Amino acid dipepetide frequency for Propionivibrio dicarboxylicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.237AlaAla: 15.237 ± 0.173	1.419AlaCys: 1.419 ± 0.037	6.228AlaAsp: 6.228 ± 0.082	7.166AlaGlu: 7.166 ± 0.091	4.122AlaPhe: 4.122 ± 0.062	9.339AlaGly: 9.339 ± 0.097	2.244AlaHis: 2.244 ± 0.045	6.393AlaIle: 6.393 ± 0.083	4.265AlaLys: 4.265 ± 0.077	13.749AlaLeu: 13.749 ± 0.236	3.273AlaMet: 3.273 ± 0.053	3.277AlaAsn: 3.277 ± 0.049	4.864AlaPro: 4.864 ± 0.088	4.542AlaGln: 4.542 ± 0.111	7.809AlaArg: 7.809 ± 0.098	6.351AlaSer: 6.351 ± 0.083	5.833AlaThr: 5.833 ± 0.083	8.255AlaVal: 8.255 ± 0.107	1.493AlaTrp: 1.493 ± 0.033	2.527AlaTyr: 2.527 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.217CysAla: 1.217 ± 0.032	0.187CysCys: 0.187 ± 0.012	0.665CysAsp: 0.665 ± 0.025	0.569CysGlu: 0.569 ± 0.022	0.42CysPhe: 0.42 ± 0.017	1.135CysGly: 1.135 ± 0.037	0.345CysHis: 0.345 ± 0.02	0.52CysIle: 0.52 ± 0.023	0.311CysLys: 0.311 ± 0.015	1.124CysLeu: 1.124 ± 0.031	0.241CysMet: 0.241 ± 0.014	0.325CysAsn: 0.325 ± 0.017	0.59CysPro: 0.59 ± 0.023	0.367CysGln: 0.367 ± 0.017	0.762CysArg: 0.762 ± 0.024	0.612CysSer: 0.612 ± 0.022	0.485CysThr: 0.485 ± 0.024	0.792CysVal: 0.792 ± 0.025	0.135CysTrp: 0.135 ± 0.008	0.27CysTyr: 0.27 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.841AspAla: 6.841 ± 0.102	0.589AspCys: 0.589 ± 0.019	3.038AspAsp: 3.038 ± 0.054	3.339AspGlu: 3.339 ± 0.052	2.264AspPhe: 2.264 ± 0.047	4.431AspGly: 4.431 ± 0.071	1.095AspHis: 1.095 ± 0.027	3.21AspIle: 3.21 ± 0.056	1.952AspLys: 1.952 ± 0.044	5.455AspLeu: 5.455 ± 0.072	1.259AspMet: 1.259 ± 0.031	1.417AspAsn: 1.417 ± 0.034	2.642AspPro: 2.642 ± 0.054	1.678AspGln: 1.678 ± 0.101	3.349AspArg: 3.349 ± 0.058	2.579AspSer: 2.579 ± 0.049	2.64AspThr: 2.64 ± 0.051	3.906AspVal: 3.906 ± 0.061	0.914AspTrp: 0.914 ± 0.025	1.505AspTyr: 1.505 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.956GluAla: 6.956 ± 0.104	0.533GluCys: 0.533 ± 0.02	2.436GluAsp: 2.436 ± 0.046	3.076GluGlu: 3.076 ± 0.059	1.995GluPhe: 1.995 ± 0.043	3.402GluGly: 3.402 ± 0.057	1.353GluHis: 1.353 ± 0.032	3.739GluIle: 3.739 ± 0.057	2.751GluLys: 2.751 ± 0.05	5.952GluLeu: 5.952 ± 0.072	1.565GluMet: 1.565 ± 0.035	1.792GluAsn: 1.792 ± 0.042	2.051GluPro: 2.051 ± 0.042	2.435GluGln: 2.435 ± 0.047	4.715GluArg: 4.715 ± 0.07	3.095GluSer: 3.095 ± 0.052	3.275GluThr: 3.275 ± 0.058	3.921GluVal: 3.921 ± 0.063	0.679GluTrp: 0.679 ± 0.022	1.191GluTyr: 1.191 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.319PheAla: 4.319 ± 0.064	0.487PheCys: 0.487 ± 0.02	2.512PheAsp: 2.512 ± 0.048	2.035PheGlu: 2.035 ± 0.041	1.618PhePhe: 1.618 ± 0.035	3.609PheGly: 3.609 ± 0.059	0.752PheHis: 0.752 ± 0.022	1.833PheIle: 1.833 ± 0.039	1.249PheLys: 1.249 ± 0.032	3.507PheLeu: 3.507 ± 0.061	0.849PheMet: 0.849 ± 0.029	1.234PheAsn: 1.234 ± 0.03	1.631PhePro: 1.631 ± 0.036	1.025PheGln: 1.025 ± 0.029	2.205PheArg: 2.205 ± 0.048	2.703PheSer: 2.703 ± 0.055	1.751PheThr: 1.751 ± 0.037	3.053PheVal: 3.053 ± 0.058	0.491PheTrp: 0.491 ± 0.021	0.945PheTyr: 0.945 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.896GlyAla: 7.896 ± 0.093	1.039GlyCys: 1.039 ± 0.032	4.061GlyAsp: 4.061 ± 0.06	4.579GlyGlu: 4.579 ± 0.069	3.396GlyPhe: 3.396 ± 0.058	6.202GlyGly: 6.202 ± 0.112	1.703GlyHis: 1.703 ± 0.038	5.143GlyIle: 5.143 ± 0.069	3.904GlyLys: 3.904 ± 0.059	8.302GlyLeu: 8.302 ± 0.122	2.358GlyMet: 2.358 ± 0.049	2.501GlyAsn: 2.501 ± 0.057	2.279GlyPro: 2.279 ± 0.049	2.807GlyGln: 2.807 ± 0.05	4.956GlyArg: 4.956 ± 0.071	4.323GlySer: 4.323 ± 0.081	4.102GlyThr: 4.102 ± 0.072	6.249GlyVal: 6.249 ± 0.074	1.106GlyTrp: 1.106 ± 0.03	2.229GlyTyr: 2.229 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.296HisAla: 2.296 ± 0.044	0.295HisCys: 0.295 ± 0.016	1.17HisAsp: 1.17 ± 0.032	1.176HisGlu: 1.176 ± 0.029	0.93HisPhe: 0.93 ± 0.026	1.823HisGly: 1.823 ± 0.039	0.567HisHis: 0.567 ± 0.022	1.017HisIle: 1.017 ± 0.029	0.529HisLys: 0.529 ± 0.019	2.26HisLeu: 2.26 ± 0.044	0.41HisMet: 0.41 ± 0.018	0.507HisAsn: 0.507 ± 0.021	1.379HisPro: 1.379 ± 0.032	0.704HisGln: 0.704 ± 0.023	1.458HisArg: 1.458 ± 0.039	1.005HisSer: 1.005 ± 0.026	0.882HisThr: 0.882 ± 0.025	1.425HisVal: 1.425 ± 0.037	0.333HisTrp: 0.333 ± 0.015	0.565HisTyr: 0.565 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.218IleAla: 7.218 ± 0.096	0.607IleCys: 0.607 ± 0.022	3.957IleAsp: 3.957 ± 0.059	3.913IleGlu: 3.913 ± 0.07	1.803IlePhe: 1.803 ± 0.043	5.115IleGly: 5.115 ± 0.068	1.026IleHis: 1.026 ± 0.025	2.482IleIle: 2.482 ± 0.054	1.843IleLys: 1.843 ± 0.047	4.765IleLeu: 4.765 ± 0.063	1.003IleMet: 1.003 ± 0.033	1.843IleAsn: 1.843 ± 0.045	2.674IlePro: 2.674 ± 0.04	1.528IleGln: 1.528 ± 0.045	3.534IleArg: 3.534 ± 0.047	3.255IleSer: 3.255 ± 0.057	2.725IleThr: 2.725 ± 0.051	4.612IleVal: 4.612 ± 0.064	0.459IleTrp: 0.459 ± 0.018	1.196IleTyr: 1.196 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.323LysAla: 4.323 ± 0.078	0.263LysCys: 0.263 ± 0.015	1.868LysAsp: 1.868 ± 0.039	2.057LysGlu: 2.057 ± 0.041	1.134LysPhe: 1.134 ± 0.032	2.576LysGly: 2.576 ± 0.049	0.753LysHis: 0.753 ± 0.025	2.197LysIle: 2.197 ± 0.046	1.805LysLys: 1.805 ± 0.05	3.747LysLeu: 3.747 ± 0.061	0.992LysMet: 0.992 ± 0.034	1.229LysAsn: 1.229 ± 0.031	2.053LysPro: 2.053 ± 0.047	1.438LysGln: 1.438 ± 0.035	2.477LysArg: 2.477 ± 0.044	2.129LysSer: 2.129 ± 0.043	2.246LysThr: 2.246 ± 0.047	2.601LysVal: 2.601 ± 0.054	0.364LysTrp: 0.364 ± 0.016	0.816LysTyr: 0.816 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.685LeuAla: 13.685 ± 0.127	1.173LeuCys: 1.173 ± 0.031	5.996LeuAsp: 5.996 ± 0.079	5.427LeuGlu: 5.427 ± 0.073	3.897LeuPhe: 3.897 ± 0.063	8.351LeuGly: 8.351 ± 0.087	2.021LeuHis: 2.021 ± 0.042	5.666LeuIle: 5.666 ± 0.078	3.988LeuLys: 3.988 ± 0.073	10.921LeuLeu: 10.921 ± 0.126	2.508LeuMet: 2.508 ± 0.05	2.912LeuAsn: 2.912 ± 0.051	5.744LeuPro: 5.744 ± 0.066	3.391LeuGln: 3.391 ± 0.058	7.315LeuArg: 7.315 ± 0.093	6.929LeuSer: 6.929 ± 0.088	5.593LeuThr: 5.593 ± 0.207	7.714LeuVal: 7.714 ± 0.086	1.117LeuTrp: 1.117 ± 0.034	2.058LeuTyr: 2.058 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.985MetAla: 2.985 ± 0.045	0.182MetCys: 0.182 ± 0.011	1.06MetAsp: 1.06 ± 0.025	1.162MetGlu: 1.162 ± 0.033	0.781MetPhe: 0.781 ± 0.026	1.678MetGly: 1.678 ± 0.04	0.47MetHis: 0.47 ± 0.017	1.405MetIle: 1.405 ± 0.033	1.152MetLys: 1.152 ± 0.028	2.654MetLeu: 2.654 ± 0.047	0.676MetMet: 0.676 ± 0.024	0.942MetAsn: 0.942 ± 0.026	1.459MetPro: 1.459 ± 0.035	0.991MetGln: 0.991 ± 0.027	1.694MetArg: 1.694 ± 0.038	1.621MetSer: 1.621 ± 0.035	1.708MetThr: 1.708 ± 0.035	1.657MetVal: 1.657 ± 0.043	0.198MetTrp: 0.198 ± 0.011	0.35MetTyr: 0.35 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.523AsnAla: 3.523 ± 0.057	0.329AsnCys: 0.329 ± 0.016	1.595AsnAsp: 1.595 ± 0.039	1.541AsnGlu: 1.541 ± 0.039	1.105AsnPhe: 1.105 ± 0.032	2.504AsnGly: 2.504 ± 0.062	0.579AsnHis: 0.579 ± 0.019	1.575AsnIle: 1.575 ± 0.035	0.933AsnLys: 0.933 ± 0.03	2.947AsnLeu: 2.947 ± 0.054	0.654AsnMet: 0.654 ± 0.025	0.919AsnAsn: 0.919 ± 0.031	1.833AsnPro: 1.833 ± 0.035	0.966AsnGln: 0.966 ± 0.032	1.904AsnArg: 1.904 ± 0.041	1.5AsnSer: 1.5 ± 0.046	1.555AsnThr: 1.555 ± 0.038	2.238AsnVal: 2.238 ± 0.047	0.363AsnTrp: 0.363 ± 0.018	0.783AsnTyr: 0.783 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.567ProAla: 5.567 ± 0.083	0.455ProCys: 0.455 ± 0.02	3.003ProAsp: 3.003 ± 0.055	3.479ProGlu: 3.479 ± 0.058	1.829ProPhe: 1.829 ± 0.04	3.943ProGly: 3.943 ± 0.058	0.917ProHis: 0.917 ± 0.024	2.374ProIle: 2.374 ± 0.04	1.583ProLys: 1.583 ± 0.038	4.711ProLeu: 4.711 ± 0.068	1.168ProMet: 1.168 ± 0.031	1.307ProAsn: 1.307 ± 0.034	2.328ProPro: 2.328 ± 0.057	1.566ProGln: 1.566 ± 0.032	2.362ProArg: 2.362 ± 0.046	2.545ProSer: 2.545 ± 0.043	2.467ProThr: 2.467 ± 0.043	4.016ProVal: 4.016 ± 0.066	0.588ProTrp: 0.588 ± 0.021	1.114ProTyr: 1.114 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.549GlnAla: 4.549 ± 0.072	0.333GlnCys: 0.333 ± 0.016	1.45GlnAsp: 1.45 ± 0.029	1.807GlnGlu: 1.807 ± 0.041	1.152GlnPhe: 1.152 ± 0.029	2.513GlnGly: 2.513 ± 0.044	0.815GlnHis: 0.815 ± 0.026	2.202GlnIle: 2.202 ± 0.119	1.316GlnLys: 1.316 ± 0.036	3.686GlnLeu: 3.686 ± 0.072	0.988GlnMet: 0.988 ± 0.028	0.984GlnAsn: 0.984 ± 0.028	1.555GlnPro: 1.555 ± 0.033	1.535GlnGln: 1.535 ± 0.036	2.822GlnArg: 2.822 ± 0.053	2.003GlnSer: 2.003 ± 0.039	1.823GlnThr: 1.823 ± 0.038	2.746GlnVal: 2.746 ± 0.192	0.428GlnTrp: 0.428 ± 0.02	0.769GlnTyr: 0.769 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.606ArgAla: 6.606 ± 0.079	0.751ArgCys: 0.751 ± 0.026	3.555ArgAsp: 3.555 ± 0.061	4.16ArgGlu: 4.16 ± 0.065	2.868ArgPhe: 2.868 ± 0.049	4.113ArgGly: 4.113 ± 0.057	1.813ArgHis: 1.813 ± 0.039	4.109ArgIle: 4.109 ± 0.061	2.455ArgLys: 2.455 ± 0.046	7.944ArgLeu: 7.944 ± 0.102	1.717ArgMet: 1.717 ± 0.043	2.027ArgAsn: 2.027 ± 0.039	2.833ArgPro: 2.833 ± 0.046	3.054ArgGln: 3.054 ± 0.058	5.087ArgArg: 5.087 ± 0.078	3.36ArgSer: 3.36 ± 0.058	3.013ArgThr: 3.013 ± 0.049	4.602ArgVal: 4.602 ± 0.07	0.931ArgTrp: 0.931 ± 0.028	1.844ArgTyr: 1.844 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.467SerAla: 6.467 ± 0.082	0.605SerCys: 0.605 ± 0.024	2.899SerAsp: 2.899 ± 0.068	3.023SerGlu: 3.023 ± 0.048	2.224SerPhe: 2.224 ± 0.041	5.498SerGly: 5.498 ± 0.089	1.11SerHis: 1.11 ± 0.028	3.179SerIle: 3.179 ± 0.051	1.812SerLys: 1.812 ± 0.04	6.329SerLeu: 6.329 ± 0.075	1.407SerMet: 1.407 ± 0.036	1.589SerAsn: 1.589 ± 0.045	2.755SerPro: 2.755 ± 0.055	1.879SerGln: 1.879 ± 0.06	3.469SerArg: 3.469 ± 0.053	3.501SerSer: 3.501 ± 0.086	2.989SerThr: 2.989 ± 0.067	4.34SerVal: 4.34 ± 0.061	0.682SerTrp: 0.682 ± 0.021	1.277SerTyr: 1.277 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.903ThrAla: 5.903 ± 0.119	0.486ThrCys: 0.486 ± 0.02	2.502ThrAsp: 2.502 ± 0.081	2.466ThrGlu: 2.466 ± 0.047	1.662ThrPhe: 1.662 ± 0.036	4.507ThrGly: 4.507 ± 0.065	1.092ThrHis: 1.092 ± 0.031	2.76ThrIle: 2.76 ± 0.057	1.436ThrLys: 1.436 ± 0.035	6.212ThrLeu: 6.212 ± 0.083	1.089ThrMet: 1.089 ± 0.029	1.375ThrAsn: 1.375 ± 0.037	3.436ThrPro: 3.436 ± 0.063	1.935ThrGln: 1.935 ± 0.062	3.277ThrArg: 3.277 ± 0.048	2.816ThrSer: 2.816 ± 0.098	3.296ThrThr: 3.296 ± 0.209	4.036ThrVal: 4.036 ± 0.062	0.549ThrTrp: 0.549 ± 0.019	1.075ThrTyr: 1.075 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.148ValAla: 9.148 ± 0.144	0.866ValCys: 0.866 ± 0.031	4.247ValAsp: 4.247 ± 0.055	4.206ValGlu: 4.206 ± 0.058	3.08ValPhe: 3.08 ± 0.053	5.711ValGly: 5.711 ± 0.101	1.272ValHis: 1.272 ± 0.032	4.192ValIle: 4.192 ± 0.06	2.569ValLys: 2.569 ± 0.05	7.982ValLeu: 7.982 ± 0.085	1.935ValMet: 1.935 ± 0.042	2.155ValAsn: 2.155 ± 0.04	3.441ValPro: 3.441 ± 0.054	2.14ValGln: 2.14 ± 0.05	4.8ValArg: 4.8 ± 0.07	4.654ValSer: 4.654 ± 0.06	3.938ValThr: 3.938 ± 0.062	6.215ValVal: 6.215 ± 0.078	0.83ValTrp: 0.83 ± 0.025	1.536ValTyr: 1.536 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.034TrpAla: 1.034 ± 0.031	0.151TrpCys: 0.151 ± 0.011	0.554TrpAsp: 0.554 ± 0.021	0.559TrpGlu: 0.559 ± 0.021	0.492TrpPhe: 0.492 ± 0.021	0.761TrpGly: 0.761 ± 0.024	0.314TrpHis: 0.314 ± 0.016	0.661TrpIle: 0.661 ± 0.02	0.488TrpLys: 0.488 ± 0.018	1.679TrpLeu: 1.679 ± 0.04	0.34TrpMet: 0.34 ± 0.016	0.4TrpAsn: 0.4 ± 0.018	0.555TrpPro: 0.555 ± 0.022	0.624TrpGln: 0.624 ± 0.022	1.008TrpArg: 1.008 ± 0.03	0.695TrpSer: 0.695 ± 0.021	0.526TrpThr: 0.526 ± 0.023	0.853TrpVal: 0.853 ± 0.025	0.202TrpTrp: 0.202 ± 0.014	0.28TrpTyr: 0.28 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.618TyrAla: 2.618 ± 0.048	0.323TyrCys: 0.323 ± 0.016	1.306TyrAsp: 1.306 ± 0.03	1.17TyrGlu: 1.17 ± 0.033	1.034TyrPhe: 1.034 ± 0.025	1.922TyrGly: 1.922 ± 0.036	0.49TyrHis: 0.49 ± 0.018	0.905TyrIle: 0.905 ± 0.023	0.728TyrLys: 0.728 ± 0.023	2.481TyrLeu: 2.481 ± 0.044	0.391TyrMet: 0.391 ± 0.018	0.61TyrAsn: 0.61 ± 0.024	1.22TyrPro: 1.22 ± 0.028	0.87TyrGln: 0.87 ± 0.027	1.842TyrArg: 1.842 ± 0.04	1.357TyrSer: 1.357 ± 0.032	1.064TyrThr: 1.064 ± 0.029	1.686TyrVal: 1.686 ± 0.037	0.314TyrTrp: 0.314 ± 0.016	0.641TyrTyr: 0.641 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4057 proteins (1358461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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