Amino acid dipepetide frequency for Vagococcus elongatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.14AlaAla: 5.14 ± 0.103	0.546AlaCys: 0.546 ± 0.027	3.67AlaAsp: 3.67 ± 0.07	4.836AlaGlu: 4.836 ± 0.079	2.896AlaPhe: 2.896 ± 0.063	4.813AlaGly: 4.813 ± 0.09	1.24AlaHis: 1.24 ± 0.04	5.315AlaIle: 5.315 ± 0.098	4.681AlaLys: 4.681 ± 0.096	6.447AlaLeu: 6.447 ± 0.105	1.823AlaMet: 1.823 ± 0.055	2.765AlaAsn: 2.765 ± 0.064	1.9AlaPro: 1.9 ± 0.054	2.365AlaGln: 2.365 ± 0.06	2.39AlaArg: 2.39 ± 0.056	3.924AlaSer: 3.924 ± 0.072	3.481AlaThr: 3.481 ± 0.078	4.92AlaVal: 4.92 ± 0.089	0.501AlaTrp: 0.501 ± 0.026	2.278AlaTyr: 2.278 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.437CysAla: 0.437 ± 0.025	0.083CysCys: 0.083 ± 0.012	0.409CysAsp: 0.409 ± 0.024	0.469CysGlu: 0.469 ± 0.026	0.407CysPhe: 0.407 ± 0.022	0.674CysGly: 0.674 ± 0.035	0.202CysHis: 0.202 ± 0.016	0.444CysIle: 0.444 ± 0.026	0.269CysLys: 0.269 ± 0.019	0.7CysLeu: 0.7 ± 0.029	0.172CysMet: 0.172 ± 0.014	0.244CysAsn: 0.244 ± 0.019	0.325CysPro: 0.325 ± 0.022	0.314CysGln: 0.314 ± 0.022	0.318CysArg: 0.318 ± 0.019	0.481CysSer: 0.481 ± 0.026	0.334CysThr: 0.334 ± 0.021	0.425CysVal: 0.425 ± 0.023	0.054CysTrp: 0.054 ± 0.008	0.31CysTyr: 0.31 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.1AspAla: 3.1 ± 0.068	0.412AspCys: 0.412 ± 0.027	3.023AspAsp: 3.023 ± 0.066	4.707AspGlu: 4.707 ± 0.084	3.16AspPhe: 3.16 ± 0.068	3.748AspGly: 3.748 ± 0.097	0.967AspHis: 0.967 ± 0.035	4.506AspIle: 4.506 ± 0.071	3.922AspLys: 3.922 ± 0.075	5.239AspLeu: 5.239 ± 0.088	1.52AspMet: 1.52 ± 0.048	2.328AspAsn: 2.328 ± 0.058	1.656AspPro: 1.656 ± 0.05	1.803AspGln: 1.803 ± 0.051	1.982AspArg: 1.982 ± 0.053	3.083AspSer: 3.083 ± 0.067	2.841AspThr: 2.841 ± 0.067	3.987AspVal: 3.987 ± 0.068	0.652AspTrp: 0.652 ± 0.032	2.66AspTyr: 2.66 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.309GluAla: 5.309 ± 0.097	0.415GluCys: 0.415 ± 0.026	4.203GluAsp: 4.203 ± 0.092	7.353GluGlu: 7.353 ± 0.118	2.982GluPhe: 2.982 ± 0.057	4.225GluGly: 4.225 ± 0.074	1.26GluHis: 1.26 ± 0.045	6.244GluIle: 6.244 ± 0.092	7.596GluLys: 7.596 ± 0.099	7.598GluLeu: 7.598 ± 0.116	2.457GluMet: 2.457 ± 0.053	4.458GluAsn: 4.458 ± 0.086	1.86GluPro: 1.86 ± 0.053	3.066GluGln: 3.066 ± 0.066	3.11GluArg: 3.11 ± 0.065	3.724GluSer: 3.724 ± 0.074	4.264GluThr: 4.264 ± 0.074	5.158GluVal: 5.158 ± 0.088	0.608GluTrp: 0.608 ± 0.034	2.309GluTyr: 2.309 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.664PheAla: 2.664 ± 0.062	0.384PheCys: 0.384 ± 0.025	2.918PheAsp: 2.918 ± 0.06	3.111PheGlu: 3.111 ± 0.062	2.428PhePhe: 2.428 ± 0.07	3.218PheGly: 3.218 ± 0.085	0.831PheHis: 0.831 ± 0.034	3.62PheIle: 3.62 ± 0.076	2.744PheLys: 2.744 ± 0.069	4.489PheLeu: 4.489 ± 0.097	1.191PheMet: 1.191 ± 0.038	2.164PheAsn: 2.164 ± 0.047	1.631PhePro: 1.631 ± 0.051	1.614PheGln: 1.614 ± 0.051	1.508PheArg: 1.508 ± 0.041	3.703PheSer: 3.703 ± 0.076	2.394PheThr: 2.394 ± 0.052	3.06PheVal: 3.06 ± 0.069	0.442PheTrp: 0.442 ± 0.024	1.862PheTyr: 1.862 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.373GlyAla: 4.373 ± 0.09	0.537GlyCys: 0.537 ± 0.026	3.379GlyAsp: 3.379 ± 0.069	4.726GlyGlu: 4.726 ± 0.091	3.195GlyPhe: 3.195 ± 0.074	4.593GlyGly: 4.593 ± 0.095	1.159GlyHis: 1.159 ± 0.04	5.719GlyIle: 5.719 ± 0.101	5.234GlyLys: 5.234 ± 0.085	6.406GlyLeu: 6.406 ± 0.09	2.027GlyMet: 2.027 ± 0.049	2.912GlyAsn: 2.912 ± 0.063	1.415GlyPro: 1.415 ± 0.045	2.199GlyGln: 2.199 ± 0.051	2.547GlyArg: 2.547 ± 0.07	3.935GlySer: 3.935 ± 0.09	4.038GlyThr: 4.038 ± 0.087	4.925GlyVal: 4.925 ± 0.087	0.589GlyTrp: 0.589 ± 0.03	2.741GlyTyr: 2.741 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.059HisAla: 1.059 ± 0.038	0.181HisCys: 0.181 ± 0.016	0.977HisAsp: 0.977 ± 0.033	1.287HisGlu: 1.287 ± 0.041	0.979HisPhe: 0.979 ± 0.041	1.348HisGly: 1.348 ± 0.043	0.566HisHis: 0.566 ± 0.03	1.227HisIle: 1.227 ± 0.037	0.87HisLys: 0.87 ± 0.033	1.951HisLeu: 1.951 ± 0.056	0.421HisMet: 0.421 ± 0.022	0.685HisAsn: 0.685 ± 0.032	0.967HisPro: 0.967 ± 0.036	0.946HisGln: 0.946 ± 0.035	0.847HisArg: 0.847 ± 0.035	1.136HisSer: 1.136 ± 0.037	0.946HisThr: 0.946 ± 0.04	1.206HisVal: 1.206 ± 0.039	0.198HisTrp: 0.198 ± 0.016	0.835HisTyr: 0.835 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.51IleAla: 5.51 ± 0.089	0.649IleCys: 0.649 ± 0.03	4.848IleAsp: 4.848 ± 0.08	5.839IleGlu: 5.839 ± 0.103	3.678IlePhe: 3.678 ± 0.083	5.42IleGly: 5.42 ± 0.086	1.415IleHis: 1.415 ± 0.046	5.953IleIle: 5.953 ± 0.101	5.122IleLys: 5.122 ± 0.089	7.167IleLeu: 7.167 ± 0.096	1.844IleMet: 1.844 ± 0.058	3.529IleAsn: 3.529 ± 0.068	3.199IlePro: 3.199 ± 0.061	2.828IleGln: 2.828 ± 0.065	3.098IleArg: 3.098 ± 0.062	5.312IleSer: 5.312 ± 0.092	4.124IleThr: 4.124 ± 0.072	5.353IleVal: 5.353 ± 0.086	0.505IleTrp: 0.505 ± 0.023	2.574IleTyr: 2.574 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.375LysAla: 4.375 ± 0.082	0.295LysCys: 0.295 ± 0.02	4.159LysAsp: 4.159 ± 0.087	7.434LysGlu: 7.434 ± 0.117	2.369LysPhe: 2.369 ± 0.059	4.04LysGly: 4.04 ± 0.08	1.244LysHis: 1.244 ± 0.04	6.144LysIle: 6.144 ± 0.1	7.074LysLys: 7.074 ± 0.107	5.915LysLeu: 5.915 ± 0.092	2.365LysMet: 2.365 ± 0.047	4.422LysAsn: 4.422 ± 0.088	1.872LysPro: 1.872 ± 0.058	2.852LysGln: 2.852 ± 0.07	2.988LysArg: 2.988 ± 0.064	3.719LysSer: 3.719 ± 0.075	4.012LysThr: 4.012 ± 0.062	4.767LysVal: 4.767 ± 0.085	0.616LysTrp: 0.616 ± 0.028	2.509LysTyr: 2.509 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	7.335LeuAla: 7.335 ± 0.105	0.672LeuCys: 0.672 ± 0.029	5.271LeuAsp: 5.271 ± 0.088	7.1LeuGlu: 7.1 ± 0.102	4.335LeuPhe: 4.335 ± 0.099	6.322LeuGly: 6.322 ± 0.101	1.538LeuHis: 1.538 ± 0.045	7.037LeuIle: 7.037 ± 0.115	7.003LeuLys: 7.003 ± 0.115	9.794LeuLeu: 9.794 ± 0.165	2.493LeuMet: 2.493 ± 0.056	4.467LeuAsn: 4.467 ± 0.079	3.881LeuPro: 3.881 ± 0.079	3.088LeuGln: 3.088 ± 0.061	3.479LeuArg: 3.479 ± 0.076	7.091LeuSer: 7.091 ± 0.105	5.97LeuThr: 5.97 ± 0.077	6.216LeuVal: 6.216 ± 0.094	0.702LeuTrp: 0.702 ± 0.032	3.049LeuTyr: 3.049 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.991MetAla: 1.991 ± 0.054	0.166MetCys: 0.166 ± 0.014	1.428MetAsp: 1.428 ± 0.048	1.913MetGlu: 1.913 ± 0.048	1.073MetPhe: 1.073 ± 0.041	1.844MetGly: 1.844 ± 0.052	0.356MetHis: 0.356 ± 0.021	2.22MetIle: 2.22 ± 0.057	2.354MetLys: 2.354 ± 0.047	2.483MetLeu: 2.483 ± 0.055	0.912MetMet: 0.912 ± 0.038	1.462MetAsn: 1.462 ± 0.042	0.969MetPro: 0.969 ± 0.032	0.78MetGln: 0.78 ± 0.031	1.009MetArg: 1.009 ± 0.034	1.849MetSer: 1.849 ± 0.05	1.982MetThr: 1.982 ± 0.056	1.769MetVal: 1.769 ± 0.048	0.173MetTrp: 0.173 ± 0.016	0.724MetTyr: 0.724 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.524AsnAla: 2.524 ± 0.06	0.351AsnCys: 0.351 ± 0.022	2.493AsnAsp: 2.493 ± 0.058	3.303AsnGlu: 3.303 ± 0.072	2.171AsnPhe: 2.171 ± 0.062	3.225AsnGly: 3.225 ± 0.074	1.161AsnHis: 1.161 ± 0.039	3.777AsnIle: 3.777 ± 0.07	3.265AsnLys: 3.265 ± 0.075	4.304AsnLeu: 4.304 ± 0.067	1.226AsnMet: 1.226 ± 0.04	2.303AsnAsn: 2.303 ± 0.065	1.915AsnPro: 1.915 ± 0.049	2.347AsnGln: 2.347 ± 0.059	1.885AsnArg: 1.885 ± 0.054	2.579AsnSer: 2.579 ± 0.053	2.132AsnThr: 2.132 ± 0.06	3.024AsnVal: 3.024 ± 0.067	0.491AsnTrp: 0.491 ± 0.03	2.095AsnTyr: 2.095 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	2.242ProAla: 2.242 ± 0.06	0.223ProCys: 0.223 ± 0.018	1.918ProAsp: 1.918 ± 0.052	3.288ProGlu: 3.288 ± 0.074	1.67ProPhe: 1.67 ± 0.047	1.936ProGly: 1.936 ± 0.054	0.619ProHis: 0.619 ± 0.031	2.451ProIle: 2.451 ± 0.066	2.202ProLys: 2.202 ± 0.053	3.085ProLeu: 3.085 ± 0.066	0.795ProMet: 0.795 ± 0.032	1.534ProAsn: 1.534 ± 0.043	0.669ProPro: 0.669 ± 0.031	1.165ProGln: 1.165 ± 0.042	0.981ProArg: 0.981 ± 0.039	2.027ProSer: 2.027 ± 0.048	1.858ProThr: 1.858 ± 0.051	2.617ProVal: 2.617 ± 0.063	0.315ProTrp: 0.315 ± 0.02	1.344ProTyr: 1.344 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.701GlnAla: 2.701 ± 0.061	0.204GlnCys: 0.204 ± 0.016	1.658GlnAsp: 1.658 ± 0.043	3.106GlnGlu: 3.106 ± 0.068	1.534GlnPhe: 1.534 ± 0.045	2.382GlnGly: 2.382 ± 0.061	0.702GlnHis: 0.702 ± 0.03	2.602GlnIle: 2.602 ± 0.057	3.159GlnLys: 3.159 ± 0.076	4.103GlnLeu: 4.103 ± 0.092	1.14GlnMet: 1.14 ± 0.04	1.601GlnAsn: 1.601 ± 0.047	1.115GlnPro: 1.115 ± 0.044	1.905GlnGln: 1.905 ± 0.076	1.609GlnArg: 1.609 ± 0.048	2.101GlnSer: 2.101 ± 0.062	2.173GlnThr: 2.173 ± 0.059	2.509GlnVal: 2.509 ± 0.059	0.374GlnTrp: 0.374 ± 0.025	1.236GlnTyr: 1.236 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.073ArgAla: 2.073 ± 0.053	0.25ArgCys: 0.25 ± 0.018	1.889ArgAsp: 1.889 ± 0.058	3.223ArgGlu: 3.223 ± 0.074	1.774ArgPhe: 1.774 ± 0.045	2.24ArgGly: 2.24 ± 0.063	0.807ArgHis: 0.807 ± 0.035	2.885ArgIle: 2.885 ± 0.066	3.218ArgLys: 3.218 ± 0.064	3.839ArgLeu: 3.839 ± 0.078	1.133ArgMet: 1.133 ± 0.037	1.746ArgAsn: 1.746 ± 0.046	1.253ArgPro: 1.253 ± 0.049	1.872ArgGln: 1.872 ± 0.056	1.948ArgArg: 1.948 ± 0.058	2.032ArgSer: 2.032 ± 0.052	1.885ArgThr: 1.885 ± 0.044	2.562ArgVal: 2.562 ± 0.057	0.349ArgTrp: 0.349 ± 0.021	1.616ArgTyr: 1.616 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.769SerAla: 3.769 ± 0.075	0.406SerCys: 0.406 ± 0.023	3.326SerAsp: 3.326 ± 0.071	4.502SerGlu: 4.502 ± 0.067	3.241SerPhe: 3.241 ± 0.072	4.605SerGly: 4.605 ± 0.082	1.244SerHis: 1.244 ± 0.041	4.74SerIle: 4.74 ± 0.075	4.052SerLys: 4.052 ± 0.07	6.514SerLeu: 6.514 ± 0.09	1.61SerMet: 1.61 ± 0.043	2.643SerAsn: 2.643 ± 0.053	1.905SerPro: 1.905 ± 0.049	2.455SerGln: 2.455 ± 0.052	2.437SerArg: 2.437 ± 0.059	3.983SerSer: 3.983 ± 0.077	3.079SerThr: 3.079 ± 0.07	4.192SerVal: 4.192 ± 0.078	0.612SerTrp: 0.612 ± 0.028	2.427SerTyr: 2.427 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.758ThrAla: 3.758 ± 0.079	0.346ThrCys: 0.346 ± 0.023	3.038ThrAsp: 3.038 ± 0.067	3.873ThrGlu: 3.873 ± 0.07	2.451ThrPhe: 2.451 ± 0.054	4.4ThrGly: 4.4 ± 0.083	1.058ThrHis: 1.058 ± 0.035	4.635ThrIle: 4.635 ± 0.074	3.517ThrLys: 3.517 ± 0.071	5.384ThrLeu: 5.384 ± 0.091	1.322ThrMet: 1.322 ± 0.041	2.41ThrAsn: 2.41 ± 0.061	2.323ThrPro: 2.323 ± 0.059	1.739ThrGln: 1.739 ± 0.05	1.931ThrArg: 1.931 ± 0.049	3.327ThrSer: 3.327 ± 0.073	3.035ThrThr: 3.035 ± 0.069	4.148ThrVal: 4.148 ± 0.092	0.478ThrTrp: 0.478 ± 0.032	1.967ThrTyr: 1.967 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.021ValAla: 5.021 ± 0.095	0.597ValCys: 0.597 ± 0.027	3.891ValAsp: 3.891 ± 0.068	4.876ValGlu: 4.876 ± 0.082	3.176ValPhe: 3.176 ± 0.069	4.565ValGly: 4.565 ± 0.09	1.119ValHis: 1.119 ± 0.041	5.496ValIle: 5.496 ± 0.083	4.415ValLys: 4.415 ± 0.079	6.502ValLeu: 6.502 ± 0.118	1.904ValMet: 1.904 ± 0.049	3.037ValAsn: 3.037 ± 0.064	2.532ValPro: 2.532 ± 0.063	2.068ValGln: 2.068 ± 0.055	2.49ValArg: 2.49 ± 0.057	4.918ValSer: 4.918 ± 0.083	4.175ValThr: 4.175 ± 0.095	4.95ValVal: 4.95 ± 0.094	0.552ValTrp: 0.552 ± 0.031	2.264ValTyr: 2.264 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.437TrpAla: 0.437 ± 0.025	0.051TrpCys: 0.051 ± 0.008	0.495TrpAsp: 0.495 ± 0.029	0.71TrpGlu: 0.71 ± 0.043	0.424TrpPhe: 0.424 ± 0.025	0.506TrpGly: 0.506 ± 0.023	0.223TrpHis: 0.223 ± 0.016	0.569TrpIle: 0.569 ± 0.027	0.596TrpLys: 0.596 ± 0.029	1.049TrpLeu: 1.049 ± 0.035	0.259TrpMet: 0.259 ± 0.02	0.394TrpAsn: 0.394 ± 0.02	0.192TrpPro: 0.192 ± 0.016	0.495TrpGln: 0.495 ± 0.024	0.39TrpArg: 0.39 ± 0.022	0.523TrpSer: 0.523 ± 0.027	0.462TrpThr: 0.462 ± 0.026	0.52TrpVal: 0.52 ± 0.025	0.106TrpTrp: 0.106 ± 0.011	0.299TrpTyr: 0.299 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.045	0.302TyrCys: 0.302 ± 0.02	2.305TyrAsp: 2.305 ± 0.058	2.546TyrGlu: 2.546 ± 0.062	2.035TyrPhe: 2.035 ± 0.067	2.546TyrGly: 2.546 ± 0.063	0.923TyrHis: 0.923 ± 0.032	2.384TyrIle: 2.384 ± 0.06	1.878TyrLys: 1.878 ± 0.054	3.871TyrLeu: 3.871 ± 0.073	0.842TyrMet: 0.842 ± 0.036	1.469TyrAsn: 1.469 ± 0.044	1.358TyrPro: 1.358 ± 0.039	2.014TyrGln: 2.014 ± 0.06	1.65TyrArg: 1.65 ± 0.046	2.293TyrSer: 2.293 ± 0.054	1.955TyrThr: 1.955 ± 0.082	2.238TyrVal: 2.238 ± 0.049	0.384TyrTrp: 0.384 ± 0.024	1.555TyrTyr: 1.555 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2619 proteins (802562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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