Amino acid dipepetide frequency for Acinetobacter phage vB_AbaP_Alexa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.624AlaAla: 11.624 ± 0.929
0.949AlaCys: 0.949 ± 0.254
6.721AlaAsp: 6.721 ± 0.729
5.931AlaGlu: 5.931 ± 0.728
3.558AlaPhe: 3.558 ± 0.494
8.145AlaGly: 8.145 ± 0.771
1.582AlaHis: 1.582 ± 0.477
5.614AlaIle: 5.614 ± 0.494
6.642AlaLys: 6.642 ± 0.697
7.117AlaLeu: 7.117 ± 0.881
2.214AlaMet: 2.214 ± 0.56
4.982AlaAsn: 4.982 ± 0.539
3.4AlaPro: 3.4 ± 0.492
3.875AlaGln: 3.875 ± 0.542
4.112AlaArg: 4.112 ± 0.545
4.666AlaSer: 4.666 ± 0.548
6.01AlaThr: 6.01 ± 0.776
6.721AlaVal: 6.721 ± 0.763
1.661AlaTrp: 1.661 ± 0.399
2.926AlaTyr: 2.926 ± 0.448
0.0AlaXaa: 0.0 ± 0.0
Cys
0.712CysAla: 0.712 ± 0.257
0.079CysCys: 0.079 ± 0.076
0.474CysAsp: 0.474 ± 0.19
0.474CysGlu: 0.474 ± 0.177
0.237CysPhe: 0.237 ± 0.147
0.633CysGly: 0.633 ± 0.25
0.395CysHis: 0.395 ± 0.209
0.87CysIle: 0.87 ± 0.238
0.316CysLys: 0.316 ± 0.134
0.395CysLeu: 0.395 ± 0.162
0.079CysMet: 0.079 ± 0.091
0.316CysAsn: 0.316 ± 0.133
1.028CysPro: 1.028 ± 0.249
0.237CysGln: 0.237 ± 0.154
0.87CysArg: 0.87 ± 0.286
0.633CysSer: 0.633 ± 0.217
0.316CysThr: 0.316 ± 0.157
1.028CysVal: 1.028 ± 0.212
0.237CysTrp: 0.237 ± 0.146
0.554CysTyr: 0.554 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
6.642AspAla: 6.642 ± 0.886
0.791AspCys: 0.791 ± 0.262
3.558AspAsp: 3.558 ± 0.591
5.14AspGlu: 5.14 ± 0.704
2.768AspPhe: 2.768 ± 0.615
6.089AspGly: 6.089 ± 0.826
1.028AspHis: 1.028 ± 0.327
3.4AspIle: 3.4 ± 0.471
2.61AspLys: 2.61 ± 0.47
3.954AspLeu: 3.954 ± 0.418
1.502AspMet: 1.502 ± 0.356
3.163AspAsn: 3.163 ± 0.487
2.372AspPro: 2.372 ± 0.407
2.926AspGln: 2.926 ± 0.493
2.53AspArg: 2.53 ± 0.396
2.451AspSer: 2.451 ± 0.506
3.4AspThr: 3.4 ± 0.574
4.349AspVal: 4.349 ± 0.614
0.87AspTrp: 0.87 ± 0.257
1.74AspTyr: 1.74 ± 0.361
0.0AspXaa: 0.0 ± 0.0
Glu
5.852GluAla: 5.852 ± 0.728
0.791GluCys: 0.791 ± 0.213
1.186GluAsp: 1.186 ± 0.302
2.689GluGlu: 2.689 ± 0.444
2.451GluPhe: 2.451 ± 0.615
4.745GluGly: 4.745 ± 0.502
1.423GluHis: 1.423 ± 0.311
3.796GluIle: 3.796 ± 0.506
3.321GluLys: 3.321 ± 0.478
6.089GluLeu: 6.089 ± 0.671
1.344GluMet: 1.344 ± 0.302
1.977GluAsn: 1.977 ± 0.331
2.689GluPro: 2.689 ± 0.541
2.926GluGln: 2.926 ± 0.614
3.954GluArg: 3.954 ± 0.637
3.558GluSer: 3.558 ± 0.696
3.321GluThr: 3.321 ± 0.414
3.954GluVal: 3.954 ± 0.507
1.502GluTrp: 1.502 ± 0.286
1.819GluTyr: 1.819 ± 0.477
0.0GluXaa: 0.0 ± 0.0
Phe
2.689PheAla: 2.689 ± 0.413
0.316PheCys: 0.316 ± 0.154
2.293PheAsp: 2.293 ± 0.433
1.582PheGlu: 1.582 ± 0.349
0.87PhePhe: 0.87 ± 0.207
3.796PheGly: 3.796 ± 0.429
0.791PheHis: 0.791 ± 0.207
1.898PheIle: 1.898 ± 0.401
2.372PheLys: 2.372 ± 0.592
2.451PheLeu: 2.451 ± 0.448
1.423PheMet: 1.423 ± 0.356
2.214PheAsn: 2.214 ± 0.386
1.107PhePro: 1.107 ± 0.242
1.028PheGln: 1.028 ± 0.272
1.502PheArg: 1.502 ± 0.303
1.977PheSer: 1.977 ± 0.488
2.372PheThr: 2.372 ± 0.375
1.661PheVal: 1.661 ± 0.422
0.395PheTrp: 0.395 ± 0.172
0.791PheTyr: 0.791 ± 0.198
0.0PheXaa: 0.0 ± 0.0
Gly
7.908GlyAla: 7.908 ± 1.049
0.474GlyCys: 0.474 ± 0.194
4.033GlyAsp: 4.033 ± 0.572
4.112GlyGlu: 4.112 ± 0.547
3.163GlyPhe: 3.163 ± 0.56
7.67GlyGly: 7.67 ± 0.915
1.502GlyHis: 1.502 ± 0.423
4.586GlyIle: 4.586 ± 0.7
5.377GlyLys: 5.377 ± 0.643
5.852GlyLeu: 5.852 ± 0.733
2.135GlyMet: 2.135 ± 0.473
4.507GlyAsn: 4.507 ± 0.756
1.423GlyPro: 1.423 ± 0.339
3.638GlyGln: 3.638 ± 0.608
3.796GlyArg: 3.796 ± 0.519
5.14GlySer: 5.14 ± 0.658
6.801GlyThr: 6.801 ± 1.051
4.982GlyVal: 4.982 ± 0.676
1.423GlyTrp: 1.423 ± 0.293
3.717GlyTyr: 3.717 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
2.056HisAla: 2.056 ± 0.427
0.316HisCys: 0.316 ± 0.153
0.712HisAsp: 0.712 ± 0.206
1.344HisGlu: 1.344 ± 0.388
0.554HisPhe: 0.554 ± 0.217
1.344HisGly: 1.344 ± 0.36
0.474HisHis: 0.474 ± 0.181
0.87HisIle: 0.87 ± 0.311
0.87HisLys: 0.87 ± 0.246
1.502HisLeu: 1.502 ± 0.337
0.474HisMet: 0.474 ± 0.186
1.265HisAsn: 1.265 ± 0.326
0.474HisPro: 0.474 ± 0.2
0.316HisGln: 0.316 ± 0.166
1.028HisArg: 1.028 ± 0.294
0.633HisSer: 0.633 ± 0.247
1.502HisThr: 1.502 ± 0.386
0.712HisVal: 0.712 ± 0.197
0.712HisTrp: 0.712 ± 0.229
0.87HisTyr: 0.87 ± 0.237
0.0HisXaa: 0.0 ± 0.0
Ile
5.298IleAla: 5.298 ± 0.705
0.712IleCys: 0.712 ± 0.262
5.377IleAsp: 5.377 ± 0.572
4.191IleGlu: 4.191 ± 0.589
1.344IlePhe: 1.344 ± 0.337
5.061IleGly: 5.061 ± 0.726
1.186IleHis: 1.186 ± 0.231
3.321IleIle: 3.321 ± 0.547
3.242IleLys: 3.242 ± 0.364
4.191IleLeu: 4.191 ± 0.596
1.107IleMet: 1.107 ± 0.327
2.372IleAsn: 2.372 ± 0.37
2.61IlePro: 2.61 ± 0.396
1.819IleGln: 1.819 ± 0.374
3.321IleArg: 3.321 ± 0.48
2.847IleSer: 2.847 ± 0.498
4.033IleThr: 4.033 ± 0.831
4.666IleVal: 4.666 ± 0.497
0.316IleTrp: 0.316 ± 0.15
1.661IleTyr: 1.661 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
6.089LysAla: 6.089 ± 0.867
0.237LysCys: 0.237 ± 0.111
2.372LysAsp: 2.372 ± 0.347
3.163LysGlu: 3.163 ± 0.451
1.819LysPhe: 1.819 ± 0.355
4.112LysGly: 4.112 ± 0.646
1.028LysHis: 1.028 ± 0.272
4.349LysIle: 4.349 ± 0.602
3.479LysLys: 3.479 ± 0.602
5.298LysLeu: 5.298 ± 0.736
1.819LysMet: 1.819 ± 0.462
3.242LysAsn: 3.242 ± 0.47
2.926LysPro: 2.926 ± 0.572
3.242LysGln: 3.242 ± 0.543
3.875LysArg: 3.875 ± 0.567
3.796LysSer: 3.796 ± 0.558
3.4LysThr: 3.4 ± 0.504
3.638LysVal: 3.638 ± 0.453
1.186LysTrp: 1.186 ± 0.236
1.502LysTyr: 1.502 ± 0.328
0.0LysXaa: 0.0 ± 0.0
Leu
6.01LeuAla: 6.01 ± 0.663
0.949LeuCys: 0.949 ± 0.289
5.219LeuAsp: 5.219 ± 0.472
4.033LeuGlu: 4.033 ± 0.552
2.372LeuPhe: 2.372 ± 0.404
5.298LeuGly: 5.298 ± 0.855
1.344LeuHis: 1.344 ± 0.315
3.638LeuIle: 3.638 ± 0.486
5.219LeuLys: 5.219 ± 0.658
6.247LeuLeu: 6.247 ± 0.636
1.265LeuMet: 1.265 ± 0.324
3.4LeuAsn: 3.4 ± 0.492
4.982LeuPro: 4.982 ± 0.579
2.847LeuGln: 2.847 ± 0.463
5.377LeuArg: 5.377 ± 0.731
5.219LeuSer: 5.219 ± 0.646
5.931LeuThr: 5.931 ± 0.682
5.377LeuVal: 5.377 ± 0.731
1.344LeuTrp: 1.344 ± 0.281
1.74LeuTyr: 1.74 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
3.084MetAla: 3.084 ± 0.409
0.158MetCys: 0.158 ± 0.108
1.265MetAsp: 1.265 ± 0.307
0.633MetGlu: 0.633 ± 0.205
0.791MetPhe: 0.791 ± 0.254
2.53MetGly: 2.53 ± 0.523
0.712MetHis: 0.712 ± 0.238
0.949MetIle: 0.949 ± 0.232
1.344MetLys: 1.344 ± 0.341
2.056MetLeu: 2.056 ± 0.355
0.712MetMet: 0.712 ± 0.307
1.344MetAsn: 1.344 ± 0.333
1.107MetPro: 1.107 ± 0.313
1.502MetGln: 1.502 ± 0.345
1.977MetArg: 1.977 ± 0.442
1.582MetSer: 1.582 ± 0.419
1.186MetThr: 1.186 ± 0.314
1.661MetVal: 1.661 ± 0.522
0.158MetTrp: 0.158 ± 0.11
0.395MetTyr: 0.395 ± 0.168
0.0MetXaa: 0.0 ± 0.0
Asn
4.428AsnAla: 4.428 ± 0.532
0.316AsnCys: 0.316 ± 0.206
4.033AsnAsp: 4.033 ± 0.623
2.926AsnGlu: 2.926 ± 0.462
1.502AsnPhe: 1.502 ± 0.348
4.191AsnGly: 4.191 ± 0.632
0.633AsnHis: 0.633 ± 0.209
2.451AsnIle: 2.451 ± 0.491
2.214AsnLys: 2.214 ± 0.407
3.875AsnLeu: 3.875 ± 0.688
1.423AsnMet: 1.423 ± 0.269
1.819AsnAsn: 1.819 ± 0.358
2.53AsnPro: 2.53 ± 0.35
1.107AsnGln: 1.107 ± 0.241
3.084AsnArg: 3.084 ± 0.446
1.265AsnSer: 1.265 ± 0.274
3.4AsnThr: 3.4 ± 0.598
3.479AsnVal: 3.479 ± 0.599
0.474AsnTrp: 0.474 ± 0.155
1.582AsnTyr: 1.582 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
