Amino acid dipepetide frequency for Cutaneotrichosporon oleaginosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.043AlaAla: 14.043 ± 0.111	1.214AlaCys: 1.214 ± 0.026	5.259AlaAsp: 5.259 ± 0.042	6.507AlaGlu: 6.507 ± 0.054	3.42AlaPhe: 3.42 ± 0.038	7.493AlaGly: 7.493 ± 0.059	2.569AlaHis: 2.569 ± 0.032	4.047AlaIle: 4.047 ± 0.036	4.311AlaLys: 4.311 ± 0.049	10.087AlaLeu: 10.087 ± 0.075	2.337AlaMet: 2.337 ± 0.028	2.827AlaAsn: 2.827 ± 0.032	7.944AlaPro: 7.944 ± 0.081	3.9AlaGln: 3.9 ± 0.043	7.405AlaArg: 7.405 ± 0.058	8.505AlaSer: 8.505 ± 0.064	5.942AlaThr: 5.942 ± 0.043	6.637AlaVal: 6.637 ± 0.045	1.511AlaTrp: 1.511 ± 0.023	2.403AlaTyr: 2.403 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.151CysAla: 1.151 ± 0.022	0.215CysCys: 0.215 ± 0.008	0.599CysAsp: 0.599 ± 0.013	0.557CysGlu: 0.557 ± 0.011	0.429CysPhe: 0.429 ± 0.011	0.997CysGly: 0.997 ± 0.027	0.282CysHis: 0.282 ± 0.009	0.565CysIle: 0.565 ± 0.013	0.407CysLys: 0.407 ± 0.013	1.075CysLeu: 1.075 ± 0.018	0.286CysMet: 0.286 ± 0.009	0.336CysAsn: 0.336 ± 0.012	0.701CysPro: 0.701 ± 0.017	0.334CysGln: 0.334 ± 0.01	0.767CysArg: 0.767 ± 0.018	0.773CysSer: 0.773 ± 0.016	0.668CysThr: 0.668 ± 0.017	0.849CysVal: 0.849 ± 0.019	0.187CysTrp: 0.187 ± 0.007	0.293CysTyr: 0.293 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.929AspAla: 5.929 ± 0.046	0.518AspCys: 0.518 ± 0.013	4.372AspAsp: 4.372 ± 0.056	4.797AspGlu: 4.797 ± 0.051	1.802AspPhe: 1.802 ± 0.025	4.256AspGly: 4.256 ± 0.035	1.106AspHis: 1.106 ± 0.02	2.429AspIle: 2.429 ± 0.029	2.296AspLys: 2.296 ± 0.03	4.766AspLeu: 4.766 ± 0.04	1.3AspMet: 1.3 ± 0.022	1.439AspAsn: 1.439 ± 0.02	3.378AspPro: 3.378 ± 0.04	1.424AspGln: 1.424 ± 0.02	3.091AspArg: 3.091 ± 0.042	3.429AspSer: 3.429 ± 0.039	2.671AspThr: 2.671 ± 0.027	3.982AspVal: 3.982 ± 0.039	0.843AspTrp: 0.843 ± 0.017	1.336AspTyr: 1.336 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.497GluAla: 6.497 ± 0.057	0.605GluCys: 0.605 ± 0.013	3.956GluAsp: 3.956 ± 0.043	5.289GluGlu: 5.289 ± 0.063	1.606GluPhe: 1.606 ± 0.023	4.32GluGly: 4.32 ± 0.042	1.434GluHis: 1.434 ± 0.02	2.411GluIle: 2.411 ± 0.028	2.834GluLys: 2.834 ± 0.041	5.117GluLeu: 5.117 ± 0.048	1.489GluMet: 1.489 ± 0.021	1.54GluAsn: 1.54 ± 0.022	3.029GluPro: 3.029 ± 0.039	2.056GluGln: 2.056 ± 0.027	4.86GluArg: 4.86 ± 0.043	3.458GluSer: 3.458 ± 0.035	2.989GluThr: 2.989 ± 0.032	3.826GluVal: 3.826 ± 0.035	0.985GluTrp: 0.985 ± 0.018	1.47GluTyr: 1.47 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.325PheAla: 3.325 ± 0.034	0.462PheCys: 0.462 ± 0.013	2.027PheAsp: 2.027 ± 0.024	1.854PheGlu: 1.854 ± 0.024	1.309PhePhe: 1.309 ± 0.024	2.795PheGly: 2.795 ± 0.043	0.779PheHis: 0.779 ± 0.017	1.413PheIle: 1.413 ± 0.026	1.246PheLys: 1.246 ± 0.02	2.901PheLeu: 2.901 ± 0.038	0.71PheMet: 0.71 ± 0.014	1.116PheAsn: 1.116 ± 0.018	1.845PhePro: 1.845 ± 0.026	1.0PheGln: 1.0 ± 0.018	1.817PheArg: 1.817 ± 0.024	2.388PheSer: 2.388 ± 0.029	1.859PheThr: 1.859 ± 0.026	2.352PheVal: 2.352 ± 0.027	0.527PheTrp: 0.527 ± 0.013	0.863PheTyr: 0.863 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	7.207GlyAla: 7.207 ± 0.059	0.862GlyCys: 0.862 ± 0.017	3.771GlyAsp: 3.771 ± 0.036	4.29GlyGlu: 4.29 ± 0.043	2.506GlyPhe: 2.506 ± 0.035	7.047GlyGly: 7.047 ± 0.084	1.8GlyHis: 1.8 ± 0.03	3.015GlyIle: 3.015 ± 0.033	3.386GlyLys: 3.386 ± 0.041	6.152GlyLeu: 6.152 ± 0.047	1.875GlyMet: 1.875 ± 0.025	2.025GlyAsn: 2.025 ± 0.029	3.947GlyPro: 3.947 ± 0.044	2.437GlyGln: 2.437 ± 0.031	5.025GlyArg: 5.025 ± 0.043	5.641GlySer: 5.641 ± 0.053	4.105GlyThr: 4.105 ± 0.037	5.114GlyVal: 5.114 ± 0.042	1.408GlyTrp: 1.408 ± 0.024	1.962GlyTyr: 1.962 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.509HisAla: 2.509 ± 0.029	0.309HisCys: 0.309 ± 0.009	1.283HisAsp: 1.283 ± 0.023	1.27HisGlu: 1.27 ± 0.02	0.814HisPhe: 0.814 ± 0.015	1.741HisGly: 1.741 ± 0.03	0.843HisHis: 0.843 ± 0.019	1.077HisIle: 1.077 ± 0.017	0.82HisLys: 0.82 ± 0.016	2.329HisLeu: 2.329 ± 0.026	0.516HisMet: 0.516 ± 0.013	0.697HisAsn: 0.697 ± 0.016	1.989HisPro: 1.989 ± 0.025	0.806HisGln: 0.806 ± 0.018	1.618HisArg: 1.618 ± 0.019	1.822HisSer: 1.822 ± 0.029	1.388HisThr: 1.388 ± 0.021	1.611HisVal: 1.611 ± 0.022	0.332HisTrp: 0.332 ± 0.009	0.604HisTyr: 0.604 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.302IleAla: 4.302 ± 0.04	0.547IleCys: 0.547 ± 0.013	2.447IleAsp: 2.447 ± 0.027	2.35IleGlu: 2.35 ± 0.027	1.418IlePhe: 1.418 ± 0.024	2.805IleGly: 2.805 ± 0.035	0.935IleHis: 0.935 ± 0.016	1.839IleIle: 1.839 ± 0.03	1.738IleLys: 1.738 ± 0.025	3.566IleLeu: 3.566 ± 0.036	0.899IleMet: 0.899 ± 0.019	1.313IleAsn: 1.313 ± 0.022	2.682IlePro: 2.682 ± 0.029	1.259IleGln: 1.259 ± 0.021	2.361IleArg: 2.361 ± 0.025	2.821IleSer: 2.821 ± 0.028	2.347IleThr: 2.347 ± 0.025	2.984IleVal: 2.984 ± 0.033	0.519IleTrp: 0.519 ± 0.015	0.973IleTyr: 0.973 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.488LysAla: 4.488 ± 0.049	0.424LysCys: 0.424 ± 0.021	2.281LysAsp: 2.281 ± 0.029	2.795LysGlu: 2.795 ± 0.036	1.098LysPhe: 1.098 ± 0.018	2.83LysGly: 2.83 ± 0.035	0.988LysHis: 0.988 ± 0.018	1.617LysIle: 1.617 ± 0.025	2.609LysLys: 2.609 ± 0.043	3.418LysLeu: 3.418 ± 0.039	0.888LysMet: 0.888 ± 0.017	1.134LysAsn: 1.134 ± 0.02	2.659LysPro: 2.659 ± 0.03	1.38LysGln: 1.38 ± 0.021	3.391LysArg: 3.391 ± 0.035	2.519LysSer: 2.519 ± 0.029	2.233LysThr: 2.233 ± 0.03	2.58LysVal: 2.58 ± 0.033	0.64LysTrp: 0.64 ± 0.013	1.031LysTyr: 1.031 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	9.983LeuAla: 9.983 ± 0.076	1.144LeuCys: 1.144 ± 0.017	5.108LeuAsp: 5.108 ± 0.043	5.116LeuGlu: 5.116 ± 0.044	3.044LeuPhe: 3.044 ± 0.033	6.373LeuGly: 6.373 ± 0.05	2.223LeuHis: 2.223 ± 0.026	3.337LeuIle: 3.337 ± 0.031	3.451LeuLys: 3.451 ± 0.038	8.389LeuLeu: 8.389 ± 0.074	1.771LeuMet: 1.771 ± 0.021	2.61LeuAsn: 2.61 ± 0.029	6.514LeuPro: 6.514 ± 0.056	3.138LeuGln: 3.138 ± 0.032	6.249LeuArg: 6.249 ± 0.049	6.956LeuSer: 6.956 ± 0.05	4.786LeuThr: 4.786 ± 0.042	5.819LeuVal: 5.819 ± 0.047	1.127LeuTrp: 1.127 ± 0.02	2.027LeuTyr: 2.027 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.339MetAla: 2.339 ± 0.024	0.271MetCys: 0.271 ± 0.008	1.225MetAsp: 1.225 ± 0.02	1.093MetGlu: 1.093 ± 0.017	0.732MetPhe: 0.732 ± 0.017	1.66MetGly: 1.66 ± 0.026	0.464MetHis: 0.464 ± 0.012	0.809MetIle: 0.809 ± 0.014	0.726MetLys: 0.726 ± 0.013	1.965MetLeu: 1.965 ± 0.025	0.55MetMet: 0.55 ± 0.014	0.632MetAsn: 0.632 ± 0.012	1.595MetPro: 1.595 ± 0.023	0.74MetGln: 0.74 ± 0.016	1.549MetArg: 1.549 ± 0.02	2.012MetSer: 2.012 ± 0.024	1.306MetThr: 1.306 ± 0.018	1.294MetVal: 1.294 ± 0.021	0.315MetTrp: 0.315 ± 0.008	0.533MetTyr: 0.533 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.05AsnAla: 3.05 ± 0.03	0.319AsnCys: 0.319 ± 0.012	1.497AsnAsp: 1.497 ± 0.019	1.523AsnGlu: 1.523 ± 0.02	0.976AsnPhe: 0.976 ± 0.018	2.477AsnGly: 2.477 ± 0.034	0.623AsnHis: 0.623 ± 0.015	1.359AsnIle: 1.359 ± 0.024	1.142AsnLys: 1.142 ± 0.018	2.575AsnLeu: 2.575 ± 0.03	0.677AsnMet: 0.677 ± 0.014	0.959AsnAsn: 0.959 ± 0.021	2.092AsnPro: 2.092 ± 0.027	0.895AsnGln: 0.895 ± 0.019	1.582AsnArg: 1.582 ± 0.023	1.925AsnSer: 1.925 ± 0.031	1.631AsnThr: 1.631 ± 0.023	2.026AsnVal: 2.026 ± 0.025	0.422AsnTrp: 0.422 ± 0.011	0.734AsnTyr: 0.734 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.987ProAla: 7.987 ± 0.081	0.585ProCys: 0.585 ± 0.017	3.366ProAsp: 3.366 ± 0.034	3.972ProGlu: 3.972 ± 0.04	2.037ProPhe: 2.037 ± 0.025	4.687ProGly: 4.687 ± 0.05	1.793ProHis: 1.793 ± 0.026	2.414ProIle: 2.414 ± 0.026	2.658ProLys: 2.658 ± 0.033	5.852ProLeu: 5.852 ± 0.051	1.234ProMet: 1.234 ± 0.02	1.961ProAsn: 1.961 ± 0.028	8.175ProPro: 8.175 ± 0.119	2.513ProGln: 2.513 ± 0.035	4.813ProArg: 4.813 ± 0.059	7.284ProSer: 7.284 ± 0.082	4.882ProThr: 4.882 ± 0.054	4.265ProVal: 4.265 ± 0.042	0.778ProTrp: 0.778 ± 0.016	1.465ProTyr: 1.465 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.72GlnAla: 3.72 ± 0.046	0.393GlnCys: 0.393 ± 0.012	1.426GlnAsp: 1.426 ± 0.02	1.69GlnGlu: 1.69 ± 0.026	1.036GlnPhe: 1.036 ± 0.019	2.122GlnGly: 2.122 ± 0.026	1.008GlnHis: 1.008 ± 0.02	1.371GlnIle: 1.371 ± 0.016	1.28GlnLys: 1.28 ± 0.021	3.207GlnLeu: 3.207 ± 0.034	0.834GlnMet: 0.834 ± 0.017	0.995GlnAsn: 0.995 ± 0.017	2.588GlnPro: 2.588 ± 0.038	2.213GlnGln: 2.213 ± 0.091	2.746GlnArg: 2.746 ± 0.03	2.366GlnSer: 2.366 ± 0.028	1.864GlnThr: 1.864 ± 0.025	1.994GlnVal: 1.994 ± 0.023	0.534GlnTrp: 0.534 ± 0.013	0.917GlnTyr: 0.917 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.52ArgAla: 7.52 ± 0.062	0.752ArgCys: 0.752 ± 0.016	3.778ArgAsp: 3.778 ± 0.042	4.272ArgGlu: 4.272 ± 0.05	2.047ArgPhe: 2.047 ± 0.027	4.781ArgGly: 4.781 ± 0.044	1.681ArgHis: 1.681 ± 0.021	2.675ArgIle: 2.675 ± 0.027	3.142ArgLys: 3.142 ± 0.038	6.078ArgLeu: 6.078 ± 0.047	1.464ArgMet: 1.464 ± 0.018	1.879ArgAsn: 1.879 ± 0.022	4.681ArgPro: 4.681 ± 0.053	2.444ArgGln: 2.444 ± 0.03	6.75ArgArg: 6.75 ± 0.074	5.034ArgSer: 5.034 ± 0.049	3.727ArgThr: 3.727 ± 0.032	4.351ArgVal: 4.351 ± 0.038	1.04ArgTrp: 1.04 ± 0.018	1.527ArgTyr: 1.527 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.981SerAla: 7.981 ± 0.06	0.765SerCys: 0.765 ± 0.018	3.855SerAsp: 3.855 ± 0.039	3.599SerGlu: 3.599 ± 0.034	2.514SerPhe: 2.514 ± 0.03	5.6SerGly: 5.6 ± 0.049	1.855SerHis: 1.855 ± 0.029	2.949SerIle: 2.949 ± 0.028	2.808SerLys: 2.808 ± 0.031	6.657SerLeu: 6.657 ± 0.048	1.603SerMet: 1.603 ± 0.024	2.171SerAsn: 2.171 ± 0.028	6.739SerPro: 6.739 ± 0.083	2.452SerGln: 2.452 ± 0.029	5.039SerArg: 5.039 ± 0.051	7.898SerSer: 7.898 ± 0.106	5.045SerThr: 5.045 ± 0.056	4.543SerVal: 4.543 ± 0.039	0.951SerTrp: 0.951 ± 0.019	1.673SerTyr: 1.673 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.784ThrAla: 5.784 ± 0.045	0.656ThrCys: 0.656 ± 0.017	2.618ThrAsp: 2.618 ± 0.028	2.692ThrGlu: 2.692 ± 0.027	2.034ThrPhe: 2.034 ± 0.022	4.068ThrGly: 4.068 ± 0.044	1.44ThrHis: 1.44 ± 0.021	2.395ThrIle: 2.395 ± 0.025	2.047ThrLys: 2.047 ± 0.024	5.39ThrLeu: 5.39 ± 0.036	1.095ThrMet: 1.095 ± 0.018	1.603ThrAsn: 1.603 ± 0.023	5.598ThrPro: 5.598 ± 0.056	1.78ThrGln: 1.78 ± 0.025	3.502ThrArg: 3.502 ± 0.036	4.817ThrSer: 4.817 ± 0.048	3.678ThrThr: 3.678 ± 0.042	3.601ThrVal: 3.601 ± 0.035	0.796ThrTrp: 0.796 ± 0.016	1.372ThrTyr: 1.372 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	6.663ValAla: 6.663 ± 0.042	0.868ValCys: 0.868 ± 0.016	3.852ValAsp: 3.852 ± 0.034	3.874ValGlu: 3.874 ± 0.041	2.33ValPhe: 2.33 ± 0.03	4.57ValGly: 4.57 ± 0.042	1.59ValHis: 1.59 ± 0.02	2.677ValIle: 2.677 ± 0.031	2.623ValLys: 2.623 ± 0.033	6.107ValLeu: 6.107 ± 0.047	1.397ValMet: 1.397 ± 0.019	1.901ValAsn: 1.901 ± 0.023	4.484ValPro: 4.484 ± 0.041	2.266ValGln: 2.266 ± 0.029	4.416ValArg: 4.416 ± 0.036	4.46ValSer: 4.46 ± 0.036	3.559ValThr: 3.559 ± 0.03	4.927ValVal: 4.927 ± 0.043	1.003ValTrp: 1.003 ± 0.019	1.669ValTyr: 1.669 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.433TrpAla: 1.433 ± 0.018	0.216TrpCys: 0.216 ± 0.008	0.918TrpAsp: 0.918 ± 0.02	0.88TrpGlu: 0.88 ± 0.015	0.51TrpPhe: 0.51 ± 0.013	1.054TrpGly: 1.054 ± 0.02	0.357TrpHis: 0.357 ± 0.011	0.612TrpIle: 0.612 ± 0.014	0.627TrpLys: 0.627 ± 0.012	1.294TrpLeu: 1.294 ± 0.019	0.369TrpMet: 0.369 ± 0.01	0.513TrpAsn: 0.513 ± 0.012	0.686TrpPro: 0.686 ± 0.016	0.49TrpGln: 0.49 ± 0.011	1.152TrpArg: 1.152 ± 0.019	1.022TrpSer: 1.022 ± 0.016	0.855TrpThr: 0.855 ± 0.018	0.931TrpVal: 0.931 ± 0.017	0.321TrpTrp: 0.321 ± 0.01	0.371TrpTyr: 0.371 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.449TyrAla: 2.449 ± 0.03	0.347TyrCys: 0.347 ± 0.011	1.526TyrAsp: 1.526 ± 0.021	1.352TyrGlu: 1.352 ± 0.02	0.927TyrPhe: 0.927 ± 0.017	1.899TyrGly: 1.899 ± 0.027	0.607TyrHis: 0.607 ± 0.015	1.092TyrIle: 1.092 ± 0.02	0.854TyrLys: 0.854 ± 0.014	2.24TyrLeu: 2.24 ± 0.029	0.514TyrMet: 0.514 ± 0.011	0.834TyrAsn: 0.834 ± 0.017	1.4TyrPro: 1.4 ± 0.022	0.78TyrGln: 0.78 ± 0.015	1.488TyrArg: 1.488 ± 0.022	1.567TyrSer: 1.567 ± 0.022	1.431TyrThr: 1.431 ± 0.022	1.548TyrVal: 1.548 ± 0.019	0.368TyrTrp: 0.368 ± 0.01	0.74TyrTyr: 0.74 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8317 proteins (3759876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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