Amino acid dipepetide frequency for Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.452AlaAla: 8.452 ± 0.111	1.047AlaCys: 1.047 ± 0.036	4.947AlaAsp: 4.947 ± 0.072	5.839AlaGlu: 5.839 ± 0.087	3.445AlaPhe: 3.445 ± 0.052	6.255AlaGly: 6.255 ± 0.088	1.637AlaHis: 1.637 ± 0.032	6.304AlaIle: 6.304 ± 0.071	5.52AlaLys: 5.52 ± 0.081	9.994AlaLeu: 9.994 ± 0.111	2.783AlaMet: 2.783 ± 0.055	4.002AlaAsn: 4.002 ± 0.062	3.045AlaPro: 3.045 ± 0.052	4.06AlaGln: 4.06 ± 0.067	3.48AlaArg: 3.48 ± 0.054	5.886AlaSer: 5.886 ± 0.063	4.587AlaThr: 4.587 ± 0.072	6.038AlaVal: 6.038 ± 0.073	0.945AlaTrp: 0.945 ± 0.026	2.419AlaTyr: 2.419 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.89CysAla: 0.89 ± 0.026	0.183CysCys: 0.183 ± 0.015	0.628CysAsp: 0.628 ± 0.021	0.67CysGlu: 0.67 ± 0.022	0.448CysPhe: 0.448 ± 0.018	0.909CysGly: 0.909 ± 0.032	0.489CysHis: 0.489 ± 0.031	0.665CysIle: 0.665 ± 0.024	0.453CysLys: 0.453 ± 0.017	1.032CysLeu: 1.032 ± 0.031	0.251CysMet: 0.251 ± 0.016	0.388CysAsn: 0.388 ± 0.017	0.469CysPro: 0.469 ± 0.025	0.525CysGln: 0.525 ± 0.018	0.44CysArg: 0.44 ± 0.018	0.788CysSer: 0.788 ± 0.024	0.472CysThr: 0.472 ± 0.019	0.661CysVal: 0.661 ± 0.025	0.138CysTrp: 0.138 ± 0.008	0.36CysTyr: 0.36 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.785AspAla: 4.785 ± 0.068	0.604AspCys: 0.604 ± 0.021	3.151AspAsp: 3.151 ± 0.06	3.828AspGlu: 3.828 ± 0.063	2.486AspPhe: 2.486 ± 0.043	4.026AspGly: 4.026 ± 0.082	0.945AspHis: 0.945 ± 0.025	4.006AspIle: 4.006 ± 0.065	3.468AspLys: 3.468 ± 0.056	5.152AspLeu: 5.152 ± 0.064	1.452AspMet: 1.452 ± 0.029	2.682AspAsn: 2.682 ± 0.054	2.072AspPro: 2.072 ± 0.039	1.652AspGln: 1.652 ± 0.04	2.109AspArg: 2.109 ± 0.047	3.866AspSer: 3.866 ± 0.062	2.942AspThr: 2.942 ± 0.065	3.614AspVal: 3.614 ± 0.056	0.811AspTrp: 0.811 ± 0.026	2.054AspTyr: 2.054 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.323GluAla: 5.323 ± 0.072	0.498GluCys: 0.498 ± 0.02	2.781GluAsp: 2.781 ± 0.048	3.28GluGlu: 3.28 ± 0.06	2.473GluPhe: 2.473 ± 0.05	3.541GluGly: 3.541 ± 0.055	1.489GluHis: 1.489 ± 0.033	3.712GluIle: 3.712 ± 0.055	3.143GluLys: 3.143 ± 0.058	7.59GluLeu: 7.59 ± 0.081	1.624GluMet: 1.624 ± 0.037	2.314GluAsn: 2.314 ± 0.046	2.037GluPro: 2.037 ± 0.045	4.307GluGln: 4.307 ± 0.063	3.168GluArg: 3.168 ± 0.058	3.775GluSer: 3.775 ± 0.046	3.049GluThr: 3.049 ± 0.044	4.289GluVal: 4.289 ± 0.055	0.645GluTrp: 0.645 ± 0.022	1.798GluTyr: 1.798 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.686PheAla: 3.686 ± 0.055	0.474PheCys: 0.474 ± 0.019	2.807PheAsp: 2.807 ± 0.043	2.632PheGlu: 2.632 ± 0.044	1.603PhePhe: 1.603 ± 0.04	3.156PheGly: 3.156 ± 0.056	0.74PheHis: 0.74 ± 0.023	2.857PheIle: 2.857 ± 0.053	2.018PheLys: 2.018 ± 0.038	3.159PheLeu: 3.159 ± 0.051	1.033PheMet: 1.033 ± 0.028	2.213PheAsn: 2.213 ± 0.041	1.345PhePro: 1.345 ± 0.029	1.107PheGln: 1.107 ± 0.028	1.303PheArg: 1.303 ± 0.028	3.474PheSer: 3.474 ± 0.057	2.325PheThr: 2.325 ± 0.044	2.64PheVal: 2.64 ± 0.045	0.512PheTrp: 0.512 ± 0.02	1.367PheTyr: 1.367 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.536GlyAla: 5.536 ± 0.077	0.952GlyCys: 0.952 ± 0.028	3.762GlyAsp: 3.762 ± 0.066	4.377GlyGlu: 4.377 ± 0.077	3.258GlyPhe: 3.258 ± 0.053	4.774GlyGly: 4.774 ± 0.07	1.641GlyHis: 1.641 ± 0.044	4.632GlyIle: 4.632 ± 0.062	3.798GlyLys: 3.798 ± 0.061	7.281GlyLeu: 7.281 ± 0.088	2.107GlyMet: 2.107 ± 0.041	2.638GlyAsn: 2.638 ± 0.056	1.672GlyPro: 1.672 ± 0.039	2.997GlyGln: 2.997 ± 0.054	2.964GlyArg: 2.964 ± 0.055	4.305GlySer: 4.305 ± 0.081	3.354GlyThr: 3.354 ± 0.061	5.261GlyVal: 5.261 ± 0.068	0.923GlyTrp: 0.923 ± 0.028	2.617GlyTyr: 2.617 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.571HisAla: 1.571 ± 0.034	0.326HisCys: 0.326 ± 0.015	1.053HisAsp: 1.053 ± 0.03	1.094HisGlu: 1.094 ± 0.026	1.044HisPhe: 1.044 ± 0.028	1.589HisGly: 1.589 ± 0.038	0.574HisHis: 0.574 ± 0.024	1.365HisIle: 1.365 ± 0.032	1.059HisLys: 1.059 ± 0.029	2.156HisLeu: 2.156 ± 0.04	0.493HisMet: 0.493 ± 0.019	0.909HisAsn: 0.909 ± 0.024	1.038HisPro: 1.038 ± 0.032	1.162HisGln: 1.162 ± 0.031	0.931HisArg: 0.931 ± 0.027	1.496HisSer: 1.496 ± 0.032	1.025HisThr: 1.025 ± 0.031	1.143HisVal: 1.143 ± 0.031	0.348HisTrp: 0.348 ± 0.016	0.818HisTyr: 0.818 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.823IleAla: 6.823 ± 0.077	0.736IleCys: 0.736 ± 0.024	4.368IleAsp: 4.368 ± 0.063	4.732IleGlu: 4.732 ± 0.054	2.204IlePhe: 2.204 ± 0.04	4.744IleGly: 4.744 ± 0.062	1.17IleHis: 1.17 ± 0.032	3.768IleIle: 3.768 ± 0.061	3.344IleLys: 3.344 ± 0.05	5.238IleLeu: 5.238 ± 0.072	1.306IleMet: 1.306 ± 0.034	3.157IleAsn: 3.157 ± 0.056	2.5IlePro: 2.5 ± 0.051	2.128IleGln: 2.128 ± 0.038	2.571IleArg: 2.571 ± 0.038	4.751IleSer: 4.751 ± 0.066	3.647IleThr: 3.647 ± 0.073	3.98IleVal: 3.98 ± 0.055	0.641IleTrp: 0.641 ± 0.022	1.731IleTyr: 1.731 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.978LysAla: 4.978 ± 0.077	0.348LysCys: 0.348 ± 0.021	2.631LysAsp: 2.631 ± 0.049	2.943LysGlu: 2.943 ± 0.054	1.567LysPhe: 1.567 ± 0.037	3.448LysGly: 3.448 ± 0.05	1.236LysHis: 1.236 ± 0.025	2.834LysIle: 2.834 ± 0.049	2.475LysLys: 2.475 ± 0.056	5.926LysLeu: 5.926 ± 0.078	1.436LysMet: 1.436 ± 0.035	1.931LysAsn: 1.931 ± 0.041	2.392LysPro: 2.392 ± 0.04	3.328LysGln: 3.328 ± 0.058	2.647LysArg: 2.647 ± 0.048	3.324LysSer: 3.324 ± 0.061	2.662LysThr: 2.662 ± 0.048	3.957LysVal: 3.957 ± 0.059	0.517LysTrp: 0.517 ± 0.021	1.385LysTyr: 1.385 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	10.538LeuAla: 10.538 ± 0.105	1.152LeuCys: 1.152 ± 0.028	5.777LeuAsp: 5.777 ± 0.061	6.061LeuGlu: 6.061 ± 0.083	4.29LeuPhe: 4.29 ± 0.07	7.052LeuGly: 7.052 ± 0.086	1.904LeuHis: 1.904 ± 0.038	6.314LeuIle: 6.314 ± 0.074	5.588LeuLys: 5.588 ± 0.075	11.092LeuLeu: 11.092 ± 0.148	2.83LeuMet: 2.83 ± 0.054	4.729LeuAsn: 4.729 ± 0.062	4.784LeuPro: 4.784 ± 0.068	3.81LeuGln: 3.81 ± 0.068	3.969LeuArg: 3.969 ± 0.063	8.391LeuSer: 8.391 ± 0.09	6.383LeuThr: 6.383 ± 0.075	7.262LeuVal: 7.262 ± 0.077	1.063LeuTrp: 1.063 ± 0.028	2.773LeuTyr: 2.773 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.698MetAla: 2.698 ± 0.048	0.22MetCys: 0.22 ± 0.013	1.251MetAsp: 1.251 ± 0.029	1.162MetGlu: 1.162 ± 0.034	0.91MetPhe: 0.91 ± 0.028	1.859MetGly: 1.859 ± 0.037	0.499MetHis: 0.499 ± 0.018	1.416MetIle: 1.416 ± 0.033	1.469MetLys: 1.469 ± 0.032	3.065MetLeu: 3.065 ± 0.053	0.854MetMet: 0.854 ± 0.026	1.053MetAsn: 1.053 ± 0.025	1.263MetPro: 1.263 ± 0.031	1.304MetGln: 1.304 ± 0.034	1.134MetArg: 1.134 ± 0.029	2.053MetSer: 2.053 ± 0.041	1.664MetThr: 1.664 ± 0.04	1.822MetVal: 1.822 ± 0.039	0.244MetTrp: 0.244 ± 0.016	0.53MetTyr: 0.53 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.612AsnAla: 3.612 ± 0.063	0.486AsnCys: 0.486 ± 0.021	2.467AsnAsp: 2.467 ± 0.057	2.352AsnGlu: 2.352 ± 0.035	1.531AsnPhe: 1.531 ± 0.038	3.006AsnGly: 3.006 ± 0.055	0.947AsnHis: 0.947 ± 0.026	2.865AsnIle: 2.865 ± 0.053	2.278AsnLys: 2.278 ± 0.044	4.037AsnLeu: 4.037 ± 0.055	1.03AsnMet: 1.03 ± 0.027	1.99AsnAsn: 1.99 ± 0.042	2.0AsnPro: 2.0 ± 0.042	2.212AsnGln: 2.212 ± 0.04	2.046AsnArg: 2.046 ± 0.046	2.881AsnSer: 2.881 ± 0.051	2.312AsnThr: 2.312 ± 0.043	2.501AsnVal: 2.501 ± 0.049	0.611AsnTrp: 0.611 ± 0.02	1.417AsnTyr: 1.417 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.164ProAla: 3.164 ± 0.053	0.315ProCys: 0.315 ± 0.017	2.176ProAsp: 2.176 ± 0.044	3.069ProGlu: 3.069 ± 0.047	1.667ProPhe: 1.667 ± 0.032	2.219ProGly: 2.219 ± 0.041	0.798ProHis: 0.798 ± 0.022	2.541ProIle: 2.541 ± 0.044	2.166ProLys: 2.166 ± 0.043	4.131ProLeu: 4.131 ± 0.058	1.073ProMet: 1.073 ± 0.03	1.648ProAsn: 1.648 ± 0.036	1.0ProPro: 1.0 ± 0.026	1.722ProGln: 1.722 ± 0.04	1.285ProArg: 1.285 ± 0.033	2.593ProSer: 2.593 ± 0.044	2.035ProThr: 2.035 ± 0.04	2.993ProVal: 2.993 ± 0.057	0.521ProTrp: 0.521 ± 0.02	1.172ProTyr: 1.172 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.85GlnAla: 4.85 ± 0.072	0.411GlnCys: 0.411 ± 0.019	2.128GlnAsp: 2.128 ± 0.04	2.28GlnGlu: 2.28 ± 0.045	1.81GlnPhe: 1.81 ± 0.036	3.187GlnGly: 3.187 ± 0.05	1.151GlnHis: 1.151 ± 0.029	2.663GlnIle: 2.663 ± 0.048	1.978GlnLys: 1.978 ± 0.044	5.802GlnLeu: 5.802 ± 0.081	1.182GlnMet: 1.182 ± 0.029	1.581GlnAsn: 1.581 ± 0.033	1.652GlnPro: 1.652 ± 0.037	3.223GlnGln: 3.223 ± 0.065	2.135GlnArg: 2.135 ± 0.039	2.967GlnSer: 2.967 ± 0.048	2.455GlnThr: 2.455 ± 0.047	3.334GlnVal: 3.334 ± 0.055	0.628GlnTrp: 0.628 ± 0.022	1.483GlnTyr: 1.483 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.382ArgAla: 3.382 ± 0.053	0.464ArgCys: 0.464 ± 0.018	2.33ArgAsp: 2.33 ± 0.046	2.655ArgGlu: 2.655 ± 0.046	2.084ArgPhe: 2.084 ± 0.037	2.486ArgGly: 2.486 ± 0.041	1.018ArgHis: 1.018 ± 0.027	2.796ArgIle: 2.796 ± 0.053	2.134ArgLys: 2.134 ± 0.043	4.796ArgLeu: 4.796 ± 0.073	1.07ArgMet: 1.07 ± 0.028	1.724ArgAsn: 1.724 ± 0.034	1.494ArgPro: 1.494 ± 0.031	2.05ArgGln: 2.05 ± 0.042	2.094ArgArg: 2.094 ± 0.041	2.592ArgSer: 2.592 ± 0.045	1.931ArgThr: 1.931 ± 0.035	3.142ArgVal: 3.142 ± 0.046	0.589ArgTrp: 0.589 ± 0.019	1.655ArgTyr: 1.655 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.971SerAla: 5.971 ± 0.079	0.772SerCys: 0.772 ± 0.028	3.955SerAsp: 3.955 ± 0.064	4.106SerGlu: 4.106 ± 0.058	3.071SerPhe: 3.071 ± 0.052	5.088SerGly: 5.088 ± 0.069	1.621SerHis: 1.621 ± 0.037	4.392SerIle: 4.392 ± 0.066	3.318SerLys: 3.318 ± 0.051	7.592SerLeu: 7.592 ± 0.084	1.809SerMet: 1.809 ± 0.034	2.769SerAsn: 2.769 ± 0.046	2.606SerPro: 2.606 ± 0.044	3.44SerGln: 3.44 ± 0.055	2.963SerArg: 2.963 ± 0.051	4.856SerSer: 4.856 ± 0.077	3.308SerThr: 3.308 ± 0.052	4.687SerVal: 4.687 ± 0.079	0.915SerTrp: 0.915 ± 0.027	2.214SerTyr: 2.214 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.867ThrAla: 4.867 ± 0.072	0.554ThrCys: 0.554 ± 0.025	3.015ThrAsp: 3.015 ± 0.074	