Amino acid dipepetide frequency for Geobacter pickeringii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.245AlaAla: 13.245 ± 0.184	1.287AlaCys: 1.287 ± 0.044	5.311AlaAsp: 5.311 ± 0.075	7.252AlaGlu: 7.252 ± 0.112	3.863AlaPhe: 3.863 ± 0.062	9.853AlaGly: 9.853 ± 0.121	1.672AlaHis: 1.672 ± 0.042	5.466AlaIle: 5.466 ± 0.076	4.017AlaLys: 4.017 ± 0.074	10.54AlaLeu: 10.54 ± 0.14	2.514AlaMet: 2.514 ± 0.058	2.5AlaAsn: 2.5 ± 0.066	4.388AlaPro: 4.388 ± 0.098	2.505AlaGln: 2.505 ± 0.051	6.789AlaArg: 6.789 ± 0.101	4.875AlaSer: 4.875 ± 0.075	5.502AlaThr: 5.502 ± 0.092	8.405AlaVal: 8.405 ± 0.109	0.962AlaTrp: 0.962 ± 0.036	2.268AlaTyr: 2.268 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.122CysAla: 1.122 ± 0.037	0.221CysCys: 0.221 ± 0.018	0.613CysAsp: 0.613 ± 0.028	0.551CysGlu: 0.551 ± 0.024	0.458CysPhe: 0.458 ± 0.02	1.357CysGly: 1.357 ± 0.052	0.85CysHis: 0.85 ± 0.097	0.602CysIle: 0.602 ± 0.029	0.332CysLys: 0.332 ± 0.019	1.007CysLeu: 1.007 ± 0.032	0.243CysMet: 0.243 ± 0.016	0.352CysAsn: 0.352 ± 0.02	0.661CysPro: 0.661 ± 0.035	0.302CysGln: 0.302 ± 0.019	0.903CysArg: 0.903 ± 0.029	0.767CysSer: 0.767 ± 0.035	0.641CysThr: 0.641 ± 0.03	0.765CysVal: 0.765 ± 0.029	0.107CysTrp: 0.107 ± 0.011	0.348CysTyr: 0.348 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.823AspAla: 4.823 ± 0.08	0.638AspCys: 0.638 ± 0.033	2.641AspAsp: 2.641 ± 0.052	3.867AspGlu: 3.867 ± 0.071	2.249AspPhe: 2.249 ± 0.047	4.355AspGly: 4.355 ± 0.08	1.011AspHis: 1.011 ± 0.034	3.108AspIle: 3.108 ± 0.064	1.931AspLys: 1.931 ± 0.051	5.438AspLeu: 5.438 ± 0.076	1.068AspMet: 1.068 ± 0.029	1.324AspAsn: 1.324 ± 0.04	2.805AspPro: 2.805 ± 0.06	1.298AspGln: 1.298 ± 0.032	3.741AspArg: 3.741 ± 0.077	2.261AspSer: 2.261 ± 0.053	2.433AspThr: 2.433 ± 0.053	3.603AspVal: 3.603 ± 0.06	0.515AspTrp: 0.515 ± 0.023	1.682AspTyr: 1.682 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.622GluAla: 6.622 ± 0.105	0.593GluCys: 0.593 ± 0.027	2.327GluAsp: 2.327 ± 0.058	5.536GluGlu: 5.536 ± 0.11	2.329GluPhe: 2.329 ± 0.051	5.289GluGly: 5.289 ± 0.083	1.213GluHis: 1.213 ± 0.036	4.399GluIle: 4.399 ± 0.085	4.04GluLys: 4.04 ± 0.092	7.227GluLeu: 7.227 ± 0.118	1.944GluMet: 1.944 ± 0.051	1.957GluAsn: 1.957 ± 0.039	2.488GluPro: 2.488 ± 0.051	2.295GluGln: 2.295 ± 0.061	5.72GluArg: 5.72 ± 0.098	3.008GluSer: 3.008 ± 0.06	3.516GluThr: 3.516 ± 0.071	4.981GluVal: 4.981 ± 0.083	0.62GluTrp: 0.62 ± 0.026	1.655GluTyr: 1.655 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.967PheAla: 3.967 ± 0.066	0.552PheCys: 0.552 ± 0.024	2.443PheAsp: 2.443 ± 0.05	2.091PheGlu: 2.091 ± 0.048	1.86PhePhe: 1.86 ± 0.053	3.553PheGly: 3.553 ± 0.064	0.824PheHis: 0.824 ± 0.029	2.132PheIle: 2.132 ± 0.055	1.343PheLys: 1.343 ± 0.033	4.131PheLeu: 4.131 ± 0.082	0.869PheMet: 0.869 ± 0.033	1.272PheAsn: 1.272 ± 0.04	1.898PhePro: 1.898 ± 0.05	1.022PheGln: 1.022 ± 0.027	2.756PheArg: 2.756 ± 0.059	2.558PheSer: 2.558 ± 0.058	2.406PheThr: 2.406 ± 0.052	2.932PheVal: 2.932 ± 0.055	0.453PheTrp: 0.453 ± 0.022	1.12PheTyr: 1.12 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.063GlyAla: 8.063 ± 0.114	1.318GlyCys: 1.318 ± 0.048	4.153GlyAsp: 4.153 ± 0.06	6.126GlyGlu: 6.126 ± 0.093	3.6GlyPhe: 3.6 ± 0.062	7.849GlyGly: 7.849 ± 0.122	1.669GlyHis: 1.669 ± 0.045	5.808GlyIle: 5.808 ± 0.079	4.565GlyLys: 4.565 ± 0.079	7.452GlyLeu: 7.452 ± 0.09	2.518GlyMet: 2.518 ± 0.054	2.6GlyAsn: 2.6 ± 0.058	2.392GlyPro: 2.392 ± 0.051	2.057GlyGln: 2.057 ± 0.052	5.705GlyArg: 5.705 ± 0.089	4.663GlySer: 4.663 ± 0.097	5.186GlyThr: 5.186 ± 0.108	6.816GlyVal: 6.816 ± 0.095	1.013GlyTrp: 1.013 ± 0.034	2.692GlyTyr: 2.692 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.733HisAla: 1.733 ± 0.042	0.321HisCys: 0.321 ± 0.019	1.179HisAsp: 1.179 ± 0.036	1.142HisGlu: 1.142 ± 0.037	0.885HisPhe: 0.885 ± 0.031	1.975HisGly: 1.975 ± 0.048	0.564HisHis: 0.564 ± 0.026	0.95HisIle: 0.95 ± 0.035	0.659HisLys: 0.659 ± 0.029	2.229HisLeu: 2.229 ± 0.051	0.389HisMet: 0.389 ± 0.019	0.628HisAsn: 0.628 ± 0.03	1.418HisPro: 1.418 ± 0.044	0.529HisGln: 0.529 ± 0.024	1.454HisArg: 1.454 ± 0.045	0.969HisSer: 0.969 ± 0.038	0.924HisThr: 0.924 ± 0.037	1.266HisVal: 1.266 ± 0.038	0.211HisTrp: 0.211 ± 0.014	0.598HisTyr: 0.598 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.931IleAla: 5.931 ± 0.082	0.669IleCys: 0.669 ± 0.028	3.428IleAsp: 3.428 ± 0.064	3.479IleGlu: 3.479 ± 0.074	2.262IlePhe: 2.262 ± 0.059	4.612IleGly: 4.612 ± 0.075	1.137IleHis: 1.137 ± 0.036	3.197IleIle: 3.197 ± 0.073	2.124IleLys: 2.124 ± 0.05	5.278IleLeu: 5.278 ± 0.088	1.215IleMet: 1.215 ± 0.041	1.743IleAsn: 1.743 ± 0.05	3.126IlePro: 3.126 ± 0.062	1.356IleGln: 1.356 ± 0.033	3.684IleArg: 3.684 ± 0.066	3.202IleSer: 3.202 ± 0.06	3.281IleThr: 3.281 ± 0.064	4.486IleVal: 4.486 ± 0.077	0.447IleTrp: 0.447 ± 0.019	1.423IleTyr: 1.423 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.126LysAla: 4.126 ± 0.092	0.45LysCys: 0.45 ± 0.025	2.097LysAsp: 2.097 ± 0.046	3.714LysGlu: 3.714 ± 0.071	1.275LysPhe: 1.275 ± 0.038	4.132LysGly: 4.132 ± 0.071	0.762LysHis: 0.762 ± 0.024	2.72LysIle: 2.72 ± 0.06	3.124LysLys: 3.124 ± 0.078	3.929LysLeu: 3.929 ± 0.067	1.215LysMet: 1.215 ± 0.043	1.477LysAsn: 1.477 ± 0.041	2.021LysPro: 2.021 ± 0.054	1.243LysGln: 1.243 ± 0.037	2.898LysArg: 2.898 ± 0.061	2.318LysSer: 2.318 ± 0.053	2.159LysThr: 2.159 ± 0.055	3.426LysVal: 3.426 ± 0.069	0.368LysTrp: 0.368 ± 0.022	1.127LysTyr: 1.127 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.008LeuAla: 12.008 ± 0.134	1.208LeuCys: 1.208 ± 0.035	5.424LeuAsp: 5.424 ± 0.093	6.275LeuGlu: 6.275 ± 0.098	4.215LeuPhe: 4.215 ± 0.078	7.787LeuGly: 7.787 ± 0.111	1.939LeuHis: 1.939 ± 0.046	4.663LeuIle: 4.663 ± 0.077	4.874LeuLys: 4.874 ± 0.091	10.615LeuLeu: 10.615 ± 0.166	2.314LeuMet: 2.314 ± 0.047	2.915LeuAsn: 2.915 ± 0.055	5.19LeuPro: 5.19 ± 0.09	2.766LeuGln: 2.766 ± 0.055	6.894LeuArg: 6.894 ± 0.106	5.883LeuSer: 5.883 ± 0.086	5.407LeuThr: 5.407 ± 0.085	7.823LeuVal: 7.823 ± 0.106	0.875LeuTrp: 0.875 ± 0.034	2.462LeuTyr: 2.462 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.894MetAla: 2.894 ± 0.067	0.157MetCys: 0.157 ± 0.015	1.071MetAsp: 1.071 ± 0.032	1.746MetGlu: 1.746 ± 0.048	0.679MetPhe: 0.679 ± 0.03	2.001MetGly: 2.001 ± 0.043	0.404MetHis: 0.404 ± 0.021	1.238MetIle: 1.238 ± 0.038	1.607MetLys: 1.607 ± 0.049	2.165MetLeu: 2.165 ± 0.053	0.595MetMet: 0.595 ± 0.026	0.889MetAsn: 0.889 ± 0.032	1.154MetPro: 1.154 ± 0.035	0.684MetGln: 0.684 ± 0.03	1.427MetArg: 1.427 ± 0.045	1.236MetSer: 1.236 ± 0.041	1.521MetThr: 1.521 ± 0.041	1.957MetVal: 1.957 ± 0.048	0.135MetTrp: 0.135 ± 0.011	0.398MetTyr: 0.398 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.59AsnAla: 2.59 ± 0.064	0.428AsnCys: 0.428 ± 0.028	1.373AsnAsp: 1.373 ± 0.044	1.408AsnGlu: 1.408 ± 0.04	1.131AsnPhe: 1.131 ± 0.038	2.624AsnGly: 2.624 ± 0.071	0.593AsnHis: 0.593 ± 0.029	1.788AsnIle: 1.788 ± 0.041	1.02AsnLys: 1.02 ± 0.033	3.263AsnLeu: 3.263 ± 0.061	0.586AsnMet: 0.586 ± 0.027	0.903AsnAsn: 0.903 ± 0.037	2.08AsnPro: 2.08 ± 0.045	0.744AsnGln: 0.744 ± 0.031	2.208AsnArg: 2.208 ± 0.047	1.451AsnSer: 1.451 ± 0.053	1.419AsnThr: 1.419 ± 0.051	2.253AsnVal: 2.253 ± 0.06	0.327AsnTrp: 0.327 ± 0.019	0.861AsnTyr: 0.861 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.417ProAla: 5.417 ± 0.107	0.449ProCys: 0.449 ± 0.023	2.758ProAsp: 2.758 ± 0.055	3.676ProGlu: 3.676 ± 0.059	2.071ProPhe: 2.071 ± 0.046	3.868ProGly: 3.868 ± 0.063	1.05ProHis: 1.05 ± 0.034	1.835ProIle: 1.835 ± 0.044	1.772ProLys: 1.772 ± 0.046	5.087ProLeu: 5.087 ± 0.074	0.983ProMet: 0.983 ± 0.035	1.163ProAsn: 1.163 ± 0.035	2.529ProPro: 2.529 ± 0.069	1.339ProGln: 1.339 ± 0.041	2.669ProArg: 2.669 ± 0.056	2.337ProSer: 2.337 ± 0.054	2.365ProThr: 2.365 ± 0.056	4.174ProVal: 4.174 ± 0.073	0.54ProTrp: 0.54 ± 0.023	1.251ProTyr: 1.251 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.771GlnAla: 2.771 ± 0.06	0.296GlnCys: 0.296 ± 0.019	1.1GlnAsp: 1.1 ± 0.035	1.922GlnGlu: 1.922 ± 0.051	1.019GlnPhe: 1.019 ± 0.039	2.246GlnGly: 2.246 ± 0.054	0.487GlnHis: 0.487 ± 0.026	1.681GlnIle: 1.681 ± 0.041	1.442GlnLys: 1.442 ± 0.037	2.636GlnLeu: 2.636 ± 0.061	0.768GlnMet: 0.768 ± 0.03	0.832GlnAsn: 0.832 ± 0.029	1.134GlnPro: 1.134 ± 0.04	0.975GlnGln: 0.975 ± 0.033	1.956GlnArg: 1.956 ± 0.047	1.398GlnSer: 1.398 ± 0.042	1.433GlnThr: 1.433 ± 0.04	2.205GlnVal: 2.205 ± 0.053	0.299GlnTrp: 0.299 ± 0.022	0.698GlnTyr: 0.698 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.279ArgAla: 5.279 ± 0.082	0.786ArgCys: 0.786 ± 0.029	3.508ArgAsp: 3.508 ± 0.061	6.173ArgGlu: 6.173 ± 0.111	3.111ArgPhe: 3.111 ± 0.062	5.235ArgGly: 5.235 ± 0.098	1.595ArgHis: 1.595 ± 0.043	4.306ArgIle: 4.306 ± 0.071	3.089ArgLys: 3.089 ± 0.062	7.59ArgLeu: 7.59 ± 0.125	1.849ArgMet: 1.849 ± 0.045	1.95ArgAsn: 1.95 ± 0.051	2.724ArgPro: 2.724 ± 0.056	2.436ArgGln: 2.436 ± 0.059	5.2ArgArg: 5.2 ± 0.1	3.397ArgSer: 3.397 ± 0.063	3.3ArgThr: 3.3 ± 0.058	4.713ArgVal: 4.713 ± 0.082	0.766ArgTrp: 0.766 ± 0.034	2.012ArgTyr: 2.012 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.993SerAla: 4.993 ± 0.077	0.804SerCys: 0.804 ± 0.042	2.59SerAsp: 2.59 ± 0.06	2.63SerGlu: 2.63 ± 0.056	2.575SerPhe: 2.575 ± 0.047	5.086SerGly: 5.086 ± 0.085	1.124SerHis: 1.124 ± 0.039	2.829SerIle: 2.829 ± 0.058	1.69SerLys: 1.69 ± 0.045	5.944SerLeu: 5.944 ± 0.083	1.133SerMet: 1.133 ± 0.035	1.324SerAsn: 1.324 ± 0.049	2.746SerPro: 2.746 ± 0.053	1.41SerGln: 1.41 ± 0.041	3.7SerArg: 3.7 ± 0.062	3.073SerSer: 3.073 ± 0.067	2.685SerThr: 2.685 ± 0.07	3.927SerVal: 3.927 ± 0.062	0.619SerTrp: 0.619 ± 0.026	1.584SerTyr: 1.584 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.702ThrAla: 5.702 ± 0.104	0.622ThrCys: 0.622 ± 0.037	2.685ThrAsp: 2.685 ± 0.062	2.845ThrGlu: 2.845 ± 0.06	2.267ThrPhe: 2.267 ± 0.051	5.277ThrGly: 5.277 ± 0.095	0.977ThrHis: 0.977 ± 0.032	3.329ThrIle: 3.329 ± 0.064	1.862ThrLys: 1.862 ± 0.055	5.736ThrLeu: 5.736 ± 0.087	1.189ThrMet: 1.189 ± 0.037	1.461ThrAsn: 1.461 ± 0.058	3.142ThrPro: 3.142 ± 0.071	1.094ThrGln: 1.094 ± 0.037	2.996ThrArg: 2.996 ± 0.061	2.695ThrSer: 2.695 ± 0.072	3.074ThrThr: 3.074 ± 0.09	5.214ThrVal: 5.214 ± 0.081	0.57ThrTrp: 0.57 ± 0.027	1.321ThrTyr: 1.321 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.875ValAla: 8.875 ± 0.115	0.948ValCys: 0.948 ± 0.032	4.062ValAsp: 4.062 ± 0.07	5.237ValGlu: 5.237 ± 0.079	2.711ValPhe: 2.711 ± 0.054	5.833ValGly: 5.833 ± 0.079	1.294ValHis: 1.294 ± 0.039	4.471ValIle: 4.471 ± 0.079	3.749ValLys: 3.749 ± 0.076	6.986ValLeu: 6.986 ± 0.099	1.902ValMet: 1.902 ± 0.044	2.529ValAsn: 2.529 ± 0.062	3.687ValPro: 3.687 ± 0.068	1.924ValGln: 1.924 ± 0.044	5.194ValArg: 5.194 ± 0.067	4.446ValSer: 4.446 ± 0.073	5.044ValThr: 5.044 ± 0.085	6.586ValVal: 6.586 ± 0.101	0.651ValTrp: 0.651 ± 0.027	1.755ValTyr: 1.755 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.712TrpAla: 0.712 ± 0.029	0.105TrpCys: 0.105 ± 0.013	0.508TrpAsp: 0.508 ± 0.027	0.681TrpGlu: 0.681 ± 0.025	0.447TrpPhe: 0.447 ± 0.022	0.904TrpGly: 0.904 ± 0.034	0.246TrpHis: 0.246 ± 0.015	0.464TrpIle: 0.464 ± 0.023	0.461TrpLys: 0.461 ± 0.026	1.126TrpLeu: 1.126 ± 0.036	0.237TrpMet: 0.237 ± 0.015	0.36TrpAsn: 0.36 ± 0.022	0.395TrpPro: 0.395 ± 0.02	0.428TrpGln: 0.428 ± 0.023	0.771TrpArg: 0.771 ± 0.034	0.58TrpSer: 0.58 ± 0.028	0.428TrpThr: 0.428 ± 0.023	0.601TrpVal: 0.601 ± 0.028	0.151TrpTrp: 0.151 ± 0.013	0.3TrpTyr: 0.3 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.339TyrAla: 2.339 ± 0.056	0.352TyrCys: 0.352 ± 0.022	1.521TyrAsp: 1.521 ± 0.039	1.409TyrGlu: 1.409 ± 0.041	1.175TyrPhe: 1.175 ± 0.035	2.409TyrGly: 2.409 ± 0.057	0.612TyrHis: 0.612 ± 0.023	1.095TyrIle: 1.095 ± 0.033	0.882TyrLys: 0.882 ± 0.032	3.16TyrLeu: 3.16 ± 0.067	0.424TyrMet: 0.424 ± 0.023	0.869TyrAsn: 0.869 ± 0.034	1.353TyrPro: 1.353 ± 0.04	0.894TyrGln: 0.894 ± 0.03	2.352TyrArg: 2.352 ± 0.054	1.35TyrSer: 1.35 ± 0.045	1.333TyrThr: 1.333 ± 0.04	1.749TyrVal: 1.749 ± 0.048	0.277TyrTrp: 0.277 ± 0.017	0.866TyrTyr: 0.866 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2968 proteins (969683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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