Amino acid dipepetide frequency for Paludibacterium purpuratum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.304AlaAla: 14.304 ± 0.17	1.395AlaCys: 1.395 ± 0.036	6.457AlaAsp: 6.457 ± 0.084	6.81AlaGlu: 6.81 ± 0.1	3.863AlaPhe: 3.863 ± 0.065	9.574AlaGly: 9.574 ± 0.118	2.684AlaHis: 2.684 ± 0.058	5.484AlaIle: 5.484 ± 0.077	3.378AlaLys: 3.378 ± 0.071	14.277AlaLeu: 14.277 ± 0.167	3.406AlaMet: 3.406 ± 0.058	3.176AlaAsn: 3.176 ± 0.056	4.985AlaPro: 4.985 ± 0.086	5.221AlaGln: 5.221 ± 0.074	8.364AlaArg: 8.364 ± 0.097	6.339AlaSer: 6.339 ± 0.079	5.294AlaThr: 5.294 ± 0.083	7.741AlaVal: 7.741 ± 0.096	1.766AlaTrp: 1.766 ± 0.044	2.409AlaTyr: 2.409 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.191CysAla: 1.191 ± 0.029	0.166CysCys: 0.166 ± 0.014	0.653CysAsp: 0.653 ± 0.029	0.494CysGlu: 0.494 ± 0.021	0.349CysPhe: 0.349 ± 0.018	1.088CysGly: 1.088 ± 0.027	0.334CysHis: 0.334 ± 0.016	0.468CysIle: 0.468 ± 0.02	0.292CysLys: 0.292 ± 0.015	1.27CysLeu: 1.27 ± 0.036	0.236CysMet: 0.236 ± 0.014	0.283CysAsn: 0.283 ± 0.015	0.56CysPro: 0.56 ± 0.026	0.465CysGln: 0.465 ± 0.021	0.807CysArg: 0.807 ± 0.032	0.55CysSer: 0.55 ± 0.02	0.459CysThr: 0.459 ± 0.019	0.714CysVal: 0.714 ± 0.025	0.173CysTrp: 0.173 ± 0.012	0.327CysTyr: 0.327 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.242AspAla: 6.242 ± 0.084	0.568AspCys: 0.568 ± 0.022	3.151AspAsp: 3.151 ± 0.065	3.203AspGlu: 3.203 ± 0.059	2.201AspPhe: 2.201 ± 0.044	4.683AspGly: 4.683 ± 0.074	1.119AspHis: 1.119 ± 0.031	2.847AspIle: 2.847 ± 0.055	1.899AspLys: 1.899 ± 0.05	5.572AspLeu: 5.572 ± 0.076	1.417AspMet: 1.417 ± 0.034	1.588AspAsn: 1.588 ± 0.04	2.714AspPro: 2.714 ± 0.05	2.055AspGln: 2.055 ± 0.043	3.478AspArg: 3.478 ± 0.06	2.813AspSer: 2.813 ± 0.054	2.627AspThr: 2.627 ± 0.05	3.727AspVal: 3.727 ± 0.06	1.109AspTrp: 1.109 ± 0.028	1.636AspTyr: 1.636 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.106GluAla: 6.106 ± 0.09	0.495GluCys: 0.495 ± 0.02	2.161GluAsp: 2.161 ± 0.046	2.574GluGlu: 2.574 ± 0.058	1.607GluPhe: 1.607 ± 0.039	3.299GluGly: 3.299 ± 0.058	1.449GluHis: 1.449 ± 0.035	2.909GluIle: 2.909 ± 0.063	1.817GluLys: 1.817 ± 0.048	5.846GluLeu: 5.846 ± 0.087	1.402GluMet: 1.402 ± 0.033	1.513GluAsn: 1.513 ± 0.034	2.262GluPro: 2.262 ± 0.05	2.803GluGln: 2.803 ± 0.048	4.406GluArg: 4.406 ± 0.071	2.71GluSer: 2.71 ± 0.05	2.716GluThr: 2.716 ± 0.049	3.732GluVal: 3.732 ± 0.064	0.705GluTrp: 0.705 ± 0.025	1.124GluTyr: 1.124 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.209PheAla: 4.209 ± 0.063	0.481PheCys: 0.481 ± 0.02	2.628PheAsp: 2.628 ± 0.051	1.946PheGlu: 1.946 ± 0.042	1.401PhePhe: 1.401 ± 0.039	3.187PheGly: 3.187 ± 0.057	0.861PheHis: 0.861 ± 0.029	1.706PheIle: 1.706 ± 0.037	1.127PheLys: 1.127 ± 0.03	3.376PheLeu: 3.376 ± 0.057	0.829PheMet: 0.829 ± 0.028	1.283PheAsn: 1.283 ± 0.035	1.552PhePro: 1.552 ± 0.037	1.121PheGln: 1.121 ± 0.031	1.772PheArg: 1.772 ± 0.038	2.429PheSer: 2.429 ± 0.05	1.745PheThr: 1.745 ± 0.044	2.576PheVal: 2.576 ± 0.054	0.565PheTrp: 0.565 ± 0.025	1.022PheTyr: 1.022 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.727GlyAla: 7.727 ± 0.098	0.984GlyCys: 0.984 ± 0.03	3.905GlyAsp: 3.905 ± 0.064	4.415GlyGlu: 4.415 ± 0.066	3.231GlyPhe: 3.231 ± 0.052	6.244GlyGly: 6.244 ± 0.116	1.941GlyHis: 1.941 ± 0.043	4.297GlyIle: 4.297 ± 0.066	3.352GlyLys: 3.352 ± 0.066	8.67GlyLeu: 8.67 ± 0.094	2.398GlyMet: 2.398 ± 0.044	2.522GlyAsn: 2.522 ± 0.074	2.389GlyPro: 2.389 ± 0.052	3.561GlyGln: 3.561 ± 0.067	5.074GlyArg: 5.074 ± 0.069	4.447GlySer: 4.447 ± 0.091	3.866GlyThr: 3.866 ± 0.071	5.968GlyVal: 5.968 ± 0.088	1.326GlyTrp: 1.326 ± 0.038	2.378GlyTyr: 2.378 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.649HisAla: 2.649 ± 0.049	0.335HisCys: 0.335 ± 0.018	1.431HisAsp: 1.431 ± 0.035	1.152HisGlu: 1.152 ± 0.031	1.088HisPhe: 1.088 ± 0.032	2.304HisGly: 2.304 ± 0.05	0.675HisHis: 0.675 ± 0.026	1.126HisIle: 1.126 ± 0.032	0.633HisLys: 0.633 ± 0.025	2.538HisLeu: 2.538 ± 0.049	0.497HisMet: 0.497 ± 0.021	0.633HisAsn: 0.633 ± 0.022	1.582HisPro: 1.582 ± 0.038	0.98HisGln: 0.98 ± 0.031	1.506HisArg: 1.506 ± 0.04	1.201HisSer: 1.201 ± 0.031	1.096HisThr: 1.096 ± 0.031	1.514HisVal: 1.514 ± 0.041	0.455HisTrp: 0.455 ± 0.021	0.802HisTyr: 0.802 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.043IleAla: 6.043 ± 0.078	0.503IleCys: 0.503 ± 0.02	3.54IleAsp: 3.54 ± 0.056	3.236IleGlu: 3.236 ± 0.056	1.373IlePhe: 1.373 ± 0.036	4.71IleGly: 4.71 ± 0.069	1.053IleHis: 1.053 ± 0.031	1.812IleIle: 1.812 ± 0.044	1.757IleLys: 1.757 ± 0.043	4.411IleLeu: 4.411 ± 0.067	0.964IleMet: 0.964 ± 0.031	1.659IleAsn: 1.659 ± 0.036	2.051IlePro: 2.051 ± 0.043	1.659IleGln: 1.659 ± 0.036	3.053IleArg: 3.053 ± 0.056	2.8IleSer: 2.8 ± 0.05	2.321IleThr: 2.321 ± 0.053	3.67IleVal: 3.67 ± 0.062	0.544IleTrp: 0.544 ± 0.025	1.139IleTyr: 1.139 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.307LysAla: 3.307 ± 0.068	0.186LysCys: 0.186 ± 0.013	1.441LysAsp: 1.441 ± 0.039	1.46LysGlu: 1.46 ± 0.044	0.896LysPhe: 0.896 ± 0.03	2.149LysGly: 2.149 ± 0.056	0.76LysHis: 0.76 ± 0.025	1.69LysIle: 1.69 ± 0.038	1.419LysLys: 1.419 ± 0.048	3.72LysLeu: 3.72 ± 0.061	0.873LysMet: 0.873 ± 0.028	1.135LysAsn: 1.135 ± 0.039	1.832LysPro: 1.832 ± 0.04	1.575LysGln: 1.575 ± 0.038	2.132LysArg: 2.132 ± 0.045	1.905LysSer: 1.905 ± 0.038	1.862LysThr: 1.862 ± 0.046	2.37LysVal: 2.37 ± 0.059	0.368LysTrp: 0.368 ± 0.02	0.716LysTyr: 0.716 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	16.123LeuAla: 16.123 ± 0.178	1.355LeuCys: 1.355 ± 0.035	6.423LeuAsp: 6.423 ± 0.077	4.949LeuGlu: 4.949 ± 0.081	4.08LeuPhe: 4.08 ± 0.067	8.451LeuGly: 8.451 ± 0.099	2.414LeuHis: 2.414 ± 0.053	5.486LeuIle: 5.486 ± 0.077	3.842LeuLys: 3.842 ± 0.063	12.642LeuLeu: 12.642 ± 0.184	2.789LeuMet: 2.789 ± 0.051	3.248LeuAsn: 3.248 ± 0.054	6.595LeuPro: 6.595 ± 0.099	4.477LeuGln: 4.477 ± 0.063	7.11LeuArg: 7.11 ± 0.087	7.926LeuSer: 7.926 ± 0.096	6.417LeuThr: 6.417 ± 0.091	7.321LeuVal: 7.321 ± 0.093	1.329LeuTrp: 1.329 ± 0.042	2.531LeuTyr: 2.531 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.14MetAla: 3.14 ± 0.059	0.181MetCys: 0.181 ± 0.012	1.108MetAsp: 1.108 ± 0.03	1.012MetGlu: 1.012 ± 0.032	0.716MetPhe: 0.716 ± 0.024	1.757MetGly: 1.757 ± 0.042	0.615MetHis: 0.615 ± 0.024	1.163MetIle: 1.163 ± 0.034	1.045MetLys: 1.045 ± 0.033	3.154MetLeu: 3.154 ± 0.058	0.709MetMet: 0.709 ± 0.027	0.887MetAsn: 0.887 ± 0.027	1.514MetPro: 1.514 ± 0.039	1.247MetGln: 1.247 ± 0.029	1.725MetArg: 1.725 ± 0.042	1.687MetSer: 1.687 ± 0.038	1.585MetThr: 1.585 ± 0.036	1.785MetVal: 1.785 ± 0.041	0.21MetTrp: 0.21 ± 0.014	0.416MetTyr: 0.416 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.187AsnAla: 3.187 ± 0.059	0.283AsnCys: 0.283 ± 0.014	1.556AsnAsp: 1.556 ± 0.042	1.275AsnGlu: 1.275 ± 0.036	0.957AsnPhe: 0.957 ± 0.032	2.596AsnGly: 2.596 ± 0.065	0.695AsnHis: 0.695 ± 0.021	1.466AsnIle: 1.466 ± 0.04	0.919AsnLys: 0.919 ± 0.031	3.229AsnLeu: 3.229 ± 0.056	0.74AsnMet: 0.74 ± 0.023	0.965AsnAsn: 0.965 ± 0.035	1.882AsnPro: 1.882 ± 0.044	1.337AsnGln: 1.337 ± 0.04	1.91AsnArg: 1.91 ± 0.043	1.443AsnSer: 1.443 ± 0.049	1.57AsnThr: 1.57 ± 0.042	1.963AsnVal: 1.963 ± 0.045	0.416AsnTrp: 0.416 ± 0.018	0.782AsnTyr: 0.782 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.974ProAla: 5.974 ± 0.079	0.49ProCys: 0.49 ± 0.026	3.209ProAsp: 3.209 ± 0.053	2.965ProGlu: 2.965 ± 0.053	1.848ProPhe: 1.848 ± 0.041	3.891ProGly: 3.891 ± 0.065	1.134ProHis: 1.134 ± 0.028	2.119ProIle: 2.119 ± 0.049	1.356ProLys: 1.356 ± 0.034	5.469ProLeu: 5.469 ± 0.088	1.253ProMet: 1.253 ± 0.036	1.355ProAsn: 1.355 ± 0.034	2.332ProPro: 2.332 ± 0.061	2.072ProGln: 2.072 ± 0.04	2.566ProArg: 2.566 ± 0.048	2.657ProSer: 2.657 ± 0.05	2.427ProThr: 2.427 ± 0.037	3.858ProVal: 3.858 ± 0.06	0.756ProTrp: 0.756 ± 0.028	1.221ProTyr: 1.221 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.826GlnAla: 5.826 ± 0.083	0.425GlnCys: 0.425 ± 0.019	2.017GlnAsp: 2.017 ± 0.046	1.841GlnGlu: 1.841 ± 0.042	1.334GlnPhe: 1.334 ± 0.033	3.33GlnGly: 3.33 ± 0.058	1.225GlnHis: 1.225 ± 0.03	2.142GlnIle: 2.142 ± 0.046	1.207GlnLys: 1.207 ± 0.033	5.078GlnLeu: 5.078 ± 0.07	1.123GlnMet: 1.123 ± 0.028	1.163GlnAsn: 1.163 ± 0.038	2.267GlnPro: 2.267 ± 0.046	2.637GlnGln: 2.637 ± 0.065	3.104GlnArg: 3.104 ± 0.057	2.677GlnSer: 2.677 ± 0.061	2.329GlnThr: 2.329 ± 0.049	3.164GlnVal: 3.164 ± 0.059	0.718GlnTrp: 0.718 ± 0.025	1.041GlnTyr: 1.041 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.858ArgAla: 6.858 ± 0.085	0.653ArgCys: 0.653 ± 0.027	3.598ArgAsp: 3.598 ± 0.063	3.874ArgGlu: 3.874 ± 0.071	2.842ArgPhe: 2.842 ± 0.051	3.928ArgGly: 3.928 ± 0.056	2.127ArgHis: 2.127 ± 0.05	3.476ArgIle: 3.476 ± 0.056	1.914ArgLys: 1.914 ± 0.042	8.578ArgLeu: 8.578 ± 0.103	1.717ArgMet: 1.717 ± 0.039	1.691ArgAsn: 1.691 ± 0.042	3.08ArgPro: 3.08 ± 0.052	4.047ArgGln: 4.047 ± 0.079	4.81ArgArg: 4.81 ± 0.08	2.965ArgSer: 2.965 ± 0.05	2.8ArgThr: 2.8 ± 0.049	4.564ArgVal: 4.564 ± 0.072	0.988ArgTrp: 0.988 ± 0.032	2.109ArgTyr: 2.109 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.652SerAla: 6.652 ± 0.088	0.586SerCys: 0.586 ± 0.024	2.84SerAsp: 2.84 ± 0.054	2.693SerGlu: 2.693 ± 0.049	2.113SerPhe: 2.113 ± 0.042	5.165SerGly: 5.165 ± 0.091	1.412SerHis: 1.412 ± 0.038	2.734SerIle: 2.734 ± 0.046	1.56SerLys: 1.56 ± 0.041	6.787SerLeu: 6.787 ± 0.085	1.5SerMet: 1.5 ± 0.038	1.649SerAsn: 1.649 ± 0.045	2.781SerPro: 2.781 ± 0.054	2.474SerGln: 2.474 ± 0.06	3.492SerArg: 3.492 ± 0.051	3.214SerSer: 3.214 ± 0.078	2.903SerThr: 2.903 ± 0.059	3.998SerVal: 3.998 ± 0.059	0.825SerTrp: 0.825 ± 0.029	1.445SerTyr: 1.445 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.299ThrAla: 5.299 ± 0.086	0.476ThrCys: 0.476 ± 0.02	2.483ThrAsp: 2.483 ± 0.05	2.291ThrGlu: 2.291 ± 0.044	1.706ThrPhe: 1.706 ± 0.04	4.21ThrGly: 4.21 ± 0.074	1.206ThrHis: 1.206 ± 0.031	2.305ThrIle: 2.305 ± 0.049	1.042ThrLys: 1.042 ± 0.028	7.162ThrLeu: 7.162 ± 0.094	1.081ThrMet: 1.081 ± 0.032	1.218ThrAsn: 1.218 ± 0.036	3.236ThrPro: 3.236 ± 0.06	2.047ThrGln: 2.047 ± 0.043	3.294ThrArg: 3.294 ± 0.052	2.597ThrSer: 2.597 ± 0.056	2.428ThrThr: 2.428 ± 0.055	4.071ThrVal: 4.071 ± 0.074	0.599ThrTrp: 0.599 ± 0.023	1.029ThrTyr: 1.029 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.384ValAla: 8.384 ± 0.077	0.826ValCys: 0.826 ± 0.027	4.147ValAsp: 4.147 ± 0.066	4.031ValGlu: 4.031 ± 0.061	2.605ValPhe: 2.605 ± 0.048	5.224ValGly: 5.224 ± 0.08	1.457ValHis: 1.457 ± 0.033	3.441ValIle: 3.441 ± 0.059	2.262ValLys: 2.262 ± 0.046	8.197ValLeu: 8.197 ± 0.106	1.866ValMet: 1.866 ± 0.041	2.12ValAsn: 2.12 ± 0.047	3.352ValPro: 3.352 ± 0.057	2.467ValGln: 2.467 ± 0.051	4.418ValArg: 4.418 ± 0.061	4.349ValSer: 4.349 ± 0.064	3.596ValThr: 3.596 ± 0.068	5.62ValVal: 5.62 ± 0.09	0.854ValTrp: 0.854 ± 0.026	1.603ValTyr: 1.603 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.095TrpAla: 1.095 ± 0.03	0.18TrpCys: 0.18 ± 0.013	0.554TrpAsp: 0.554 ± 0.021	0.48TrpGlu: 0.48 ± 0.021	0.558TrpPhe: 0.558 ± 0.021	0.926TrpGly: 0.926 ± 0.032	0.476TrpHis: 0.476 ± 0.019	0.605TrpIle: 0.605 ± 0.022	0.349TrpLys: 0.349 ± 0.019	2.48TrpLeu: 2.48 ± 0.064	0.372TrpMet: 0.372 ± 0.019	0.353TrpAsn: 0.353 ± 0.019	0.673TrpPro: 0.673 ± 0.024	1.114TrpGln: 1.114 ± 0.033	1.384TrpArg: 1.384 ± 0.046	0.704TrpSer: 0.704 ± 0.03	0.523TrpThr: 0.523 ± 0.02	0.942TrpVal: 0.942 ± 0.028	0.231TrpTrp: 0.231 ± 0.015	0.335TrpTyr: 0.335 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.615TyrAla: 2.615 ± 0.051	0.311TyrCys: 0.311 ± 0.019	1.35TyrAsp: 1.35 ± 0.043	0.936TyrGlu: 0.936 ± 0.027	1.046TyrPhe: 1.046 ± 0.031	1.978TyrGly: 1.978 ± 0.048	0.559TyrHis: 0.559 ± 0.022	1.019TyrIle: 1.019 ± 0.029	0.629TyrLys: 0.629 ± 0.028	3.053TyrLeu: 3.053 ± 0.053	0.482TyrMet: 0.482 ± 0.02	0.731TyrAsn: 0.731 ± 0.024	1.314TyrPro: 1.314 ± 0.034	1.289TyrGln: 1.289 ± 0.033	2.213TyrArg: 2.213 ± 0.048	1.406TyrSer: 1.406 ± 0.039	1.217TyrThr: 1.217 ± 0.037	1.523TyrVal: 1.523 ± 0.033	0.395TyrTrp: 0.395 ± 0.018	0.727TyrTyr: 0.727 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3774 proteins (1213726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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