Amino acid dipepetide frequency for Peptostreptococcaceae bacterium AS15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.876AlaAla: 2.876 ± 0.105	0.666AlaCys: 0.666 ± 0.037	3.218AlaAsp: 3.218 ± 0.073	3.109AlaGlu: 3.109 ± 0.083	2.469AlaPhe: 2.469 ± 0.062	3.677AlaGly: 3.677 ± 0.093	0.811AlaHis: 0.811 ± 0.035	5.401AlaIle: 5.401 ± 0.102	5.512AlaLys: 5.512 ± 0.093	5.296AlaLeu: 5.296 ± 0.095	1.859AlaMet: 1.859 ± 0.053	2.967AlaAsn: 2.967 ± 0.073	1.369AlaPro: 1.369 ± 0.051	1.681AlaGln: 1.681 ± 0.056	1.93AlaArg: 1.93 ± 0.053	3.272AlaSer: 3.272 ± 0.078	3.101AlaThr: 3.101 ± 0.073	4.162AlaVal: 4.162 ± 0.087	0.29AlaTrp: 0.29 ± 0.017	2.216AlaTyr: 2.216 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.551CysAla: 0.551 ± 0.027	0.124CysCys: 0.124 ± 0.013	0.666CysAsp: 0.666 ± 0.032	0.647CysGlu: 0.647 ± 0.027	0.434CysPhe: 0.434 ± 0.028	0.877CysGly: 0.877 ± 0.042	0.193CysHis: 0.193 ± 0.018	0.996CysIle: 0.996 ± 0.041	0.823CysLys: 0.823 ± 0.041	0.793CysLeu: 0.793 ± 0.032	0.271CysMet: 0.271 ± 0.02	0.54CysAsn: 0.54 ± 0.028	0.382CysPro: 0.382 ± 0.029	0.215CysGln: 0.215 ± 0.017	0.276CysArg: 0.276 ± 0.019	0.717CysSer: 0.717 ± 0.034	0.495CysThr: 0.495 ± 0.032	0.669CysVal: 0.669 ± 0.034	0.044CysTrp: 0.044 ± 0.008	0.368CysTyr: 0.368 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.099AspAla: 3.099 ± 0.075	0.57AspCys: 0.57 ± 0.026	4.024AspAsp: 4.024 ± 0.082	5.969AspGlu: 5.969 ± 0.092	3.361AspPhe: 3.361 ± 0.08	3.629AspGly: 3.629 ± 0.107	0.538AspHis: 0.538 ± 0.034	7.05AspIle: 7.05 ± 0.106	6.337AspLys: 6.337 ± 0.112	4.608AspLeu: 4.608 ± 0.077	2.052AspMet: 2.052 ± 0.053	3.67AspAsn: 3.67 ± 0.09	1.178AspPro: 1.178 ± 0.048	0.669AspGln: 0.669 ± 0.027	1.886AspArg: 1.886 ± 0.054	3.504AspSer: 3.504 ± 0.073	3.072AspThr: 3.072 ± 0.08	4.455AspVal: 4.455 ± 0.084	0.369AspTrp: 0.369 ± 0.021	3.057AspTyr: 3.057 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	3.376GluAla: 3.376 ± 0.08	0.473GluCys: 0.473 ± 0.027	4.433GluAsp: 4.433 ± 0.082	6.446GluGlu: 6.446 ± 0.123	3.052GluPhe: 3.052 ± 0.064	3.201GluGly: 3.201 ± 0.078	0.937GluHis: 0.937 ± 0.042	7.074GluIle: 7.074 ± 0.119	9.008GluLys: 9.008 ± 0.138	5.998GluLeu: 5.998 ± 0.105	2.061GluMet: 2.061 ± 0.051	5.747GluAsn: 5.747 ± 0.113	1.276GluPro: 1.276 ± 0.046	2.1GluGln: 2.1 ± 0.055	2.255GluArg: 2.255 ± 0.062	3.443GluSer: 3.443 ± 0.072	2.793GluThr: 2.793 ± 0.062	4.711GluVal: 4.711 ± 0.092	0.302GluTrp: 0.302 ± 0.024	2.997GluTyr: 2.997 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.872PheAla: 2.872 ± 0.08	0.568PheCys: 0.568 ± 0.036	3.176PheAsp: 3.176 ± 0.066	3.478PheGlu: 3.478 ± 0.074	2.353PhePhe: 2.353 ± 0.068	2.597PheGly: 2.597 ± 0.072	0.503PheHis: 0.503 ± 0.03	4.179PheIle: 4.179 ± 0.09	3.391PheLys: 3.391 ± 0.072	3.995PheLeu: 3.995 ± 0.088	1.275PheMet: 1.275 ± 0.043	2.258PheAsn: 2.258 ± 0.063	1.163PhePro: 1.163 ± 0.041	0.893PheGln: 0.893 ± 0.035	1.304PheArg: 1.304 ± 0.046	3.779PheSer: 3.779 ± 0.079	2.426PheThr: 2.426 ± 0.065	3.108PheVal: 3.108 ± 0.067	0.286PheTrp: 0.286 ± 0.02	1.815PheTyr: 1.815 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.544GlyAla: 3.544 ± 0.089	0.657GlyCys: 0.657 ± 0.036	3.336GlyAsp: 3.336 ± 0.074	3.878GlyGlu: 3.878 ± 0.087	2.883GlyPhe: 2.883 ± 0.064	4.24GlyGly: 4.24 ± 0.106	0.922GlyHis: 0.922 ± 0.042	5.444GlyIle: 5.444 ± 0.09	5.782GlyLys: 5.782 ± 0.11	4.604GlyLeu: 4.604 ± 0.091	1.759GlyMet: 1.759 ± 0.061	3.061GlyAsn: 3.061 ± 0.075	0.877GlyPro: 0.877 ± 0.038	1.738GlyGln: 1.738 ± 0.052	2.153GlyArg: 2.153 ± 0.061	3.56GlySer: 3.56 ± 0.085	3.024GlyThr: 3.024 ± 0.076	4.103GlyVal: 4.103 ± 0.09	0.341GlyTrp: 0.341 ± 0.021	2.923GlyTyr: 2.923 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	0.673HisAla: 0.673 ± 0.033	0.212HisCys: 0.212 ± 0.02	0.762HisAsp: 0.762 ± 0.041	0.804HisGlu: 0.804 ± 0.036	0.661HisPhe: 0.661 ± 0.033	0.789HisGly: 0.789 ± 0.039	0.282HisHis: 0.282 ± 0.021	1.41HisIle: 1.41 ± 0.047	0.953HisLys: 0.953 ± 0.036	1.159HisLeu: 1.159 ± 0.046	0.305HisMet: 0.305 ± 0.022	0.704HisAsn: 0.704 ± 0.032	0.557HisPro: 0.557 ± 0.027	0.371HisGln: 0.371 ± 0.024	0.48HisArg: 0.48 ± 0.03	0.864HisSer: 0.864 ± 0.038	0.703HisThr: 0.703 ± 0.035	0.695HisVal: 0.695 ± 0.028	0.094HisTrp: 0.094 ± 0.01	0.562HisTyr: 0.562 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.931IleAla: 5.931 ± 0.098	1.102IleCys: 1.102 ± 0.041	6.381IleAsp: 6.381 ± 0.107	6.518IleGlu: 6.518 ± 0.093	4.417IlePhe: 4.417 ± 0.109	5.473IleGly: 5.473 ± 0.106	1.202IleHis: 1.202 ± 0.047	8.342IleIle: 8.342 ± 0.164	8.043IleLys: 8.043 ± 0.119	8.434IleLeu: 8.434 ± 0.136	2.361IleMet: 2.361 ± 0.055	5.284IleAsn: 5.284 ± 0.09	2.997IlePro: 2.997 ± 0.065	2.533IleGln: 2.533 ± 0.059	3.406IleArg: 3.406 ± 0.067	7.773IleSer: 7.773 ± 0.131	4.689IleThr: 4.689 ± 0.097	6.263IleVal: 6.263 ± 0.108	0.412IleTrp: 0.412 ± 0.027	3.729IleTyr: 3.729 ± 0.085	0.0IleXaa: 0.0 ± 0.0
Lys	4.857LysAla: 4.857 ± 0.088	0.681LysCys: 0.681 ± 0.036	6.591LysAsp: 6.591 ± 0.12	7.557LysGlu: 7.557 ± 0.124	3.259LysPhe: 3.259 ± 0.066	4.523LysGly: 4.523 ± 0.075	1.064LysHis: 1.064 ± 0.044	9.293LysIle: 9.293 ± 0.144	9.871LysLys: 9.871 ± 0.141	7.832LysLeu: 7.832 ± 0.112	2.777LysMet: 2.777 ± 0.057	7.226LysAsn: 7.226 ± 0.115	1.959LysPro: 1.959 ± 0.067	2.731LysGln: 2.731 ± 0.064	3.02LysArg: 3.02 ± 0.064	6.222LysSer: 6.222 ± 0.104	4.73LysThr: 4.73 ± 0.085	5.68LysVal: 5.68 ± 0.109	0.558LysTrp: 0.558 ± 0.027	4.488LysTyr: 4.488 ± 0.083	0.0LysXaa: 0.0 ± 0.0
Leu	4.886LeuAla: 4.886 ± 0.085	0.97LeuCys: 0.97 ± 0.039	5.176LeuAsp: 5.176 ± 0.097	6.232LeuGlu: 6.232 ± 0.096	3.824LeuPhe: 3.824 ± 0.103	5.14LeuGly: 5.14 ± 0.087	0.992LeuHis: 0.992 ± 0.035	7.676LeuIle: 7.676 ± 0.131	8.108LeuLys: 8.108 ± 0.12	7.329LeuLeu: 7.329 ± 0.133	2.253LeuMet: 2.253 ± 0.062	4.627LeuAsn: 4.627 ± 0.087	2.764LeuPro: 2.764 ± 0.068	2.297LeuGln: 2.297 ± 0.065	3.088LeuArg: 3.088 ± 0.068	7.259LeuSer: 7.259 ± 0.106	4.347LeuThr: 4.347 ± 0.093	4.769LeuVal: 4.769 ± 0.088	0.427LeuTrp: 0.427 ± 0.025	3.16LeuTyr: 3.16 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.764MetAla: 1.764 ± 0.054	0.248MetCys: 0.248 ± 0.017	1.751MetAsp: 1.751 ± 0.052	1.881MetGlu: 1.881 ± 0.048	1.067MetPhe: 1.067 ± 0.039	1.688MetGly: 1.688 ± 0.05	0.302MetHis: 0.302 ± 0.017	2.573MetIle: 2.573 ± 0.066	2.812MetLys: 2.812 ± 0.059	2.521MetLeu: 2.521 ± 0.058	0.86MetMet: 0.86 ± 0.038	1.55MetAsn: 1.55 ± 0.052	0.934MetPro: 0.934 ± 0.037	0.968MetGln: 0.968 ± 0.037	1.007MetArg: 1.007 ± 0.04	2.157MetSer: 2.157 ± 0.055	1.49MetThr: 1.49 ± 0.052	1.645MetVal: 1.645 ± 0.047	0.12MetTrp: 0.12 ± 0.013	1.07MetTyr: 1.07 ± 0.042	0.0MetXaa: 0.0 ± 0.0
Asn	3.14AsnAla: 3.14 ± 0.072	0.565AsnCys: 0.565 ± 0.033	3.124AsnAsp: 3.124 ± 0.079	3.766AsnGlu: 3.766 ± 0.077	2.805AsnPhe: 2.805 ± 0.068	3.306AsnGly: 3.306 ± 0.072	0.799AsnHis: 0.799 ± 0.038	6.952AsnIle: 6.952 ± 0.109	5.369AsnLys: 5.369 ± 0.097	5.232AsnLeu: 5.232 ± 0.092	1.825AsnMet: 1.825 ± 0.051	3.625AsnAsn: 3.625 ± 0.096	2.12AsnPro: 2.12 ± 0.062	1.752AsnGln: 1.752 ± 0.058	1.766AsnArg: 1.766 ± 0.047	3.77AsnSer: 3.77 ± 0.071	3.179AsnThr: 3.179 ± 0.073	3.574AsnVal: 3.574 ± 0.072	0.357AsnTrp: 0.357 ± 0.025	2.669AsnTyr: 2.669 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.472ProAla: 1.472 ± 0.051	0.246ProCys: 0.246 ± 0.02	1.537ProAsp: 1.537 ± 0.052	1.682ProGlu: 1.682 ± 0.049	1.321ProPhe: 1.321 ± 0.04	1.176ProGly: 1.176 ± 0.049	0.464ProHis: 0.464 ± 0.025	2.443ProIle: 2.443 ± 0.072	2.31ProLys: 2.31 ± 0.054	2.208ProLeu: 2.208 ± 0.053	0.776ProMet: 0.776 ± 0.034	1.525ProAsn: 1.525 ± 0.047	0.67ProPro: 0.67 ± 0.045	0.933ProGln: 0.933 ± 0.04	0.778ProArg: 0.778 ± 0.038	1.803ProSer: 1.803 ± 0.052	1.629ProThr: 1.629 ± 0.056	2.019ProVal: 2.019 ± 0.051	0.17ProTrp: 0.17 ± 0.014	1.239ProTyr: 1.239 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.513GlnAla: 1.513 ± 0.054	0.196GlnCys: 0.196 ± 0.016	1.83GlnAsp: 1.83 ± 0.051	2.052GlnGlu: 2.052 ± 0.062	0.908GlnPhe: 0.908 ± 0.033	1.711GlnGly: 1.711 ± 0.049	0.297GlnHis: 0.297 ± 0.021	2.679GlnIle: 2.679 ± 0.067	2.963GlnLys: 2.963 ± 0.065	2.141GlnLeu: 2.141 ± 0.055	0.832GlnMet: 0.832 ± 0.034	1.97GlnAsn: 1.97 ± 0.078	0.551GlnPro: 0.551 ± 0.035	0.744GlnGln: 0.744 ± 0.045	1.271GlnArg: 1.271 ± 0.044	1.784GlnSer: 1.784 ± 0.055	1.324GlnThr: 1.324 ± 0.045	1.654GlnVal: 1.654 ± 0.051	0.252GlnTrp: 0.252 ± 0.025	1.074GlnTyr: 1.074 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.064ArgAla: 2.064 ± 0.052	0.379ArgCys: 0.379 ± 0.025	2.05ArgAsp: 2.05 ± 0.058	2.634ArgGlu: 2.634 ± 0.067	1.472ArgPhe: 1.472 ± 0.045	1.881ArgGly: 1.881 ± 0.055	0.491ArgHis: 0.491 ± 0.025	2.837ArgIle: 2.837 ± 0.06	3.065ArgLys: 3.065 ± 0.064	3.166ArgLeu: 3.166 ± 0.074	0.93ArgMet: 0.93 ± 0.033	1.848ArgAsn: 1.848 ± 0.047	0.933ArgPro: 0.933 ± 0.036	1.366ArgGln: 1.366 ± 0.043	1.338ArgArg: 1.338 ± 0.049	1.624ArgSer: 1.624 ± 0.051	1.487ArgThr: 1.487 ± 0.049	2.158ArgVal: 2.158 ± 0.055	0.242ArgTrp: 0.242 ± 0.018	1.599ArgTyr: 1.599 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.601SerAla: 3.601 ± 0.077	0.667SerCys: 0.667 ± 0.036	4.172SerAsp: 4.172 ± 0.073	4.139SerGlu: 4.139 ± 0.09	3.377SerPhe: 3.377 ± 0.079	4.444SerGly: 4.444 ± 0.101	0.96SerHis: 0.96 ± 0.041	6.271SerIle: 6.271 ± 0.103	6.327SerLys: 6.327 ± 0.11	6.117SerLeu: 6.117 ± 0.106	1.897SerMet: 1.897 ± 0.048	3.994SerAsn: 3.994 ± 0.071	1.732SerPro: 1.732 ± 0.055	2.16SerGln: 2.16 ± 0.054	2.164SerArg: 2.164 ± 0.061	4.741SerSer: 4.741 ± 0.108	3.216SerThr: 3.216 ± 0.074	4.088SerVal: 4.088 ± 0.07	0.382SerTrp: 0.382 ± 0.021	3.082SerTyr: 3.082 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	3.292ThrAla: 3.292 ± 0.08	0.423ThrCys: 0.423 ± 0.023	3.095ThrAsp: 3.095 ± 0.078	2.459ThrGlu: 2.459 ± 0.062	2.188ThrPhe: 2.188 ± 0.054	3.547ThrGly: 3.547 ± 0.092	0.766ThrHis: 0.766 ± 0.037	4.362ThrIle: 4.362 ± 0.079	4.258ThrLys: 4.258 ± 0.086	4.495ThrLeu: 4.495 ± 0.084	1.298ThrMet: 1.298 ± 0.048	2.678ThrAsn: 2.678 ± 0.067	1.862ThrPro: 1.862 ± 0.061	1.496ThrGln: 1.496 ± 0.051	1.618ThrArg: 1.618 ± 0.054	3.362ThrSer: 3.362 ± 0.08	2.796ThrThr: 2.796 ± 0.075	3.887ThrVal: 3.887 ± 0.108	0.28ThrTrp: 0.28 ± 0.022	1.927ThrTyr: 1.927 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	3.792ValAla: 3.792 ± 0.085	0.758ValCys: 0.758 ± 0.037	4.192ValAsp: 4.192 ± 0.076	4.879ValGlu: 4.879 ± 0.091	3.119ValPhe: 3.119 ± 0.064	4.079ValGly: 4.079 ± 0.097	0.826ValHis: 0.826 ± 0.03	5.974ValIle: 5.974 ± 0.095	5.845ValLys: 5.845 ± 0.11	5.59ValLeu: 5.59 ± 0.091	1.692ValMet: 1.692 ± 0.043	3.404ValAsn: 3.404 ± 0.072	1.831ValPro: 1.831 ± 0.054	1.775ValGln: 1.775 ± 0.052	2.193ValArg: 2.193 ± 0.059	4.641ValSer: 4.641 ± 0.095	3.162ValThr: 3.162 ± 0.097	4.257ValVal: 4.257 ± 0.093	0.336ValTrp: 0.336 ± 0.022	2.478ValTyr: 2.478 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.346TrpAla: 0.346 ± 0.023	0.067TrpCys: 0.067 ± 0.01	0.368TrpAsp: 0.368 ± 0.024	0.413TrpGlu: 0.413 ± 0.025	0.238TrpPhe: 0.238 ± 0.018	0.413TrpGly: 0.413 ± 0.028	0.107TrpHis: 0.107 ± 0.012	0.507TrpIle: 0.507 ± 0.028	0.46TrpLys: 0.46 ± 0.027	0.402TrpLeu: 0.402 ± 0.022	0.179TrpMet: 0.179 ± 0.015	0.379TrpAsn: 0.379 ± 0.024	0.078TrpPro: 0.078 ± 0.011	0.222TrpGln: 0.222 ± 0.018	0.193TrpArg: 0.193 ± 0.015	0.331TrpSer: 0.331 ± 0.022	0.261TrpThr: 0.261 ± 0.022	0.268TrpVal: 0.268 ± 0.017	0.045TrpTrp: 0.045 ± 0.008	0.28TrpTyr: 0.28 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.232TyrAla: 2.232 ± 0.05	0.509TyrCys: 0.509 ± 0.031	3.213TyrAsp: 3.213 ± 0.074	3.14TyrGlu: 3.14 ± 0.068	2.212TyrPhe: 2.212 ± 0.06	2.439TyrGly: 2.439 ± 0.06	0.585TyrHis: 0.585 ± 0.028	3.823TyrIle: 3.823 ± 0.086	3.685TyrLys: 3.685 ± 0.078	3.404TyrLeu: 3.404 ± 0.079	1.146TyrMet: 1.146 ± 0.034	2.636TyrAsn: 2.636 ± 0.067	1.169TyrPro: 1.169 ± 0.04	1.098TyrGln: 1.098 ± 0.042	1.439TyrArg: 1.439 ± 0.045	2.926TyrSer: 2.926 ± 0.063	2.167TyrThr: 2.167 ± 0.067	2.658TyrVal: 2.658 ± 0.063	0.25TyrTrp: 0.25 ± 0.018	1.9TyrTyr: 1.9 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2299 proteins (731109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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