Amino acid dipepetide frequency for Peptostreptococcaceae bacterium oral taxon 113 str. W5053

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.144AlaAla: 4.144 ± 0.108
0.822AlaCys: 0.822 ± 0.035
2.925AlaAsp: 2.925 ± 0.071
3.858AlaGlu: 3.858 ± 0.083
3.091AlaPhe: 3.091 ± 0.078
4.29AlaGly: 4.29 ± 0.098
1.085AlaHis: 1.085 ± 0.041
4.97AlaIle: 4.97 ± 0.097
4.994AlaLys: 4.994 ± 0.074
7.009AlaLeu: 7.009 ± 0.114
2.064AlaMet: 2.064 ± 0.058
2.214AlaAsn: 2.214 ± 0.062
1.643AlaPro: 1.643 ± 0.059
1.95AlaGln: 1.95 ± 0.055
2.414AlaArg: 2.414 ± 0.065
3.176AlaSer: 3.176 ± 0.072
2.68AlaThr: 2.68 ± 0.065
4.458AlaVal: 4.458 ± 0.103
0.574AlaTrp: 0.574 ± 0.028
2.435AlaTyr: 2.435 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.69CysAla: 0.69 ± 0.032
0.181CysCys: 0.181 ± 0.018
0.541CysAsp: 0.541 ± 0.032
0.683CysGlu: 0.683 ± 0.032
0.578CysPhe: 0.578 ± 0.032
1.07CysGly: 1.07 ± 0.05
0.286CysHis: 0.286 ± 0.024
0.979CysIle: 0.979 ± 0.046
0.742CysLys: 0.742 ± 0.041
1.032CysLeu: 1.032 ± 0.046
0.266CysMet: 0.266 ± 0.022
0.475CysAsn: 0.475 ± 0.026
0.486CysPro: 0.486 ± 0.033
0.301CysGln: 0.301 ± 0.02
0.464CysArg: 0.464 ± 0.032
0.701CysSer: 0.701 ± 0.03
0.533CysThr: 0.533 ± 0.029
0.71CysVal: 0.71 ± 0.033
0.096CysTrp: 0.096 ± 0.011
0.419CysTyr: 0.419 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.971AspAla: 2.971 ± 0.079
0.565AspCys: 0.565 ± 0.035
2.186AspAsp: 2.186 ± 0.075
4.435AspGlu: 4.435 ± 0.086
3.146AspPhe: 3.146 ± 0.071
3.317AspGly: 3.317 ± 0.075
0.758AspHis: 0.758 ± 0.033
4.598AspIle: 4.598 ± 0.094
4.078AspLys: 4.078 ± 0.082
4.923AspLeu: 4.923 ± 0.102
1.605AspMet: 1.605 ± 0.051
2.062AspAsn: 2.062 ± 0.055
1.416AspPro: 1.416 ± 0.047
0.968AspGln: 0.968 ± 0.043
2.091AspArg: 2.091 ± 0.077
2.547AspSer: 2.547 ± 0.065
2.368AspThr: 2.368 ± 0.068
3.253AspVal: 3.253 ± 0.086
0.526AspTrp: 0.526 ± 0.026
2.528AspTyr: 2.528 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.65GluAla: 4.65 ± 0.109
0.595GluCys: 0.595 ± 0.035
4.16GluAsp: 4.16 ± 0.084
8.078GluGlu: 8.078 ± 0.148
2.851GluPhe: 2.851 ± 0.061
4.363GluGly: 4.363 ± 0.092
1.333GluHis: 1.333 ± 0.05
6.792GluIle: 6.792 ± 0.119
8.974GluLys: 8.974 ± 0.158
6.835GluLeu: 6.835 ± 0.109
2.448GluMet: 2.448 ± 0.061
4.968GluAsn: 4.968 ± 0.097
1.565GluPro: 1.565 ± 0.053
2.504GluGln: 2.504 ± 0.073
3.56GluArg: 3.56 ± 0.081
3.723GluSer: 3.723 ± 0.085
3.25GluThr: 3.25 ± 0.071
4.318GluVal: 4.318 ± 0.097
0.589GluTrp: 0.589 ± 0.031
3.152GluTyr: 3.152 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
2.902PheAla: 2.902 ± 0.075
0.638PheCys: 0.638 ± 0.038
2.539PheAsp: 2.539 ± 0.065
3.054PheGlu: 3.054 ± 0.07
2.952PhePhe: 2.952 ± 0.095
3.267PheGly: 3.267 ± 0.086
1.022PheHis: 1.022 ± 0.047
3.976PheIle: 3.976 ± 0.101
2.741PheLys: 2.741 ± 0.06
5.186PheLeu: 5.186 ± 0.104
1.373PheMet: 1.373 ± 0.053
1.962PheAsn: 1.962 ± 0.057
1.573PhePro: 1.573 ± 0.05
1.704PheGln: 1.704 ± 0.052
1.894PheArg: 1.894 ± 0.055
3.741PheSer: 3.741 ± 0.084
2.338PheThr: 2.338 ± 0.06
3.098PheVal: 3.098 ± 0.085
0.494PheTrp: 0.494 ± 0.032
2.168PheTyr: 2.168 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.15GlyAla: 4.15 ± 0.093
0.83GlyCys: 0.83 ± 0.045
3.106GlyAsp: 3.106 ± 0.081
5.171GlyGlu: 5.171 ± 0.091
3.141GlyPhe: 3.141 ± 0.078
4.712GlyGly: 4.712 ± 0.105
1.149GlyHis: 1.149 ± 0.04
6.374GlyIle: 6.374 ± 0.123
6.595GlyLys: 6.595 ± 0.102
6.173GlyLeu: 6.173 ± 0.1
2.114GlyMet: 2.114 ± 0.073
3.083GlyAsn: 3.083 ± 0.08
1.25GlyPro: 1.25 ± 0.064
1.894GlyGln: 1.894 ± 0.05
2.709GlyArg: 2.709 ± 0.073
3.675GlySer: 3.675 ± 0.074
3.261GlyThr: 3.261 ± 0.08
4.488GlyVal: 4.488 ± 0.094
0.541GlyTrp: 0.541 ± 0.033
2.933GlyTyr: 2.933 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.968HisAla: 0.968 ± 0.038
0.274HisCys: 0.274 ± 0.025
0.816HisAsp: 0.816 ± 0.037
1.171HisGlu: 1.171 ± 0.043
0.974HisPhe: 0.974 ± 0.042
1.21HisGly: 1.21 ± 0.039
0.494HisHis: 0.494 ± 0.029
1.514HisIle: 1.514 ± 0.052
1.15HisLys: 1.15 ± 0.041
1.906HisLeu: 1.906 ± 0.055
0.51HisMet: 0.51 ± 0.03
0.69HisAsn: 0.69 ± 0.037
0.907HisPro: 0.907 ± 0.044
0.666HisGln: 0.666 ± 0.035
1.053HisArg: 1.053 ± 0.04
1.029HisSer: 1.029 ± 0.039
0.832HisThr: 0.832 ± 0.04
0.958HisVal: 0.958 ± 0.039
0.211HisTrp: 0.211 ± 0.016
0.802HisTyr: 0.802 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.898IleAla: 5.898 ± 0.103
1.104IleCys: 1.104 ± 0.048
4.147IleAsp: 4.147 ± 0.083
5.654IleGlu: 5.654 ± 0.112
4.602IlePhe: 4.602 ± 0.113
5.845IleGly: 5.845 ± 0.125
1.798IleHis: 1.798 ± 0.05
6.483IleIle: 6.483 ± 0.135
5.619IleLys: 5.619 ± 0.101
9.219IleLeu: 9.219 ± 0.156
1.989IleMet: 1.989 ± 0.063
3.642IleAsn: 3.642 ± 0.085
3.395IlePro: 3.395 ± 0.081
3.05IleGln: 3.05 ± 0.072
3.792IleArg: 3.792 ± 0.077
5.782IleSer: 5.782 ± 0.109
3.75IleThr: 3.75 ± 0.083
5.152IleVal: 5.152 ± 0.095
0.608IleTrp: 0.608 ± 0.035
3.032IleTyr: 3.032 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
4.741LysAla: 4.741 ± 0.094
0.584LysCys: 0.584 ± 0.036
5.042LysAsp: 5.042 ± 0.098
8.875LysGlu: 8.875 ± 0.15
2.485LysPhe: 2.485 ± 0.064
4.998LysGly: 4.998 ± 0.083
1.248LysHis: 1.248 ± 0.048
7.061LysIle: 7.061 ± 0.109
8.366LysLys: 8.366 ± 0.114
6.483LysLeu: 6.483 ± 0.108
2.635LysMet: 2.635 ± 0.058
5.536LysAsn: 5.536 ± 0.108
1.806LysPro: 1.806 ± 0.056
2.592LysGln: 2.592 ± 0.072
3.842LysArg: 3.842 ± 0.077
4.272LysSer: 4.272 ± 0.092
4.39LysThr: 4.39 ± 0.08
4.733LysVal: 4.733 ± 0.086
0.65LysTrp: 0.65 ± 0.03
3.042LysTyr: 3.042 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
5.902LeuAla: 5.902 ± 0.11
1.309LeuCys: 1.309 ± 0.043
4.795LeuAsp: 4.795 ± 0.08
7.019LeuGlu: 7.019 ± 0.123
5.139LeuPhe: 5.139 ± 0.127
6.166LeuGly: 6.166 ± 0.12
1.586LeuHis: 1.586 ± 0.047
7.893LeuIle: 7.893 ± 0.128
7.977LeuLys: 7.977 ± 0.117
9.699LeuLeu: 9.699 ± 0.161
2.885LeuMet: 2.885 ± 0.065
4.645LeuAsn: 4.645 ± 0.093
3.608LeuPro: 3.608 ± 0.085
2.845LeuGln: 2.845 ± 0.07
4.138LeuArg: 4.138 ± 0.103
7.811LeuSer: 7.811 ± 0.122
4.736LeuThr: 4.736 ± 0.082
5.315LeuVal: 5.315 ± 0.085
0.944LeuTrp: 0.944 ± 0.041
3.632LeuTyr: 3.632 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.03MetAla: 2.03 ± 0.062
0.232MetCys: 0.232 ± 0.021
1.875MetAsp: 1.875 ± 0.055
2.792MetGlu: 2.792 ± 0.075
1.096MetPhe: 1.096 ± 0.051
2.05MetGly: 2.05 ± 0.055
0.454MetHis: 0.454 ± 0.028
2.578MetIle: 2.578 ± 0.073
2.955MetLys: 2.955 ± 0.074
2.49MetLeu: 2.49 ± 0.071
0.954MetMet: 0.954 ± 0.039
1.68MetAsn: 1.68 ± 0.048
0.915MetPro: 0.915 ± 0.04
1.024MetGln: 1.024 ± 0.04
1.226MetArg: 1.226 ± 0.048
1.648MetSer: 1.648 ± 0.056
1.461MetThr: 1.461 ± 0.054
1.747MetVal: 1.747 ± 0.055
0.166MetTrp: 0.166 ± 0.017
0.794MetTyr: 0.794 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.752AsnAla: 2.752 ± 0.076
0.584AsnCys: 0.584 ± 0.034
1.941AsnAsp: 1.941 ± 0.057
3.128AsnGlu: 3.128 ± 0.073
2.285AsnPhe: 2.285 ± 0.065
3.131AsnGly: 3.131 ± 0.077
1.002AsnHis: 1.002 ± 0.044
4.512AsnIle: 4.512 ± 0.1
3.574AsnLys: 3.574 ± 0.085
4.942AsnLeu: 4.942 ± 0.102
1.429AsnMet: 1.429 ± 0.05
2.125AsnAsn: 2.125 ± 0.074
2.117AsnPro: 2.117 ± 0.056
1.702AsnGln: 1.702 ± 0.051
2.358AsnArg: 2.358 ± 0.06
2.448AsnSer: 2.448 ± 0.054
2.275AsnThr: 2.275 ± 0.061
2.675AsnVal: 2.675 ± 0.068
0.414AsnTrp: 0.414 ± 0.026
2.054AsnTyr: 2.054 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
1.733ProAla: 1.733 ± 0.065
0.33ProCys: 0.33 ± 0.024
1.517ProAsp: 1.517 ± 0.051
2.667ProGlu: 2.667 ± 0.067
1.589ProPhe: 1.589 ± 0.053
2.002ProGly: 2.002 ± 0.068
0.6ProHis: 0.6 ± 0.033
2.397ProIle: 2.397 ± 0.055
2.49ProLys: 2.49 ± 0.065
3.018ProLeu: 3.018 ± 0.073
0.97ProMet: 0.97 ± 0.037
1.285ProAsn: 1.285 ± 0.043
0.744ProPro: 0.744 ± 0.043
0.917ProGln: 0.917 ± 0.038
0.936ProArg: 0.936 ± 0.04
1.683ProSer: 1.683 ± 0.049
1.57ProThr: 1.57 ± 0.057
2.418ProVal: 2.418 ± 0.069
0.358ProTrp: 0.358 ± 0.023
1.342ProTyr: 1.342 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
1.926GlnAla: 1.926 ± 0.057
0.29GlnCys: 0.29 ± 0.024
1.424GlnAsp: 1.424 ± 0.056
2.677GlnGlu: 2.677 ± 0.072
1.208GlnPhe: 1.208 ± 0.04
2.258GlnGly: 2.258 ± 0.065
0.446GlnHis: 0.446 ± 0.026
2.718GlnIle: 2.718 ± 0.065
3.158GlnLys: 3.158 ± 0.075
2.582GlnLeu: 2.582 ± 0.066
1.014GlnMet: 1.014 ± 0.041
1.725GlnAsn: 1.725 ± 0.051
0.653GlnPro: 0.653 ± 0.029
0.965GlnGln: 0.965 ± 0.041
1.686GlnArg: 1.686 ± 0.052
1.835GlnSer: 1.835 ± 0.055
1.331GlnThr: 1.331 ± 0.044
1.808GlnVal: 1.808 ± 0.056
0.328GlnTrp: 0.328 ± 0.022
1.074GlnTyr: 1.074 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.242ArgAla: 2.242 ± 0.066
0.469ArgCys: 0.469 ± 0.031
2.016ArgAsp: 2.016 ± 0.06
3.872ArgGlu: 3.872 ± 0.086
2.04ArgPhe: 2.04 ± 0.064
2.723ArgGly: 2.723 ± 0.07
0.738ArgHis: 0.738 ± 0.031
3.933ArgIle: 3.933 ± 0.085
4.003ArgLys: 4.003 ± 0.084
4.251ArgLeu: 4.251 ± 0.085
1.534ArgMet: 1.534 ± 0.044
2.022ArgAsn: 2.022 ± 0.058
1.115ArgPro: 1.115 ± 0.039
1.482ArgGln: 1.482 ± 0.05
2.125ArgArg: 2.125 ± 0.072
2.027ArgSer: 2.027 ± 0.057
1.902ArgThr: 1.902 ± 0.054
2.568ArgVal: 2.568 ± 0.066
0.384ArgTrp: 0.384 ± 0.026
1.797ArgTyr: 1.797 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.346SerAla: 3.346 ± 0.08
0.675SerCys: 0.675 ± 0.036
2.805SerAsp: 2.805 ± 0.069
4.037SerGlu: 4.037 ± 0.079
3.368SerPhe: 3.368 ± 0.068
4.619SerGly: 4.619 ± 0.091
1.08SerHis: 1.08 ± 0.039
5.133SerIle: 5.133 ± 0.088
4.542SerLys: 4.542 ± 0.086
5.95SerLeu: 5.95 ± 0.111
1.85SerMet: 1.85 ± 0.055
2.358SerAsn: 2.358 ± 0.061
1.84SerPro: 1.84 ± 0.053
1.693SerGln: 1.693 ± 0.061
2.357SerArg: 2.357 ± 0.062
3.557SerSer: 3.557 ± 0.087
2.696SerThr: 2.696 ± 0.068
3.984SerVal: 3.984 ± 0.079
0.472SerTrp: 0.472 ± 0.026
2.493SerTyr: 2.493 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.186ThrAla: 3.186 ± 0.075
0.454ThrCys: 0.454 ± 0.03
2.496ThrAsp: 2.496 ± 0.067
3.427ThrGlu: 3.427 ± 0.079
2.091ThrPhe: 2.091 ± 0.057
3.81ThrGly: 3.81 ± 0.087
0.838ThrHis: 0.838 ± 0.037
3.736ThrIle: 3.736 ± 0.08
3.443ThrLys: 3.443 ± 0.078
4.87ThrLeu: 4.87 ± 0.082
1.318ThrMet: 1.318 ± 0.043
1.874ThrAsn: 1.874 ± 0.05
1.838ThrPro: 1.838 ± 0.063
1.35ThrGln: 1.35 ± 0.049
1.662ThrArg: 1.662 ± 0.044
2.632ThrSer: 2.632 ± 0.063
2.32ThrThr: 2.32 ± 0.071
3.618ThrVal: 3.618 ± 0.091
0.402ThrTrp: 0.402 ± 0.026
1.592ThrTyr: 1.592 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.747ValAla: 3.747 ± 0.085
0.723ValCys: 0.723 ± 0.035
3.426ValAsp: 3.426 ± 0.085
4.608ValGlu: 4.608 ± 0.116
3.458ValPhe: 3.458 ± 0.078
4.072ValGly: 4.072 ± 0.088
1.202ValHis: 1.202 ± 0.047
4.87ValIle: 4.87 ± 0.102
4.517ValLys: 4.517 ± 0.093
6.723ValLeu: 6.723 ± 0.118
1.81ValMet: 1.81 ± 0.057
2.896ValAsn: 2.896 ± 0.076
2.067ValPro: 2.067 ± 0.067
1.802ValGln: 1.802 ± 0.053
2.565ValArg: 2.565 ± 0.061
3.792ValSer: 3.792 ± 0.091
2.837ValThr: 2.837 ± 0.073
4.054ValVal: 4.054 ± 0.095
0.496ValTrp: 0.496 ± 0.027
2.39ValTyr: 2.39 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.029
0.102TrpCys: 0.102 ± 0.014
0.491TrpAsp: 0.491 ± 0.027
0.656TrpGlu: 0.656 ± 0.032
0.325TrpPhe: 0.325 ± 0.024
0.614TrpGly: 0.614 ± 0.044
0.157TrpHis: 0.157 ± 0.016
0.982TrpIle: 0.982 ± 0.041
0.854TrpLys: 0.854 ± 0.036
0.698TrpLeu: 0.698 ± 0.034
0.344TrpMet: 0.344 ± 0.023
0.502TrpAsn: 0.502 ± 0.03
0.182TrpPro: 0.182 ± 0.017
0.296TrpGln: 0.296 ± 0.023
0.387TrpArg: 0.387 ± 0.027
0.4TrpSer: 0.4 ± 0.024
0.424TrpThr: 0.424 ± 0.024
0.467TrpVal: 0.467 ± 0.026
0.083TrpTrp: 0.083 ± 0.011
0.285TrpTyr: 0.285 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.368TyrAla: 2.368 ± 0.066
0.472TyrCys: 0.472 ± 0.029
2.096TyrAsp: 2.096 ± 0.055
2.845TyrGlu: 2.845 ± 0.074
2.205TyrPhe: 2.205 ± 0.064
2.832TyrGly: 2.832 ± 0.066
0.858TyrHis: 0.858 ± 0.04
3.062TyrIle: 3.062 ± 0.076
2.606TyrLys: 2.606 ± 0.075
4.054TyrLeu: 4.054 ± 0.086
1.054TyrMet: 1.054 ± 0.043
1.706TyrAsn: 1.706 ± 0.056
1.442TyrPro: 1.442 ± 0.047
1.403TyrGln: 1.403 ± 0.05
1.984TyrArg: 1.984 ± 0.058
2.374TyrSer: 2.374 ± 0.057
2.005TyrThr: 2.005 ± 0.061
2.232TyrVal: 2.232 ± 0.059
0.365TyrTrp: 0.365 ± 0.025
1.778TyrTyr: 1.778 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2325 proteins (625010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski