Amino acid dipepetide frequency for Rhodopirellula sp. MGV

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.446AlaAla: 10.446 ± 0.103	1.12AlaCys: 1.12 ± 0.027	6.12AlaAsp: 6.12 ± 0.067	6.257AlaGlu: 6.257 ± 0.068	3.536AlaPhe: 3.536 ± 0.046	7.23AlaGly: 7.23 ± 0.071	1.379AlaHis: 1.379 ± 0.03	6.528AlaIle: 6.528 ± 0.068	4.179AlaLys: 4.179 ± 0.063	7.65AlaLeu: 7.65 ± 0.07	2.749AlaMet: 2.749 ± 0.037	3.374AlaAsn: 3.374 ± 0.049	3.692AlaPro: 3.692 ± 0.046	3.054AlaGln: 3.054 ± 0.038	4.771AlaArg: 4.771 ± 0.055	7.018AlaSer: 7.018 ± 0.066	6.022AlaThr: 6.022 ± 0.069	6.655AlaVal: 6.655 ± 0.056	1.17AlaTrp: 1.17 ± 0.025	2.017AlaTyr: 2.017 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.752CysAla: 0.752 ± 0.02	0.23CysCys: 0.23 ± 0.012	0.848CysAsp: 0.848 ± 0.024	0.782CysGlu: 0.782 ± 0.023	0.469CysPhe: 0.469 ± 0.017	1.07CysGly: 1.07 ± 0.027	0.41CysHis: 0.41 ± 0.019	0.452CysIle: 0.452 ± 0.014	0.368CysLys: 0.368 ± 0.016	1.138CysLeu: 1.138 ± 0.03	0.197CysMet: 0.197 ± 0.01	0.339CysAsn: 0.339 ± 0.013	0.552CysPro: 0.552 ± 0.019	0.45CysGln: 0.45 ± 0.016	0.795CysArg: 0.795 ± 0.027	0.753CysSer: 0.753 ± 0.02	0.474CysThr: 0.474 ± 0.019	0.877CysVal: 0.877 ± 0.022	0.171CysTrp: 0.171 ± 0.009	0.294CysTyr: 0.294 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.581AspAla: 6.581 ± 0.072	0.69AspCys: 0.69 ± 0.023	4.394AspAsp: 4.394 ± 0.06	4.461AspGlu: 4.461 ± 0.05	2.517AspPhe: 2.517 ± 0.038	5.569AspGly: 5.569 ± 0.096	1.551AspHis: 1.551 ± 0.034	2.485AspIle: 2.485 ± 0.044	1.749AspLys: 1.749 ± 0.036	6.169AspLeu: 6.169 ± 0.064	1.018AspMet: 1.018 ± 0.023	1.841AspAsn: 1.841 ± 0.039	3.721AspPro: 3.721 ± 0.051	3.201AspGln: 3.201 ± 0.045	4.606AspArg: 4.606 ± 0.05	4.423AspSer: 4.423 ± 0.062	2.728AspThr: 2.728 ± 0.051	4.51AspVal: 4.51 ± 0.055	1.066AspTrp: 1.066 ± 0.026	1.639AspTyr: 1.639 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.579GluAla: 5.579 ± 0.071	0.559GluCys: 0.559 ± 0.018	2.917GluAsp: 2.917 ± 0.041	3.07GluGlu: 3.07 ± 0.05	2.367GluPhe: 2.367 ± 0.038	3.576GluGly: 3.576 ± 0.045	1.374GluHis: 1.374 ± 0.034	3.695GluIle: 3.695 ± 0.044	2.355GluLys: 2.355 ± 0.045	6.971GluLeu: 6.971 ± 0.086	1.56GluMet: 1.56 ± 0.03	2.143GluAsn: 2.143 ± 0.033	2.69GluPro: 2.69 ± 0.04	3.112GluGln: 3.112 ± 0.045	4.125GluArg: 4.125 ± 0.062	5.074GluSer: 5.074 ± 0.063	4.047GluThr: 4.047 ± 0.051	4.079GluVal: 4.079 ± 0.048	0.653GluTrp: 0.653 ± 0.02	1.38GluTyr: 1.38 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.981PheAla: 3.981 ± 0.047	0.473PheCys: 0.473 ± 0.017	3.143PheAsp: 3.143 ± 0.047	2.525PheGlu: 2.525 ± 0.037	1.411PhePhe: 1.411 ± 0.03	3.355PheGly: 3.355 ± 0.051	0.813PheHis: 0.813 ± 0.022	1.452PheIle: 1.452 ± 0.027	1.028PheLys: 1.028 ± 0.027	3.163PheLeu: 3.163 ± 0.046	0.604PheMet: 0.604 ± 0.019	1.226PheAsn: 1.226 ± 0.025	1.555PhePro: 1.555 ± 0.027	1.45PheGln: 1.45 ± 0.026	2.39PheArg: 2.39 ± 0.035	2.513PheSer: 2.513 ± 0.035	1.933PheThr: 1.933 ± 0.046	2.937PheVal: 2.937 ± 0.04	0.57PheTrp: 0.57 ± 0.018	0.937PheTyr: 0.937 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	5.6GlyAla: 5.6 ± 0.068	1.025GlyCys: 1.025 ± 0.028	4.999GlyAsp: 4.999 ± 0.079	4.653GlyGlu: 4.653 ± 0.054	2.997GlyPhe: 2.997 ± 0.039	6.242GlyGly: 6.242 ± 0.097	1.562GlyHis: 1.562 ± 0.025	4.116GlyIle: 4.116 ± 0.054	3.332GlyLys: 3.332 ± 0.048	6.731GlyLeu: 6.731 ± 0.067	1.945GlyMet: 1.945 ± 0.037	2.919GlyAsn: 2.919 ± 0.065	2.926GlyPro: 2.926 ± 0.049	3.229GlyGln: 3.229 ± 0.044	4.604GlyArg: 4.604 ± 0.051	4.869GlySer: 4.869 ± 0.068	4.599GlyThr: 4.599 ± 0.076	5.204GlyVal: 5.204 ± 0.057	1.193GlyTrp: 1.193 ± 0.03	2.099GlyTyr: 2.099 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.906HisAla: 1.906 ± 0.036	0.348HisCys: 0.348 ± 0.013	1.312HisAsp: 1.312 ± 0.025	1.166HisGlu: 1.166 ± 0.031	0.937HisPhe: 0.937 ± 0.022	1.624HisGly: 1.624 ± 0.036	0.669HisHis: 0.669 ± 0.021	0.74HisIle: 0.74 ± 0.021	0.484HisLys: 0.484 ± 0.014	2.154HisLeu: 2.154 ± 0.033	0.331HisMet: 0.331 ± 0.015	0.596HisAsn: 0.596 ± 0.016	1.336HisPro: 1.336 ± 0.023	1.106HisGln: 1.106 ± 0.022	1.677HisArg: 1.677 ± 0.029	1.387HisSer: 1.387 ± 0.028	0.903HisThr: 0.903 ± 0.022	1.413HisVal: 1.413 ± 0.028	0.454HisTrp: 0.454 ± 0.016	0.623HisTyr: 0.623 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.42IleAla: 6.42 ± 0.056	0.634IleCys: 0.634 ± 0.018	4.708IleAsp: 4.708 ± 0.052	4.376IleGlu: 4.376 ± 0.052	1.346IlePhe: 1.346 ± 0.026	4.564IleGly: 4.564 ± 0.054	1.089IleHis: 1.089 ± 0.024	1.898IleIle: 1.898 ± 0.032	1.654IleLys: 1.654 ± 0.031	3.86IleLeu: 3.86 ± 0.053	0.675IleMet: 0.675 ± 0.022	1.815IleAsn: 1.815 ± 0.033	2.491IlePro: 2.491 ± 0.036	1.823IleGln: 1.823 ± 0.032	3.691IleArg: 3.691 ± 0.046	3.286IleSer: 3.286 ± 0.046	2.731IleThr: 2.731 ± 0.049	4.104IleVal: 4.104 ± 0.052	0.593IleTrp: 0.593 ± 0.019	1.119IleTyr: 1.119 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.099LysAla: 3.099 ± 0.059	0.3LysCys: 0.3 ± 0.013	1.777LysAsp: 1.777 ± 0.033	1.79LysGlu: 1.79 ± 0.038	1.136LysPhe: 1.136 ± 0.026	1.9LysGly: 1.9 ± 0.034	0.822LysHis: 0.822 ± 0.022	1.781LysIle: 1.781 ± 0.038	1.562LysLys: 1.562 ± 0.041	3.983LysLeu: 3.983 ± 0.054	0.832LysMet: 0.832 ± 0.023	1.085LysAsn: 1.085 ± 0.024	2.029LysPro: 2.029 ± 0.042	1.799LysGln: 1.799 ± 0.034	2.728LysArg: 2.728 ± 0.048	2.542LysSer: 2.542 ± 0.044	2.2LysThr: 2.2 ± 0.04	2.354LysVal: 2.354 ± 0.035	0.455LysTrp: 0.455 ± 0.016	0.775LysTyr: 0.775 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	10.346LeuAla: 10.346 ± 0.095	1.137LeuCys: 1.137 ± 0.026	6.174LeuAsp: 6.174 ± 0.067	5.536LeuGlu: 5.536 ± 0.066	3.32LeuPhe: 3.32 ± 0.051	6.851LeuGly: 6.851 ± 0.061	1.984LeuHis: 1.984 ± 0.038	5.124LeuIle: 5.124 ± 0.054	3.33LeuLys: 3.33 ± 0.049	9.217LeuLeu: 9.217 ± 0.093	2.015LeuMet: 2.015 ± 0.034	2.983LeuAsn: 2.983 ± 0.038	5.267LeuPro: 5.267 ± 0.058	3.785LeuGln: 3.785 ± 0.041	6.403LeuArg: 6.403 ± 0.07	6.857LeuSer: 6.857 ± 0.058	5.439LeuThr: 5.439 ± 0.065	7.006LeuVal: 7.006 ± 0.063	1.145LeuTrp: 1.145 ± 0.027	2.015LeuTyr: 2.015 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.038MetAla: 2.038 ± 0.035	0.2MetCys: 0.2 ± 0.01	1.092MetAsp: 1.092 ± 0.022	1.035MetGlu: 1.035 ± 0.025	0.749MetPhe: 0.749 ± 0.018	1.45MetGly: 1.45 ± 0.026	0.463MetHis: 0.463 ± 0.016	1.318MetIle: 1.318 ± 0.026	0.944MetLys: 0.944 ± 0.025	2.376MetLeu: 2.376 ± 0.041	0.656MetMet: 0.656 ± 0.017	0.845MetAsn: 0.845 ± 0.023	1.336MetPro: 1.336 ± 0.03	0.962MetGln: 0.962 ± 0.024	1.528MetArg: 1.528 ± 0.032	1.56MetSer: 1.56 ± 0.029	1.479MetThr: 1.479 ± 0.027	1.598MetVal: 1.598 ± 0.026	0.245MetTrp: 0.245 ± 0.012	0.367MetTyr: 0.367 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.335AsnAla: 3.335 ± 0.044	0.376AsnCys: 0.376 ± 0.014	2.314AsnAsp: 2.314 ± 0.051	2.225AsnGlu: 2.225 ± 0.034	1.123AsnPhe: 1.123 ± 0.027	2.831AsnGly: 2.831 ± 0.071	0.8AsnHis: 0.8 ± 0.02	1.268AsnIle: 1.268 ± 0.027	0.817AsnLys: 0.817 ± 0.026	3.098AsnLeu: 3.098 ± 0.046	0.542AsnMet: 0.542 ± 0.018	1.119AsnAsn: 1.119 ± 0.035	2.022AsnPro: 2.022 ± 0.037	1.589AsnGln: 1.589 ± 0.038	2.537AsnArg: 2.537 ± 0.035	2.127AsnSer: 2.127 ± 0.043	1.649AsnThr: 1.649 ± 0.038	2.493AsnVal: 2.493 ± 0.039	0.527AsnTrp: 0.527 ± 0.018	0.814AsnTyr: 0.814 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	4.679ProAla: 4.679 ± 0.059	0.386ProCys: 0.386 ± 0.015	3.346ProAsp: 3.346 ± 0.051	3.505ProGlu: 3.505 ± 0.045	1.74ProPhe: 1.74 ± 0.034	3.532ProGly: 3.532 ± 0.053	0.974ProHis: 0.974 ± 0.021	2.874ProIle: 2.874 ± 0.039	1.829ProLys: 1.829 ± 0.036	4.21ProLeu: 4.21 ± 0.047	1.17ProMet: 1.17 ± 0.025	1.998ProAsn: 1.998 ± 0.032	2.525ProPro: 2.525 ± 0.045	1.908ProGln: 1.908 ± 0.029	2.452ProArg: 2.452 ± 0.043	3.831ProSer: 3.831 ± 0.046	3.158ProThr: 3.158 ± 0.047	3.621ProVal: 3.621 ± 0.047	0.664ProTrp: 0.664 ± 0.018	1.103ProTyr: 1.103 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.918GlnAla: 3.918 ± 0.045	0.424GlnCys: 0.424 ± 0.015	1.816GlnAsp: 1.816 ± 0.03	1.796GlnGlu: 1.796 ± 0.034	1.725GlnPhe: 1.725 ± 0.027	2.385GlnGly: 2.385 ± 0.039	0.944GlnHis: 0.944 ± 0.023	2.498GlnIle: 2.498 ± 0.042	1.319GlnLys: 1.319 ± 0.027	4.675GlnLeu: 4.675 ± 0.056	1.033GlnMet: 1.033 ± 0.024	1.308GlnAsn: 1.308 ± 0.028	2.288GlnPro: 2.288 ± 0.034	2.334GlnGln: 2.334 ± 0.045	3.104GlnArg: 3.104 ± 0.051	3.549GlnSer: 3.549 ± 0.05	2.756GlnThr: 2.756 ± 0.043	2.82GlnVal: 2.82 ± 0.035	0.699GlnTrp: 0.699 ± 0.02	0.999GlnTyr: 0.999 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	4.464ArgAla: 4.464 ± 0.057	0.862ArgCys: 0.862 ± 0.027	3.976ArgAsp: 3.976 ± 0.05	3.923ArgGlu: 3.923 ± 0.056	2.969ArgPhe: 2.969 ± 0.042	4.036ArgGly: 4.036 ± 0.049	1.493ArgHis: 1.493 ± 0.033	3.534ArgIle: 3.534 ± 0.045	2.375ArgLys: 2.375 ± 0.043	7.255ArgLeu: 7.255 ± 0.071	1.719ArgMet: 1.719 ± 0.033	2.139ArgAsn: 2.139 ± 0.033	2.989ArgPro: 2.989 ± 0.045	3.24ArgGln: 3.24 ± 0.046	5.201ArgArg: 5.201 ± 0.072	4.496ArgSer: 4.496 ± 0.055	3.21ArgThr: 3.21 ± 0.039	4.392ArgVal: 4.392 ± 0.05	1.23ArgTrp: 1.23 ± 0.022	1.958ArgTyr: 1.958 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.985SerAla: 5.985 ± 0.058	0.671SerCys: 0.671 ± 0.022	4.968SerAsp: 4.968 ± 0.068	4.382SerGlu: 4.382 ± 0.054	2.561SerPhe: 2.561 ± 0.035	6.117SerGly: 6.117 ± 0.09	1.419SerHis: 1.419 ± 0.028	4.021SerIle: 4.021 ± 0.042	2.325SerLys: 2.325 ± 0.041	6.929SerLeu: 6.929 ± 0.065	1.617SerMet: 1.617 ± 0.028	2.433SerAsn: 2.433 ± 0.042	3.634SerPro: 3.634 ± 0.045	2.871SerGln: 2.871 ± 0.04	4.2SerArg: 4.2 ± 0.054	4.829SerSer: 4.829 ± 0.074	3.885SerThr: 3.885 ± 0.07	5.256SerVal: 5.256 ± 0.063	0.856SerTrp: 0.856 ± 0.021	1.439SerTyr: 1.439 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.415ThrAla: 5.415 ± 0.066	0.54ThrCys: 0.54 ± 0.019	3.614ThrAsp: 3.614 ± 0.062	3.364ThrGlu: 3.364 ± 0.043	2.229ThrPhe: 2.229 ± 0.046	4.544ThrGly: 4.544 ± 0.075	1.078ThrHis: 1.078 ± 0.021	3.451ThrIle: 3.451 ± 0.054	1.861ThrLys: 1.861 ± 0.035	5.697ThrLeu: 5.697 ± 0.066	1.148ThrMet: 1.148 ± 0.026	1.903ThrAsn: 1.903 ± 0.04	3.311ThrPro: 3.311 ± 0.047	1.979ThrGln: 1.979 ± 0.029	3.026ThrArg: 3.026 ± 0.037	3.844ThrSer: 3.844 ± 0.06	3.377ThrThr: 3.377 ± 0.073	4.387ThrVal: 4.387 ± 0.083	0.739ThrTrp: 0.739 ± 0.022	1.309ThrTyr: 1.309 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.375ValAla: 7.375 ± 0.06	0.925ValCys: 0.925 ± 0.024	5.005ValAsp: 5.005 ± 0.071	4.381ValGlu: 4.381 ± 0.055	2.706ValPhe: 2.706 ± 0.04	5.227ValGly: 5.227 ± 0.059	1.386ValHis: 1.386 ± 0.026	3.98ValIle: 3.98 ± 0.049	2.187ValLys: 2.187 ± 0.037	6.613ValLeu: 6.613 ± 0.066	1.604ValMet: 1.604 ± 0.031	2.303ValAsn: 2.303 ± 0.047	3.408ValPro: 3.408 ± 0.043	2.502ValGln: 2.502 ± 0.037	4.619ValArg: 4.619 ± 0.051	5.025ValSer: 5.025 ± 0.056	4.336ValThr: 4.336 ± 0.072	5.768ValVal: 5.768 ± 0.067	0.989ValTrp: 0.989 ± 0.025	1.672ValTyr: 1.672 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.02TrpAla: 1.02 ± 0.024	0.205TrpCys: 0.205 ± 0.01	0.791TrpAsp: 0.791 ± 0.02	0.665TrpGlu: 0.665 ± 0.018	0.585TrpPhe: 0.585 ± 0.021	0.818TrpGly: 0.818 ± 0.025	0.357TrpHis: 0.357 ± 0.012	0.873TrpIle: 0.873 ± 0.024	0.631TrpLys: 0.631 ± 0.017	1.604TrpLeu: 1.604 ± 0.034	0.441TrpMet: 0.441 ± 0.015	0.54TrpAsn: 0.54 ± 0.017	0.616TrpPro: 0.616 ± 0.019	0.744TrpGln: 0.744 ± 0.019	0.902TrpArg: 0.902 ± 0.019	0.963TrpSer: 0.963 ± 0.022	0.817TrpThr: 0.817 ± 0.021	0.917TrpVal: 0.917 ± 0.022	0.239TrpTrp: 0.239 ± 0.014	0.362TrpTyr: 0.362 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.031TyrAla: 2.031 ± 0.033	0.319TyrCys: 0.319 ± 0.012	1.602TyrAsp: 1.602 ± 0.052	1.436TyrGlu: 1.436 ± 0.027	1.038TyrPhe: 1.038 ± 0.023	1.923TyrGly: 1.923 ± 0.04	0.6TyrHis: 0.6 ± 0.016	0.789TyrIle: 0.789 ± 0.019	0.618TyrLys: 0.618 ± 0.02	2.441TyrLeu: 2.441 ± 0.036	0.384TyrMet: 0.384 ± 0.015	0.695TyrAsn: 0.695 ± 0.023	1.116TyrPro: 1.116 ± 0.025	1.253TyrGln: 1.253 ± 0.028	2.101TyrArg: 2.101 ± 0.035	1.453TyrSer: 1.453 ± 0.027	1.073TyrThr: 1.073 ± 0.032	1.619TyrVal: 1.619 ± 0.036	0.429TyrTrp: 0.429 ± 0.018	0.698TyrTyr: 0.698 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5273 proteins (2047646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---