Amino acid dipepetide frequency for Ruminococcus bromii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.638AlaAla: 5.638 ± 0.115	1.061AlaCys: 1.061 ± 0.041	4.506AlaAsp: 4.506 ± 0.071	5.102AlaGlu: 5.102 ± 0.097	2.97AlaPhe: 2.97 ± 0.073	4.416AlaGly: 4.416 ± 0.107	1.003AlaHis: 1.003 ± 0.041	5.125AlaIle: 5.125 ± 0.087	5.363AlaLys: 5.363 ± 0.101	6.106AlaLeu: 6.106 ± 0.104	1.84AlaMet: 1.84 ± 0.054	3.09AlaAsn: 3.09 ± 0.064	1.947AlaPro: 1.947 ± 0.066	2.183AlaGln: 2.183 ± 0.056	2.332AlaArg: 2.332 ± 0.068	3.926AlaSer: 3.926 ± 0.076	3.429AlaThr: 3.429 ± 0.095	5.863AlaVal: 5.863 ± 0.105	0.429AlaTrp: 0.429 ± 0.025	2.426AlaTyr: 2.426 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.157CysAla: 1.157 ± 0.038	0.374CysCys: 0.374 ± 0.025	1.235CysAsp: 1.235 ± 0.042	1.069CysGlu: 1.069 ± 0.038	0.719CysPhe: 0.719 ± 0.032	1.741CysGly: 1.741 ± 0.058	0.299CysHis: 0.299 ± 0.019	1.235CysIle: 1.235 ± 0.041	1.212CysLys: 1.212 ± 0.044	1.124CysLeu: 1.124 ± 0.041	0.39CysMet: 0.39 ± 0.024	0.908CysAsn: 0.908 ± 0.03	0.638CysPro: 0.638 ± 0.034	0.416CysGln: 0.416 ± 0.023	0.663CysArg: 0.663 ± 0.032	1.217CysSer: 1.217 ± 0.038	0.857CysThr: 0.857 ± 0.031	1.176CysVal: 1.176 ± 0.039	0.12CysTrp: 0.12 ± 0.012	0.642CysTyr: 0.642 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	3.538AspAla: 3.538 ± 0.075	1.079AspCys: 1.079 ± 0.04	4.023AspAsp: 4.023 ± 0.08	5.237AspGlu: 5.237 ± 0.094	3.242AspPhe: 3.242 ± 0.081	4.784AspGly: 4.784 ± 0.093	0.586AspHis: 0.586 ± 0.028	5.111AspIle: 5.111 ± 0.082	5.065AspLys: 5.065 ± 0.084	4.302AspLeu: 4.302 ± 0.091	1.699AspMet: 1.699 ± 0.049	3.783AspAsn: 3.783 ± 0.093	1.324AspPro: 1.324 ± 0.048	0.742AspGln: 0.742 ± 0.032	1.989AspArg: 1.989 ± 0.052	4.161AspSer: 4.161 ± 0.102	3.296AspThr: 3.296 ± 0.072	4.061AspVal: 4.061 ± 0.073	0.509AspTrp: 0.509 ± 0.031	3.199AspTyr: 3.199 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	4.24GluAla: 4.24 ± 0.087	1.013GluCys: 1.013 ± 0.041	3.396GluAsp: 3.396 ± 0.078	4.681GluGlu: 4.681 ± 0.1	2.799GluPhe: 2.799 ± 0.058	3.013GluGly: 3.013 ± 0.069	1.148GluHis: 1.148 ± 0.044	5.833GluIle: 5.833 ± 0.109	6.12GluLys: 6.12 ± 0.1	6.189GluLeu: 6.189 ± 0.099	1.822GluMet: 1.822 ± 0.052	4.975GluAsn: 4.975 ± 0.094	1.7GluPro: 1.7 ± 0.052	2.626GluGln: 2.626 ± 0.065	2.707GluArg: 2.707 ± 0.073	3.693GluSer: 3.693 ± 0.078	3.264GluThr: 3.264 ± 0.073	3.886GluVal: 3.886 ± 0.081	0.596GluTrp: 0.596 ± 0.028	3.153GluTyr: 3.153 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.261PheAla: 3.261 ± 0.074	0.925PheCys: 0.925 ± 0.036	3.383PheAsp: 3.383 ± 0.075	2.986PheGlu: 2.986 ± 0.079	1.945PhePhe: 1.945 ± 0.06	3.314PheGly: 3.314 ± 0.07	0.597PheHis: 0.597 ± 0.029	3.233PheIle: 3.233 ± 0.073	2.779PheLys: 2.779 ± 0.06	3.468PheLeu: 3.468 ± 0.085	0.992PheMet: 0.992 ± 0.036	2.288PheAsn: 2.288 ± 0.049	1.328PhePro: 1.328 ± 0.044	0.946PheGln: 0.946 ± 0.034	1.471PheArg: 1.471 ± 0.045	3.457PheSer: 3.457 ± 0.068	2.476PheThr: 2.476 ± 0.063	3.084PheVal: 3.084 ± 0.071	0.379PheTrp: 0.379 ± 0.029	1.834PheTyr: 1.834 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.328GlyAla: 4.328 ± 0.111	1.19GlyCys: 1.19 ± 0.044	3.655GlyAsp: 3.655 ± 0.071	4.144GlyGlu: 4.144 ± 0.079	3.082GlyPhe: 3.082 ± 0.061	4.384GlyGly: 4.384 ± 0.094	0.965GlyHis: 0.965 ± 0.034	5.489GlyIle: 5.489 ± 0.091	5.591GlyLys: 5.591 ± 0.087	4.892GlyLeu: 4.892 ± 0.094	1.818GlyMet: 1.818 ± 0.056	3.429GlyAsn: 3.429 ± 0.086	0.862GlyPro: 0.862 ± 0.057	1.619GlyGln: 1.619 ± 0.047	2.396GlyArg: 2.396 ± 0.057	4.023GlySer: 4.023 ± 0.085	3.808GlyThr: 3.808 ± 0.077	4.881GlyVal: 4.881 ± 0.092	0.592GlyTrp: 0.592 ± 0.03	3.097GlyTyr: 3.097 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	0.815HisAla: 0.815 ± 0.032	0.355HisCys: 0.355 ± 0.023	0.734HisAsp: 0.734 ± 0.031	0.709HisGlu: 0.709 ± 0.033	0.778HisPhe: 0.778 ± 0.031	1.071HisGly: 1.071 ± 0.039	0.317HisHis: 0.317 ± 0.029	1.375HisIle: 1.375 ± 0.044	1.114HisLys: 1.114 ± 0.037	1.23HisLeu: 1.23 ± 0.045	0.356HisMet: 0.356 ± 0.023	0.933HisAsn: 0.933 ± 0.037	0.698HisPro: 0.698 ± 0.032	0.394HisGln: 0.394 ± 0.021	0.69HisArg: 0.69 ± 0.037	1.083HisSer: 1.083 ± 0.036	0.879HisThr: 0.879 ± 0.03	0.688HisVal: 0.688 ± 0.027	0.129HisTrp: 0.129 ± 0.012	0.734HisTyr: 0.734 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.852IleAla: 5.852 ± 0.098	1.515IleCys: 1.515 ± 0.052	5.306IleAsp: 5.306 ± 0.095	5.041IleGlu: 5.041 ± 0.097	3.123IlePhe: 3.123 ± 0.075	4.891IleGly: 4.891 ± 0.093	1.109IleHis: 1.109 ± 0.042	6.629IleIle: 6.629 ± 0.136	6.198IleLys: 6.198 ± 0.094	6.359IleLeu: 6.359 ± 0.105	1.848IleMet: 1.848 ± 0.056	4.478IleAsn: 4.478 ± 0.08	2.872IlePro: 2.872 ± 0.061	1.936IleGln: 1.936 ± 0.048	2.901IleArg: 2.901 ± 0.077	5.907IleSer: 5.907 ± 0.101	4.677IleThr: 4.677 ± 0.08	5.157IleVal: 5.157 ± 0.095	0.544IleTrp: 0.544 ± 0.028	2.947IleTyr: 2.947 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.203LysAla: 5.203 ± 0.085	1.082LysCys: 1.082 ± 0.041	4.443LysAsp: 4.443 ± 0.077	5.4LysGlu: 5.4 ± 0.091	2.798LysPhe: 2.798 ± 0.062	4.097LysGly: 4.097 ± 0.079	1.171LysHis: 1.171 ± 0.044	6.449LysIle: 6.449 ± 0.086	6.354LysLys: 6.354 ± 0.112	6.51LysLeu: 6.51 ± 0.093	2.156LysMet: 2.156 ± 0.061	5.017LysAsn: 5.017 ± 0.099	2.439LysPro: 2.439 ± 0.064	2.584LysGln: 2.584 ± 0.06	3.362LysArg: 3.362 ± 0.083	5.267LysSer: 5.267 ± 0.086	4.73LysThr: 4.73 ± 0.08	4.42LysVal: 4.42 ± 0.074	0.617LysTrp: 0.617 ± 0.03	3.79LysTyr: 3.79 ± 0.08	0.0LysXaa: 0.0 ± 0.0
Leu	5.633LeuAla: 5.633 ± 0.086	1.691LeuCys: 1.691 ± 0.044	5.014LeuAsp: 5.014 ± 0.082	4.92LeuGlu: 4.92 ± 0.09	3.843LeuPhe: 3.843 ± 0.097	5.19LeuGly: 5.19 ± 0.109	1.304LeuHis: 1.304 ± 0.047	6.174LeuIle: 6.174 ± 0.123	6.665LeuLys: 6.665 ± 0.109	7.153LeuLeu: 7.153 ± 0.124	2.193LeuMet: 2.193 ± 0.062	4.552LeuAsn: 4.552 ± 0.073	3.113LeuPro: 3.113 ± 0.065	2.238LeuGln: 2.238 ± 0.056	3.193LeuArg: 3.193 ± 0.073	6.783LeuSer: 6.783 ± 0.129	4.765LeuThr: 4.765 ± 0.086	4.793LeuVal: 4.793 ± 0.084	0.655LeuTrp: 0.655 ± 0.032	3.279LeuTyr: 3.279 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.785MetAla: 1.785 ± 0.05	0.414MetCys: 0.414 ± 0.025	1.316MetAsp: 1.316 ± 0.046	1.367MetGlu: 1.367 ± 0.039	1.176MetPhe: 1.176 ± 0.038	1.526MetGly: 1.526 ± 0.057	0.357MetHis: 0.357 ± 0.02	1.842MetIle: 1.842 ± 0.051	2.148MetLys: 2.148 ± 0.058	2.613MetLeu: 2.613 ± 0.068	0.675MetMet: 0.675 ± 0.036	1.493MetAsn: 1.493 ± 0.047	1.049MetPro: 1.049 ± 0.038	0.941MetGln: 0.941 ± 0.033	1.022MetArg: 1.022 ± 0.041	1.798MetSer: 1.798 ± 0.052	1.493MetThr: 1.493 ± 0.045	1.44MetVal: 1.44 ± 0.046	0.188MetTrp: 0.188 ± 0.017	0.869MetTyr: 0.869 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.9AsnAla: 3.9 ± 0.086	0.984AsnCys: 0.984 ± 0.035	3.27AsnAsp: 3.27 ± 0.073	3.62AsnGlu: 3.62 ± 0.076	2.189AsnPhe: 2.189 ± 0.065	4.402AsnGly: 4.402 ± 0.086	0.82AsnHis: 0.82 ± 0.038	4.763AsnIle: 4.763 ± 0.103	4.091AsnLys: 4.091 ± 0.076	4.547AsnLeu: 4.547 ± 0.078	1.358AsnMet: 1.358 ± 0.045	3.463AsnAsn: 3.463 ± 0.095	2.269AsnPro: 2.269 ± 0.059	1.582AsnGln: 1.582 ± 0.048	2.11AsnArg: 2.11 ± 0.054	4.061AsnSer: 4.061 ± 0.096	3.17AsnThr: 3.17 ± 0.074	3.643AsnVal: 3.643 ± 0.076	0.476AsnTrp: 0.476 ± 0.029	2.541AsnTyr: 2.541 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.895ProAla: 1.895 ± 0.055	0.482ProCys: 0.482 ± 0.025	2.133ProAsp: 2.133 ± 0.055	2.539ProGlu: 2.539 ± 0.066	1.494ProPhe: 1.494 ± 0.045	1.428ProGly: 1.428 ± 0.043	0.546ProHis: 0.546 ± 0.03	2.254ProIle: 2.254 ± 0.066	2.342ProLys: 2.342 ± 0.051	2.46ProLeu: 2.46 ± 0.061	0.762ProMet: 0.762 ± 0.032	1.735ProAsn: 1.735 ± 0.053	0.738ProPro: 0.738 ± 0.034	1.096ProGln: 1.096 ± 0.041	0.942ProArg: 0.942 ± 0.04	2.016ProSer: 2.016 ± 0.055	1.938ProThr: 1.938 ± 0.071	2.372ProVal: 2.372 ± 0.065	0.252ProTrp: 0.252 ± 0.021	1.427ProTyr: 1.427 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	1.989GlnAla: 1.989 ± 0.055	0.363GlnCys: 0.363 ± 0.021	1.218GlnAsp: 1.218 ± 0.04	1.649GlnGlu: 1.649 ± 0.047	1.137GlnPhe: 1.137 ± 0.042	1.656GlnGly: 1.656 ± 0.06	0.452GlnHis: 0.452 ± 0.024	2.357GlnIle: 2.357 ± 0.061	2.644GlnLys: 2.644 ± 0.063	2.465GlnLeu: 2.465 ± 0.054	0.808GlnMet: 0.808 ± 0.035	1.963GlnAsn: 1.963 ± 0.057	0.88GlnPro: 0.88 ± 0.036	1.107GlnGln: 1.107 ± 0.043	1.32GlnArg: 1.32 ± 0.045	1.964GlnSer: 1.964 ± 0.055	1.627GlnThr: 1.627 ± 0.042	1.466GlnVal: 1.466 ± 0.043	0.226GlnTrp: 0.226 ± 0.02	1.329GlnTyr: 1.329 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.247ArgAla: 2.247 ± 0.065	0.655ArgCys: 0.655 ± 0.029	2.018ArgAsp: 2.018 ± 0.058	2.625ArgGlu: 2.625 ± 0.064	1.697ArgPhe: 1.697 ± 0.048	2.095ArgGly: 2.095 ± 0.065	0.716ArgHis: 0.716 ± 0.037	3.161ArgIle: 3.161 ± 0.07	3.169ArgLys: 3.169 ± 0.069	3.381ArgLeu: 3.381 ± 0.079	1.045ArgMet: 1.045 ± 0.04	2.102ArgAsn: 2.102 ± 0.059	1.073ArgPro: 1.073 ± 0.04	1.258ArgGln: 1.258 ± 0.045	1.852ArgArg: 1.852 ± 0.06	2.044ArgSer: 2.044 ± 0.05	1.915ArgThr: 1.915 ± 0.054	2.286ArgVal: 2.286 ± 0.053	0.311ArgTrp: 0.311 ± 0.024	1.677ArgTyr: 1.677 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.967SerAla: 4.967 ± 0.106	0.915SerCys: 0.915 ± 0.036	4.786SerAsp: 4.786 ± 0.103	4.731SerGlu: 4.731 ± 0.095	3.096SerPhe: 3.096 ± 0.062	5.033SerGly: 5.033 ± 0.091	1.0SerHis: 1.0 ± 0.037	4.864SerIle: 4.864 ± 0.085	4.933SerLys: 4.933 ± 0.077	5.532SerLeu: 5.532 ± 0.095	1.601SerMet: 1.601 ± 0.048	3.662SerAsn: 3.662 ± 0.088	1.896SerPro: 1.896 ± 0.053	2.136SerGln: 2.136 ± 0.06	2.326SerArg: 2.326 ± 0.058	4.799SerSer: 4.799 ± 0.13	3.51SerThr: 3.51 ± 0.085	5.16SerVal: 5.16 ± 0.1	0.476SerTrp: 0.476 ± 0.027	2.832SerTyr: 2.832 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	4.571ThrAla: 4.571 ± 0.094	0.69ThrCys: 0.69 ± 0.036	3.739ThrAsp: 3.739 ± 0.076	3.713ThrGlu: 3.713 ± 0.09	2.363ThrPhe: 2.363 ± 0.062	3.884ThrGly: 3.884 ± 0.073	0.887ThrHis: 0.887 ± 0.038	4.122ThrIle: 4.122 ± 0.087	3.641ThrLys: 3.641 ± 0.071	4.812ThrLeu: 4.812 ± 0.084	1.249ThrMet: 1.249 ± 0.034	2.76ThrAsn: 2.76 ± 0.071	2.25ThrPro: 2.25 ± 0.051	1.574ThrGln: 1.574 ± 0.052	1.666ThrArg: 1.666 ± 0.049	3.591ThrSer: 3.591 ± 0.101	3.39ThrThr: 3.39 ± 0.126	4.625ThrVal: 4.625 ± 0.107	0.367ThrTrp: 0.367 ± 0.024	2.177ThrTyr: 2.177 ± 0.069	0.0ThrXaa: 0.0 ± 0.0
Val	4.52ValAla: 4.52 ± 0.085	1.34ValCys: 1.34 ± 0.045	4.087ValAsp: 4.087 ± 0.077	4.204ValGlu: 4.204 ± 0.077	3.239ValPhe: 3.239 ± 0.068	3.913ValGly: 3.913 ± 0.077	0.942ValHis: 0.942 ± 0.035	5.435ValIle: 5.435 ± 0.091	4.862ValLys: 4.862 ± 0.081	5.798ValLeu: 5.798 ± 0.12	1.745ValMet: 1.745 ± 0.058	3.509ValAsn: 3.509 ± 0.072	2.339ValPro: 2.339 ± 0.05	1.665ValGln: 1.665 ± 0.049	2.382ValArg: 2.382 ± 0.063	4.942ValSer: 4.942 ± 0.093	4.092ValThr: 4.092 ± 0.095	4.707ValVal: 4.707 ± 0.085	0.533ValTrp: 0.533 ± 0.027	2.637ValTyr: 2.637 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.456TrpAla: 0.456 ± 0.023	0.173TrpCys: 0.173 ± 0.017	0.468TrpAsp: 0.468 ± 0.028	0.425TrpGlu: 0.425 ± 0.027	0.376TrpPhe: 0.376 ± 0.024	0.532TrpGly: 0.532 ± 0.027	0.168TrpHis: 0.168 ± 0.016	0.547TrpIle: 0.547 ± 0.028	0.558TrpLys: 0.558 ± 0.031	0.754TrpLeu: 0.754 ± 0.03	0.196TrpMet: 0.196 ± 0.016	0.533TrpAsn: 0.533 ± 0.026	0.127TrpPro: 0.127 ± 0.014	0.356TrpGln: 0.356 ± 0.021	0.313TrpArg: 0.313 ± 0.019	0.505TrpSer: 0.505 ± 0.03	0.413TrpThr: 0.413 ± 0.025	0.485TrpVal: 0.485 ± 0.029	0.097TrpTrp: 0.097 ± 0.011	0.38TrpTyr: 0.38 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.76TyrAla: 2.76 ± 0.059	0.891TyrCys: 0.891 ± 0.032	3.0TyrAsp: 3.0 ± 0.071	2.69TyrGlu: 2.69 ± 0.064	2.078TyrPhe: 2.078 ± 0.051	2.875TyrGly: 2.875 ± 0.072	0.694TyrHis: 0.694 ± 0.031	3.293TyrIle: 3.293 ± 0.084	3.04TyrLys: 3.04 ± 0.072	3.456TyrLeu: 3.456 ± 0.067	0.958TyrMet: 0.958 ± 0.035	2.587TyrAsn: 2.587 ± 0.067	1.308TyrPro: 1.308 ± 0.038	1.22TyrGln: 1.22 ± 0.042	1.691TyrArg: 1.691 ± 0.052	3.019TyrSer: 3.019 ± 0.072	2.345TyrThr: 2.345 ± 0.074	2.699TyrVal: 2.699 ± 0.064	0.365TyrTrp: 0.365 ± 0.026	2.053TyrTyr: 2.053 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2484 proteins (738748 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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