Amino acid dipepetide frequency for Penicillium solitum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.438AlaAla: 8.438 ± 0.051	1.077AlaCys: 1.077 ± 0.015	4.198AlaAsp: 4.198 ± 0.028	5.0AlaGlu: 5.0 ± 0.038	3.183AlaPhe: 3.183 ± 0.027	5.716AlaGly: 5.716 ± 0.039	1.796AlaHis: 1.796 ± 0.019	4.484AlaIle: 4.484 ± 0.033	3.828AlaLys: 3.828 ± 0.031	7.745AlaLeu: 7.745 ± 0.044	2.0AlaMet: 2.0 ± 0.02	2.975AlaAsn: 2.975 ± 0.027	4.719AlaPro: 4.719 ± 0.044	3.345AlaGln: 3.345 ± 0.025	4.662AlaArg: 4.662 ± 0.033	7.141AlaSer: 7.141 ± 0.043	5.241AlaThr: 5.241 ± 0.036	5.337AlaVal: 5.337 ± 0.037	1.154AlaTrp: 1.154 ± 0.015	2.154AlaTyr: 2.154 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.013	0.232CysCys: 0.232 ± 0.008	0.683CysAsp: 0.683 ± 0.012	0.599CysGlu: 0.599 ± 0.011	0.561CysPhe: 0.561 ± 0.01	0.939CysGly: 0.939 ± 0.017	0.336CysHis: 0.336 ± 0.008	0.729CysIle: 0.729 ± 0.012	0.48CysLys: 0.48 ± 0.009	1.284CysLeu: 1.284 ± 0.019	0.28CysMet: 0.28 ± 0.008	0.442CysAsn: 0.442 ± 0.009	0.633CysPro: 0.633 ± 0.014	0.463CysGln: 0.463 ± 0.01	0.725CysArg: 0.725 ± 0.013	0.909CysSer: 0.909 ± 0.016	0.696CysThr: 0.696 ± 0.012	0.837CysVal: 0.837 ± 0.015	0.201CysTrp: 0.201 ± 0.006	0.363CysTyr: 0.363 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.476AspAla: 4.476 ± 0.03	0.626AspCys: 0.626 ± 0.011	3.905AspAsp: 3.905 ± 0.04	4.273AspGlu: 4.273 ± 0.035	2.173AspPhe: 2.173 ± 0.02	3.881AspGly: 3.881 ± 0.031	1.354AspHis: 1.354 ± 0.015	3.274AspIle: 3.274 ± 0.025	2.288AspLys: 2.288 ± 0.022	5.215AspLeu: 5.215 ± 0.033	1.291AspMet: 1.291 ± 0.014	1.936AspAsn: 1.936 ± 0.022	3.433AspPro: 3.433 ± 0.028	2.062AspGln: 2.062 ± 0.021	3.035AspArg: 3.035 ± 0.029	4.278AspSer: 4.278 ± 0.032	3.096AspThr: 3.096 ± 0.023	3.595AspVal: 3.595 ± 0.026	0.909AspTrp: 0.909 ± 0.014	1.606AspTyr: 1.606 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.097GluAla: 5.097 ± 0.036	0.637GluCys: 0.637 ± 0.011	4.116GluAsp: 4.116 ± 0.036	5.173GluGlu: 5.173 ± 0.054	2.017GluPhe: 2.017 ± 0.018	3.606GluGly: 3.606 ± 0.03	1.434GluHis: 1.434 ± 0.018	3.219GluIle: 3.219 ± 0.025	3.506GluLys: 3.506 ± 0.03	5.151GluLeu: 5.151 ± 0.041	1.483GluMet: 1.483 ± 0.018	2.392GluAsn: 2.392 ± 0.02	2.865GluPro: 2.865 ± 0.046	2.463GluGln: 2.463 ± 0.025	3.681GluArg: 3.681 ± 0.03	4.459GluSer: 4.459 ± 0.036	3.657GluThr: 3.657 ± 0.028	3.473GluVal: 3.473 ± 0.031	0.872GluTrp: 0.872 ± 0.012	1.689GluTyr: 1.689 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.127PheAla: 3.127 ± 0.028	0.583PheCys: 0.583 ± 0.012	2.353PheAsp: 2.353 ± 0.024	2.167PheGlu: 2.167 ± 0.018	1.715PhePhe: 1.715 ± 0.021	2.934PheGly: 2.934 ± 0.027	0.943PheHis: 0.943 ± 0.013	1.95PheIle: 1.95 ± 0.023	1.469PheLys: 1.469 ± 0.017	3.584PheLeu: 3.584 ± 0.029	0.877PheMet: 0.877 ± 0.013	1.51PheAsn: 1.51 ± 0.015	2.009PhePro: 2.009 ± 0.022	1.475PheGln: 1.475 ± 0.014	1.936PheArg: 1.936 ± 0.021	3.049PheSer: 3.049 ± 0.024	2.197PheThr: 2.197 ± 0.02	2.481PheVal: 2.481 ± 0.026	0.678PheTrp: 0.678 ± 0.011	1.169PheTyr: 1.169 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.278GlyAla: 5.278 ± 0.042	0.888GlyCys: 0.888 ± 0.013	3.578GlyAsp: 3.578 ± 0.029	3.511GlyGlu: 3.511 ± 0.028	2.943GlyPhe: 2.943 ± 0.023	5.395GlyGly: 5.395 ± 0.058	1.73GlyHis: 1.73 ± 0.022	3.745GlyIle: 3.745 ± 0.028	3.281GlyLys: 3.281 ± 0.028	6.243GlyLeu: 6.243 ± 0.042	1.633GlyMet: 1.633 ± 0.019	2.591GlyAsn: 2.591 ± 0.022	3.36GlyPro: 3.36 ± 0.032	2.56GlyGln: 2.56 ± 0.02	3.86GlyArg: 3.86 ± 0.031	5.765GlySer: 5.765 ± 0.041	3.985GlyThr: 3.985 ± 0.034	4.426GlyVal: 4.426 ± 0.032	1.173GlyTrp: 1.173 ± 0.017	2.19GlyTyr: 2.19 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.823HisAla: 1.823 ± 0.017	0.334HisCys: 0.334 ± 0.009	1.34HisAsp: 1.34 ± 0.016	1.379HisGlu: 1.379 ± 0.016	0.937HisPhe: 0.937 ± 0.015	1.762HisGly: 1.762 ± 0.02	0.815HisHis: 0.815 ± 0.015	1.28HisIle: 1.28 ± 0.017	0.891HisLys: 0.891 ± 0.014	2.278HisLeu: 2.278 ± 0.024	0.532HisMet: 0.532 ± 0.01	0.91HisAsn: 0.91 ± 0.012	1.678HisPro: 1.678 ± 0.019	0.984HisGln: 0.984 ± 0.014	1.551HisArg: 1.551 ± 0.017	1.91HisSer: 1.91 ± 0.019	1.361HisThr: 1.361 ± 0.016	1.447HisVal: 1.447 ± 0.019	0.375HisTrp: 0.375 ± 0.009	0.703HisTyr: 0.703 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.414IleAla: 4.414 ± 0.034	0.819IleCys: 0.819 ± 0.014	2.969IleAsp: 2.969 ± 0.024	2.983IleGlu: 2.983 ± 0.028	2.173IlePhe: 2.173 ± 0.023	3.46IleGly: 3.46 ± 0.03	1.263IleHis: 1.263 ± 0.015	2.733IleIle: 2.733 ± 0.03	2.144IleLys: 2.144 ± 0.019	4.783IleLeu: 4.783 ± 0.038	1.102IleMet: 1.102 ± 0.014	1.867IleAsn: 1.867 ± 0.02	3.289IlePro: 3.289 ± 0.025	2.045IleGln: 2.045 ± 0.021	2.817IleArg: 2.817 ± 0.025	4.166IleSer: 4.166 ± 0.031	2.978IleThr: 2.978 ± 0.022	3.326IleVal: 3.326 ± 0.03	0.775IleTrp: 0.775 ± 0.013	1.507IleTyr: 1.507 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.926LysAla: 3.926 ± 0.033	0.5LysCys: 0.5 ± 0.013	2.689LysAsp: 2.689 ± 0.025	3.177LysGlu: 3.177 ± 0.028	1.468LysPhe: 1.468 ± 0.017	2.821LysGly: 2.821 ± 0.024	1.074LysHis: 1.074 ± 0.013	2.258LysIle: 2.258 ± 0.022	2.984LysLys: 2.984 ± 0.041	3.907LysLeu: 3.907 ± 0.029	0.986LysMet: 0.986 ± 0.012	1.739LysAsn: 1.739 ± 0.018	2.643LysPro: 2.643 ± 0.026	1.816LysGln: 1.816 ± 0.019	3.139LysArg: 3.139 ± 0.03	3.524LysSer: 3.524 ± 0.03	2.739LysThr: 2.739 ± 0.021	2.701LysVal: 2.701 ± 0.025	0.692LysTrp: 0.692 ± 0.011	1.347LysTyr: 1.347 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.849LeuAla: 7.849 ± 0.043	1.22LeuCys: 1.22 ± 0.017	5.298LeuAsp: 5.298 ± 0.035	5.531LeuGlu: 5.531 ± 0.043	3.455LeuPhe: 3.455 ± 0.03	6.144LeuGly: 6.144 ± 0.04	2.256LeuHis: 2.256 ± 0.025	4.165LeuIle: 4.165 ± 0.031	4.036LeuLys: 4.036 ± 0.03	8.487LeuLeu: 8.487 ± 0.061	1.894LeuMet: 1.894 ± 0.019	3.317LeuAsn: 3.317 ± 0.024	5.456LeuPro: 5.456 ± 0.035	3.906LeuGln: 3.906 ± 0.029	5.584LeuArg: 5.584 ± 0.04	7.418LeuSer: 7.418 ± 0.041	4.85LeuThr: 4.85 ± 0.031	5.564LeuVal: 5.564 ± 0.036	1.246LeuTrp: 1.246 ± 0.015	2.396LeuTyr: 2.396 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.02	0.257MetCys: 0.257 ± 0.007	1.296MetAsp: 1.296 ± 0.015	1.312MetGlu: 1.312 ± 0.015	0.807MetPhe: 0.807 ± 0.012	1.566MetGly: 1.566 ± 0.019	0.508MetHis: 0.508 ± 0.01	1.113MetIle: 1.113 ± 0.016	1.006MetLys: 1.006 ± 0.012	1.897MetLeu: 1.897 ± 0.02	0.578MetMet: 0.578 ± 0.011	0.858MetAsn: 0.858 ± 0.014	1.273MetPro: 1.273 ± 0.016	0.903MetGln: 0.903 ± 0.015	1.245MetArg: 1.245 ± 0.016	1.974MetSer: 1.974 ± 0.019	1.363MetThr: 1.363 ± 0.016	1.394MetVal: 1.394 ± 0.017	0.279MetTrp: 0.279 ± 0.007	0.515MetTyr: 0.515 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.149AsnAla: 3.149 ± 0.025	0.469AsnCys: 0.469 ± 0.011	1.992AsnAsp: 1.992 ± 0.021	2.112AsnGlu: 2.112 ± 0.022	1.426AsnPhe: 1.426 ± 0.015	2.914AsnGly: 2.914 ± 0.027	0.889AsnHis: 0.889 ± 0.013	2.171AsnIle: 2.171 ± 0.022	1.551AsnLys: 1.551 ± 0.018	3.354AsnLeu: 3.354 ± 0.021	0.9AsnMet: 0.9 ± 0.013	1.481AsnAsn: 1.481 ± 0.02	2.64AsnPro: 2.64 ± 0.021	1.429AsnGln: 1.429 ± 0.018	1.952AsnArg: 1.952 ± 0.016	2.813AsnSer: 2.813 ± 0.025	2.287AsnThr: 2.287 ± 0.023	2.343AsnVal: 2.343 ± 0.022	0.591AsnTrp: 0.591 ± 0.01	1.099AsnTyr: 1.099 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.132ProAla: 5.132 ± 0.045	0.536ProCys: 0.536 ± 0.01	3.249ProAsp: 3.249 ± 0.025	3.949ProGlu: 3.949 ± 0.042	2.111ProPhe: 2.111 ± 0.022	3.883ProGly: 3.883 ± 0.035	1.356ProHis: 1.356 ± 0.019	2.696ProIle: 2.696 ± 0.024	2.606ProLys: 2.606 ± 0.024	4.717ProLeu: 4.717 ± 0.03	1.151ProMet: 1.151 ± 0.016	2.297ProAsn: 2.297 ± 0.023	4.603ProPro: 4.603 ± 0.066	2.45ProGln: 2.45 ± 0.029	3.347ProArg: 3.347 ± 0.033	6.025ProSer: 6.025 ± 0.051	4.126ProThr: 4.126 ± 0.033	3.693ProVal: 3.693 ± 0.035	0.777ProTrp: 0.777 ± 0.013	1.513ProTyr: 1.513 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.381GlnAla: 3.381 ± 0.031	0.46GlnCys: 0.46 ± 0.009	2.057GlnAsp: 2.057 ± 0.02	2.401GlnGlu: 2.401 ± 0.024	1.377GlnPhe: 1.377 ± 0.014	2.438GlnGly: 2.438 ± 0.028	1.056GlnHis: 1.056 ± 0.015	2.039GlnIle: 2.039 ± 0.022	1.981GlnLys: 1.981 ± 0.021	3.517GlnLeu: 3.517 ± 0.031	0.962GlnMet: 0.962 ± 0.015	1.644GlnAsn: 1.644 ± 0.019	2.551GlnPro: 2.551 ± 0.028	2.179GlnGln: 2.179 ± 0.046	2.544GlnArg: 2.544 ± 0.023	3.32GlnSer: 3.32 ± 0.03	2.449GlnThr: 2.449 ± 0.023	2.231GlnVal: 2.231 ± 0.021	0.613GlnTrp: 0.613 ± 0.01	1.2GlnTyr: 1.2 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.487ArgAla: 4.487 ± 0.032	0.683ArgCys: 0.683 ± 0.013	3.283ArgAsp: 3.283 ± 0.027	3.643ArgGlu: 3.643 ± 0.033	2.146ArgPhe: 2.146 ± 0.02	3.636ArgGly: 3.636 ± 0.033	1.491ArgHis: 1.491 ± 0.018	2.851ArgIle: 2.851 ± 0.025	3.207ArgLys: 3.207 ± 0.027	5.354ArgLeu: 5.354 ± 0.035	1.299ArgMet: 1.299 ± 0.016	2.178ArgAsn: 2.178 ± 0.02	3.343ArgPro: 3.343 ± 0.031	2.498ArgGln: 2.498 ± 0.024	4.623ArgArg: 4.623 ± 0.044	4.639ArgSer: 4.639 ± 0.037	3.203ArgThr: 3.203 ± 0.027	3.354ArgVal: 3.354 ± 0.024	0.93ArgTrp: 0.93 ± 0.012	1.615ArgTyr: 1.615 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.042	0.873SerCys: 0.873 ± 0.015	4.406SerAsp: 4.406 ± 0.032	4.313SerGlu: 4.313 ± 0.033	3.13SerPhe: 3.13 ± 0.023	5.599SerGly: 5.599 ± 0.037	2.053SerHis: 2.053 ± 0.022	4.186SerIle: 4.186 ± 0.031	3.65SerLys: 3.65 ± 0.029	7.446SerLeu: 7.446 ± 0.043	1.796SerMet: 1.796 ± 0.018	3.118SerAsn: 3.118 ± 0.028	5.591SerPro: 5.591 ± 0.059	3.399SerGln: 3.399 ± 0.031	4.823SerArg: 4.823 ± 0.04	8.586SerSer: 8.586 ± 0.074	5.704SerThr: 5.704 ± 0.046	4.78SerVal: 4.78 ± 0.03	1.185SerTrp: 1.185 ± 0.014	2.112SerTyr: 2.112 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.202ThrAla: 5.202 ± 0.033	0.742ThrCys: 0.742 ± 0.013	3.001ThrAsp: 3.001 ± 0.024	3.345ThrGlu: 3.345 ± 0.03	2.244ThrPhe: 2.244 ± 0.022	4.3ThrGly: 4.3 ± 0.035	1.334ThrHis: 1.334 ± 0.019	3.206ThrIle: 3.206 ± 0.024	2.596ThrLys: 2.596 ± 0.025	5.347ThrLeu: 5.347 ± 0.034	1.217ThrMet: 1.217 ± 0.016	2.173ThrAsn: 2.173 ± 0.019	4.376ThrPro: 4.376 ± 0.041	2.252ThrGln: 2.252 ± 0.024	3.116ThrArg: 3.116 ± 0.027	5.334ThrSer: 5.334 ± 0.045	4.272ThrThr: 4.272 ± 0.042	3.822ThrVal: 3.822 ± 0.031	0.864ThrTrp: 0.864 ± 0.014	1.632ThrTyr: 1.632 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.21ValAla: 5.21 ± 0.033	0.835ValCys: 0.835 ± 0.012	3.762ValAsp: 3.762 ± 0.03	3.737ValGlu: 3.737 ± 0.034	2.569ValPhe: 2.569 ± 0.023	4.066ValGly: 4.066 ± 0.03	1.456ValHis: 1.456 ± 0.016	3.224ValIle: 3.224 ± 0.025	2.722ValLys: 2.722 ± 0.023	5.662ValLeu: 5.662 ± 0.035	1.367ValMet: 1.367 ± 0.016	2.321ValAsn: 2.321 ± 0.022	3.611ValPro: 3.611 ± 0.028	2.445ValGln: 2.445 ± 0.022	3.279ValArg: 3.279 ± 0.022	4.87ValSer: 4.87 ± 0.027	3.572ValThr: 3.572 ± 0.031	4.263ValVal: 4.263 ± 0.034	0.861ValTrp: 0.861 ± 0.013	1.751ValTyr: 1.751 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.16TrpAla: 1.16 ± 0.014	0.194TrpCys: 0.194 ± 0.006	0.91TrpAsp: 0.91 ± 0.015	0.855TrpGlu: 0.855 ± 0.012	0.543TrpPhe: 0.543 ± 0.011	0.962TrpGly: 0.962 ± 0.013	0.358TrpHis: 0.358 ± 0.009	0.825TrpIle: 0.825 ± 0.014	0.826TrpLys: 0.826 ± 0.013	1.395TrpLeu: 1.395 ± 0.016	0.393TrpMet: 0.393 ± 0.009	0.667TrpAsn: 0.667 ± 0.012	0.606TrpPro: 0.606 ± 0.01	0.574TrpGln: 0.574 ± 0.009	0.934TrpArg: 0.934 ± 0.012	1.123TrpSer: 1.123 ± 0.015	0.943TrpThr: 0.943 ± 0.013	0.912TrpVal: 0.912 ± 0.011	0.294TrpTrp: 0.294 ± 0.008	0.457TrpTyr: 0.457 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.163TyrAla: 2.163 ± 0.021	0.403TyrCys: 0.403 ± 0.008	1.622TyrAsp: 1.622 ± 0.017	1.531TyrGlu: 1.531 ± 0.018	1.228TyrPhe: 1.228 ± 0.014	2.112TyrGly: 2.112 ± 0.025	0.789TyrHis: 0.789 ± 0.013	1.463TyrIle: 1.463 ± 0.019	1.076TyrLys: 1.076 ± 0.015	2.708TyrLeu: 2.708 ± 0.025	0.649TyrMet: 0.649 ± 0.012	1.145TyrAsn: 1.145 ± 0.015	1.535TyrPro: 1.535 ± 0.02	1.154TyrGln: 1.154 ± 0.014	1.612TyrArg: 1.612 ± 0.016	2.11TyrSer: 2.11 ± 0.022	1.655TyrThr: 1.655 ± 0.016	1.603TyrVal: 1.603 ± 0.019	0.46TyrTrp: 0.46 ± 0.01	0.95TyrTyr: 0.95 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11867 proteins (5659238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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