3.251ThrGlu: 3.251 ± 0.053	1.977ThrPhe: 1.977 ± 0.04	4.018ThrGly: 4.018 ± 0.058	1.084ThrHis: 1.084 ± 0.029	3.232ThrIle: 3.232 ± 0.08	2.251ThrLys: 2.251 ± 0.038	6.079ThrLeu: 6.079 ± 0.083	1.167ThrMet: 1.167 ± 0.03	2.061ThrAsn: 2.061 ± 0.04	2.687ThrPro: 2.687 ± 0.05	2.691ThrGln: 2.691 ± 0.046	2.146ThrArg: 2.146 ± 0.041	3.587ThrSer: 3.587 ± 0.069	2.755ThrThr: 2.755 ± 0.057	3.663ThrVal: 3.663 ± 0.072	0.569ThrTrp: 0.569 ± 0.02	1.436ThrTyr: 1.436 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.3ValAla: 6.3 ± 0.073	0.761ValCys: 0.761 ± 0.023	4.189ValAsp: 4.189 ± 0.061	4.58ValGlu: 4.58 ± 0.079	2.606ValPhe: 2.606 ± 0.039	4.482ValGly: 4.482 ± 0.07	1.163ValHis: 1.163 ± 0.026	4.851ValIle: 4.851 ± 0.056	3.629ValLys: 3.629 ± 0.059	6.55ValLeu: 6.55 ± 0.077	1.99ValMet: 1.99 ± 0.044	3.178ValAsn: 3.178 ± 0.058	2.441ValPro: 2.441 ± 0.042	2.263ValGln: 2.263 ± 0.038	2.679ValArg: 2.679 ± 0.042	4.995ValSer: 4.995 ± 0.062	4.232ValThr: 4.232 ± 0.078	4.967ValVal: 4.967 ± 0.077	0.716ValTrp: 0.716 ± 0.023	1.844ValTyr: 1.844 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.857TrpAla: 0.857 ± 0.026	0.15TrpCys: 0.15 ± 0.01	0.609TrpAsp: 0.609 ± 0.024	0.482TrpGlu: 0.482 ± 0.019	0.54TrpPhe: 0.54 ± 0.021	0.767TrpGly: 0.767 ± 0.023	0.356TrpHis: 0.356 ± 0.015	0.642TrpIle: 0.642 ± 0.023	0.479TrpLys: 0.479 ± 0.017	1.662TrpLeu: 1.662 ± 0.037	0.327TrpMet: 0.327 ± 0.017	0.427TrpAsn: 0.427 ± 0.018	0.464TrpPro: 0.464 ± 0.019	0.964TrpGln: 0.964 ± 0.025	0.643TrpArg: 0.643 ± 0.02	0.774TrpSer: 0.774 ± 0.024	0.479TrpThr: 0.479 ± 0.019	0.808TrpVal: 0.808 ± 0.024	0.181TrpTrp: 0.181 ± 0.011	0.365TrpTyr: 0.365 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.404TyrAla: 2.404 ± 0.046	0.406TyrCys: 0.406 ± 0.017	1.681TyrAsp: 1.681 ± 0.04	1.446TyrGlu: 1.446 ± 0.039	1.437TyrPhe: 1.437 ± 0.036	2.242TyrGly: 2.242 ± 0.04	0.732TyrHis: 0.732 ± 0.027	1.681TyrIle: 1.681 ± 0.035	1.398TyrLys: 1.398 ± 0.034	3.43TyrLeu: 3.43 ± 0.049	0.653TyrMet: 0.653 ± 0.02	1.185TyrAsn: 1.185 ± 0.037	1.325TyrPro: 1.325 ± 0.032	1.954TyrGln: 1.954 ± 0.045	1.778TyrArg: 1.778 ± 0.037	2.097TyrSer: 2.097 ± 0.04	1.474TyrThr: 1.474 ± 0.036	1.656TyrVal: 1.656 ± 0.039	0.458TyrTrp: 0.458 ± 0.017	1.056TyrTyr: 1.056 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4181 proteins (1420895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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