Amino acid dipepetide frequency for Rhodoferax koreense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.788AlaAla: 18.788 ± 0.174	1.295AlaCys: 1.295 ± 0.031	6.701AlaAsp: 6.701 ± 0.064	7.106AlaGlu: 7.106 ± 0.079	4.216AlaPhe: 4.216 ± 0.049	11.188AlaGly: 11.188 ± 0.111	2.657AlaHis: 2.657 ± 0.047	5.391AlaIle: 5.391 ± 0.068	4.167AlaLys: 4.167 ± 0.065	15.096AlaLeu: 15.096 ± 0.15	3.755AlaMet: 3.755 ± 0.053	3.15AlaAsn: 3.15 ± 0.067	6.381AlaPro: 6.381 ± 0.081	6.033AlaGln: 6.033 ± 0.087	8.849AlaArg: 8.849 ± 0.098	7.336AlaSer: 7.336 ± 0.08	6.628AlaThr: 6.628 ± 0.081	9.556AlaVal: 9.556 ± 0.085	1.952AlaTrp: 1.952 ± 0.041	2.565AlaTyr: 2.565 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.027	0.097CysCys: 0.097 ± 0.007	0.515CysAsp: 0.515 ± 0.016	0.495CysGlu: 0.495 ± 0.016	0.311CysPhe: 0.311 ± 0.014	0.917CysGly: 0.917 ± 0.025	0.242CysHis: 0.242 ± 0.01	0.395CysIle: 0.395 ± 0.018	0.203CysLys: 0.203 ± 0.009	0.818CysLeu: 0.818 ± 0.021	0.19CysMet: 0.19 ± 0.011	0.218CysAsn: 0.218 ± 0.011	0.433CysPro: 0.433 ± 0.019	0.253CysGln: 0.253 ± 0.013	0.54CysArg: 0.54 ± 0.015	0.452CysSer: 0.452 ± 0.018	0.508CysThr: 0.508 ± 0.023	0.679CysVal: 0.679 ± 0.023	0.12CysTrp: 0.12 ± 0.009	0.185CysTyr: 0.185 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.301AspAla: 7.301 ± 0.076	0.409AspCys: 0.409 ± 0.018	2.574AspAsp: 2.574 ± 0.041	2.819AspGlu: 2.819 ± 0.048	2.09AspPhe: 2.09 ± 0.034	4.665AspGly: 4.665 ± 0.063	1.139AspHis: 1.139 ± 0.024	2.464AspIle: 2.464 ± 0.043	1.627AspLys: 1.627 ± 0.036	5.275AspLeu: 5.275 ± 0.046	1.242AspMet: 1.242 ± 0.022	1.245AspAsn: 1.245 ± 0.032	2.781AspPro: 2.781 ± 0.043	1.673AspGln: 1.673 ± 0.028	3.193AspArg: 3.193 ± 0.045	2.161AspSer: 2.161 ± 0.033	2.624AspThr: 2.624 ± 0.044	4.013AspVal: 4.013 ± 0.045	0.887AspTrp: 0.887 ± 0.023	1.343AspTyr: 1.343 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.974GluAla: 6.974 ± 0.09	0.348GluCys: 0.348 ± 0.015	2.197GluAsp: 2.197 ± 0.034	2.457GluGlu: 2.457 ± 0.049	1.748GluPhe: 1.748 ± 0.033	3.526GluGly: 3.526 ± 0.047	1.206GluHis: 1.206 ± 0.028	2.673GluIle: 2.673 ± 0.044	1.898GluLys: 1.898 ± 0.038	5.475GluLeu: 5.475 ± 0.069	1.295GluMet: 1.295 ± 0.03	1.29GluAsn: 1.29 ± 0.03	2.492GluPro: 2.492 ± 0.048	2.239GluGln: 2.239 ± 0.038	4.144GluArg: 4.144 ± 0.051	2.427GluSer: 2.427 ± 0.041	2.543GluThr: 2.543 ± 0.042	4.045GluVal: 4.045 ± 0.061	0.621GluTrp: 0.621 ± 0.019	0.934GluTyr: 0.934 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.357PheAla: 4.357 ± 0.055	0.388PheCys: 0.388 ± 0.016	2.598PheAsp: 2.598 ± 0.04	2.118PheGlu: 2.118 ± 0.035	1.384PhePhe: 1.384 ± 0.036	3.43PheGly: 3.43 ± 0.05	0.701PheHis: 0.701 ± 0.02	1.486PheIle: 1.486 ± 0.033	1.237PheLys: 1.237 ± 0.03	2.947PheLeu: 2.947 ± 0.047	0.847PheMet: 0.847 ± 0.024	1.15PheAsn: 1.15 ± 0.029	1.557PhePro: 1.557 ± 0.032	1.14PheGln: 1.14 ± 0.025	1.836PheArg: 1.836 ± 0.037	2.169PheSer: 2.169 ± 0.038	1.999PheThr: 1.999 ± 0.045	2.865PheVal: 2.865 ± 0.048	0.528PheTrp: 0.528 ± 0.017	0.842PheTyr: 0.842 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.47GlyAla: 9.47 ± 0.099	0.898GlyCys: 0.898 ± 0.023	3.848GlyAsp: 3.848 ± 0.05	4.242GlyGlu: 4.242 ± 0.049	3.437GlyPhe: 3.437 ± 0.049	7.148GlyGly: 7.148 ± 0.101	1.911GlyHis: 1.911 ± 0.038	4.116GlyIle: 4.116 ± 0.049	3.131GlyLys: 3.131 ± 0.058	9.245GlyLeu: 9.245 ± 0.088	2.342GlyMet: 2.342 ± 0.042	2.231GlyAsn: 2.231 ± 0.07	3.227GlyPro: 3.227 ± 0.042	3.564GlyGln: 3.564 ± 0.05	5.573GlyArg: 5.573 ± 0.059	4.609GlySer: 4.609 ± 0.065	4.589GlyThr: 4.589 ± 0.077	6.679GlyVal: 6.679 ± 0.074	1.444GlyTrp: 1.444 ± 0.031	2.269GlyTyr: 2.269 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.863HisAla: 2.863 ± 0.048	0.256HisCys: 0.256 ± 0.013	1.107HisAsp: 1.107 ± 0.028	1.02HisGlu: 1.02 ± 0.025	0.85HisPhe: 0.85 ± 0.023	2.066HisGly: 2.066 ± 0.038	0.6HisHis: 0.6 ± 0.022	0.949HisIle: 0.949 ± 0.024	0.56HisLys: 0.56 ± 0.019	2.243HisLeu: 2.243 ± 0.039	0.509HisMet: 0.509 ± 0.018	0.527HisAsn: 0.527 ± 0.019	1.385HisPro: 1.385 ± 0.034	0.729HisGln: 0.729 ± 0.02	1.466HisArg: 1.466 ± 0.034	0.941HisSer: 0.941 ± 0.024	1.083HisThr: 1.083 ± 0.025	1.607HisVal: 1.607 ± 0.033	0.39HisTrp: 0.39 ± 0.016	0.581HisTyr: 0.581 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.281IleAla: 6.281 ± 0.075	0.388IleCys: 0.388 ± 0.015	3.218IleAsp: 3.218 ± 0.042	2.983IleGlu: 2.983 ± 0.056	1.345IlePhe: 1.345 ± 0.031	4.371IleGly: 4.371 ± 0.057	0.833IleHis: 0.833 ± 0.023	1.464IleIle: 1.464 ± 0.028	1.46IleLys: 1.46 ± 0.033	3.243IleLeu: 3.243 ± 0.048	0.792IleMet: 0.792 ± 0.022	1.357IleAsn: 1.357 ± 0.027	2.03IlePro: 2.03 ± 0.036	1.315IleGln: 1.315 ± 0.026	2.505IleArg: 2.505 ± 0.037	2.33IleSer: 2.33 ± 0.042	2.513IleThr: 2.513 ± 0.053	3.556IleVal: 3.556 ± 0.05	0.485IleTrp: 0.485 ± 0.018	0.947IleTyr: 0.947 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.229LysAla: 4.229 ± 0.071	0.152LysCys: 0.152 ± 0.009	1.637LysAsp: 1.637 ± 0.036	1.5LysGlu: 1.5 ± 0.035	1.017LysPhe: 1.017 ± 0.028	2.405LysGly: 2.405 ± 0.044	0.635LysHis: 0.635 ± 0.018	1.534LysIle: 1.534 ± 0.034	1.47LysLys: 1.47 ± 0.042	3.615LysLeu: 3.615 ± 0.057	0.86LysMet: 0.86 ± 0.026	0.968LysAsn: 0.968 ± 0.026	2.142LysPro: 2.142 ± 0.042	1.177LysGln: 1.177 ± 0.026	2.056LysArg: 2.056 ± 0.034	1.801LysSer: 1.801 ± 0.034	2.063LysThr: 2.063 ± 0.044	2.452LysVal: 2.452 ± 0.05	0.366LysTrp: 0.366 ± 0.015	0.636LysTyr: 0.636 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.426LeuAla: 15.426 ± 0.12	1.026LeuCys: 1.026 ± 0.023	5.579LeuAsp: 5.579 ± 0.06	4.835LeuGlu: 4.835 ± 0.054	3.411LeuPhe: 3.411 ± 0.044	8.858LeuGly: 8.858 ± 0.082	2.234LeuHis: 2.234 ± 0.04	4.229LeuIle: 4.229 ± 0.053	3.66LeuLys: 3.66 ± 0.052	11.276LeuLeu: 11.276 ± 0.127	2.565LeuMet: 2.565 ± 0.045	2.826LeuAsn: 2.826 ± 0.04	6.107LeuPro: 6.107 ± 0.069	4.501LeuGln: 4.501 ± 0.062	7.553LeuArg: 7.553 ± 0.088	6.175LeuSer: 6.175 ± 0.069	5.428LeuThr: 5.428 ± 0.129	8.239LeuVal: 8.239 ± 0.09	1.305LeuTrp: 1.305 ± 0.031	1.942LeuTyr: 1.942 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.435MetAla: 3.435 ± 0.051	0.16MetCys: 0.16 ± 0.009	1.129MetAsp: 1.129 ± 0.027	1.033MetGlu: 1.033 ± 0.026	0.765MetPhe: 0.765 ± 0.021	1.869MetGly: 1.869 ± 0.035	0.564MetHis: 0.564 ± 0.017	0.912MetIle: 0.912 ± 0.024	1.05MetLys: 1.05 ± 0.029	2.751MetLeu: 2.751 ± 0.041	0.546MetMet: 0.546 ± 0.018	0.869MetAsn: 0.869 ± 0.024	1.583MetPro: 1.583 ± 0.029	1.148MetGln: 1.148 ± 0.023	1.731MetArg: 1.731 ± 0.031	1.495MetSer: 1.495 ± 0.031	1.544MetThr: 1.544 ± 0.026	1.901MetVal: 1.901 ± 0.032	0.224MetTrp: 0.224 ± 0.012	0.374MetTyr: 0.374 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.467AsnAla: 3.467 ± 0.054	0.248AsnCys: 0.248 ± 0.012	1.347AsnAsp: 1.347 ± 0.03	1.226AsnGlu: 1.226 ± 0.031	1.018AsnPhe: 1.018 ± 0.025	2.342AsnGly: 2.342 ± 0.058	0.536AsnHis: 0.536 ± 0.017	1.198AsnIle: 1.198 ± 0.025	0.818AsnLys: 0.818 ± 0.024	2.778AsnLeu: 2.778 ± 0.055	0.564AsnMet: 0.564 ± 0.017	0.79AsnAsn: 0.79 ± 0.032	1.807AsnPro: 1.807 ± 0.036	0.972AsnGln: 0.972 ± 0.02	1.639AsnArg: 1.639 ± 0.031	1.222AsnSer: 1.222 ± 0.032	1.622AsnThr: 1.622 ± 0.049	1.966AsnVal: 1.966 ± 0.041	0.405AsnTrp: 0.405 ± 0.015	0.692AsnTyr: 0.692 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.464ProAla: 7.464 ± 0.087	0.347ProCys: 0.347 ± 0.016	3.023ProAsp: 3.023 ± 0.04	3.122ProGlu: 3.122 ± 0.05	1.773ProPhe: 1.773 ± 0.033	4.781ProGly: 4.781 ± 0.056	1.086ProHis: 1.086 ± 0.024	1.917ProIle: 1.917 ± 0.034	1.563ProLys: 1.563 ± 0.034	5.218ProLeu: 5.218 ± 0.064	1.363ProMet: 1.363 ± 0.028	1.343ProAsn: 1.343 ± 0.031	2.735ProPro: 2.735 ± 0.054	2.044ProGln: 2.044 ± 0.034	2.987ProArg: 2.987 ± 0.048	2.84ProSer: 2.84 ± 0.047	2.729ProThr: 2.729 ± 0.051	4.364ProVal: 4.364 ± 0.048	0.804ProTrp: 0.804 ± 0.025	1.163ProTyr: 1.163 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	6.129GlnAla: 6.129 ± 0.079	0.266GlnCys: 0.266 ± 0.013	1.652GlnAsp: 1.652 ± 0.034	1.46GlnGlu: 1.46 ± 0.03	1.255GlnPhe: 1.255 ± 0.027	3.024GlnGly: 3.024 ± 0.037	0.927GlnHis: 0.927 ± 0.022	1.849GlnIle: 1.849 ± 0.04	1.22GlnLys: 1.22 ± 0.027	4.271GlnLeu: 4.271 ± 0.046	1.002GlnMet: 1.002 ± 0.027	0.947GlnAsn: 0.947 ± 0.023	2.334GlnPro: 2.334 ± 0.039	1.995GlnGln: 1.995 ± 0.047	3.372GlnArg: 3.372 ± 0.046	2.057GlnSer: 2.057 ± 0.038	2.064GlnThr: 2.064 ± 0.045	3.069GlnVal: 3.069 ± 0.078	0.619GlnTrp: 0.619 ± 0.019	0.74GlnTyr: 0.74 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.656ArgAla: 7.656 ± 0.085	0.561ArgCys: 0.561 ± 0.02	3.325ArgAsp: 3.325 ± 0.041	3.879ArgGlu: 3.879 ± 0.05	2.696ArgPhe: 2.696 ± 0.042	4.608ArgGly: 4.608 ± 0.055	1.837ArgHis: 1.837 ± 0.035	3.433ArgIle: 3.433 ± 0.044	2.044ArgLys: 2.044 ± 0.036	7.839ArgLeu: 7.839 ± 0.08	1.873ArgMet: 1.873 ± 0.033	1.75ArgAsn: 1.75 ± 0.031	3.146ArgPro: 3.146 ± 0.042	2.916ArgGln: 2.916 ± 0.049	4.906ArgArg: 4.906 ± 0.072	3.389ArgSer: 3.389 ± 0.047	3.194ArgThr: 3.194 ± 0.042	4.796ArgVal: 4.796 ± 0.052	1.151ArgTrp: 1.151 ± 0.027	1.683ArgTyr: 1.683 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.736SerAla: 6.736 ± 0.075	0.386SerCys: 0.386 ± 0.016	2.547SerAsp: 2.547 ± 0.042	2.376SerGlu: 2.376 ± 0.044	2.188SerPhe: 2.188 ± 0.038	5.169SerGly: 5.169 ± 0.071	1.126SerHis: 1.126 ± 0.025	2.413SerIle: 2.413 ± 0.039	1.589SerLys: 1.589 ± 0.034	5.91SerLeu: 5.91 ± 0.065	1.372SerMet: 1.372 ± 0.029	1.434SerAsn: 1.434 ± 0.039	2.933SerPro: 2.933 ± 0.042	1.893SerGln: 1.893 ± 0.034	3.403SerArg: 3.403 ± 0.046	3.036SerSer: 3.036 ± 0.05	3.012SerThr: 3.012 ± 0.057	4.058SerVal: 4.058 ± 0.051	0.695SerTrp: 0.695 ± 0.02	1.259SerTyr: 1.259 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.753ThrAla: 6.753 ± 0.133	0.376ThrCys: 0.376 ± 0.018	2.571ThrAsp: 2.571 ± 0.051	2.432ThrGlu: 2.432 ± 0.041	1.715ThrPhe: 1.715 ± 0.036	4.991ThrGly: 4.991 ± 0.087	1.113ThrHis: 1.113 ± 0.027	2.163ThrIle: 2.163 ± 0.051	1.383ThrLys: 1.383 ± 0.031	6.299ThrLeu: 6.299 ± 0.096	1.155ThrMet: 1.155 ± 0.029	1.315ThrAsn: 1.315 ± 0.038	3.632ThrPro: 3.632 ± 0.048	2.005ThrGln: 2.005 ± 0.037	3.197ThrArg: 3.197 ± 0.041	2.91ThrSer: 2.91 ± 0.056	3.141ThrThr: 3.141 ± 0.142	4.511ThrVal: 4.511 ± 0.098	0.658ThrTrp: 0.658 ± 0.023	1.107ThrTyr: 1.107 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.271ValAla: 10.271 ± 0.103	0.741ValCys: 0.741 ± 0.023	4.166ValAsp: 4.166 ± 0.058	3.916ValGlu: 3.916 ± 0.054	2.866ValPhe: 2.866 ± 0.044	5.685ValGly: 5.685 ± 0.068	1.605ValHis: 1.605 ± 0.033	3.395ValIle: 3.395 ± 0.049	2.484ValLys: 2.484 ± 0.044	8.436ValLeu: 8.436 ± 0.07	1.971ValMet: 1.971 ± 0.035	2.241ValAsn: 2.241 ± 0.058	4.168ValPro: 4.168 ± 0.043	3.052ValGln: 3.052 ± 0.044	4.956ValArg: 4.956 ± 0.058	4.245ValSer: 4.245 ± 0.069	4.128ValThr: 4.128 ± 0.07	6.623ValVal: 6.623 ± 0.07	1.001ValTrp: 1.001 ± 0.027	1.584ValTyr: 1.584 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.369TrpAla: 1.369 ± 0.033	0.167TrpCys: 0.167 ± 0.011	0.627TrpAsp: 0.627 ± 0.017	0.487TrpGlu: 0.487 ± 0.017	0.549TrpPhe: 0.549 ± 0.02	0.933TrpGly: 0.933 ± 0.026	0.371TrpHis: 0.371 ± 0.014	0.648TrpIle: 0.648 ± 0.017	0.446TrpLys: 0.446 ± 0.016	2.088TrpLeu: 2.088 ± 0.042	0.418TrpMet: 0.418 ± 0.017	0.415TrpAsn: 0.415 ± 0.015	0.719TrpPro: 0.719 ± 0.023	0.77TrpGln: 0.77 ± 0.021	1.188TrpArg: 1.188 ± 0.027	0.808TrpSer: 0.808 ± 0.022	0.76TrpThr: 0.76 ± 0.02	0.972TrpVal: 0.972 ± 0.027	0.288TrpTrp: 0.288 ± 0.014	0.289TrpTyr: 0.289 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.677TyrAla: 2.677 ± 0.041	0.227TyrCys: 0.227 ± 0.012	1.163TyrAsp: 1.163 ± 0.029	1.029TyrGlu: 1.029 ± 0.026	0.944TyrPhe: 0.944 ± 0.026	1.995TyrGly: 1.995 ± 0.041	0.407TyrHis: 0.407 ± 0.014	0.788TyrIle: 0.788 ± 0.023	0.706TyrLys: 0.706 ± 0.023	2.349TyrLeu: 2.349 ± 0.04	0.421TyrMet: 0.421 ± 0.018	0.593TyrAsn: 0.593 ± 0.023	1.074TyrPro: 1.074 ± 0.026	0.834TyrGln: 0.834 ± 0.026	1.588TyrArg: 1.588 ± 0.034	1.132TyrSer: 1.132 ± 0.025	1.255TyrThr: 1.255 ± 0.045	1.585TyrVal: 1.585 ± 0.032	0.368TyrTrp: 0.368 ± 0.015	0.529TyrTyr: 0.529 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5262 proteins (1754731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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