4.112ProAla: 4.112 ± 0.569
0.237ProCys: 0.237 ± 0.12
3.558ProAsp: 3.558 ± 0.681
3.321ProGlu: 3.321 ± 0.585
1.265ProPhe: 1.265 ± 0.375
3.4ProGly: 3.4 ± 0.496
0.791ProHis: 0.791 ± 0.218
2.293ProIle: 2.293 ± 0.372
3.084ProLys: 3.084 ± 0.544
2.372ProLeu: 2.372 ± 0.495
1.028ProMet: 1.028 ± 0.27
1.423ProAsn: 1.423 ± 0.319
2.056ProPro: 2.056 ± 0.483
1.74ProGln: 1.74 ± 0.276
1.977ProArg: 1.977 ± 0.328
2.056ProSer: 2.056 ± 0.513
3.321ProThr: 3.321 ± 0.506
3.717ProVal: 3.717 ± 0.736
0.554ProTrp: 0.554 ± 0.185
0.87ProTyr: 0.87 ± 0.257
0.0ProXaa: 0.0 ± 0.0
Gln
4.349GlnAla: 4.349 ± 0.667
0.554GlnCys: 0.554 ± 0.205
1.344GlnAsp: 1.344 ± 0.376
1.898GlnGlu: 1.898 ± 0.382
1.107GlnPhe: 1.107 ± 0.319
2.53GlnGly: 2.53 ± 0.517
0.316GlnHis: 0.316 ± 0.171
3.084GlnIle: 3.084 ± 0.62
3.084GlnLys: 3.084 ± 0.475
2.926GlnLeu: 2.926 ± 0.541
1.028GlnMet: 1.028 ± 0.265
1.502GlnAsn: 1.502 ± 0.359
2.293GlnPro: 2.293 ± 0.518
1.898GlnGln: 1.898 ± 0.51
2.372GlnArg: 2.372 ± 0.661
2.214GlnSer: 2.214 ± 0.442
3.479GlnThr: 3.479 ± 0.51
1.898GlnVal: 1.898 ± 0.424
0.633GlnTrp: 0.633 ± 0.202
1.028GlnTyr: 1.028 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
5.614ArgAla: 5.614 ± 0.703
0.554ArgCys: 0.554 ± 0.2
3.005ArgAsp: 3.005 ± 0.54
3.875ArgGlu: 3.875 ± 0.5
1.819ArgPhe: 1.819 ± 0.344
3.479ArgGly: 3.479 ± 0.6
0.87ArgHis: 0.87 ± 0.278
2.451ArgIle: 2.451 ± 0.432
3.954ArgLys: 3.954 ± 0.516
4.666ArgLeu: 4.666 ± 0.497
1.582ArgMet: 1.582 ± 0.355
2.53ArgAsn: 2.53 ± 0.43
2.056ArgPro: 2.056 ± 0.471
2.056ArgGln: 2.056 ± 0.351
3.005ArgArg: 3.005 ± 0.481
3.005ArgSer: 3.005 ± 0.427
3.558ArgThr: 3.558 ± 0.631
4.586ArgVal: 4.586 ± 0.548
0.949ArgTrp: 0.949 ± 0.285
1.661ArgTyr: 1.661 ± 0.273
0.0ArgXaa: 0.0 ± 0.0
Ser
4.191SerAla: 4.191 ± 0.586
0.474SerCys: 0.474 ± 0.16
3.163SerAsp: 3.163 ± 0.595
3.4SerGlu: 3.4 ± 0.39
1.661SerPhe: 1.661 ± 0.394
4.666SerGly: 4.666 ± 0.691
1.028SerHis: 1.028 ± 0.264
3.005SerIle: 3.005 ± 0.38
4.27SerLys: 4.27 ± 0.534
4.586SerLeu: 4.586 ± 0.7
1.582SerMet: 1.582 ± 0.566
2.451SerAsn: 2.451 ± 0.452
2.056SerPro: 2.056 ± 0.303
1.74SerGln: 1.74 ± 0.4
3.084SerArg: 3.084 ± 0.533
2.056SerSer: 2.056 ± 0.454
2.293SerThr: 2.293 ± 0.393
3.717SerVal: 3.717 ± 0.468
1.186SerTrp: 1.186 ± 0.276
1.582SerTyr: 1.582 ± 0.384
0.0SerXaa: 0.0 ± 0.0
Thr
7.908ThrAla: 7.908 ± 0.924
0.633ThrCys: 0.633 ± 0.258
4.824ThrAsp: 4.824 ± 0.583
3.4ThrGlu: 3.4 ± 0.607
3.321ThrPhe: 3.321 ± 0.461
6.01ThrGly: 6.01 ± 0.948
1.107ThrHis: 1.107 ± 0.334
4.982ThrIle: 4.982 ± 0.642
2.926ThrLys: 2.926 ± 0.477
4.824ThrLeu: 4.824 ± 0.577
1.344ThrMet: 1.344 ± 0.3
2.293ThrAsn: 2.293 ± 0.396
3.4ThrPro: 3.4 ± 0.524
2.135ThrGln: 2.135 ± 0.432
2.372ThrArg: 2.372 ± 0.348
3.084ThrSer: 3.084 ± 0.446
4.507ThrThr: 4.507 ± 0.832
4.507ThrVal: 4.507 ± 0.719
0.791ThrTrp: 0.791 ± 0.205
1.582ThrTyr: 1.582 ± 0.359
0.0ThrXaa: 0.0 ± 0.0
Val
5.298ValAla: 5.298 ± 0.758
0.712ValCys: 0.712 ± 0.217
4.903ValAsp: 4.903 ± 0.611
3.717ValGlu: 3.717 ± 0.565
1.977ValPhe: 1.977 ± 0.322
5.219ValGly: 5.219 ± 0.936
1.028ValHis: 1.028 ± 0.292
5.061ValIle: 5.061 ± 0.613
3.717ValLys: 3.717 ± 0.613
5.061ValLeu: 5.061 ± 0.589
1.74ValMet: 1.74 ± 0.387
3.638ValAsn: 3.638 ± 0.477
2.847ValPro: 2.847 ± 0.438
2.926ValGln: 2.926 ± 0.542
4.349ValArg: 4.349 ± 0.566
3.321ValSer: 3.321 ± 0.467
4.349ValThr: 4.349 ± 0.706
4.112ValVal: 4.112 ± 0.613
1.186ValTrp: 1.186 ± 0.283
1.819ValTyr: 1.819 ± 0.361
0.0ValXaa: 0.0 ± 0.0
Trp
1.819TrpAla: 1.819 ± 0.494
0.158TrpCys: 0.158 ± 0.101
1.028TrpAsp: 1.028 ± 0.224
1.265TrpGlu: 1.265 ± 0.328
0.316TrpPhe: 0.316 ± 0.13
1.344TrpGly: 1.344 ± 0.318
0.316TrpHis: 0.316 ± 0.135
0.633TrpIle: 0.633 ± 0.222
1.107TrpLys: 1.107 ± 0.347
1.502TrpLeu: 1.502 ± 0.236
0.474TrpMet: 0.474 ± 0.176
0.712TrpAsn: 0.712 ± 0.236
0.554TrpPro: 0.554 ± 0.274
0.633TrpGln: 0.633 ± 0.211
0.87TrpArg: 0.87 ± 0.256
1.186TrpSer: 1.186 ± 0.265
1.028TrpThr: 1.028 ± 0.286
0.633TrpVal: 0.633 ± 0.226
0.316TrpTrp: 0.316 ± 0.206
0.395TrpTyr: 0.395 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.768TyrAla: 2.768 ± 0.455
0.474TyrCys: 0.474 ± 0.207
2.214TyrAsp: 2.214 ± 0.412
2.293TyrGlu: 2.293 ± 0.444
0.633TyrPhe: 0.633 ± 0.163
2.056TyrGly: 2.056 ± 0.407
0.474TyrHis: 0.474 ± 0.238
1.423TyrIle: 1.423 ± 0.346
1.423TyrLys: 1.423 ± 0.309
2.847TyrLeu: 2.847 ± 0.511
0.791TyrMet: 0.791 ± 0.29
1.582TyrAsn: 1.582 ± 0.433
1.265TyrPro: 1.265 ± 0.265
0.949TyrGln: 0.949 ± 0.253
1.819TyrArg: 1.819 ± 0.386
1.502TyrSer: 1.502 ± 0.362
1.74TyrThr: 1.74 ± 0.409
1.582TyrVal: 1.582 ± 0.429
0.395TyrTrp: 0.395 ± 0.138
0.633TyrTyr: 0.633 ± 0.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (12647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski