Amino acid dipepetide frequency for Alfalfa leaf curl virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.805AlaAla: 0.805 ± 0.967
0.0AlaCys: 0.0 ± 0.0
6.441AlaAsp: 6.441 ± 2.463
1.61AlaGlu: 1.61 ± 0.97
0.805AlaPhe: 0.805 ± 0.92
1.61AlaGly: 1.61 ± 0.846
0.0AlaHis: 0.0 ± 0.0
0.0AlaIle: 0.0 ± 0.0
2.415AlaLys: 2.415 ± 1.52
2.415AlaLeu: 2.415 ± 0.874
0.0AlaMet: 0.0 ± 0.0
3.221AlaAsn: 3.221 ± 2.858
1.61AlaPro: 1.61 ± 0.97
5.636AlaGln: 5.636 ± 3.276
4.831AlaArg: 4.831 ± 1.785
7.246AlaSer: 7.246 ± 2.167
4.026AlaThr: 4.026 ± 1.013
0.805AlaVal: 0.805 ± 0.667
1.61AlaTrp: 1.61 ± 1.003
3.221AlaTyr: 3.221 ± 1.535
0.0AlaXaa: 0.0 ± 0.0
Cys
1.61CysAla: 1.61 ± 1.129
0.805CysCys: 0.805 ± 1.116
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.805CysPhe: 0.805 ± 1.116
0.805CysGly: 0.805 ± 0.598
0.0CysHis: 0.0 ± 0.0
1.61CysIle: 1.61 ± 0.907
0.805CysLys: 0.805 ± 0.598
2.415CysLeu: 2.415 ± 1.168
1.61CysMet: 1.61 ± 1.097
0.805CysAsn: 0.805 ± 0.598
1.61CysPro: 1.61 ± 0.761
0.0CysGln: 0.0 ± 0.0
3.221CysArg: 3.221 ± 1.522
0.805CysSer: 0.805 ± 0.92
1.61CysThr: 1.61 ± 0.97
0.805CysVal: 0.805 ± 0.876
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.026AspAla: 4.026 ± 1.804
0.805AspCys: 0.805 ± 0.714
2.415AspAsp: 2.415 ± 1.299
1.61AspGlu: 1.61 ± 0.761
2.415AspPhe: 2.415 ± 1.223
3.221AspGly: 3.221 ± 1.639
0.805AspHis: 0.805 ± 0.714
5.636AspIle: 5.636 ± 2.253
4.026AspLys: 4.026 ± 1.134
3.221AspLeu: 3.221 ± 1.915
1.61AspMet: 1.61 ± 0.803
2.415AspAsn: 2.415 ± 1.398
5.636AspPro: 5.636 ± 1.999
2.415AspGln: 2.415 ± 1.196
2.415AspArg: 2.415 ± 1.398
4.831AspSer: 4.831 ± 1.52
0.0AspThr: 0.0 ± 0.0
3.221AspVal: 3.221 ± 1.022
0.0AspTrp: 0.0 ± 0.0
4.831AspTyr: 4.831 ± 1.317
0.0AspXaa: 0.0 ± 0.0
Glu
2.415GluAla: 2.415 ± 2.759
0.0GluCys: 0.0 ± 0.0
3.221GluAsp: 3.221 ± 1.984
7.246GluGlu: 7.246 ± 2.446
2.415GluPhe: 2.415 ± 0.792
4.831GluGly: 4.831 ± 1.768
2.415GluHis: 2.415 ± 1.168
2.415GluIle: 2.415 ± 1.341
0.805GluLys: 0.805 ± 0.598
4.831GluLeu: 4.831 ± 2.426
0.805GluMet: 0.805 ± 0.896
4.026GluAsn: 4.026 ± 1.766
4.026GluPro: 4.026 ± 2.023
2.415GluGln: 2.415 ± 0.859
1.61GluArg: 1.61 ± 0.761
4.026GluSer: 4.026 ± 1.337
0.805GluThr: 0.805 ± 0.667
0.805GluVal: 0.805 ± 0.876
