Amino acid dipepetide frequency for Wohlfahrtiimonas chitiniclastica SH04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.166AlaAla: 8.166 ± 0.159
0.908AlaCys: 0.908 ± 0.038
4.138AlaAsp: 4.138 ± 0.093
5.301AlaGlu: 5.301 ± 0.113
3.743AlaPhe: 3.743 ± 0.083
5.579AlaGly: 5.579 ± 0.136
2.28AlaHis: 2.28 ± 0.082
6.826AlaIle: 6.826 ± 0.115
5.421AlaLys: 5.421 ± 0.1
10.778AlaLeu: 10.778 ± 0.151
2.786AlaMet: 2.786 ± 0.072
3.368AlaAsn: 3.368 ± 0.104
3.434AlaPro: 3.434 ± 0.08
3.759AlaGln: 3.759 ± 0.078
3.885AlaArg: 3.885 ± 0.094
4.424AlaSer: 4.424 ± 0.069
4.67AlaThr: 4.67 ± 0.097
5.718AlaVal: 5.718 ± 0.103
0.979AlaTrp: 0.979 ± 0.043
2.643AlaTyr: 2.643 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.75CysAla: 0.75 ± 0.037
0.094CysCys: 0.094 ± 0.013
0.556CysAsp: 0.556 ± 0.028
0.539CysGlu: 0.539 ± 0.029
0.427CysPhe: 0.427 ± 0.027
0.742CysGly: 0.742 ± 0.035
0.338CysHis: 0.338 ± 0.025
0.644CysIle: 0.644 ± 0.036
0.295CysLys: 0.295 ± 0.024
0.864CysLeu: 0.864 ± 0.042
0.2CysMet: 0.2 ± 0.018
0.281CysAsn: 0.281 ± 0.025
0.407CysPro: 0.407 ± 0.028
0.406CysGln: 0.406 ± 0.021
0.333CysArg: 0.333 ± 0.022
0.556CysSer: 0.556 ± 0.028
0.489CysThr: 0.489 ± 0.031
0.618CysVal: 0.618 ± 0.03
0.074CysTrp: 0.074 ± 0.011
0.321CysTyr: 0.321 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.309AspAla: 5.309 ± 0.103
0.461AspCys: 0.461 ± 0.023
3.185AspAsp: 3.185 ± 0.083
3.855AspGlu: 3.855 ± 0.089
2.62AspPhe: 2.62 ± 0.071
3.514AspGly: 3.514 ± 0.117
1.681AspHis: 1.681 ± 0.056
3.636AspIle: 3.636 ± 0.084
2.506AspLys: 2.506 ± 0.067
5.438AspLeu: 5.438 ± 0.107
1.172AspMet: 1.172 ± 0.046
2.185AspAsn: 2.185 ± 0.078
2.236AspPro: 2.236 ± 0.062
2.826AspGln: 2.826 ± 0.101
2.594AspArg: 2.594 ± 0.065
2.402AspSer: 2.402 ± 0.066
2.331AspThr: 2.331 ± 0.086
4.09AspVal: 4.09 ± 0.089
0.771AspTrp: 0.771 ± 0.029
2.223AspTyr: 2.223 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.736GluAla: 5.736 ± 0.111
0.496GluCys: 0.496 ± 0.03
3.092GluAsp: 3.092 ± 0.075
3.662GluGlu: 3.662 ± 0.099
2.326GluPhe: 2.326 ± 0.056
3.866GluGly: 3.866 ± 0.082
1.636GluHis: 1.636 ± 0.054
4.484GluIle: 4.484 ± 0.086
4.084GluLys: 4.084 ± 0.09
5.908GluLeu: 5.908 ± 0.123
1.908GluMet: 1.908 ± 0.054
2.804GluAsn: 2.804 ± 0.06
2.011GluPro: 2.011 ± 0.064
2.628GluGln: 2.628 ± 0.07
3.258GluArg: 3.258 ± 0.085
3.336GluSer: 3.336 ± 0.063
3.066GluThr: 3.066 ± 0.072
3.955GluVal: 3.955 ± 0.092
0.713GluTrp: 0.713 ± 0.034
1.833GluTyr: 1.833 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.577PheAla: 3.577 ± 0.08
0.441PheCys: 0.441 ± 0.021
2.74PheAsp: 2.74 ± 0.067
2.409PheGlu: 2.409 ± 0.061
2.002PhePhe: 2.002 ± 0.064
3.153PheGly: 3.153 ± 0.081
0.845PheHis: 0.845 ± 0.038
3.176PheIle: 3.176 ± 0.082
2.365PheLys: 2.365 ± 0.053
3.846PheLeu: 3.846 ± 0.086
1.239PheMet: 1.239 ± 0.045
2.085PheAsn: 2.085 ± 0.057
1.487PhePro: 1.487 ± 0.048
1.168PheGln: 1.168 ± 0.041
1.401PheArg: 1.401 ± 0.052
2.992PheSer: 2.992 ± 0.077
2.491PheThr: 2.491 ± 0.069
2.841PheVal: 2.841 ± 0.07
0.519PheTrp: 0.519 ± 0.033
1.503PheTyr: 1.503 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.662GlyAla: 5.662 ± 0.112
0.756GlyCys: 0.756 ± 0.041
3.527GlyAsp: 3.527 ± 0.12
3.783GlyGlu: 3.783 ± 0.092
3.087GlyPhe: 3.087 ± 0.089
4.893GlyGly: 4.893 ± 0.188
1.746GlyHis: 1.746 ± 0.059
5.427GlyIle: 5.427 ± 0.107
3.989GlyLys: 3.989 ± 0.105
6.972GlyLeu: 6.972 ± 0.111
2.007GlyMet: 2.007 ± 0.054
2.795GlyAsn: 2.795 ± 0.124
1.444GlyPro: 1.444 ± 0.045
2.949GlyGln: 2.949 ± 0.106
2.895GlyArg: 2.895 ± 0.08
3.779GlySer: 3.779 ± 0.096
3.831GlyThr: 3.831 ± 0.167
4.759GlyVal: 4.759 ± 0.088
0.754GlyTrp: 0.754 ± 0.037
2.297GlyTyr: 2.297 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.082HisAla: 2.082 ± 0.063
0.275HisCys: 0.275 ± 0.02
1.365HisAsp: 1.365 ± 0.042
1.192HisGlu: 1.192 ± 0.041
1.114HisPhe: 1.114 ± 0.042
1.629HisGly: 1.629 ± 0.052
0.96HisHis: 0.96 ± 0.041
1.67HisIle: 1.67 ± 0.045
1.166HisLys: 1.166 ± 0.037
2.64HisLeu: 2.64 ± 0.081
0.595HisMet: 0.595 ± 0.028
1.145HisAsn: 1.145 ± 0.042
1.334HisPro: 1.334 ± 0.048
1.26HisGln: 1.26 ± 0.048
1.116HisArg: 1.116 ± 0.044
1.345HisSer: 1.345 ± 0.044
1.28HisThr: 1.28 ± 0.048
1.474HisVal: 1.474 ± 0.044
0.272HisTrp: 0.272 ± 0.021
1.03HisTyr: 1.03 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
7.127IleAla: 7.127 ± 0.125
0.671IleCys: 0.671 ± 0.032
4.691IleAsp: 4.691 ± 0.084
5.535IleGlu: 5.535 ± 0.11
3.129IlePhe: 3.129 ± 0.089
5.062IleGly: 5.062 ± 0.087
1.681IleHis: 1.681 ± 0.056
5.244IleIle: 5.244 ± 0.111
3.573IleLys: 3.573 ± 0.074
6.652IleLeu: 6.652 ± 0.141
1.663IleMet: 1.663 ± 0.062
3.278IleAsn: 3.278 ± 0.083
2.906IlePro: 2.906 ± 0.077
2.472IleGln: 2.472 ± 0.074
2.878IleArg: 2.878 ± 0.059
4.186IleSer: 4.186 ± 0.073
4.496IleThr: 4.496 ± 0.092
5.032IleVal: 5.032 ± 0.101
0.671IleTrp: 0.671 ± 0.034
2.176IleTyr: 2.176 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
5.581LysAla: 5.581 ± 0.097
0.295LysCys: 0.295 ± 0.022
3.574LysAsp: 3.574 ± 0.095
3.846LysGlu: 3.846 ± 0.088
1.607LysPhe: 1.607 ± 0.048
3.782LysGly: 3.782 ± 0.114
1.271LysHis: 1.271 ± 0.046
3.757LysIle: 3.757 ± 0.083
3.428LysLys: 3.428 ± 0.09
4.442LysLeu: 4.442 ± 0.105
1.77LysMet: 1.77 ± 0.056
2.754LysAsn: 2.754 ± 0.079
2.136LysPro: 2.136 ± 0.053
2.28LysGln: 2.28 ± 0.063
2.598LysArg: 2.598 ± 0.078
2.987LysSer: 2.987 ± 0.068
3.322LysThr: 3.322 ± 0.076
3.743LysVal: 3.743 ± 0.078
0.472LysTrp: 0.472 ± 0.031
1.514LysTyr: 1.514 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
8.809LeuAla: 8.809 ± 0.141
0.982LeuCys: 0.982 ± 0.036
5.378LeuAsp: 5.378 ± 0.09
5.73LeuGlu: 5.73 ± 0.112
4.339LeuPhe: 4.339 ± 0.097
6.741LeuGly: 6.741 ± 0.109
2.094LeuHis: 2.094 ± 0.056
7.059LeuIle: 7.059 ± 0.133
6.179LeuLys: 6.179 ± 0.107
10.255LeuLeu: 10.255 ± 0.189
3.149LeuMet: 3.149 ± 0.073
4.983LeuAsn: 4.983 ± 0.126
4.911LeuPro: 4.911 ± 0.096
3.44LeuGln: 3.44 ± 0.086
4.172LeuArg: 4.172 ± 0.084
7.863LeuSer: 7.863 ± 0.12
6.769LeuThr: 6.769 ± 0.119
6.312LeuVal: 6.312 ± 0.11
1.077LeuTrp: 1.077 ± 0.048
3.053LeuTyr: 3.053 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.674MetAla: 2.674 ± 0.063
0.203MetCys: 0.203 ± 0.018
1.397MetAsp: 1.397 ± 0.05
1.208MetGlu: 1.208 ± 0.044
0.836MetPhe: 0.836 ± 0.035
1.925MetGly: 1.925 ± 0.063
0.632MetHis: 0.632 ± 0.032
2.291MetIle: 2.291 ± 0.064
1.686MetLys: 1.686 ± 0.05
2.795MetLeu: 2.795 ± 0.069
1.022MetMet: 1.022 ± 0.045
1.351MetAsn: 1.351 ± 0.056
1.351MetPro: 1.351 ± 0.054
1.169MetGln: 1.169 ± 0.048
1.369MetArg: 1.369 ± 0.05
1.872MetSer: 1.872 ± 0.054
1.832MetThr: 1.832 ± 0.054
1.875MetVal: 1.875 ± 0.065
0.22MetTrp: 0.22 ± 0.02
0.556MetTyr: 0.556 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.799AsnAla: 3.799 ± 0.089
0.337AsnCys: 0.337 ± 0.023
2.508AsnAsp: 2.508 ± 0.093
2.517AsnGlu: 2.517 ± 0.062
1.809AsnPhe: 1.809 ± 0.054
3.155AsnGly: 3.155 ± 0.105
1.205AsnHis: 1.205 ± 0.054
3.53AsnIle: 3.53 ± 0.09
2.004AsnLys: 2.004 ± 0.058
4.133AsnLeu: 4.133 ± 0.102
0.945AsnMet: 0.945 ± 0.038
2.013AsnAsn: 2.013 ± 0.101
2.177AsnPro: 2.177 ± 0.062
2.165AsnGln: 2.165 ± 0.065
1.993AsnArg: 1.993 ± 0.065
2.204AsnSer: 2.204 ± 0.071
2.271AsnThr: 2.271 ± 0.093
3.013AsnVal: 3.013 ± 0.091
0.487AsnTrp: 0.487 ± 0.026
1.372AsnTyr: 1.372 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.78ProAla: 2.78 ± 0.071
0.304ProCys: 0.304 ± 0.021
2.096ProAsp: 2.096 ± 0.065
3.208ProGlu: 3.208 ± 0.078
1.861ProPhe: 1.861 ± 0.054
1.815ProGly: 1.815 ± 0.058
0.974ProHis: 0.974 ± 0.042
3.07ProIle: 3.07 ± 0.071
2.646ProLys: 2.646 ± 0.066
4.001ProLeu: 4.001 ± 0.103
1.295ProMet: 1.295 ± 0.046
1.976ProAsn: 1.976 ± 0.063
1.171ProPro: 1.171 ± 0.051
1.472ProGln: 1.472 ± 0.049
1.365ProArg: 1.365 ± 0.05
2.3ProSer: 2.3 ± 0.068
2.213ProThr: 2.213 ± 0.053
2.866ProVal: 2.866 ± 0.077
0.458ProTrp: 0.458 ± 0.026
1.469ProTyr: 1.469 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
3.862GlnAla: 3.862 ± 0.087
0.312GlnCys: 0.312 ± 0.022
1.816GlnAsp: 1.816 ± 0.06
2.071GlnGlu: 2.071 ± 0.057
1.598GlnPhe: 1.598 ± 0.047
2.631GlnGly: 2.631 ± 0.075
1.062GlnHis: 1.062 ± 0.045
2.291GlnIle: 2.291 ± 0.061
2.72GlnLys: 2.72 ± 0.065
4.496GlnLeu: 4.496 ± 0.091
1.171GlnMet: 1.171 ± 0.043
1.958GlnAsn: 1.958 ± 0.092
1.461GlnPro: 1.461 ± 0.043
2.011GlnGln: 2.011 ± 0.067
1.904GlnArg: 1.904 ± 0.06
2.64GlnSer: 2.64 ± 0.065
2.475GlnThr: 2.475 ± 0.075
2.308GlnVal: 2.308 ± 0.068
0.516GlnTrp: 0.516 ± 0.031
1.544GlnTyr: 1.544 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.648ArgAla: 3.648 ± 0.084
0.349ArgCys: 0.349 ± 0.023
2.348ArgAsp: 2.348 ± 0.066
2.741ArgGlu: 2.741 ± 0.075
2.084ArgPhe: 2.084 ± 0.061
2.529ArgGly: 2.529 ± 0.075
1.053ArgHis: 1.053 ± 0.037
3.402ArgIle: 3.402 ± 0.083
2.231ArgLys: 2.231 ± 0.066
5.029ArgLeu: 5.029 ± 0.103
1.214ArgMet: 1.214 ± 0.04
1.776ArgAsn: 1.776 ± 0.058
1.471ArgPro: 1.471 ± 0.046
1.661ArgGln: 1.661 ± 0.052
2.005ArgArg: 2.005 ± 0.063
2.459ArgSer: 2.459 ± 0.059
2.385ArgThr: 2.385 ± 0.059
2.78ArgVal: 2.78 ± 0.078
0.447ArgTrp: 0.447 ± 0.027
1.801ArgTyr: 1.801 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.876SerAla: 4.876 ± 0.089
0.469SerCys: 0.469 ± 0.029
3.265SerAsp: 3.265 ± 0.073
3.556SerGlu: 3.556 ± 0.078
2.64SerPhe: 2.64 ± 0.068
4.41SerGly: 4.41 ± 0.109
1.475SerHis: 1.475 ± 0.048
4.424SerIle: 4.424 ± 0.091
2.767SerLys: 2.767 ± 0.069
6.203SerLeu: 6.203 ± 0.107
1.716SerMet: 1.716 ± 0.053
2.348SerAsn: 2.348 ± 0.075
2.145SerPro: 2.145 ± 0.063
2.074SerGln: 2.074 ± 0.065
2.397SerArg: 2.397 ± 0.064
3.361SerSer: 3.361 ± 0.081
3.201SerThr: 3.201 ± 0.073
3.92SerVal: 3.92 ± 0.077
0.633SerTrp: 0.633 ± 0.033
1.83SerTyr: 1.83 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.879ThrAla: 4.879 ± 0.108
0.453ThrCys: 0.453 ± 0.029
3.032ThrAsp: 3.032 ± 0.088
3.428ThrGlu: 3.428 ± 0.08
2.306ThrPhe: 2.306 ± 0.057
4.258ThrGly: 4.258 ± 0.141
1.504ThrHis: 1.504 ± 0.054
4.158ThrIle: 4.158 ± 0.098
2.645ThrLys: 2.645 ± 0.081
6.999ThrLeu: 6.999 ± 0.155
1.258ThrMet: 1.258 ± 0.044
2.013ThrAsn: 2.013 ± 0.069
2.737ThrPro: 2.737 ± 0.064
2.396ThrGln: 2.396 ± 0.062
2.121ThrArg: 2.121 ± 0.058
2.777ThrSer: 2.777 ± 0.069
3.299ThrThr: 3.299 ± 0.09
4.16ThrVal: 4.16 ± 0.13
0.587ThrTrp: 0.587 ± 0.029
1.663ThrTyr: 1.663 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
6.09ValAla: 6.09 ± 0.115
0.601ValCys: 0.601 ± 0.03
3.857ValAsp: 3.857 ± 0.094
3.992ValGlu: 3.992 ± 0.083
2.594ValPhe: 2.594 ± 0.071
4.662ValGly: 4.662 ± 0.087
1.317ValHis: 1.317 ± 0.045
5.272ValIle: 5.272 ± 0.104
3.654ValLys: 3.654 ± 0.096
6.66ValLeu: 6.66 ± 0.122
2.164ValMet: 2.164 ± 0.06
2.932ValAsn: 2.932 ± 0.088
2.74ValPro: 2.74 ± 0.067
2.168ValGln: 2.168 ± 0.064
2.846ValArg: 2.846 ± 0.081
3.972ValSer: 3.972 ± 0.077
4.177ValThr: 4.177 ± 0.11
5.138ValVal: 5.138 ± 0.107
0.701ValTrp: 0.701 ± 0.032
1.847ValTyr: 1.847 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.736TrpAla: 0.736 ± 0.035
0.134TrpCys: 0.134 ± 0.015
0.518TrpAsp: 0.518 ± 0.028
0.43TrpGlu: 0.43 ± 0.028
0.504TrpPhe: 0.504 ± 0.027
0.667TrpGly: 0.667 ± 0.038
0.318TrpHis: 0.318 ± 0.021
0.825TrpIle: 0.825 ± 0.038
0.441TrpLys: 0.441 ± 0.025
1.534TrpLeu: 1.534 ± 0.058
0.376TrpMet: 0.376 ± 0.022
0.412TrpAsn: 0.412 ± 0.023
0.332TrpPro: 0.332 ± 0.021
0.779TrpGln: 0.779 ± 0.043
0.604TrpArg: 0.604 ± 0.037
0.579TrpSer: 0.579 ± 0.033
0.458TrpThr: 0.458 ± 0.027
0.748TrpVal: 0.748 ± 0.038
0.124TrpTrp: 0.124 ± 0.014
0.337TrpTyr: 0.337 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.664TyrAla: 2.664 ± 0.068
0.393TyrCys: 0.393 ± 0.024
1.955TyrAsp: 1.955 ± 0.059
1.798TyrGlu: 1.798 ± 0.059
1.655TyrPhe: 1.655 ± 0.05
2.339TyrGly: 2.339 ± 0.064
0.87TyrHis: 0.87 ± 0.038
1.936TyrIle: 1.936 ± 0.061
1.36TyrLys: 1.36 ± 0.05
3.651TyrLeu: 3.651 ± 0.076
0.612TyrMet: 0.612 ± 0.035
1.179TyrAsn: 1.179 ± 0.047
1.449TyrPro: 1.449 ± 0.052
1.764TyrGln: 1.764 ± 0.06
1.68TyrArg: 1.68 ± 0.055
1.68TyrSer: 1.68 ± 0.059
1.618TyrThr: 1.618 ± 0.055
2.031TyrVal: 2.031 ± 0.053
0.38TyrTrp: 0.38 ± 0.026
1.136TyrTyr: 1.136 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2004 proteins (650783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski