
2.129ArgIle: 2.129 ± 0.687
3.65ArgLys: 3.65 ± 1.398
4.258ArgLeu: 4.258 ± 0.888
1.369ArgMet: 1.369 ± 0.024
3.498ArgAsn: 3.498 ± 0.263
2.129ArgPro: 2.129 ± 0.287
1.673ArgGln: 1.673 ± 0.539
4.258ArgArg: 4.258 ± 0.888
6.235ArgSer: 6.235 ± 0.273
3.498ArgThr: 3.498 ± 0.712
4.41ArgVal: 4.41 ± 0.247
0.456ArgTrp: 0.456 ± 0.236
1.825ArgTyr: 1.825 ± 0.763
0.0ArgXaa: 0.0 ± 0.0
Ser
8.516SerAla: 8.516 ± 1.044
1.064SerCys: 1.064 ± 0.144
2.737SerAsp: 2.737 ± 0.439
4.106SerGlu: 4.106 ± 0.316
1.977SerPhe: 1.977 ± 0.128
6.539SerGly: 6.539 ± 0.778
1.521SerHis: 1.521 ± 0.108
4.714SerIle: 4.714 ± 1.298
5.474SerLys: 5.474 ± 1.122
8.516SerLeu: 8.516 ± 0.313
3.345SerMet: 3.345 ± 0.103
2.433SerAsn: 2.433 ± 0.363
2.889SerPro: 2.889 ± 0.599
1.217SerGln: 1.217 ± 0.303
4.41SerArg: 4.41 ± 0.491
7.755SerSer: 7.755 ± 0.137
5.779SerThr: 5.779 ± 1.727
5.931SerVal: 5.931 ± 0.836
1.064SerTrp: 1.064 ± 0.344
3.498SerTyr: 3.498 ± 0.712
0.0SerXaa: 0.0 ± 0.0
Thr
5.931ThrAla: 5.931 ± 0.105
1.673ThrCys: 1.673 ± 0.539
3.65ThrAsp: 3.65 ± 0.179
3.041ThrGlu: 3.041 ± 0.027
3.041ThrPhe: 3.041 ± 0.271
2.585ThrGly: 2.585 ± 0.452
2.889ThrHis: 2.889 ± 0.111
4.866ThrIle: 4.866 ± 0.492
4.562ThrLys: 4.562 ± 0.568
6.539ThrLeu: 6.539 ± 0.534
2.889ThrMet: 2.889 ± 0.679
3.65ThrAsn: 3.65 ± 0.179
3.041ThrPro: 3.041 ± 0.759
1.217ThrGln: 1.217 ± 0.184
3.193ThrArg: 3.193 ± 0.431
5.627ThrSer: 5.627 ± 0.307
5.018ThrThr: 5.018 ± 0.399
4.562ThrVal: 4.562 ± 0.651
0.456ThrTrp: 0.456 ± 0.252
1.825ThrTyr: 1.825 ± 0.699
0.0ThrXaa: 0.0 ± 0.0
Val
7.603ValAla: 7.603 ± 0.191
1.217ValCys: 1.217 ± 0.184
3.498ValAsp: 3.498 ± 0.224
4.258ValGlu: 4.258 ± 0.331
1.521ValPhe: 1.521 ± 0.352
6.235ValGly: 6.235 ± 0.273
1.521ValHis: 1.521 ± 0.352
4.562ValIle: 4.562 ± 1.138
4.41ValLys: 4.41 ± 0.247
5.322ValLeu: 5.322 ± 1.231
2.585ValMet: 2.585 ± 0.569
3.041ValAsn: 3.041 ± 0.46
2.585ValPro: 2.585 ± 0.452
2.737ValGln: 2.737 ± 0.048
5.018ValArg: 5.018 ± 0.089
5.322ValSer: 5.322 ± 0.744
5.322ValThr: 5.322 ± 0.718
5.322ValVal: 5.322 ± 0.013
0.608ValTrp: 0.608 ± 0.092
1.977ValTyr: 1.977 ± 0.615
0.0ValXaa: 0.0 ± 0.0
Trp
0.912TrpAla: 0.912 ± 0.016
0.152TrpCys: 0.152 ± 0.16
0.456TrpAsp: 0.456 ± 0.252
0.304TrpGlu: 0.304 ± 0.168
0.456TrpPhe: 0.456 ± 0.008
0.304TrpGly: 0.304 ± 0.076
0.456TrpHis: 0.456 ± 0.008
0.304TrpIle: 0.304 ± 0.168
0.608TrpLys: 0.608 ± 0.092
0.76TrpLeu: 0.76 ± 0.068
0.456TrpMet: 0.456 ± 0.252
0.152TrpAsn: 0.152 ± 0.16
0.304TrpPro: 0.304 ± 0.076
0.152TrpGln: 0.152 ± 0.084
1.369TrpArg: 1.369 ± 0.024
0.76TrpSer: 0.76 ± 0.176
0.608TrpThr: 0.608 ± 0.395
0.76TrpVal: 0.76 ± 0.312
0.152TrpTrp: 0.152 ± 0.084
0.304TrpTyr: 0.304 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.193TyrAla: 3.193 ± 0.918
0.304TyrCys: 0.304 ± 0.168
2.585TyrAsp: 2.585 ± 0.279
1.977TyrGlu: 1.977 ± 0.116
1.217TyrPhe: 1.217 ± 0.184
3.041TyrGly: 3.041 ± 0.759
1.064TyrHis: 1.064 ± 0.587
2.281TyrIle: 2.281 ± 0.528
1.825TyrLys: 1.825 ± 0.032
2.585TyrLeu: 2.585 ± 0.208
1.369TyrMet: 1.369 ± 0.024
1.825TyrAsn: 1.825 ± 0.211
1.369TyrPro: 1.369 ± 0.22
0.608TyrGln: 0.608 ± 0.152
1.521TyrArg: 1.521 ± 0.352
2.737TyrSer: 2.737 ± 0.439
2.281TyrThr: 2.281 ± 0.447
2.585TyrVal: 2.585 ± 0.208
0.304TyrTrp: 0.304 ± 0.076
1.825TyrTyr: 1.825 ± 0.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (6577 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski