Amino acid dipepetide frequency for Kipferlia bialata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.497AlaAla: 8.497 ± 0.171
1.678AlaCys: 1.678 ± 0.063
4.685AlaAsp: 4.685 ± 0.12
6.55AlaGlu: 6.55 ± 0.198
2.136AlaPhe: 2.136 ± 0.065
5.661AlaGly: 5.661 ± 0.122
1.76AlaHis: 1.76 ± 0.064
2.917AlaIle: 2.917 ± 0.085
3.416AlaLys: 3.416 ± 0.115
8.917AlaLeu: 8.917 ± 0.158
2.164AlaMet: 2.164 ± 0.065
1.825AlaAsn: 1.825 ± 0.066
5.003AlaPro: 5.003 ± 0.126
3.261AlaGln: 3.261 ± 0.092
4.513AlaArg: 4.513 ± 0.123
6.979AlaSer: 6.979 ± 0.148
5.331AlaThr: 5.331 ± 0.116
7.22AlaVal: 7.22 ± 0.128
0.753AlaTrp: 0.753 ± 0.036
2.218AlaTyr: 2.218 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.437CysAla: 1.437 ± 0.05
0.533CysCys: 0.533 ± 0.034
1.387CysAsp: 1.387 ± 0.058
1.12CysGlu: 1.12 ± 0.045
0.589CysPhe: 0.589 ± 0.035
1.738CysGly: 1.738 ± 0.057
0.521CysHis: 0.521 ± 0.027
0.974CysIle: 0.974 ± 0.051
0.614CysLys: 0.614 ± 0.036
2.183CysLeu: 2.183 ± 0.082
0.618CysMet: 0.618 ± 0.033
0.628CysAsn: 0.628 ± 0.036
1.305CysPro: 1.305 ± 0.061
0.653CysGln: 0.653 ± 0.035
1.125CysArg: 1.125 ± 0.045
1.377CysSer: 1.377 ± 0.054
1.442CysThr: 1.442 ± 0.062
2.179CysVal: 2.179 ± 0.065
0.173CysTrp: 0.173 ± 0.017
0.588CysTyr: 0.588 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
5.271AspAla: 5.271 ± 0.101
1.117AspCys: 1.117 ± 0.049
3.072AspAsp: 3.072 ± 0.1
3.33AspGlu: 3.33 ± 0.082
1.33AspPhe: 1.33 ± 0.046
4.672AspGly: 4.672 ± 0.107
1.124AspHis: 1.124 ± 0.044
2.977AspIle: 2.977 ± 0.079
1.766AspLys: 1.766 ± 0.061
5.343AspLeu: 5.343 ± 0.142
2.214AspMet: 2.214 ± 0.068
1.37AspAsn: 1.37 ± 0.053
3.246AspPro: 3.246 ± 0.082
1.463AspGln: 1.463 ± 0.048
3.425AspArg: 3.425 ± 0.114
4.805AspSer: 4.805 ± 0.108
5.927AspThr: 5.927 ± 0.123
4.763AspVal: 4.763 ± 0.123
0.806AspTrp: 0.806 ± 0.036
1.493AspTyr: 1.493 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
7.142GluAla: 7.142 ± 0.192
1.528GluCys: 1.528 ± 0.064
3.679GluAsp: 3.679 ± 0.09
5.882GluGlu: 5.882 ± 0.165
1.415GluPhe: 1.415 ± 0.057
6.614GluGly: 6.614 ± 0.161
1.149GluHis: 1.149 ± 0.047
2.086GluIle: 2.086 ± 0.065
2.268GluLys: 2.268 ± 0.089
4.124GluLeu: 4.124 ± 0.115
1.851GluMet: 1.851 ± 0.064
1.154GluAsn: 1.154 ± 0.048
2.121GluPro: 2.121 ± 0.077
1.943GluGln: 1.943 ± 0.069
7.177GluArg: 7.177 ± 0.274
4.791GluSer: 4.791 ± 0.102
4.62GluThr: 4.62 ± 0.108
4.841GluVal: 4.841 ± 0.106
1.269GluTrp: 1.269 ± 0.063
1.901GluTyr: 1.901 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
1.776PheAla: 1.776 ± 0.062
0.576PheCys: 0.576 ± 0.036
1.828PheAsp: 1.828 ± 0.078
1.309PheGlu: 1.309 ± 0.055
0.801PhePhe: 0.801 ± 0.041
1.983PheGly: 1.983 ± 0.067
0.708PheHis: 0.708 ± 0.034
1.039PheIle: 1.039 ± 0.042
0.866PheLys: 0.866 ± 0.04
1.999PheLeu: 1.999 ± 0.067
0.589PheMet: 0.589 ± 0.033
0.872PheAsn: 0.872 ± 0.041
1.25PhePro: 1.25 ± 0.054
0.866PheGln: 0.866 ± 0.043
1.354PheArg: 1.354 ± 0.052
2.461PheSer: 2.461 ± 0.075
1.811PheThr: 1.811 ± 0.091
1.885PheVal: 1.885 ± 0.063
0.266PheTrp: 0.266 ± 0.022
0.714PheTyr: 0.714 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
6.07GlyAla: 6.07 ± 0.129
1.672GlyCys: 1.672 ± 0.071
5.214GlyAsp: 5.214 ± 0.121
6.078GlyGlu: 6.078 ± 0.162
1.78GlyPhe: 1.78 ± 0.092
6.728GlyGly: 6.728 ± 0.156
1.898GlyHis: 1.898 ± 0.061
2.774GlyIle: 2.774 ± 0.081
2.789GlyLys: 2.789 ± 0.086
5.581GlyLeu: 5.581 ± 0.115
2.158GlyMet: 2.158 ± 0.078
1.766GlyAsn: 1.766 ± 0.058
3.208GlyPro: 3.208 ± 0.084
2.769GlyGln: 2.769 ± 0.079
4.548GlyArg: 4.548 ± 0.13
6.057GlySer: 6.057 ± 0.156
5.274GlyThr: 5.274 ± 0.137
7.37GlyVal: 7.37 ± 0.152
1.137GlyTrp: 1.137 ± 0.042
2.236GlyTyr: 2.236 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
1.8HisAla: 1.8 ± 0.066
0.644HisCys: 0.644 ± 0.036
1.117HisAsp: 1.117 ± 0.046
0.884HisGlu: 0.884 ± 0.041
0.684HisPhe: 0.684 ± 0.035
1.708HisGly: 1.708 ± 0.077
0.772HisHis: 0.772 ± 0.043
1.249HisIle: 1.249 ± 0.05
0.826HisLys: 0.826 ± 0.039
2.441HisLeu: 2.441 ± 0.073
0.786HisMet: 0.786 ± 0.037
0.729HisAsn: 0.729 ± 0.039
1.745HisPro: 1.745 ± 0.076
0.864HisGln: 0.864 ± 0.046
1.558HisArg: 1.558 ± 0.061
2.149HisSer: 2.149 ± 0.072
2.099HisThr: 2.099 ± 0.071
2.011HisVal: 2.011 ± 0.057
0.301HisTrp: 0.301 ± 0.024
0.634HisTyr: 0.634 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
3.0IleAla: 3.0 ± 0.084
0.698IleCys: 0.698 ± 0.035
2.417IleAsp: 2.417 ± 0.071
2.284IleGlu: 2.284 ± 0.063
0.787IlePhe: 0.787 ± 0.035
2.822IleGly: 2.822 ± 0.086
1.021IleHis: 1.021 ± 0.043
1.169IleIle: 1.169 ± 0.044
1.345IleLys: 1.345 ± 0.061
3.097IleLeu: 3.097 ± 0.08
0.766IleMet: 0.766 ± 0.039
1.009IleAsn: 1.009 ± 0.049
2.522IlePro: 2.522 ± 0.08
1.537IleGln: 1.537 ± 0.059
1.998IleArg: 1.998 ± 0.059
3.11IleSer: 3.11 ± 0.093
2.266IleThr: 2.266 ± 0.08
2.797IleVal: 2.797 ± 0.078
0.32IleTrp: 0.32 ± 0.021
0.971IleTyr: 0.971 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
3.944LysAla: 3.944 ± 0.113
0.651LysCys: 0.651 ± 0.035
1.918LysAsp: 1.918 ± 0.073
2.694LysGlu: 2.694 ± 0.111
0.621LysPhe: 0.621 ± 0.034
3.27LysGly: 3.27 ± 0.1
0.819LysHis: 0.819 ± 0.042
0.961LysIle: 0.961 ± 0.046
2.269LysLys: 2.269 ± 0.11
2.279LysLeu: 2.279 ± 0.083
0.891LysMet: 0.891 ± 0.04
0.844LysAsn: 0.844 ± 0.049
1.58LysPro: 1.58 ± 0.07
1.155LysGln: 1.155 ± 0.054
3.002LysArg: 3.002 ± 0.099
1.83LysSer: 1.83 ± 0.071
1.885LysThr: 1.885 ± 0.072
2.549LysVal: 2.549 ± 0.069
0.513LysTrp: 0.513 ± 0.032
1.047LysTyr: 1.047 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
7.625LeuAla: 7.625 ± 0.152
2.206LeuCys: 2.206 ± 0.074
5.714LeuAsp: 5.714 ± 0.116
5.319LeuGlu: 5.319 ± 0.112
2.472LeuPhe: 2.472 ± 0.063
5.875LeuGly: 5.875 ± 0.133
2.324LeuHis: 2.324 ± 0.079
2.677LeuIle: 2.677 ± 0.068
3.072LeuLys: 3.072 ± 0.1
7.978LeuLeu: 7.978 ± 0.157
1.815LeuMet: 1.815 ± 0.059
2.133LeuAsn: 2.133 ± 0.063
5.947LeuPro: 5.947 ± 0.139
3.062LeuGln: 3.062 ± 0.095
5.246LeuArg: 5.246 ± 0.135
10.252LeuSer: 10.252 ± 0.235
6.14LeuThr: 6.14 ± 0.151
6.513LeuVal: 6.513 ± 0.109
0.754LeuTrp: 0.754 ± 0.04
2.587LeuTyr: 2.587 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.307MetAla: 2.307 ± 0.067
0.616MetCys: 0.616 ± 0.032
1.663MetAsp: 1.663 ± 0.066
1.648MetGlu: 1.648 ± 0.067
0.649MetPhe: 0.649 ± 0.034
2.286MetGly: 2.286 ± 0.078
0.716MetHis: 0.716 ± 0.037
0.623MetIle: 0.623 ± 0.031
0.748MetLys: 0.748 ± 0.036
2.024MetLeu: 2.024 ± 0.065
0.576MetMet: 0.576 ± 0.035
0.539MetAsn: 0.539 ± 0.035
1.71MetPro: 1.71 ± 0.055
1.031MetGln: 1.031 ± 0.053
1.512MetArg: 1.512 ± 0.058
2.472MetSer: 2.472 ± 0.072
1.585MetThr: 1.585 ± 0.055
1.861MetVal: 1.861 ± 0.042
0.348MetTrp: 0.348 ± 0.024
0.786MetTyr: 0.786 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
1.966AsnAla: 1.966 ± 0.064
0.463AsnCys: 0.463 ± 0.029
1.122AsnAsp: 1.122 ± 0.05
1.164AsnGlu: 1.164 ± 0.048
0.44AsnPhe: 0.44 ± 0.027
1.733AsnGly: 1.733 ± 0.071
0.564AsnHis: 0.564 ± 0.029
0.989AsnIle: 0.989 ± 0.048
0.974AsnLys: 0.974 ± 0.049
2.084AsnLeu: 2.084 ± 0.091
0.706AsnMet: 0.706 ± 0.038
0.706AsnAsn: 0.706 ± 0.041
1.58AsnPro: 1.58 ± 0.052
0.841AsnGln: 0.841 ± 0.038
1.319AsnArg: 1.319 ± 0.055
1.562AsnSer: 1.562 ± 0.048
1.88AsnThr: 1.88 ± 0.066
1.785AsnVal: 1.785 ± 0.061
0.266AsnTrp: 0.266 ± 0.021
0.511AsnTyr: 0.511 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.657ProAla: 4.657 ± 0.11
0.976ProCys: 0.976 ± 0.041
2.942ProAsp: 2.942 ± 0.072
3.493ProGlu: 3.493 ± 0.119
1.6ProPhe: 1.6 ± 0.056
3.441ProGly: 3.441 ± 0.086
1.583ProHis: 1.583 ± 0.058
2.036ProIle: 2.036 ± 0.066
2.019ProLys: 2.019 ± 0.073
5.432ProLeu: 5.432 ± 0.102
1.412ProMet: 1.412 ± 0.058
1.254ProAsn: 1.254 ± 0.048
4.404ProPro: 4.404 ± 0.155
2.091ProGln: 2.091 ± 0.069
2.93ProArg: 2.93 ± 0.1
6.315ProSer: 6.315 ± 0.146
4.001ProThr: 4.001 ± 0.103
5.221ProVal: 5.221 ± 0.107
0.456ProTrp: 0.456 ± 0.029
1.587ProTyr: 1.587 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.413GlnAla: 3.413 ± 0.115
0.832GlnCys: 0.832 ± 0.044
1.745GlnAsp: 1.745 ± 0.052
2.326GlnGlu: 2.326 ± 0.077
0.872GlnPhe: 0.872 ± 0.044
3.0GlnGly: 3.0 ± 0.081
0.914GlnHis: 0.914 ± 0.047
1.185GlnIle: 1.185 ± 0.048
1.179GlnLys: 1.179 ± 0.055
2.925GlnLeu: 2.925 ± 0.089
1.274GlnMet: 1.274 ± 0.059
0.658GlnAsn: 0.658 ± 0.032
1.725GlnPro: 1.725 ± 0.069
1.691GlnGln: 1.691 ± 0.085
2.952GlnArg: 2.952 ± 0.11
2.687GlnSer: 2.687 ± 0.073
2.372GlnThr: 2.372 ± 0.075
2.482GlnVal: 2.482 ± 0.071
0.514GlnTrp: 0.514 ± 0.03
1.144GlnTyr: 1.144 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
4.528ArgAla: 4.528 ± 0.12
1.114ArgCys: 1.114 ± 0.046
3.957ArgAsp: 3.957 ± 0.129
7.182ArgGlu: 7.182 ± 0.25
1.38ArgPhe: 1.38 ± 0.052
4.568ArgGly: 4.568 ± 0.13
1.836ArgHis: 1.836 ± 0.069
1.961ArgIle: 1.961 ± 0.065
2.322ArgLys: 2.322 ± 0.086
5.532ArgLeu: 5.532 ± 0.133
1.468ArgMet: 1.468 ± 0.046
1.215ArgAsn: 1.215 ± 0.056
2.978ArgPro: 2.978 ± 0.088
2.943ArgGln: 2.943 ± 0.109
4.72ArgArg: 4.72 ± 0.155
3.44ArgSer: 3.44 ± 0.095
2.64ArgThr: 2.64 ± 0.075
5.139ArgVal: 5.139 ± 0.133
0.726ArgTrp: 0.726 ± 0.036
1.567ArgTyr: 1.567 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
7.339SerAla: 7.339 ± 0.162
1.447SerCys: 1.447 ± 0.058
5.397SerAsp: 5.397 ± 0.125
4.776SerGlu: 4.776 ± 0.096
2.327SerPhe: 2.327 ± 0.076
7.046SerGly: 7.046 ± 0.17
2.153SerHis: 2.153 ± 0.071
3.35SerIle: 3.35 ± 0.078
2.441SerLys: 2.441 ± 0.093
9.591SerLeu: 9.591 ± 0.172
2.058SerMet: 2.058 ± 0.066
1.731SerAsn: 1.731 ± 0.054
5.114SerPro: 5.114 ± 0.131
2.725SerGln: 2.725 ± 0.076
3.946SerArg: 3.946 ± 0.105
6.984SerSer: 6.984 ± 0.19
5.356SerThr: 5.356 ± 0.162
8.144SerVal: 8.144 ± 0.257
0.711SerTrp: 0.711 ± 0.038
1.913SerTyr: 1.913 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
5.273ThrAla: 5.273 ± 0.118
1.315ThrCys: 1.315 ± 0.055
4.099ThrAsp: 4.099 ± 0.116
4.2ThrGlu: 4.2 ± 0.111
1.773ThrPhe: 1.773 ± 0.065
5.223ThrGly: 5.223 ± 0.146
2.144ThrHis: 2.144 ± 0.071
2.406ThrIle: 2.406 ± 0.091
1.955ThrLys: 1.955 ± 0.066
8.115ThrLeu: 8.115 ± 0.189
1.465ThrMet: 1.465 ± 0.05
1.388ThrAsn: 1.388 ± 0.058
4.861ThrPro: 4.861 ± 0.114
2.742ThrGln: 2.742 ± 0.093
3.25ThrArg: 3.25 ± 0.08
5.04ThrSer: 5.04 ± 0.16
4.107ThrThr: 4.107 ± 0.134
6.277ThrVal: 6.277 ± 0.211
0.693ThrTrp: 0.693 ± 0.04
1.911ThrTyr: 1.911 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
6.608ValAla: 6.608 ± 0.144
2.191ValCys: 2.191 ± 0.067
4.94ValAsp: 4.94 ± 0.113
5.01ValGlu: 5.01 ± 0.107
2.389ValPhe: 2.389 ± 0.069
5.865ValGly: 5.865 ± 0.121
1.978ValHis: 1.978 ± 0.051
2.779ValIle: 2.779 ± 0.08
2.541ValLys: 2.541 ± 0.076
6.854ValLeu: 6.854 ± 0.143
1.77ValMet: 1.77 ± 0.064
1.693ValAsn: 1.693 ± 0.058
5.436ValPro: 5.436 ± 0.124
2.819ValGln: 2.819 ± 0.076
4.242ValArg: 4.242 ± 0.094
9.01ValSer: 9.01 ± 0.239
6.087ValThr: 6.087 ± 0.175
7.191ValVal: 7.191 ± 0.163
1.024ValTrp: 1.024 ± 0.044
2.972ValTyr: 2.972 ± 0.103
0.0ValXaa: 0.0 ± 0.0
Trp
0.787TrpAla: 0.787 ± 0.039
0.366TrpCys: 0.366 ± 0.031
0.826TrpAsp: 0.826 ± 0.04
0.859TrpGlu: 0.859 ± 0.042
0.296TrpPhe: 0.296 ± 0.023
0.914TrpGly: 0.914 ± 0.039
0.258TrpHis: 0.258 ± 0.021
0.39TrpIle: 0.39 ± 0.025
0.411TrpLys: 0.411 ± 0.031
0.904TrpLeu: 0.904 ± 0.042
0.32TrpMet: 0.32 ± 0.025
0.311TrpAsn: 0.311 ± 0.023
0.435TrpPro: 0.435 ± 0.026
0.455TrpGln: 0.455 ± 0.027
0.824TrpArg: 0.824 ± 0.042
0.806TrpSer: 0.806 ± 0.043
0.827TrpThr: 0.827 ± 0.052
1.014TrpVal: 1.014 ± 0.046
0.112TrpTrp: 0.112 ± 0.016
0.331TrpTyr: 0.331 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.043TyrAla: 2.043 ± 0.065
0.561TyrCys: 0.561 ± 0.032
1.791TyrAsp: 1.791 ± 0.069
1.448TyrGlu: 1.448 ± 0.049
0.609TyrPhe: 0.609 ± 0.032
1.96TyrGly: 1.96 ± 0.073
0.761TyrHis: 0.761 ± 0.038
1.395TyrIle: 1.395 ± 0.055
0.901TyrLys: 0.901 ± 0.043
2.307TyrLeu: 2.307 ± 0.075
0.799TyrMet: 0.799 ± 0.036
0.827TyrAsn: 0.827 ± 0.037
1.678TyrPro: 1.678 ± 0.063
0.981TyrGln: 0.981 ± 0.046
1.582TyrArg: 1.582 ± 0.059
2.424TyrSer: 2.424 ± 0.099
2.586TyrThr: 2.586 ± 0.105
2.153TyrVal: 2.153 ± 0.095
0.305TyrTrp: 0.305 ± 0.022
0.784TyrTyr: 0.784 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3513 proteins (600654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski