Amino acid dipepetide frequency for Leifsonia aquatica ATCC 14665

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.414AlaAla: 20.414 ± 0.181
0.656AlaCys: 0.656 ± 0.025
8.153AlaAsp: 8.153 ± 0.091
7.915AlaGlu: 7.915 ± 0.095
4.216AlaPhe: 4.216 ± 0.053
12.557AlaGly: 12.557 ± 0.109
2.343AlaHis: 2.343 ± 0.038
6.078AlaIle: 6.078 ± 0.08
2.781AlaLys: 2.781 ± 0.062
14.341AlaLeu: 14.341 ± 0.131
2.557AlaMet: 2.557 ± 0.046
2.534AlaAsn: 2.534 ± 0.048
6.334AlaPro: 6.334 ± 0.083
3.84AlaGln: 3.84 ± 0.056
8.536AlaArg: 8.536 ± 0.107
7.576AlaSer: 7.576 ± 0.085
7.948AlaThr: 7.948 ± 0.109
12.047AlaVal: 12.047 ± 0.11
1.756AlaTrp: 1.756 ± 0.037
2.454AlaTyr: 2.454 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.681CysAla: 0.681 ± 0.025
0.045CysCys: 0.045 ± 0.006
0.319CysAsp: 0.319 ± 0.016
0.205CysGlu: 0.205 ± 0.013
0.155CysPhe: 0.155 ± 0.011
0.574CysGly: 0.574 ± 0.025
0.105CysHis: 0.105 ± 0.01
0.179CysIle: 0.179 ± 0.012
0.057CysLys: 0.057 ± 0.006
0.425CysLeu: 0.425 ± 0.019
0.072CysMet: 0.072 ± 0.007
0.101CysAsn: 0.101 ± 0.01
0.291CysPro: 0.291 ± 0.016
0.121CysGln: 0.121 ± 0.011
0.303CysArg: 0.303 ± 0.015
0.371CysSer: 0.371 ± 0.018
0.34CysThr: 0.34 ± 0.017
0.439CysVal: 0.439 ± 0.021
0.078CysTrp: 0.078 ± 0.008
0.083CysTyr: 0.083 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
8.702AspAla: 8.702 ± 0.091
0.241AspCys: 0.241 ± 0.012
4.109AspAsp: 4.109 ± 0.07
4.045AspGlu: 4.045 ± 0.061
1.727AspPhe: 1.727 ± 0.036
6.23AspGly: 6.23 ± 0.088
1.193AspHis: 1.193 ± 0.034
2.3AspIle: 2.3 ± 0.042
1.064AspLys: 1.064 ± 0.039
6.084AspLeu: 6.084 ± 0.076
0.684AspMet: 0.684 ± 0.024
1.006AspAsn: 1.006 ± 0.031
4.177AspPro: 4.177 ± 0.063
1.627AspGln: 1.627 ± 0.038
4.445AspArg: 4.445 ± 0.065
2.613AspSer: 2.613 ± 0.05
2.977AspThr: 2.977 ± 0.051
5.098AspVal: 5.098 ± 0.078
0.991AspTrp: 0.991 ± 0.024
1.312AspTyr: 1.312 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.88GluAla: 6.88 ± 0.092
0.213GluCys: 0.213 ± 0.013
2.435GluAsp: 2.435 ± 0.047
2.955GluGlu: 2.955 ± 0.058
1.611GluPhe: 1.611 ± 0.045
3.723GluGly: 3.723 ± 0.06
1.396GluHis: 1.396 ± 0.035
2.418GluIle: 2.418 ± 0.049
1.388GluLys: 1.388 ± 0.041
6.502GluLeu: 6.502 ± 0.107
0.728GluMet: 0.728 ± 0.022
1.136GluAsn: 1.136 ± 0.027
3.011GluPro: 3.011 ± 0.055
2.147GluGln: 2.147 ± 0.042
5.118GluArg: 5.118 ± 0.086
2.849GluSer: 2.849 ± 0.054
3.004GluThr: 3.004 ± 0.044
4.21GluVal: 4.21 ± 0.069
0.831GluTrp: 0.831 ± 0.023
1.099GluTyr: 1.099 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.459PheAla: 4.459 ± 0.07
0.163PheCys: 0.163 ± 0.013
2.328PheAsp: 2.328 ± 0.048
1.681PheGlu: 1.681 ± 0.042
1.158PhePhe: 1.158 ± 0.032
3.522PheGly: 3.522 ± 0.062
0.56PheHis: 0.56 ± 0.02
1.218PheIle: 1.218 ± 0.035
0.476PheLys: 0.476 ± 0.022
3.007PheLeu: 3.007 ± 0.058
0.411PheMet: 0.411 ± 0.018
0.687PheAsn: 0.687 ± 0.023
1.451PhePro: 1.451 ± 0.032
0.773PheGln: 0.773 ± 0.027
1.861PheArg: 1.861 ± 0.043
1.914PheSer: 1.914 ± 0.04
2.224PheThr: 2.224 ± 0.043
3.004PheVal: 3.004 ± 0.055
0.544PheTrp: 0.544 ± 0.019
0.703PheTyr: 0.703 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.919GlyAla: 10.919 ± 0.112
0.583GlyCys: 0.583 ± 0.022
5.119GlyAsp: 5.119 ± 0.074
4.786GlyGlu: 4.786 ± 0.062
3.3GlyPhe: 3.3 ± 0.055
7.905GlyGly: 7.905 ± 0.1
1.777GlyHis: 1.777 ± 0.036
4.693GlyIle: 4.693 ± 0.068
2.147GlyLys: 2.147 ± 0.044
9.056GlyLeu: 9.056 ± 0.094
1.994GlyMet: 1.994 ± 0.039
1.742GlyAsn: 1.742 ± 0.041
3.832GlyPro: 3.832 ± 0.062
2.448GlyGln: 2.448 ± 0.051
6.296GlyArg: 6.296 ± 0.076
5.83GlySer: 5.83 ± 0.082
6.041GlyThr: 6.041 ± 0.11
8.215GlyVal: 8.215 ± 0.09
1.75GlyTrp: 1.75 ± 0.04
2.362GlyTyr: 2.362 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.233HisAla: 2.233 ± 0.048
0.094HisCys: 0.094 ± 0.008
1.302HisAsp: 1.302 ± 0.031
1.059HisGlu: 1.059 ± 0.028
0.551HisPhe: 0.551 ± 0.019
1.838HisGly: 1.838 ± 0.039
0.493HisHis: 0.493 ± 0.022
0.685HisIle: 0.685 ± 0.023
0.283HisLys: 0.283 ± 0.015
1.936HisLeu: 1.936 ± 0.042
0.255HisMet: 0.255 ± 0.015
0.339HisAsn: 0.339 ± 0.016
1.506HisPro: 1.506 ± 0.036
0.496HisGln: 0.496 ± 0.02
1.476HisArg: 1.476 ± 0.033
0.968HisSer: 0.968 ± 0.029
0.999HisThr: 0.999 ± 0.024
1.555HisVal: 1.555 ± 0.036
0.277HisTrp: 0.277 ± 0.015
0.457HisTyr: 0.457 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.195IleAla: 7.195 ± 0.075
0.221IleCys: 0.221 ± 0.012
3.229IleAsp: 3.229 ± 0.052
2.544IleGlu: 2.544 ± 0.051
1.174IlePhe: 1.174 ± 0.038
4.768IleGly: 4.768 ± 0.076
0.738IleHis: 0.738 ± 0.024
1.713IleIle: 1.713 ± 0.047
0.807IleLys: 0.807 ± 0.029
3.838IleLeu: 3.838 ± 0.069
0.586IleMet: 0.586 ± 0.019
0.919IleAsn: 0.919 ± 0.027
2.471IlePro: 2.471 ± 0.043
1.058IleGln: 1.058 ± 0.029
2.53IleArg: 2.53 ± 0.046
2.255IleSer: 2.255 ± 0.045
2.816IleThr: 2.816 ± 0.052
4.968IleVal: 4.968 ± 0.071
0.529IleTrp: 0.529 ± 0.02
0.736IleTyr: 0.736 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.542LysAla: 2.542 ± 0.055
0.073LysCys: 0.073 ± 0.007
1.195LysAsp: 1.195 ± 0.035
0.994LysGlu: 0.994 ± 0.034
0.485LysPhe: 0.485 ± 0.02
1.581LysGly: 1.581 ± 0.042
0.44LysHis: 0.44 ± 0.018
0.902LysIle: 0.902 ± 0.03
0.804LysLys: 0.804 ± 0.035
1.938LysLeu: 1.938 ± 0.051
0.355LysMet: 0.355 ± 0.018
0.584LysAsn: 0.584 ± 0.026
1.252LysPro: 1.252 ± 0.033
0.759LysGln: 0.759 ± 0.027
1.577LysArg: 1.577 ± 0.041
1.166LysSer: 1.166 ± 0.033
1.376LysThr: 1.376 ± 0.041
1.647LysVal: 1.647 ± 0.04
0.259LysTrp: 0.259 ± 0.015
0.5LysTyr: 0.5 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.77LeuAla: 14.77 ± 0.133
0.508LeuCys: 0.508 ± 0.02
6.8LeuAsp: 6.8 ± 0.074
4.652LeuGlu: 4.652 ± 0.066
3.149LeuPhe: 3.149 ± 0.055
9.519LeuGly: 9.519 ± 0.102
1.924LeuHis: 1.924 ± 0.042
4.564LeuIle: 4.564 ± 0.083
1.765LeuLys: 1.765 ± 0.049
10.714LeuLeu: 10.714 ± 0.151
1.544LeuMet: 1.544 ± 0.04
1.883LeuAsn: 1.883 ± 0.038
5.734LeuPro: 5.734 ± 0.07
2.589LeuGln: 2.589 ± 0.047
7.288LeuArg: 7.288 ± 0.082
5.929LeuSer: 5.929 ± 0.074
6.594LeuThr: 6.594 ± 0.091
9.403LeuVal: 9.403 ± 0.114
1.271LeuTrp: 1.271 ± 0.033
1.718LeuTyr: 1.718 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
1.921MetAla: 1.921 ± 0.035
0.088MetCys: 0.088 ± 0.008
0.786MetAsp: 0.786 ± 0.024
0.629MetGlu: 0.629 ± 0.025
0.529MetPhe: 0.529 ± 0.024
1.2MetGly: 1.2 ± 0.032
0.31MetHis: 0.31 ± 0.014
0.848MetIle: 0.848 ± 0.025
0.419MetLys: 0.419 ± 0.016
1.777MetLeu: 1.777 ± 0.042
0.293MetMet: 0.293 ± 0.016
0.455MetAsn: 0.455 ± 0.017
0.983MetPro: 0.983 ± 0.025
0.471MetGln: 0.471 ± 0.02
1.273MetArg: 1.273 ± 0.032
1.329MetSer: 1.329 ± 0.031
1.688MetThr: 1.688 ± 0.034
1.301MetVal: 1.301 ± 0.03
0.173MetTrp: 0.173 ± 0.011
0.289MetTyr: 0.289 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.627AsnAla: 2.627 ± 0.05
0.128AsnCys: 0.128 ± 0.01
1.136AsnAsp: 1.136 ± 0.026
0.911AsnGlu: 0.911 ± 0.029
0.669AsnPhe: 0.669 ± 0.024
2.106AsnGly: 2.106 ± 0.05
0.373AsnHis: 0.373 ± 0.016
0.889AsnIle: 0.889 ± 0.028
0.437AsnLys: 0.437 ± 0.021
1.924AsnLeu: 1.924 ± 0.037
0.303AsnMet: 0.303 ± 0.017
0.499AsnAsn: 0.499 ± 0.022
1.557AsnPro: 1.557 ± 0.033
0.602AsnGln: 0.602 ± 0.025
1.305AsnArg: 1.305 ± 0.036
1.02AsnSer: 1.02 ± 0.032
1.235AsnThr: 1.235 ± 0.034
1.742AsnVal: 1.742 ± 0.043
0.311AsnTrp: 0.311 ± 0.014
0.498AsnTyr: 0.498 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.461ProAla: 7.461 ± 0.09
0.192ProCys: 0.192 ± 0.012
3.705ProAsp: 3.705 ± 0.056
3.795ProGlu: 3.795 ± 0.067
1.781ProPhe: 1.781 ± 0.038
5.181ProGly: 5.181 ± 0.073
0.989ProHis: 0.989 ± 0.027
2.133ProIle: 2.133 ± 0.046
1.042ProLys: 1.042 ± 0.031
4.979ProLeu: 4.979 ± 0.063
0.853ProMet: 0.853 ± 0.025
1.109ProAsn: 1.109 ± 0.025
2.254ProPro: 2.254 ± 0.046
1.561ProGln: 1.561 ± 0.038
3.152ProArg: 3.152 ± 0.053
3.298ProSer: 3.298 ± 0.046
3.584ProThr: 3.584 ± 0.061
4.954ProVal: 4.954 ± 0.065
0.811ProTrp: 0.811 ± 0.026
1.105ProTyr: 1.105 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.465GlnAla: 3.465 ± 0.058
0.106GlnCys: 0.106 ± 0.009
1.24GlnAsp: 1.24 ± 0.033
1.314GlnGlu: 1.314 ± 0.033
0.862GlnPhe: 0.862 ± 0.027
1.982GlnGly: 1.982 ± 0.036
0.608GlnHis: 0.608 ± 0.022
1.321GlnIle: 1.321 ± 0.035
0.746GlnLys: 0.746 ± 0.027
3.298GlnLeu: 3.298 ± 0.053
0.447GlnMet: 0.447 ± 0.019
0.75GlnAsn: 0.75 ± 0.027
1.623GlnPro: 1.623 ± 0.044
1.219GlnGln: 1.219 ± 0.035
2.277GlnArg: 2.277 ± 0.044
1.583GlnSer: 1.583 ± 0.034
1.717GlnThr: 1.717 ± 0.037
2.34GlnVal: 2.34 ± 0.046
0.472GlnTrp: 0.472 ± 0.019
0.656GlnTyr: 0.656 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.4ArgAla: 8.4 ± 0.097
0.316ArgCys: 0.316 ± 0.017
4.096ArgAsp: 4.096 ± 0.067
4.152ArgGlu: 4.152 ± 0.062
2.414ArgPhe: 2.414 ± 0.046
5.087ArgGly: 5.087 ± 0.066
1.419ArgHis: 1.419 ± 0.038
3.615ArgIle: 3.615 ± 0.046
1.376ArgLys: 1.376 ± 0.038
7.122ArgLeu: 7.122 ± 0.105
1.663ArgMet: 1.663 ± 0.038
1.288ArgAsn: 1.288 ± 0.033
3.69ArgPro: 3.69 ± 0.061
1.885ArgGln: 1.885 ± 0.037
6.316ArgArg: 6.316 ± 0.096
4.164ArgSer: 4.164 ± 0.062
4.292ArgThr: 4.292 ± 0.057
5.954ArgVal: 5.954 ± 0.078
1.151ArgTrp: 1.151 ± 0.032
1.58ArgTyr: 1.58 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.473SerAla: 7.473 ± 0.085
0.296SerCys: 0.296 ± 0.016
3.24SerAsp: 3.24 ± 0.048
2.567SerGlu: 2.567 ± 0.045
1.937SerPhe: 1.937 ± 0.037
6.229SerGly: 6.229 ± 0.082
0.963SerHis: 0.963 ± 0.03
2.719SerIle: 2.719 ± 0.05
1.16SerLys: 1.16 ± 0.032
5.552SerLeu: 5.552 ± 0.071
1.086SerMet: 1.086 ± 0.027
1.103SerAsn: 1.103 ± 0.03
3.05SerPro: 3.05 ± 0.049
1.523SerGln: 1.523 ± 0.032
3.846SerArg: 3.846 ± 0.053
3.801SerSer: 3.801 ± 0.067
4.038SerThr: 4.038 ± 0.075
4.95SerVal: 4.95 ± 0.067
0.998SerTrp: 0.998 ± 0.028
1.25SerTyr: 1.25 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
8.678ThrAla: 8.678 ± 0.1
0.284ThrCys: 0.284 ± 0.013
3.612ThrAsp: 3.612 ± 0.06
2.88ThrGlu: 2.88 ± 0.049
2.046ThrPhe: 2.046 ± 0.042
6.282ThrGly: 6.282 ± 0.106
1.066ThrHis: 1.066 ± 0.027
3.175ThrIle: 3.175 ± 0.06
1.27ThrLys: 1.27 ± 0.043
6.091ThrLeu: 6.091 ± 0.072
0.991ThrMet: 0.991 ± 0.027
1.266ThrAsn: 1.266 ± 0.036
4.079ThrPro: 4.079 ± 0.07
1.521ThrGln: 1.521 ± 0.045
3.695ThrArg: 3.695 ± 0.056
3.593ThrSer: 3.593 ± 0.069
4.267ThrThr: 4.267 ± 0.072
6.504ThrVal: 6.504 ± 0.081
0.914ThrTrp: 0.914 ± 0.028
1.211ThrTyr: 1.211 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
12.111ValAla: 12.111 ± 0.116
0.523ValCys: 0.523 ± 0.022
5.704ValAsp: 5.704 ± 0.074
4.87ValGlu: 4.87 ± 0.069
3.04ValPhe: 3.04 ± 0.054
7.397ValGly: 7.397 ± 0.081
1.541ValHis: 1.541 ± 0.037
4.179ValIle: 4.179 ± 0.062
1.664ValLys: 1.664 ± 0.046
9.648ValLeu: 9.648 ± 0.115
1.352ValMet: 1.352 ± 0.036
1.93ValAsn: 1.93 ± 0.037
4.842ValPro: 4.842 ± 0.064
2.243ValGln: 2.243 ± 0.045
5.826ValArg: 5.826 ± 0.082
5.31ValSer: 5.31 ± 0.074
6.031ValThr: 6.031 ± 0.093
9.371ValVal: 9.371 ± 0.107
1.158ValTrp: 1.158 ± 0.033
1.723ValTyr: 1.723 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.599TrpAla: 1.599 ± 0.036
0.098TrpCys: 0.098 ± 0.008
0.731TrpAsp: 0.731 ± 0.024
0.643TrpGlu: 0.643 ± 0.026
0.575TrpPhe: 0.575 ± 0.02
1.102TrpGly: 1.102 ± 0.025
0.298TrpHis: 0.298 ± 0.016
0.762TrpIle: 0.762 ± 0.027
0.355TrpLys: 0.355 ± 0.017
1.86TrpLeu: 1.86 ± 0.044
0.338TrpMet: 0.338 ± 0.016
0.444TrpAsn: 0.444 ± 0.017
0.717TrpPro: 0.717 ± 0.026
0.527TrpGln: 0.527 ± 0.019
1.177TrpArg: 1.177 ± 0.029
0.996TrpSer: 0.996 ± 0.029
0.954TrpThr: 0.954 ± 0.026
1.131TrpVal: 1.131 ± 0.032
0.365TrpTrp: 0.365 ± 0.019
0.311TrpTyr: 0.311 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.039
0.115TyrCys: 0.115 ± 0.009
1.385TyrAsp: 1.385 ± 0.04
1.054TyrGlu: 1.054 ± 0.032
0.769TyrPhe: 0.769 ± 0.025
2.01TyrGly: 2.01 ± 0.041
0.269TyrHis: 0.269 ± 0.016
0.705TyrIle: 0.705 ± 0.028
0.386TyrLys: 0.386 ± 0.016
2.223TyrLeu: 2.223 ± 0.04
0.252TyrMet: 0.252 ± 0.016
0.499TyrAsn: 0.499 ± 0.026
1.086TyrPro: 1.086 ± 0.035
0.616TyrGln: 0.616 ± 0.022
1.684TyrArg: 1.684 ± 0.038
1.216TyrSer: 1.216 ± 0.031
1.299TyrThr: 1.299 ± 0.037
1.629TyrVal: 1.629 ± 0.041
0.343TyrTrp: 0.343 ± 0.017
0.481TyrTyr: 0.481 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4862 proteins (1291825 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski