Amino acid dipepetide frequency for Buchananella hordeovulneris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.817AlaAla: 24.817 ± 0.311	1.185AlaCys: 1.185 ± 0.044	8.158AlaAsp: 8.158 ± 0.118	8.41AlaGlu: 8.41 ± 0.144	3.379AlaPhe: 3.379 ± 0.07	12.854AlaGly: 12.854 ± 0.148	3.005AlaHis: 3.005 ± 0.069	4.533AlaIle: 4.533 ± 0.098	2.899AlaLys: 2.899 ± 0.085	15.254AlaLeu: 15.254 ± 0.208	2.144AlaMet: 2.144 ± 0.057	2.606AlaAsn: 2.606 ± 0.06	7.568AlaPro: 7.568 ± 0.179	5.583AlaGln: 5.583 ± 0.094	10.375AlaArg: 10.375 ± 0.14	6.316AlaSer: 6.316 ± 0.106	8.27AlaThr: 8.27 ± 0.106	11.261AlaVal: 11.261 ± 0.144	2.233AlaTrp: 2.233 ± 0.068	2.392AlaTyr: 2.392 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.974CysAla: 0.974 ± 0.043	0.081CysCys: 0.081 ± 0.01	0.388CysAsp: 0.388 ± 0.025	0.383CysGlu: 0.383 ± 0.023	0.207CysPhe: 0.207 ± 0.018	0.839CysGly: 0.839 ± 0.035	0.158CysHis: 0.158 ± 0.014	0.213CysIle: 0.213 ± 0.016	0.106CysLys: 0.106 ± 0.014	0.883CysLeu: 0.883 ± 0.043	0.103CysMet: 0.103 ± 0.013	0.129CysAsn: 0.129 ± 0.013	0.473CysPro: 0.473 ± 0.029	0.295CysGln: 0.295 ± 0.02	0.528CysArg: 0.528 ± 0.026	0.352CysSer: 0.352 ± 0.023	0.431CysThr: 0.431 ± 0.028	0.546CysVal: 0.546 ± 0.03	0.112CysTrp: 0.112 ± 0.013	0.184CysTyr: 0.184 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.668AspAla: 6.668 ± 0.093	0.377AspCys: 0.377 ± 0.023	2.984AspAsp: 2.984 ± 0.068	3.329AspGlu: 3.329 ± 0.083	1.875AspPhe: 1.875 ± 0.053	5.128AspGly: 5.128 ± 0.092	1.011AspHis: 1.011 ± 0.038	2.247AspIle: 2.247 ± 0.057	1.388AspLys: 1.388 ± 0.051	5.703AspLeu: 5.703 ± 0.099	0.901AspMet: 0.901 ± 0.039	1.041AspAsn: 1.041 ± 0.044	3.733AspPro: 3.733 ± 0.082	1.68AspGln: 1.68 ± 0.055	3.157AspArg: 3.157 ± 0.062	2.451AspSer: 2.451 ± 0.066	2.599AspThr: 2.599 ± 0.059	4.564AspVal: 4.564 ± 0.084	0.924AspTrp: 0.924 ± 0.033	1.361AspTyr: 1.361 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.958GluAla: 6.958 ± 0.133	0.291GluCys: 0.291 ± 0.018	2.353GluAsp: 2.353 ± 0.061	3.479GluGlu: 3.479 ± 0.096	1.739GluPhe: 1.739 ± 0.046	3.5GluGly: 3.5 ± 0.074	1.273GluHis: 1.273 ± 0.049	2.722GluIle: 2.722 ± 0.069	1.483GluLys: 1.483 ± 0.055	7.458GluLeu: 7.458 ± 0.11	1.035GluMet: 1.035 ± 0.039	1.116GluAsn: 1.116 ± 0.042	2.779GluPro: 2.779 ± 0.079	2.595GluGln: 2.595 ± 0.059	4.401GluArg: 4.401 ± 0.109	2.292GluSer: 2.292 ± 0.061	2.707GluThr: 2.707 ± 0.072	5.408GluVal: 5.408 ± 0.104	0.679GluTrp: 0.679 ± 0.03	1.033GluTyr: 1.033 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.232PheAla: 4.232 ± 0.091	0.208PheCys: 0.208 ± 0.018	1.798PheAsp: 1.798 ± 0.044	1.398PheGlu: 1.398 ± 0.044	0.996PhePhe: 0.996 ± 0.04	2.884PheGly: 2.884 ± 0.078	0.587PheHis: 0.587 ± 0.03	0.946PheIle: 0.946 ± 0.039	0.571PheLys: 0.571 ± 0.03	2.947PheLeu: 2.947 ± 0.066	0.383PheMet: 0.383 ± 0.023	0.679PheAsn: 0.679 ± 0.034	1.457PhePro: 1.457 ± 0.046	0.705PheGln: 0.705 ± 0.026	1.531PheArg: 1.531 ± 0.055	1.824PheSer: 1.824 ± 0.057	2.215PheThr: 2.215 ± 0.062	2.629PheVal: 2.629 ± 0.07	0.4PheTrp: 0.4 ± 0.024	0.584PheTyr: 0.584 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.279GlyAla: 10.279 ± 0.142	0.697GlyCys: 0.697 ± 0.032	4.102GlyAsp: 4.102 ± 0.084	4.643GlyGlu: 4.643 ± 0.102	2.581GlyPhe: 2.581 ± 0.065	7.412GlyGly: 7.412 ± 0.123	1.942GlyHis: 1.942 ± 0.05	3.467GlyIle: 3.467 ± 0.069	2.725GlyLys: 2.725 ± 0.068	8.882GlyLeu: 8.882 ± 0.148	1.706GlyMet: 1.706 ± 0.05	1.76GlyAsn: 1.76 ± 0.052	4.562GlyPro: 4.562 ± 0.084	4.553GlyGln: 4.553 ± 0.09	6.103GlyArg: 6.103 ± 0.108	4.422GlySer: 4.422 ± 0.089	5.124GlyThr: 5.124 ± 0.1	7.162GlyVal: 7.162 ± 0.11	1.564GlyTrp: 1.564 ± 0.051	2.086GlyTyr: 2.086 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.565HisAla: 2.565 ± 0.058	0.176HisCys: 0.176 ± 0.016	1.163HisAsp: 1.163 ± 0.038	1.053HisGlu: 1.053 ± 0.042	0.617HisPhe: 0.617 ± 0.029	1.857HisGly: 1.857 ± 0.052	0.509HisHis: 0.509 ± 0.029	0.708HisIle: 0.708 ± 0.032	0.325HisLys: 0.325 ± 0.02	2.685HisLeu: 2.685 ± 0.066	0.321HisMet: 0.321 ± 0.024	0.462HisAsn: 0.462 ± 0.023	1.745HisPro: 1.745 ± 0.05	0.686HisGln: 0.686 ± 0.035	1.596HisArg: 1.596 ± 0.048	1.048HisSer: 1.048 ± 0.038	1.334HisThr: 1.334 ± 0.043	1.758HisVal: 1.758 ± 0.044	0.357HisTrp: 0.357 ± 0.022	0.557HisTyr: 0.557 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.219IleAla: 5.219 ± 0.098	0.28IleCys: 0.28 ± 0.02	2.637IleAsp: 2.637 ± 0.072	2.164IleGlu: 2.164 ± 0.063	1.079IlePhe: 1.079 ± 0.043	3.459IleGly: 3.459 ± 0.078	0.639IleHis: 0.639 ± 0.031	1.478IleIle: 1.478 ± 0.054	0.972IleLys: 0.972 ± 0.038	2.916IleLeu: 2.916 ± 0.067	0.569IleMet: 0.569 ± 0.026	0.953IleAsn: 0.953 ± 0.033	1.794IlePro: 1.794 ± 0.05	0.837IleGln: 0.837 ± 0.034	1.909IleArg: 1.909 ± 0.056	2.056IleSer: 2.056 ± 0.049	2.5IleThr: 2.5 ± 0.066	3.462IleVal: 3.462 ± 0.076	0.416IleTrp: 0.416 ± 0.025	0.811IleTyr: 0.811 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.415LysAla: 2.415 ± 0.074	0.125LysCys: 0.125 ± 0.015	1.164LysAsp: 1.164 ± 0.035	1.263LysGlu: 1.263 ± 0.05	0.682LysPhe: 0.682 ± 0.033	1.488LysGly: 1.488 ± 0.047	0.499LysHis: 0.499 ± 0.028	0.983LysIle: 0.983 ± 0.04	0.741LysLys: 0.741 ± 0.041	2.327LysLeu: 2.327 ± 0.053	0.495LysMet: 0.495 ± 0.028	0.565LysAsn: 0.565 ± 0.031	1.153LysPro: 1.153 ± 0.051	0.832LysGln: 0.832 ± 0.035	1.539LysArg: 1.539 ± 0.06	1.23LysSer: 1.23 ± 0.044	1.289LysThr: 1.289 ± 0.058	1.857LysVal: 1.857 ± 0.056	0.329LysTrp: 0.329 ± 0.024	0.481LysTyr: 0.481 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	18.599LeuAla: 18.599 ± 0.247	0.68LeuCys: 0.68 ± 0.032	5.546LeuAsp: 5.546 ± 0.096	5.197LeuGlu: 5.197 ± 0.09	2.665LeuPhe: 2.665 ± 0.073	9.208LeuGly: 9.208 ± 0.123	2.214LeuHis: 2.214 ± 0.059	3.287LeuIle: 3.287 ± 0.078	1.691LeuLys: 1.691 ± 0.048	12.08LeuLeu: 12.08 ± 0.196	1.371LeuMet: 1.371 ± 0.049	1.816LeuAsn: 1.816 ± 0.055	7.178LeuPro: 7.178 ± 0.116	3.626LeuGln: 3.626 ± 0.064	8.02LeuArg: 8.02 ± 0.121	5.269LeuSer: 5.269 ± 0.079	7.861LeuThr: 7.861 ± 0.123	9.618LeuVal: 9.618 ± 0.142	1.334LeuTrp: 1.334 ± 0.055	1.732LeuTyr: 1.732 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.004MetAla: 2.004 ± 0.061	0.136MetCys: 0.136 ± 0.017	0.767MetAsp: 0.767 ± 0.033	0.786MetGlu: 0.786 ± 0.034	0.454MetPhe: 0.454 ± 0.026	1.204MetGly: 1.204 ± 0.044	0.326MetHis: 0.326 ± 0.02	0.582MetIle: 0.582 ± 0.03	0.381MetLys: 0.381 ± 0.02	1.828MetLeu: 1.828 ± 0.053	0.273MetMet: 0.273 ± 0.022	0.427MetAsn: 0.427 ± 0.022	0.938MetPro: 0.938 ± 0.035	0.55MetGln: 0.55 ± 0.027	1.376MetArg: 1.376 ± 0.042	1.171MetSer: 1.171 ± 0.04	1.219MetThr: 1.219 ± 0.042	1.232MetVal: 1.232 ± 0.039	0.206MetTrp: 0.206 ± 0.015	0.251MetTyr: 0.251 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.16AsnAla: 2.16 ± 0.055	0.162AsnCys: 0.162 ± 0.014	0.989AsnAsp: 0.989 ± 0.041	1.001AsnGlu: 1.001 ± 0.041	0.719AsnPhe: 0.719 ± 0.032	1.653AsnGly: 1.653 ± 0.062	0.427AsnHis: 0.427 ± 0.023	0.819AsnIle: 0.819 ± 0.038	0.472AsnLys: 0.472 ± 0.024	2.168AsnLeu: 2.168 ± 0.051	0.424AsnMet: 0.424 ± 0.026	0.475AsnAsn: 0.475 ± 0.026	1.537AsnPro: 1.537 ± 0.044	0.717AsnGln: 0.717 ± 0.039	1.26AsnArg: 1.26 ± 0.042	0.953AsnSer: 0.953 ± 0.039	1.02AsnThr: 1.02 ± 0.041	1.662AsnVal: 1.662 ± 0.051	0.357AsnTrp: 0.357 ± 0.021	0.597AsnTyr: 0.597 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	9.041ProAla: 9.041 ± 0.161	0.3ProCys: 0.3 ± 0.022	3.311ProAsp: 3.311 ± 0.065	3.53ProGlu: 3.53 ± 0.092	1.517ProPhe: 1.517 ± 0.049	5.795ProGly: 5.795 ± 0.096	1.441ProHis: 1.441 ± 0.044	1.617ProIle: 1.617 ± 0.049	0.977ProLys: 0.977 ± 0.039	5.734ProLeu: 5.734 ± 0.11	0.738ProMet: 0.738 ± 0.03	1.057ProAsn: 1.057 ± 0.042	3.449ProPro: 3.449 ± 0.109	2.588ProGln: 2.588 ± 0.069	3.634ProArg: 3.634 ± 0.084	3.241ProSer: 3.241 ± 0.086	4.489ProThr: 4.489 ± 0.129	4.98ProVal: 4.98 ± 0.086	0.83ProTrp: 0.83 ± 0.035	1.048ProTyr: 1.048 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	6.29GlnAla: 6.29 ± 0.109	0.233GlnCys: 0.233 ± 0.02	1.487GlnAsp: 1.487 ± 0.048	1.904GlnGlu: 1.904 ± 0.054	1.066GlnPhe: 1.066 ± 0.04	2.55GlnGly: 2.55 ± 0.056	0.731GlnHis: 0.731 ± 0.031	1.558GlnIle: 1.558 ± 0.041	0.564GlnLys: 0.564 ± 0.027	5.048GlnLeu: 5.048 ± 0.091	0.73GlnMet: 0.73 ± 0.033	0.583GlnAsn: 0.583 ± 0.031	2.199GlnPro: 2.199 ± 0.065	1.683GlnGln: 1.683 ± 0.053	3.119GlnArg: 3.119 ± 0.073	1.51GlnSer: 1.51 ± 0.046	1.82GlnThr: 1.82 ± 0.049	4.079GlnVal: 4.079 ± 0.08	0.795GlnTrp: 0.795 ± 0.037	0.68GlnTyr: 0.68 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	9.661ArgAla: 9.661 ± 0.152	0.483ArgCys: 0.483 ± 0.022	3.703ArgAsp: 3.703 ± 0.066	4.036ArgGlu: 4.036 ± 0.089	2.123ArgPhe: 2.123 ± 0.055	5.183ArgGly: 5.183 ± 0.093	1.795ArgHis: 1.795 ± 0.049	2.673ArgIle: 2.673 ± 0.064	1.4ArgLys: 1.4 ± 0.049	8.078ArgLeu: 8.078 ± 0.136	1.296ArgMet: 1.296 ± 0.044	1.263ArgAsn: 1.263 ± 0.047	4.066ArgPro: 4.066 ± 0.087	3.33ArgGln: 3.33 ± 0.072	6.458ArgArg: 6.458 ± 0.121	3.481ArgSer: 3.481 ± 0.075	3.894ArgThr: 3.894 ± 0.077	5.623ArgVal: 5.623 ± 0.084	1.284ArgTrp: 1.284 ± 0.046	1.68ArgTyr: 1.68 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	6.641SerAla: 6.641 ± 0.116	0.365SerCys: 0.365 ± 0.026	2.375SerAsp: 2.375 ± 0.06	2.489SerGlu: 2.489 ± 0.065	1.768SerPhe: 1.768 ± 0.055	4.723SerGly: 4.723 ± 0.091	1.151SerHis: 1.151 ± 0.041	1.701SerIle: 1.701 ± 0.048	1.026SerLys: 1.026 ± 0.044	5.553SerLeu: 5.553 ± 0.101	0.911SerMet: 0.911 ± 0.043	0.95SerAsn: 0.95 ± 0.041	3.433SerPro: 3.433 ± 0.077	1.912SerGln: 1.912 ± 0.055	3.379SerArg: 3.379 ± 0.073	2.631SerSer: 2.631 ± 0.069	2.703SerThr: 2.703 ± 0.065	4.045SerVal: 4.045 ± 0.08	0.835SerTrp: 0.835 ± 0.033	1.137SerTyr: 1.137 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	8.175ThrAla: 8.175 ± 0.111	0.514ThrCys: 0.514 ± 0.026	3.304ThrAsp: 3.304 ± 0.076	3.145ThrGlu: 3.145 ± 0.073	1.858ThrPhe: 1.858 ± 0.059	5.574ThrGly: 5.574 ± 0.087	1.325ThrHis: 1.325 ± 0.039	2.426ThrIle: 2.426 ± 0.055	1.413ThrLys: 1.413 ± 0.054	5.851ThrLeu: 5.851 ± 0.101	0.963ThrMet: 0.963 ± 0.035	1.27ThrAsn: 1.27 ± 0.048	4.335ThrPro: 4.335 ± 0.095	2.049ThrGln: 2.049 ± 0.056	3.711ThrArg: 3.711 ± 0.066	3.106ThrSer: 3.106 ± 0.072	3.639ThrThr: 3.639 ± 0.085	5.553ThrVal: 5.553 ± 0.099	1.052ThrTrp: 1.052 ± 0.038	1.254ThrTyr: 1.254 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	12.374ValAla: 12.374 ± 0.162	0.774ValCys: 0.774 ± 0.033	4.907ValAsp: 4.907 ± 0.093	5.257ValGlu: 5.257 ± 0.097	2.374ValPhe: 2.374 ± 0.063	7.429ValGly: 7.429 ± 0.126	1.697ValHis: 1.697 ± 0.048	3.139ValIle: 3.139 ± 0.072	1.728ValLys: 1.728 ± 0.055	9.215ValLeu: 9.215 ± 0.131	1.243ValMet: 1.243 ± 0.049	1.695ValAsn: 1.695 ± 0.05	4.98ValPro: 4.98 ± 0.1	2.481ValGln: 2.481 ± 0.053	6.288ValArg: 6.288 ± 0.111	4.579ValSer: 4.579 ± 0.083	5.52ValThr: 5.52 ± 0.093	8.741ValVal: 8.741 ± 0.134	1.189ValTrp: 1.189 ± 0.041	1.393ValTyr: 1.393 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.751TrpAla: 1.751 ± 0.053	0.132TrpCys: 0.132 ± 0.013	0.839TrpAsp: 0.839 ± 0.039	0.775TrpGlu: 0.775 ± 0.029	0.514TrpPhe: 0.514 ± 0.031	1.175TrpGly: 1.175 ± 0.043	0.391TrpHis: 0.391 ± 0.023	0.472TrpIle: 0.472 ± 0.026	0.247TrpLys: 0.247 ± 0.022	1.965TrpLeu: 1.965 ± 0.067	0.265TrpMet: 0.265 ± 0.02	0.342TrpAsn: 0.342 ± 0.021	0.805TrpPro: 0.805 ± 0.032	1.073TrpGln: 1.073 ± 0.045	1.526TrpArg: 1.526 ± 0.058	0.761TrpSer: 0.761 ± 0.035	0.754TrpThr: 0.754 ± 0.032	1.141TrpVal: 1.141 ± 0.039	0.458TrpTrp: 0.458 ± 0.024	0.299TrpTyr: 0.299 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.067	0.187TyrCys: 0.187 ± 0.016	1.144TyrAsp: 1.144 ± 0.042	1.06TyrGlu: 1.06 ± 0.041	0.761TyrPhe: 0.761 ± 0.038	1.856TyrGly: 1.856 ± 0.054	0.402TyrHis: 0.402 ± 0.021	0.579TyrIle: 0.579 ± 0.03	0.352TyrLys: 0.352 ± 0.021	2.418TyrLeu: 2.418 ± 0.058	0.239TyrMet: 0.239 ± 0.022	0.383TyrAsn: 0.383 ± 0.02	1.133TyrPro: 1.133 ± 0.042	0.852TyrGln: 0.852 ± 0.039	1.598TyrArg: 1.598 ± 0.046	1.034TyrSer: 1.034 ± 0.036	1.127TyrThr: 1.127 ± 0.038	1.683TyrVal: 1.683 ± 0.048	0.333TyrTrp: 0.333 ± 0.018	0.453TyrTyr: 0.453 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2109 proteins (729133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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