2.415GluTrp: 2.415 ± 1.196
2.415GluTyr: 2.415 ± 1.034
0.0GluXaa: 0.0 ± 0.0
Phe
0.805PheAla: 0.805 ± 0.667
1.61PheCys: 1.61 ± 0.944
1.61PheAsp: 1.61 ± 0.761
2.415PheGlu: 2.415 ± 0.792
1.61PhePhe: 1.61 ± 0.761
0.0PheGly: 0.0 ± 0.0
0.0PheHis: 0.0 ± 0.0
1.61PheIle: 1.61 ± 1.651
3.221PheLys: 3.221 ± 2.048
9.662PheLeu: 9.662 ± 1.385
0.805PheMet: 0.805 ± 0.967
2.415PheAsn: 2.415 ± 1.52
2.415PhePro: 2.415 ± 0.937
2.415PheGln: 2.415 ± 1.398
3.221PheArg: 3.221 ± 0.609
0.805PheSer: 0.805 ± 0.598
3.221PheThr: 3.221 ± 1.278
0.805PheVal: 0.805 ± 0.714
2.415PheTrp: 2.415 ± 1.877
0.805PheTyr: 0.805 ± 0.598
0.0PheXaa: 0.0 ± 0.0
Gly
1.61GlyAla: 1.61 ± 1.429
0.0GlyCys: 0.0 ± 0.0
0.0GlyAsp: 0.0 ± 0.0
2.415GlyGlu: 2.415 ± 0.859
1.61GlyPhe: 1.61 ± 0.97
4.026GlyGly: 4.026 ± 1.612
0.805GlyHis: 0.805 ± 0.714
3.221GlyIle: 3.221 ± 1.638
4.831GlyLys: 4.831 ± 1.783
6.441GlyLeu: 6.441 ± 2.631
0.805GlyMet: 0.805 ± 0.876
0.805GlyAsn: 0.805 ± 0.714
5.636GlyPro: 5.636 ± 2.165
1.61GlyGln: 1.61 ± 1.752
3.221GlyArg: 3.221 ± 1.471
7.246GlySer: 7.246 ± 2.346
1.61GlyThr: 1.61 ± 1.129
4.026GlyVal: 4.026 ± 1.449
0.805GlyTrp: 0.805 ± 0.714
1.61GlyTyr: 1.61 ± 1.073
0.0GlyXaa: 0.0 ± 0.0
His
0.805HisAla: 0.805 ± 0.598
2.415HisCys: 2.415 ± 0.792
1.61HisAsp: 1.61 ± 1.429
0.805HisGlu: 0.805 ± 0.92
2.415HisPhe: 2.415 ± 1.168
0.805HisGly: 0.805 ± 0.967
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
1.61HisLeu: 1.61 ± 0.761
0.805HisMet: 0.805 ± 0.63
1.61HisAsn: 1.61 ± 0.803
2.415HisPro: 2.415 ± 0.937
1.61HisGln: 1.61 ± 0.761
0.805HisArg: 0.805 ± 0.714
1.61HisSer: 1.61 ± 1.429
0.0HisThr: 0.0 ± 0.0
2.415HisVal: 2.415 ± 1.066
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.805IleAla: 0.805 ± 0.967
1.61IleCys: 1.61 ± 0.97
6.441IleAsp: 6.441 ± 2.556
1.61IleGlu: 1.61 ± 0.944
5.636IlePhe: 5.636 ± 1.86
2.415IleGly: 2.415 ± 1.52
1.61IleHis: 1.61 ± 0.803
1.61IleIle: 1.61 ± 0.803
5.636IleLys: 5.636 ± 2.082
6.441IleLeu: 6.441 ± 5.085
0.0IleMet: 0.0 ± 0.0
6.441IleAsn: 6.441 ± 2.259
6.441IlePro: 6.441 ± 2.388
0.0IleGln: 0.0 ± 0.0
3.221IleArg: 3.221 ± 1.941
4.831IleSer: 4.831 ± 1.39
2.415IleThr: 2.415 ± 1.965
2.415IleVal: 2.415 ± 1.059
2.415IleTrp: 2.415 ± 1.299
0.805IleTyr: 0.805 ± 1.116
0.0IleXaa: 0.0 ± 0.0
Lys
1.61LysAla: 1.61 ± 1.839
0.0LysCys: 0.0 ± 0.0
5.636LysAsp: 5.636 ± 1.487
1.61LysGlu: 1.61 ± 0.944
1.61LysPhe: 1.61 ± 0.803
2.415LysGly: 2.415 ± 0.792
0.0LysHis: 0.0 ± 0.0
4.831LysIle: 4.831 ± 1.643
6.441LysLys: 6.441 ± 2.259
1.61LysLeu: 1.61 ± 0.97
1.61LysMet: 1.61 ± 0.97
3.221LysAsn: 3.221 ± 1.302
0.805LysPro: 0.805 ± 0.598
2.415LysGln: 2.415 ± 0.859
1.61LysArg: 1.61 ± 1.141
6.441LysSer: 6.441 ± 1.94
4.026LysThr: 4.026 ± 2.312
1.61LysVal: 1.61 ± 1.633
0.805LysTrp: 0.805 ± 1.116
2.415LysTyr: 2.415 ± 1.066
0.0LysXaa: 0.0 ± 0.0
Leu
4.026LeuAla: 4.026 ± 2.136
2.415LeuCys: 2.415 ± 1.348
1.61LeuAsp: 1.61 ± 2.232
3.221LeuGlu: 3.221 ± 1.074
3.221LeuPhe: 3.221 ± 2.128
4.831LeuGly: 4.831 ± 1.187
2.415LeuHis: 2.415 ± 0.937
6.441LeuIle: 6.441 ± 2.285
2.415LeuLys: 2.415 ± 0.859
7.246LeuLeu: 7.246 ± 1.405
0.0LeuMet: 0.0 ± 0.0
4.831LeuAsn: 4.831 ± 2.681
1.61LeuPro: 1.61 ± 0.944
4.026LeuGln: 4.026 ± 1.188
6.441LeuArg: 6.441 ± 1.645
7.246LeuSer: 7.246 ± 1.405
6.441LeuThr: 6.441 ± 2.463
4.026LeuVal: 4.026 ± 1.131
1.61LeuTrp: 1.61 ± 1.129
3.221LeuTyr: 3.221 ± 1.149
0.0LeuXaa: 0.0 ± 0.0
Met
2.415MetAla: 2.415 ± 0.937
0.0MetCys: 0.0 ± 0.0
3.221MetAsp: 3.221 ± 0.609
2.415MetGlu: 2.415 ± 2.059
3.221MetPhe: 3.221 ± 0.609
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.805MetLys: 0.805 ± 0.714
0.805MetLeu: 0.805 ± 0.967
1.61MetMet: 1.61 ± 1.429
0.0MetAsn: 0.0 ± 0.0
1.61MetPro: 1.61 ± 0.761
1.61MetGln: 1.61 ± 1.073
0.805MetArg: 0.805 ± 0.876
1.61MetSer: 1.61 ± 1.174
0.805MetThr: 0.805 ± 0.714
2.415MetVal: 2.415 ± 1.435
0.0MetTrp: 0.0 ± 0.0
2.415MetTyr: 2.415 ± 0.874
0.0MetXaa: 0.0 ± 0.0
Asn
0.805AsnAla: 0.805 ± 0.714
0.0AsnCys: 0.0 ± 0.0
2.415AsnAsp: 2.415 ± 0.859
2.415AsnGlu: 2.415 ± 0.991
2.415AsnPhe: 2.415 ± 0.792
4.831AsnGly: 4.831 ± 1.475
1.61AsnHis: 1.61 ± 0.761
4.831AsnIle: 4.831 ± 2.206
0.805AsnLys: 0.805 ± 0.92
1.61AsnLeu: 1.61 ± 0.761
1.61AsnMet: 1.61 ± 1.369
2.415AsnAsn: 2.415 ± 1.784
3.221AsnPro: 3.221 ± 1.69
0.0AsnGln: 0.0 ± 0.0
1.61AsnArg: 1.61 ± 1.073
5.636AsnSer: 5.636 ± 4.287
4.026AsnThr: 4.026 ± 1.013
6.441AsnVal: 6.441 ± 1.701
1.61AsnTrp: 1.61 ± 0.761
0.805AsnTyr: 0.805 ± 0.598
0.0AsnXaa: 0.0 ± 0.0
Pro
1.61ProAla: 1.61 ± 0.97
0.805ProCys: 0.805 ± 0.598
3.221ProAsp: 3.221 ± 1.814
4.831ProGlu: 4.831 ± 1.938
1.61ProPhe: 1.61 ± 0.944
1.61ProGly: 1.61 ± 0.944
2.415ProHis: 2.415 ± 0.792
3.221ProIle: 3.221 ± 1.639
2.415ProLys: 2.415 ± 0.792
3.221ProLeu: 3.221 ± 1.194
2.415ProMet: 2.415 ± 0.922
4.831ProAsn: 4.831 ± 1.366
1.61ProPro: 1.61 ± 0.761
4.831ProGln: 4.831 ± 1.251
8.052ProArg: 8.052 ± 2.93
7.246ProSer: 7.246 ± 2.241
6.441ProThr: 6.441 ± 1.889
0.805ProVal: 0.805 ± 0.876
0.805ProTrp: 0.805 ± 0.92
1.61ProTyr: 1.61 ± 0.761
0.0ProXaa: 0.0 ± 0.0
Gln
1.61GlnAla: 1.61 ± 0.97
1.61GlnCys: 1.61 ± 0.761
0.805GlnAsp: 0.805 ± 0.667
0.805GlnGlu: 0.805 ± 0.876
2.415GlnPhe: 2.415 ± 0.874
2.415GlnGly: 2.415 ± 0.859
0.0GlnHis: 0.0 ± 0.0
5.636GlnIle: 5.636 ± 1.473
1.61GlnLys: 1.61 ± 0.803
6.441GlnLeu: 6.441 ± 1.969
4.831GlnMet: 4.831 ± 1.575
0.805GlnAsn: 0.805 ± 0.967
4.831GlnPro: 4.831 ± 1.874
0.805GlnGln: 0.805 ± 0.876
2.415GlnArg: 2.415 ± 1.277
3.221GlnSer: 3.221 ± 1.194
4.026GlnThr: 4.026 ± 2.704
1.61GlnVal: 1.61 ± 1.429
1.61GlnTrp: 1.61 ± 0.761
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.636ArgAla: 5.636 ± 1.073
1.61ArgCys: 1.61 ± 0.761
4.026ArgAsp: 4.026 ± 1.913
5.636ArgGlu: 5.636 ± 1.244
4.026ArgPhe: 4.026 ± 1.319
3.221ArgGly: 3.221 ± 1.852
2.415ArgHis: 2.415 ± 1.398
0.805ArgIle: 0.805 ± 0.876
2.415ArgLys: 2.415 ± 0.874
2.415ArgLeu: 2.415 ± 0.859
0.0ArgMet: 0.0 ± 0.0
4.831ArgAsn: 4.831 ± 0.864
3.221ArgPro: 3.221 ± 2.069
0.805ArgGln: 0.805 ± 0.92
7.246ArgArg: 7.246 ± 1.56
7.246ArgSer: 7.246 ± 2.301
6.441ArgThr: 6.441 ± 2.853
4.831ArgVal: 4.831 ± 1.364
2.415ArgTrp: 2.415 ± 0.792
0.805ArgTyr: 0.805 ± 0.714
0.0ArgXaa: 0.0 ± 0.0
Ser
1.61SerAla: 1.61 ± 1.429
0.805SerCys: 0.805 ± 0.876
2.415SerAsp: 2.415 ± 1.398
8.052SerGlu: 8.052 ± 3.977
1.61SerPhe: 1.61 ± 1.003
7.246SerGly: 7.246 ± 3.163
0.805SerHis: 0.805 ± 0.92
8.857SerIle: 8.857 ± 3.158
5.636SerLys: 5.636 ± 1.329
6.441SerLeu: 6.441 ± 1.573
0.805SerMet: 0.805 ± 0.813
2.415SerAsn: 2.415 ± 0.792
7.246SerPro: 7.246 ± 5.051
2.415SerGln: 2.415 ± 1.213
9.662SerArg: 9.662 ± 1.996
6.441SerSer: 6.441 ± 3.647
5.636SerThr: 5.636 ± 0.882
3.221SerVal: 3.221 ± 1.852
0.805SerTrp: 0.805 ± 0.714
3.221SerTyr: 3.221 ± 1.607
0.0SerXaa: 0.0 ± 0.0
Thr
3.221ThrAla: 3.221 ± 1.12
0.805ThrCys: 0.805 ± 1.116
4.026ThrAsp: 4.026 ± 0.885
4.831ThrGlu: 4.831 ± 1.995
0.0ThrPhe: 0.0 ± 0.0
3.221ThrGly: 3.221 ± 1.852
1.61ThrHis: 1.61 ± 0.761
4.831ThrIle: 4.831 ± 1.933
0.805ThrLys: 0.805 ± 0.714
2.415ThrLeu: 2.415 ± 1.398
1.61ThrMet: 1.61 ± 1.429
0.805ThrAsn: 0.805 ± 0.92
0.0ThrPro: 0.0 ± 0.0
6.441ThrGln: 6.441 ± 1.787
4.831ThrArg: 4.831 ± 2.755
4.831ThrSer: 4.831 ± 1.822
4.831ThrThr: 4.831 ± 1.089
4.026ThrVal: 4.026 ± 1.379
2.415ThrTrp: 2.415 ± 2.037
8.857ThrTyr: 8.857 ± 2.208
0.0ThrXaa: 0.0 ± 0.0
Val
4.026ValAla: 4.026 ± 1.131
2.415ValCys: 2.415 ± 1.196
2.415ValAsp: 2.415 ± 0.874
1.61ValGlu: 1.61 ± 1.752
2.415ValPhe: 2.415 ± 1.034
0.0ValGly: 0.0 ± 0.0
0.805ValHis: 0.805 ± 0.967
3.221ValIle: 3.221 ± 1.384
3.221ValLys: 3.221 ± 2.24
4.026ValLeu: 4.026 ± 2.043
0.805ValMet: 0.805 ± 0.656
0.805ValAsn: 0.805 ± 0.598
4.831ValPro: 4.831 ± 1.992
3.221ValGln: 3.221 ± 1.422
2.415ValArg: 2.415 ± 1.623
2.415ValSer: 2.415 ± 1.417
0.805ValThr: 0.805 ± 0.876
2.415ValVal: 2.415 ± 1.542
0.805ValTrp: 0.805 ± 0.92
4.026ValTyr: 4.026 ± 1.944
0.0ValXaa: 0.0 ± 0.0
Trp
4.026TrpAla: 4.026 ± 1.337
0.0TrpCys: 0.0 ± 0.0
2.415TrpAsp: 2.415 ± 1.196
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.805TrpGly: 0.805 ± 0.714
1.61TrpHis: 1.61 ± 1.429
2.415TrpIle: 2.415 ± 2.184
0.805TrpLys: 0.805 ± 1.116
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.805TrpAsn: 0.805 ± 0.967
3.221TrpPro: 3.221 ± 1.074
0.805TrpGln: 0.805 ± 0.967
0.805TrpArg: 0.805 ± 0.714
1.61TrpSer: 1.61 ± 0.907
3.221TrpThr: 3.221 ± 1.522
0.0TrpVal: 0.0 ± 0.0
0.805TrpTrp: 0.805 ± 0.967
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.831TyrAla: 4.831 ± 1.584
1.61TyrCys: 1.61 ± 1.651
1.61TyrAsp: 1.61 ± 1.429
0.805TyrGlu: 0.805 ± 0.598
1.61TyrPhe: 1.61 ± 0.803
4.026TyrGly: 4.026 ± 2.05
2.415TyrHis: 2.415 ± 1.168
1.61TyrIle: 1.61 ± 0.761
1.61TyrLys: 1.61 ± 0.944
4.026TyrLeu: 4.026 ± 1.761
3.221TyrMet: 3.221 ± 0.846
1.61TyrAsn: 1.61 ± 0.761
1.61TyrPro: 1.61 ± 0.761
4.026TyrGln: 4.026 ± 1.379
1.61TyrArg: 1.61 ± 0.907
0.0TyrSer: 0.0 ± 0.0
4.026TyrThr: 4.026 ± 1.254
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski