Amino acid dipepetide frequency for Mitsuokella sp. oral taxon 131 str. W9106

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.327AlaAla: 13.327 ± 0.221
1.549AlaCys: 1.549 ± 0.059
6.079AlaAsp: 6.079 ± 0.108
7.157AlaGlu: 7.157 ± 0.127
4.314AlaPhe: 4.314 ± 0.091
8.933AlaGly: 8.933 ± 0.169
2.393AlaHis: 2.393 ± 0.066
6.509AlaIle: 6.509 ± 0.102
5.899AlaLys: 5.899 ± 0.11
10.251AlaLeu: 10.251 ± 0.136
3.45AlaMet: 3.45 ± 0.071
2.905AlaAsn: 2.905 ± 0.073
3.618AlaPro: 3.618 ± 0.084
3.457AlaGln: 3.457 ± 0.074
6.383AlaArg: 6.383 ± 0.11
5.547AlaSer: 5.547 ± 0.119
4.03AlaThr: 4.03 ± 0.079
7.743AlaVal: 7.743 ± 0.116
1.009AlaTrp: 1.009 ± 0.038
3.443AlaTyr: 3.443 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
1.35CysAla: 1.35 ± 0.048
0.249CysCys: 0.249 ± 0.02
0.687CysAsp: 0.687 ± 0.04
0.672CysGlu: 0.672 ± 0.031
0.494CysPhe: 0.494 ± 0.025
1.271CysGly: 1.271 ± 0.041
0.329CysHis: 0.329 ± 0.022
0.866CysIle: 0.866 ± 0.036
0.484CysLys: 0.484 ± 0.03
1.157CysLeu: 1.157 ± 0.041
0.399CysMet: 0.399 ± 0.022
0.323CysAsn: 0.323 ± 0.023
0.593CysPro: 0.593 ± 0.032
0.273CysGln: 0.273 ± 0.021
0.851CysArg: 0.851 ± 0.038
0.686CysSer: 0.686 ± 0.029
0.633CysThr: 0.633 ± 0.031
0.952CysVal: 0.952 ± 0.04
0.116CysTrp: 0.116 ± 0.013
0.474CysTyr: 0.474 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
6.609AspAla: 6.609 ± 0.125
0.697AspCys: 0.697 ± 0.038
2.589AspAsp: 2.589 ± 0.073
3.725AspGlu: 3.725 ± 0.083
2.644AspPhe: 2.644 ± 0.063
4.733AspGly: 4.733 ± 0.105
1.023AspHis: 1.023 ± 0.038
3.657AspIle: 3.657 ± 0.084
2.49AspLys: 2.49 ± 0.071
4.773AspLeu: 4.773 ± 0.076
1.732AspMet: 1.732 ± 0.054
1.224AspAsn: 1.224 ± 0.049
2.141AspPro: 2.141 ± 0.054
1.051AspGln: 1.051 ± 0.038
2.951AspArg: 2.951 ± 0.066
2.431AspSer: 2.431 ± 0.058
2.804AspThr: 2.804 ± 0.062
4.279AspVal: 4.279 ± 0.085
0.648AspTrp: 0.648 ± 0.032
2.087AspTyr: 2.087 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
7.418GluAla: 7.418 ± 0.133
0.624GluCys: 0.624 ± 0.033
3.273GluAsp: 3.273 ± 0.073
5.517GluGlu: 5.517 ± 0.123
1.696GluPhe: 1.696 ± 0.049
4.544GluGly: 4.544 ± 0.076
1.541GluHis: 1.541 ± 0.044
4.25GluIle: 4.25 ± 0.088
4.891GluLys: 4.891 ± 0.098
5.475GluLeu: 5.475 ± 0.09
2.154GluMet: 2.154 ± 0.059
2.55GluAsn: 2.55 ± 0.061
2.053GluPro: 2.053 ± 0.061
2.497GluGln: 2.497 ± 0.066
4.606GluArg: 4.606 ± 0.094
3.042GluSer: 3.042 ± 0.065
3.783GluThr: 3.783 ± 0.083
4.107GluVal: 4.107 ± 0.079
0.549GluTrp: 0.549 ± 0.032
1.65GluTyr: 1.65 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
4.047PheAla: 4.047 ± 0.106
0.689PheCys: 0.689 ± 0.03
2.466PheAsp: 2.466 ± 0.062
1.882PheGlu: 1.882 ± 0.052
2.087PhePhe: 2.087 ± 0.061
3.353PheGly: 3.353 ± 0.078
1.072PheHis: 1.072 ± 0.043
2.289PheIle: 2.289 ± 0.065
1.279PheLys: 1.279 ± 0.043
4.298PheLeu: 4.298 ± 0.085
1.103PheMet: 1.103 ± 0.045
1.016PheAsn: 1.016 ± 0.043
1.468PhePro: 1.468 ± 0.046
1.08PheGln: 1.08 ± 0.039
2.094PheArg: 2.094 ± 0.058
2.844PheSer: 2.844 ± 0.07
1.951PheThr: 1.951 ± 0.046
2.867PheVal: 2.867 ± 0.069
0.465PheTrp: 0.465 ± 0.029
1.315PheTyr: 1.315 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
7.802GlyAla: 7.802 ± 0.158
1.1GlyCys: 1.1 ± 0.04
3.848GlyAsp: 3.848 ± 0.084
4.713GlyGlu: 4.713 ± 0.091
3.207GlyPhe: 3.207 ± 0.067
6.067GlyGly: 6.067 ± 0.14
1.801GlyHis: 1.801 ± 0.055
6.082GlyIle: 6.082 ± 0.097
5.118GlyLys: 5.118 ± 0.105
6.604GlyLeu: 6.604 ± 0.099
2.701GlyMet: 2.701 ± 0.067
2.565GlyAsn: 2.565 ± 0.099
1.5GlyPro: 1.5 ± 0.054
2.084GlyGln: 2.084 ± 0.059
4.638GlyArg: 4.638 ± 0.087
4.321GlySer: 4.321 ± 0.098
5.038GlyThr: 5.038 ± 0.134
5.735GlyVal: 5.735 ± 0.095
0.8GlyTrp: 0.8 ± 0.032
2.606GlyTyr: 2.606 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.579HisAla: 2.579 ± 0.068
0.332HisCys: 0.332 ± 0.019
1.292HisAsp: 1.292 ± 0.042
1.482HisGlu: 1.482 ± 0.046
1.073HisPhe: 1.073 ± 0.033
1.948HisGly: 1.948 ± 0.061
0.61HisHis: 0.61 ± 0.031
1.658HisIle: 1.658 ± 0.05
0.788HisLys: 0.788 ± 0.031
2.122HisLeu: 2.122 ± 0.064
0.561HisMet: 0.561 ± 0.027
0.634HisAsn: 0.634 ± 0.029
1.149HisPro: 1.149 ± 0.042
0.558HisGln: 0.558 ± 0.028
1.32HisArg: 1.32 ± 0.047
0.999HisSer: 0.999 ± 0.037
1.336HisThr: 1.336 ± 0.044
1.688HisVal: 1.688 ± 0.047
0.22HisTrp: 0.22 ± 0.018
0.795HisTyr: 0.795 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
7.199IleAla: 7.199 ± 0.118
0.921IleCys: 0.921 ± 0.037
3.573IleAsp: 3.573 ± 0.079
4.229IleGlu: 4.229 ± 0.082
2.333IlePhe: 2.333 ± 0.064
5.325IleGly: 5.325 ± 0.107
1.538IleHis: 1.538 ± 0.046
3.354IleIle: 3.354 ± 0.086
2.519IleLys: 2.519 ± 0.056
6.288IleLeu: 6.288 ± 0.116
1.586IleMet: 1.586 ± 0.05
1.732IleAsn: 1.732 ± 0.052
2.895IlePro: 2.895 ± 0.063
1.812IleGln: 1.812 ± 0.052
3.834IleArg: 3.834 ± 0.072
3.301IleSer: 3.301 ± 0.067
3.259IleThr: 3.259 ± 0.07
4.815IleVal: 4.815 ± 0.09
0.516IleTrp: 0.516 ± 0.03
1.718IleTyr: 1.718 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.599LysAla: 5.599 ± 0.093
0.481LysCys: 0.481 ± 0.024
3.065LysAsp: 3.065 ± 0.067
4.691LysGlu: 4.691 ± 0.1
1.453LysPhe: 1.453 ± 0.049
3.987LysGly: 3.987 ± 0.078
0.988LysHis: 0.988 ± 0.036
3.126LysIle: 3.126 ± 0.065
4.046LysLys: 4.046 ± 0.074
4.253LysLeu: 4.253 ± 0.093
1.692LysMet: 1.692 ± 0.05
1.954LysAsn: 1.954 ± 0.061
1.871LysPro: 1.871 ± 0.05
1.763LysGln: 1.763 ± 0.054
3.34LysArg: 3.34 ± 0.073
2.504LysSer: 2.504 ± 0.058
2.95LysThr: 2.95 ± 0.071
3.228LysVal: 3.228 ± 0.068
0.533LysTrp: 0.533 ± 0.029
1.425LysTyr: 1.425 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
11.093LeuAla: 11.093 ± 0.149
1.31LeuCys: 1.31 ± 0.045
5.218LeuAsp: 5.218 ± 0.087
4.759LeuGlu: 4.759 ± 0.091
4.014LeuPhe: 4.014 ± 0.092
6.962LeuGly: 6.962 ± 0.126
2.198LeuHis: 2.198 ± 0.059
4.985LeuIle: 4.985 ± 0.108
4.316LeuLys: 4.316 ± 0.085
9.337LeuLeu: 9.337 ± 0.153
2.716LeuMet: 2.716 ± 0.065
2.389LeuAsn: 2.389 ± 0.062
4.515LeuPro: 4.515 ± 0.09
3.019LeuGln: 3.019 ± 0.067
5.726LeuArg: 5.726 ± 0.099
6.071LeuSer: 6.071 ± 0.099
5.083LeuThr: 5.083 ± 0.083
6.593LeuVal: 6.593 ± 0.118
0.779LeuTrp: 0.779 ± 0.034
2.788LeuTyr: 2.788 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
3.266MetAla: 3.266 ± 0.08
0.262MetCys: 0.262 ± 0.021
1.863MetAsp: 1.863 ± 0.05
2.452MetGlu: 2.452 ± 0.071
0.81MetPhe: 0.81 ± 0.037
2.408MetGly: 2.408 ± 0.072
0.711MetHis: 0.711 ± 0.03
1.546MetIle: 1.546 ± 0.053
2.074MetLys: 2.074 ± 0.053
2.923MetLeu: 2.923 ± 0.068
0.98MetMet: 0.98 ± 0.038
1.096MetAsn: 1.096 ± 0.04
1.427MetPro: 1.427 ± 0.047
1.265MetGln: 1.265 ± 0.042
2.061MetArg: 2.061 ± 0.052
1.383MetSer: 1.383 ± 0.046
1.717MetThr: 1.717 ± 0.044
1.924MetVal: 1.924 ± 0.045
0.157MetTrp: 0.157 ± 0.016
0.616MetTyr: 0.616 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.196AsnAla: 3.196 ± 0.084
0.364AsnCys: 0.364 ± 0.022
1.489AsnAsp: 1.489 ± 0.043
1.749AsnGlu: 1.749 ± 0.056
1.18AsnPhe: 1.18 ± 0.042
2.555AsnGly: 2.555 ± 0.069
0.609AsnHis: 0.609 ± 0.03
2.067AsnIle: 2.067 ± 0.065
1.279AsnLys: 1.279 ± 0.052
2.963AsnLeu: 2.963 ± 0.065
0.95AsnMet: 0.95 ± 0.041
0.838AsnAsn: 0.838 ± 0.043
1.76AsnPro: 1.76 ± 0.049
0.834AsnGln: 0.834 ± 0.035
1.748AsnArg: 1.748 ± 0.049
1.22AsnSer: 1.22 ± 0.047
1.524AsnThr: 1.524 ± 0.067
2.41AsnVal: 2.41 ± 0.079
0.367AsnTrp: 0.367 ± 0.022
1.048AsnTyr: 1.048 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
4.121ProAla: 4.121 ± 0.081
0.511ProCys: 0.511 ± 0.028
2.212ProAsp: 2.212 ± 0.062
2.729ProGlu: 2.729 ± 0.06
1.741ProPhe: 1.741 ± 0.053
2.513ProGly: 2.513 ± 0.064
1.09ProHis: 1.09 ± 0.044
2.506ProIle: 2.506 ± 0.064
2.165ProLys: 2.165 ± 0.057
3.541ProLeu: 3.541 ± 0.067
1.166ProMet: 1.166 ± 0.042
1.348ProAsn: 1.348 ± 0.043
1.385ProPro: 1.385 ± 0.053
1.289ProGln: 1.289 ± 0.041
1.742ProArg: 1.742 ± 0.053
2.05ProSer: 2.05 ± 0.062
1.844ProThr: 1.844 ± 0.057
3.171ProVal: 3.171 ± 0.083
0.385ProTrp: 0.385 ± 0.022
1.359ProTyr: 1.359 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.339GlnAla: 3.339 ± 0.079
0.259GlnCys: 0.259 ± 0.019
1.706GlnAsp: 1.706 ± 0.042
2.544GlnGlu: 2.544 ± 0.071
1.013GlnPhe: 1.013 ± 0.037
2.13GlnGly: 2.13 ± 0.056
0.666GlnHis: 0.666 ± 0.036
1.92GlnIle: 1.92 ± 0.052
2.247GlnLys: 2.247 ± 0.055
2.464GlnLeu: 2.464 ± 0.06
1.08GlnMet: 1.08 ± 0.038
1.233GlnAsn: 1.233 ± 0.045
1.031GlnPro: 1.031 ± 0.036
1.306GlnGln: 1.306 ± 0.054
1.805GlnArg: 1.805 ± 0.056
1.527GlnSer: 1.527 ± 0.049
1.636GlnThr: 1.636 ± 0.053
1.811GlnVal: 1.811 ± 0.055
0.216GlnTrp: 0.216 ± 0.017
0.95GlnTyr: 0.95 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
5.924ArgAla: 5.924 ± 0.106
0.753ArgCys: 0.753 ± 0.034
3.091ArgAsp: 3.091 ± 0.071
4.649ArgGlu: 4.649 ± 0.091
2.397ArgPhe: 2.397 ± 0.064
3.777ArgGly: 3.777 ± 0.079
1.399ArgHis: 1.399 ± 0.045
4.58ArgIle: 4.58 ± 0.082
3.245ArgLys: 3.245 ± 0.078
5.747ArgLeu: 5.747 ± 0.102
2.123ArgMet: 2.123 ± 0.057
1.826ArgAsn: 1.826 ± 0.056
2.056ArgPro: 2.056 ± 0.055
1.977ArgGln: 1.977 ± 0.055
4.193ArgArg: 4.193 ± 0.1
2.69ArgSer: 2.69 ± 0.067
3.258ArgThr: 3.258 ± 0.066
4.103ArgVal: 4.103 ± 0.091
0.554ArgTrp: 0.554 ± 0.025
2.133ArgTyr: 2.133 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.209SerAla: 5.209 ± 0.104
0.717SerCys: 0.717 ± 0.036
2.736SerAsp: 2.736 ± 0.066
2.97SerGlu: 2.97 ± 0.065
2.453SerPhe: 2.453 ± 0.054
4.411SerGly: 4.411 ± 0.093
1.275SerHis: 1.275 ± 0.039
3.406SerIle: 3.406 ± 0.068
2.294SerLys: 2.294 ± 0.058
5.251SerLeu: 5.251 ± 0.086
1.781SerMet: 1.781 ± 0.049
1.391SerAsn: 1.391 ± 0.046
2.052SerPro: 2.052 ± 0.052
1.297SerGln: 1.297 ± 0.048
2.894SerArg: 2.894 ± 0.061
2.768SerSer: 2.768 ± 0.077
2.484SerThr: 2.484 ± 0.066
4.067SerVal: 4.067 ± 0.085
0.521SerTrp: 0.521 ± 0.027
2.0SerTyr: 2.0 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.347ThrAla: 5.347 ± 0.102
0.56ThrCys: 0.56 ± 0.032
2.848ThrAsp: 2.848 ± 0.072
3.234ThrGlu: 3.234 ± 0.066
2.038ThrPhe: 2.038 ± 0.057
4.867ThrGly: 4.867 ± 0.121
1.162ThrHis: 1.162 ± 0.044
3.349ThrIle: 3.349 ± 0.075
2.695ThrLys: 2.695 ± 0.066
4.969ThrLeu: 4.969 ± 0.082
1.636ThrMet: 1.636 ± 0.046
1.724ThrAsn: 1.724 ± 0.063
2.481ThrPro: 2.481 ± 0.071
1.51ThrGln: 1.51 ± 0.05
2.659ThrArg: 2.659 ± 0.055
2.471ThrSer: 2.471 ± 0.065
2.523ThrThr: 2.523 ± 0.067
4.145ThrVal: 4.145 ± 0.09
0.473ThrTrp: 0.473 ± 0.027
1.622ThrTyr: 1.622 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.495ValAla: 6.495 ± 0.111
0.973ValCys: 0.973 ± 0.038
3.696ValAsp: 3.696 ± 0.072
4.222ValGlu: 4.222 ± 0.083
3.017ValPhe: 3.017 ± 0.068
5.144ValGly: 5.144 ± 0.107
1.605ValHis: 1.605 ± 0.053
4.208ValIle: 4.208 ± 0.082
3.333ValLys: 3.333 ± 0.086
7.68ValLeu: 7.68 ± 0.122
2.038ValMet: 2.038 ± 0.06
2.056ValAsn: 2.056 ± 0.058
3.346ValPro: 3.346 ± 0.075
2.306ValGln: 2.306 ± 0.055
4.934ValArg: 4.934 ± 0.097
4.247ValSer: 4.247 ± 0.085
4.256ValThr: 4.256 ± 0.083
5.242ValVal: 5.242 ± 0.102
0.641ValTrp: 0.641 ± 0.026
2.059ValTyr: 2.059 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.76TrpAla: 0.76 ± 0.034
0.133TrpCys: 0.133 ± 0.014
0.505TrpAsp: 0.505 ± 0.021
0.633TrpGlu: 0.633 ± 0.034
0.329TrpPhe: 0.329 ± 0.022
0.665TrpGly: 0.665 ± 0.031
0.278TrpHis: 0.278 ± 0.022
0.571TrpIle: 0.571 ± 0.032
0.572TrpLys: 0.572 ± 0.028
0.968TrpLeu: 0.968 ± 0.035
0.308TrpMet: 0.308 ± 0.019
0.395TrpAsn: 0.395 ± 0.023
0.259TrpPro: 0.259 ± 0.019
0.512TrpGln: 0.512 ± 0.027
0.626TrpArg: 0.626 ± 0.03
0.48TrpSer: 0.48 ± 0.027
0.477TrpThr: 0.477 ± 0.031
0.476TrpVal: 0.476 ± 0.028
0.104TrpTrp: 0.104 ± 0.013
0.301TrpTyr: 0.301 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.312TyrAla: 3.312 ± 0.064
0.378TyrCys: 0.378 ± 0.024
2.053TyrAsp: 2.053 ± 0.064
2.21TyrGlu: 2.21 ± 0.057
1.371TyrPhe: 1.371 ± 0.043
2.739TyrGly: 2.739 ± 0.071
0.855TyrHis: 0.855 ± 0.037
1.818TyrIle: 1.818 ± 0.054
1.215TyrLys: 1.215 ± 0.045
2.807TyrLeu: 2.807 ± 0.063
0.785TyrMet: 0.785 ± 0.035
0.952TyrAsn: 0.952 ± 0.036
1.268TyrPro: 1.268 ± 0.045
0.994TyrGln: 0.994 ± 0.036
2.071TyrArg: 2.071 ± 0.059
1.392TyrSer: 1.392 ± 0.047
1.727TyrThr: 1.727 ± 0.059
2.141TyrVal: 2.141 ± 0.056
0.299TyrTrp: 0.299 ± 0.022
1.09TyrTyr: 1.09 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2309 proteins (714581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski