Amino acid dipepetide frequency for Thiobacimonas phage vB_ThpS-P1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.33AlaAla: 17.33 ± 1.15
1.063AlaCys: 1.063 ± 0.352
6.294AlaAsp: 6.294 ± 0.675
10.464AlaGlu: 10.464 ± 1.123
4.251AlaPhe: 4.251 ± 0.43
10.872AlaGly: 10.872 ± 1.03
1.39AlaHis: 1.39 ± 0.318
5.886AlaIle: 5.886 ± 0.535
4.169AlaLys: 4.169 ± 1.008
12.18AlaLeu: 12.18 ± 0.906
3.27AlaMet: 3.27 ± 0.502
2.289AlaAsn: 2.289 ± 0.54
6.049AlaPro: 6.049 ± 0.707
3.842AlaGln: 3.842 ± 0.728
9.483AlaArg: 9.483 ± 1.119
6.867AlaSer: 6.867 ± 1.169
8.011AlaThr: 8.011 ± 0.866
7.03AlaVal: 7.03 ± 0.752
2.044AlaTrp: 2.044 ± 0.262
2.861AlaTyr: 2.861 ± 0.406
0.0AlaXaa: 0.0 ± 0.0
Cys
0.654CysAla: 0.654 ± 0.208
0.163CysCys: 0.163 ± 0.108
0.49CysAsp: 0.49 ± 0.181
0.327CysGlu: 0.327 ± 0.186
0.327CysPhe: 0.327 ± 0.136
0.817CysGly: 0.817 ± 0.311
0.082CysHis: 0.082 ± 0.076
0.572CysIle: 0.572 ± 0.231
0.245CysLys: 0.245 ± 0.15
0.49CysLeu: 0.49 ± 0.203
0.327CysMet: 0.327 ± 0.158
0.327CysAsn: 0.327 ± 0.15
0.49CysPro: 0.49 ± 0.27
0.082CysGln: 0.082 ± 0.087
0.654CysArg: 0.654 ± 0.203
0.245CysSer: 0.245 ± 0.128
0.49CysThr: 0.49 ± 0.173
0.327CysVal: 0.327 ± 0.148
0.409CysTrp: 0.409 ± 0.172
0.327CysTyr: 0.327 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
9.401AspAla: 9.401 ± 0.86
0.572AspCys: 0.572 ± 0.215
5.068AspAsp: 5.068 ± 0.519
4.987AspGlu: 4.987 ± 0.641
1.471AspPhe: 1.471 ± 0.286
5.232AspGly: 5.232 ± 0.97
0.981AspHis: 0.981 ± 0.296
2.698AspIle: 2.698 ± 0.515
1.39AspLys: 1.39 ± 0.36
6.213AspLeu: 6.213 ± 0.815
1.144AspMet: 1.144 ± 0.33
1.308AspAsn: 1.308 ± 0.32
3.515AspPro: 3.515 ± 0.607
2.371AspGln: 2.371 ± 0.39
5.15AspArg: 5.15 ± 0.689
1.717AspSer: 1.717 ± 0.355
3.433AspThr: 3.433 ± 0.5
3.025AspVal: 3.025 ± 0.52
1.39AspTrp: 1.39 ± 0.462
1.144AspTyr: 1.144 ± 0.259
0.0AspXaa: 0.0 ± 0.0
Glu
8.502GluAla: 8.502 ± 0.996
0.327GluCys: 0.327 ± 0.168
3.76GluAsp: 3.76 ± 0.75
4.741GluGlu: 4.741 ± 0.942
2.616GluPhe: 2.616 ± 0.471
6.376GluGly: 6.376 ± 0.779
1.553GluHis: 1.553 ± 0.381
4.741GluIle: 4.741 ± 0.542
2.698GluLys: 2.698 ± 0.457
7.03GluLeu: 7.03 ± 0.819
2.044GluMet: 2.044 ± 0.339
1.39GluAsn: 1.39 ± 0.352
2.289GluPro: 2.289 ± 0.365
2.616GluGln: 2.616 ± 0.457
5.068GluArg: 5.068 ± 0.792
1.717GluSer: 1.717 ± 0.468
4.66GluThr: 4.66 ± 0.854
5.395GluVal: 5.395 ± 0.471
1.308GluTrp: 1.308 ± 0.308
1.308GluTyr: 1.308 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
3.515PheAla: 3.515 ± 0.389
0.49PheCys: 0.49 ± 0.176
2.452PheAsp: 2.452 ± 0.331
1.635PheGlu: 1.635 ± 0.361
1.226PhePhe: 1.226 ± 0.306
3.27PheGly: 3.27 ± 0.471
0.899PheHis: 0.899 ± 0.261
1.063PheIle: 1.063 ± 0.299
0.899PheLys: 0.899 ± 0.203
2.289PheLeu: 2.289 ± 0.332
0.409PheMet: 0.409 ± 0.178
1.226PheAsn: 1.226 ± 0.285
0.817PhePro: 0.817 ± 0.236
1.226PheGln: 1.226 ± 0.272
2.616PheArg: 2.616 ± 0.462
2.207PheSer: 2.207 ± 0.398
2.534PheThr: 2.534 ± 0.407
1.717PheVal: 1.717 ± 0.333
0.817PheTrp: 0.817 ± 0.287
0.49PheTyr: 0.49 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
9.891GlyAla: 9.891 ± 1.578
0.49GlyCys: 0.49 ± 0.182
5.313GlyAsp: 5.313 ± 0.69
5.886GlyGlu: 5.886 ± 0.552
2.125GlyPhe: 2.125 ± 0.48
7.602GlyGly: 7.602 ± 1.188
1.144GlyHis: 1.144 ± 0.365
3.433GlyIle: 3.433 ± 0.361
3.106GlyLys: 3.106 ± 0.52
7.357GlyLeu: 7.357 ± 0.597
1.962GlyMet: 1.962 ± 0.423
2.616GlyAsn: 2.616 ± 0.472
3.188GlyPro: 3.188 ± 0.416
2.289GlyGln: 2.289 ± 0.476
5.477GlyArg: 5.477 ± 0.497
6.621GlySer: 6.621 ± 0.92
6.049GlyThr: 6.049 ± 1.097
6.049GlyVal: 6.049 ± 0.747
1.717GlyTrp: 1.717 ± 0.421
2.207GlyTyr: 2.207 ± 0.316
0.0GlyXaa: 0.0 ± 0.0
His
2.452HisAla: 2.452 ± 0.378
0.163HisCys: 0.163 ± 0.124
0.899HisAsp: 0.899 ± 0.256
1.063HisGlu: 1.063 ± 0.288
0.817HisPhe: 0.817 ± 0.257
1.39HisGly: 1.39 ± 0.36
0.49HisHis: 0.49 ± 0.184
0.327HisIle: 0.327 ± 0.158
0.654HisLys: 0.654 ± 0.202
1.308HisLeu: 1.308 ± 0.359
0.49HisMet: 0.49 ± 0.198
0.327HisAsn: 0.327 ± 0.14
0.899HisPro: 0.899 ± 0.334
0.409HisGln: 0.409 ± 0.254
1.635HisArg: 1.635 ± 0.342
0.736HisSer: 0.736 ± 0.266
0.817HisThr: 0.817 ± 0.241
1.635HisVal: 1.635 ± 0.337
0.327HisTrp: 0.327 ± 0.158
0.654HisTyr: 0.654 ± 0.234
0.0HisXaa: 0.0 ± 0.0
Ile
6.458IleAla: 6.458 ± 0.648
0.654IleCys: 0.654 ± 0.261
3.842IleAsp: 3.842 ± 0.515
4.66IleGlu: 4.66 ± 0.769
1.226IlePhe: 1.226 ± 0.341
3.679IleGly: 3.679 ± 0.619
1.471IleHis: 1.471 ± 0.377
1.39IleIle: 1.39 ± 0.326
0.572IleLys: 0.572 ± 0.241
3.025IleLeu: 3.025 ± 0.533
0.572IleMet: 0.572 ± 0.202
0.736IleAsn: 0.736 ± 0.231
2.371IlePro: 2.371 ± 0.454
0.899IleGln: 0.899 ± 0.281
4.087IleArg: 4.087 ± 0.542
2.943IleSer: 2.943 ± 0.454
3.515IleThr: 3.515 ± 0.581
2.861IleVal: 2.861 ± 0.487
1.308IleTrp: 1.308 ± 0.253
1.063IleTyr: 1.063 ± 0.272
0.0IleXaa: 0.0 ± 0.0
Lys
4.741LysAla: 4.741 ± 0.819
0.0LysCys: 0.0 ± 0.0
1.962LysAsp: 1.962 ± 0.497
1.962LysGlu: 1.962 ± 0.386
0.981LysPhe: 0.981 ± 0.26
3.597LysGly: 3.597 ± 0.459
0.654LysHis: 0.654 ± 0.222
1.226LysIle: 1.226 ± 0.394
0.817LysLys: 0.817 ± 0.362
2.698LysLeu: 2.698 ± 0.462
1.063LysMet: 1.063 ± 0.279
0.654LysAsn: 0.654 ± 0.22
1.798LysPro: 1.798 ± 0.416
0.736LysGln: 0.736 ± 0.267
2.534LysArg: 2.534 ± 0.331
2.125LysSer: 2.125 ± 0.439
1.471LysThr: 1.471 ± 0.362
1.88LysVal: 1.88 ± 0.438
0.327LysTrp: 0.327 ± 0.166
0.572LysTyr: 0.572 ± 0.241
0.0LysXaa: 0.0 ± 0.0
Leu
11.935LeuAla: 11.935 ± 0.962
0.572LeuCys: 0.572 ± 0.234
4.905LeuAsp: 4.905 ± 0.633
6.458LeuGlu: 6.458 ± 1.012
2.125LeuPhe: 2.125 ± 0.423
6.867LeuGly: 6.867 ± 0.751
1.635LeuHis: 1.635 ± 0.34
3.679LeuIle: 3.679 ± 0.588
3.27LeuLys: 3.27 ± 0.447
6.785LeuLeu: 6.785 ± 0.885
1.88LeuMet: 1.88 ± 0.421
2.289LeuAsn: 2.289 ± 0.325
4.66LeuPro: 4.66 ± 0.461
3.106LeuGln: 3.106 ± 0.464
7.439LeuArg: 7.439 ± 0.792
6.703LeuSer: 6.703 ± 0.887
4.905LeuThr: 4.905 ± 0.67
5.477LeuVal: 5.477 ± 0.945
1.063LeuTrp: 1.063 ± 0.212
1.635LeuTyr: 1.635 ± 0.379
0.0LeuXaa: 0.0 ± 0.0
Met
2.452MetAla: 2.452 ± 0.396
0.163MetCys: 0.163 ± 0.125
0.736MetAsp: 0.736 ± 0.254
1.635MetGlu: 1.635 ± 0.394
0.409MetPhe: 0.409 ± 0.189
1.308MetGly: 1.308 ± 0.318
0.163MetHis: 0.163 ± 0.11
1.798MetIle: 1.798 ± 0.393
0.654MetLys: 0.654 ± 0.263
1.798MetLeu: 1.798 ± 0.351
0.736MetMet: 0.736 ± 0.264
0.736MetAsn: 0.736 ± 0.259
1.226MetPro: 1.226 ± 0.362
0.817MetGln: 0.817 ± 0.238
1.88MetArg: 1.88 ± 0.427
2.452MetSer: 2.452 ± 0.51
2.534MetThr: 2.534 ± 0.43
1.063MetVal: 1.063 ± 0.252
0.163MetTrp: 0.163 ± 0.109
0.245MetTyr: 0.245 ± 0.14
0.0MetXaa: 0.0 ± 0.0
Asn
2.861AsnAla: 2.861 ± 0.542
0.409AsnCys: 0.409 ± 0.13
1.717AsnAsp: 1.717 ± 0.292
1.39AsnGlu: 1.39 ± 0.266
0.899AsnPhe: 0.899 ± 0.241
2.044AsnGly: 2.044 ± 0.445
0.327AsnHis: 0.327 ± 0.137
1.144AsnIle: 1.144 ± 0.339
0.817AsnLys: 0.817 ± 0.336
1.553AsnLeu: 1.553 ± 0.388
0.654AsnMet: 0.654 ± 0.213
0.327AsnAsn: 0.327 ± 0.174
1.717AsnPro: 1.717 ± 0.42
0.817AsnGln: 0.817 ± 0.281
1.962AsnArg: 1.962 ± 0.314
1.226AsnSer: 1.226 ± 0.341
1.471AsnThr: 1.471 ± 0.382
1.798AsnVal: 1.798 ± 0.416
0.409AsnTrp: 0.409 ± 0.173
0.245AsnTyr: 0.245 ± 0.114
0.0AsnXaa: 0.0 ± 0.0
Pro
5.559ProAla: 5.559 ± 0.671
0.654ProCys: 0.654 ± 0.192
3.597ProAsp: 3.597 ± 0.386
3.515ProGlu: 3.515 ± 0.613
1.063ProPhe: 1.063 ± 0.265
4.414ProGly: 4.414 ± 0.535
0.572ProHis: 0.572 ± 0.173
1.962ProIle: 1.962 ± 0.409
1.308ProLys: 1.308 ± 0.351
3.679ProLeu: 3.679 ± 0.607
0.899ProMet: 0.899 ± 0.278
1.063ProAsn: 1.063 ± 0.23
3.025ProPro: 3.025 ± 0.408
1.471ProGln: 1.471 ± 0.318
3.924ProArg: 3.924 ± 0.613
3.106ProSer: 3.106 ± 0.616
3.188ProThr: 3.188 ± 0.454
4.087ProVal: 4.087 ± 0.675
1.144ProTrp: 1.144 ± 0.348
0.981ProTyr: 0.981 ± 0.291
0.0ProXaa: 0.0 ± 0.0
Gln
3.924GlnAla: 3.924 ± 0.633
0.082GlnCys: 0.082 ± 0.083
1.88GlnAsp: 1.88 ± 0.327
1.39GlnGlu: 1.39 ± 0.244
0.981GlnPhe: 0.981 ± 0.267
1.553GlnGly: 1.553 ± 0.339
0.327GlnHis: 0.327 ± 0.164
2.534GlnIle: 2.534 ± 0.467
1.226GlnLys: 1.226 ± 0.305
3.924GlnLeu: 3.924 ± 0.683
0.654GlnMet: 0.654 ± 0.242
0.981GlnAsn: 0.981 ± 0.231
1.635GlnPro: 1.635 ± 0.384
1.226GlnGln: 1.226 ± 0.311
2.207GlnArg: 2.207 ± 0.435
1.88GlnSer: 1.88 ± 0.433
2.289GlnThr: 2.289 ± 0.598
2.452GlnVal: 2.452 ± 0.405
0.572GlnTrp: 0.572 ± 0.18
0.736GlnTyr: 0.736 ± 0.292
0.0GlnXaa: 0.0 ± 0.0
Arg
8.256ArgAla: 8.256 ± 0.972
0.245ArgCys: 0.245 ± 0.192
4.578ArgAsp: 4.578 ± 0.711
5.068ArgGlu: 5.068 ± 0.752
2.943ArgPhe: 2.943 ± 0.5
5.395ArgGly: 5.395 ± 0.622
1.553ArgHis: 1.553 ± 0.396
3.515ArgIle: 3.515 ± 0.465
3.433ArgLys: 3.433 ± 0.509
8.093ArgLeu: 8.093 ± 0.727
2.371ArgMet: 2.371 ± 0.435
1.88ArgAsn: 1.88 ± 0.372
4.169ArgPro: 4.169 ± 0.509
2.534ArgGln: 2.534 ± 0.429
6.049ArgArg: 6.049 ± 0.971
4.496ArgSer: 4.496 ± 0.591
3.515ArgThr: 3.515 ± 0.51
5.068ArgVal: 5.068 ± 0.707
1.88ArgTrp: 1.88 ± 0.378
2.125ArgTyr: 2.125 ± 0.384
0.0ArgXaa: 0.0 ± 0.0
Ser
8.338SerAla: 8.338 ± 0.895
0.327SerCys: 0.327 ± 0.14
4.087SerAsp: 4.087 ± 0.569
3.842SerGlu: 3.842 ± 0.66
2.861SerPhe: 2.861 ± 0.466
6.049SerGly: 6.049 ± 0.866
0.736SerHis: 0.736 ± 0.236
3.106SerIle: 3.106 ± 0.482
1.962SerLys: 1.962 ± 0.398
3.842SerLeu: 3.842 ± 0.496
1.553SerMet: 1.553 ± 0.42
1.553SerAsn: 1.553 ± 0.349
1.88SerPro: 1.88 ± 0.347
1.308SerGln: 1.308 ± 0.281
4.006SerArg: 4.006 ± 0.663
3.597SerSer: 3.597 ± 0.6
4.333SerThr: 4.333 ± 0.939
3.515SerVal: 3.515 ± 0.493
0.899SerTrp: 0.899 ± 0.276
1.308SerTyr: 1.308 ± 0.281
0.0SerXaa: 0.0 ± 0.0
Thr
7.684ThrAla: 7.684 ± 1.004
0.654ThrCys: 0.654 ± 0.246
5.232ThrAsp: 5.232 ± 0.679
3.597ThrGlu: 3.597 ± 0.394
2.452ThrPhe: 2.452 ± 0.515
6.049ThrGly: 6.049 ± 0.824
1.308ThrHis: 1.308 ± 0.43
3.188ThrIle: 3.188 ± 0.513
1.471ThrLys: 1.471 ± 0.367
5.722ThrLeu: 5.722 ± 0.861
0.899ThrMet: 0.899 ± 0.2
1.553ThrAsn: 1.553 ± 0.41
4.169ThrPro: 4.169 ± 0.568
2.534ThrGln: 2.534 ± 0.566
4.66ThrArg: 4.66 ± 0.626
3.27ThrSer: 3.27 ± 0.697
3.515ThrThr: 3.515 ± 0.673
4.496ThrVal: 4.496 ± 0.8
1.063ThrTrp: 1.063 ± 0.304
1.471ThrTyr: 1.471 ± 0.341
0.0ThrXaa: 0.0 ± 0.0
Val
7.357ValAla: 7.357 ± 0.78
0.163ValCys: 0.163 ± 0.132
3.515ValAsp: 3.515 ± 0.48
5.068ValGlu: 5.068 ± 0.67
1.471ValPhe: 1.471 ± 0.376
3.842ValGly: 3.842 ± 0.701
1.144ValHis: 1.144 ± 0.252
3.433ValIle: 3.433 ± 0.594
2.044ValLys: 2.044 ± 0.341
5.64ValLeu: 5.64 ± 0.509
1.144ValMet: 1.144 ± 0.286
1.553ValAsn: 1.553 ± 0.341
3.433ValPro: 3.433 ± 0.61
3.025ValGln: 3.025 ± 0.501
5.232ValArg: 5.232 ± 0.471
5.232ValSer: 5.232 ± 0.598
5.804ValThr: 5.804 ± 1.112
4.414ValVal: 4.414 ± 0.728
0.654ValTrp: 0.654 ± 0.232
1.063ValTyr: 1.063 ± 0.3
0.0ValXaa: 0.0 ± 0.0
Trp
2.044TrpAla: 2.044 ± 0.367
0.245TrpCys: 0.245 ± 0.115
0.899TrpAsp: 0.899 ± 0.195
1.144TrpGlu: 1.144 ± 0.35
0.817TrpPhe: 0.817 ± 0.229
2.044TrpGly: 2.044 ± 0.401
0.409TrpHis: 0.409 ± 0.135
0.981TrpIle: 0.981 ± 0.242
0.654TrpLys: 0.654 ± 0.221
1.88TrpLeu: 1.88 ± 0.472
0.572TrpMet: 0.572 ± 0.183
0.654TrpAsn: 0.654 ± 0.258
0.981TrpPro: 0.981 ± 0.294
0.572TrpGln: 0.572 ± 0.173
1.144TrpArg: 1.144 ± 0.288
0.736TrpSer: 0.736 ± 0.229
1.063TrpThr: 1.063 ± 0.353
0.981TrpVal: 0.981 ± 0.257
0.327TrpTrp: 0.327 ± 0.135
0.163TrpTyr: 0.163 ± 0.107
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.289TyrAla: 2.289 ± 0.461
0.409TyrCys: 0.409 ± 0.198
0.981TyrAsp: 0.981 ± 0.211
1.39TyrGlu: 1.39 ± 0.242
0.736TyrPhe: 0.736 ± 0.193
2.125TyrGly: 2.125 ± 0.391
0.654TyrHis: 0.654 ± 0.259
0.654TyrIle: 0.654 ± 0.237
0.409TyrLys: 0.409 ± 0.179
1.88TyrLeu: 1.88 ± 0.325
0.245TyrMet: 0.245 ± 0.131
0.327TyrAsn: 0.327 ± 0.2
0.899TyrPro: 0.899 ± 0.346
0.572TyrGln: 0.572 ± 0.167
1.962TyrArg: 1.962 ± 0.464
1.226TyrSer: 1.226 ± 0.281
1.39TyrThr: 1.39 ± 0.346
1.962TyrVal: 1.962 ± 0.408
0.49TyrTrp: 0.49 ± 0.199
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (12234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski