Amino acid dipepetide frequency for Pedobacter metabolipauper

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.464AlaAla: 6.464 ± 0.085
0.612AlaCys: 0.612 ± 0.022
4.441AlaAsp: 4.441 ± 0.051
4.603AlaGlu: 4.603 ± 0.066
3.424AlaPhe: 3.424 ± 0.048
5.617AlaGly: 5.617 ± 0.075
1.133AlaHis: 1.133 ± 0.026
5.43AlaIle: 5.43 ± 0.064
4.672AlaLys: 4.672 ± 0.06
6.93AlaLeu: 6.93 ± 0.08
1.642AlaMet: 1.642 ± 0.036
3.668AlaAsn: 3.668 ± 0.055
2.211AlaPro: 2.211 ± 0.044
2.768AlaGln: 2.768 ± 0.049
2.416AlaArg: 2.416 ± 0.048
4.583AlaSer: 4.583 ± 0.067
3.767AlaThr: 3.767 ± 0.074
4.886AlaVal: 4.886 ± 0.068
0.729AlaTrp: 0.729 ± 0.023
2.871AlaTyr: 2.871 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.467CysAla: 0.467 ± 0.02
0.107CysCys: 0.107 ± 0.008
0.349CysAsp: 0.349 ± 0.015
0.342CysGlu: 0.342 ± 0.018
0.426CysPhe: 0.426 ± 0.017
0.578CysGly: 0.578 ± 0.024
0.171CysHis: 0.171 ± 0.011
0.61CysIle: 0.61 ± 0.02
0.496CysLys: 0.496 ± 0.017
0.739CysLeu: 0.739 ± 0.022
0.167CysMet: 0.167 ± 0.01
0.374CysAsn: 0.374 ± 0.017
0.265CysPro: 0.265 ± 0.015
0.189CysGln: 0.189 ± 0.012
0.292CysArg: 0.292 ± 0.013
0.536CysSer: 0.536 ± 0.018
0.421CysThr: 0.421 ± 0.02
0.393CysVal: 0.393 ± 0.018
0.069CysTrp: 0.069 ± 0.007
0.277CysTyr: 0.277 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.88AspAla: 3.88 ± 0.052
0.365AspCys: 0.365 ± 0.015
2.655AspAsp: 2.655 ± 0.047
3.38AspGlu: 3.38 ± 0.053
3.169AspPhe: 3.169 ± 0.05
3.798AspGly: 3.798 ± 0.057
1.19AspHis: 1.19 ± 0.027
3.76AspIle: 3.76 ± 0.05
3.717AspLys: 3.717 ± 0.05
5.577AspLeu: 5.577 ± 0.065
1.147AspMet: 1.147 ± 0.026
2.558AspAsn: 2.558 ± 0.042
2.317AspPro: 2.317 ± 0.043
2.302AspGln: 2.302 ± 0.048
2.163AspArg: 2.163 ± 0.039
2.87AspSer: 2.87 ± 0.05
2.623AspThr: 2.623 ± 0.04
3.436AspVal: 3.436 ± 0.045
0.719AspTrp: 0.719 ± 0.023
2.567AspTyr: 2.567 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
4.093GluAla: 4.093 ± 0.072
0.278GluCys: 0.278 ± 0.016
2.889GluAsp: 2.889 ± 0.047
3.737GluGlu: 3.737 ± 0.087
2.485GluPhe: 2.485 ± 0.039
3.3GluGly: 3.3 ± 0.052
1.128GluHis: 1.128 ± 0.026
4.637GluIle: 4.637 ± 0.058
4.798GluLys: 4.798 ± 0.067
5.848GluLeu: 5.848 ± 0.071
1.493GluMet: 1.493 ± 0.03
3.527GluAsn: 3.527 ± 0.049
1.643GluPro: 1.643 ± 0.032
2.488GluGln: 2.488 ± 0.048
2.641GluArg: 2.641 ± 0.042
3.116GluSer: 3.116 ± 0.049
3.079GluThr: 3.079 ± 0.042
3.683GluVal: 3.683 ± 0.055
0.63GluTrp: 0.63 ± 0.021
2.128GluTyr: 2.128 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.222PheAla: 3.222 ± 0.05
0.442PheCys: 0.442 ± 0.018
2.911PheAsp: 2.911 ± 0.042
2.83PheGlu: 2.83 ± 0.043
2.433PhePhe: 2.433 ± 0.046
3.348PheGly: 3.348 ± 0.058
0.76PheHis: 0.76 ± 0.021
3.723PheIle: 3.723 ± 0.055
3.614PheLys: 3.614 ± 0.049
4.401PheLeu: 4.401 ± 0.06
1.122PheMet: 1.122 ± 0.028
3.234PheAsn: 3.234 ± 0.049
1.683PhePro: 1.683 ± 0.036
1.384PheGln: 1.384 ± 0.031
1.741PheArg: 1.741 ± 0.04
3.97PheSer: 3.97 ± 0.052
3.131PheThr: 3.131 ± 0.052
2.746PheVal: 2.746 ± 0.049
0.593PheTrp: 0.593 ± 0.022
2.153PheTyr: 2.153 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.464GlyAla: 4.464 ± 0.061
0.58GlyCys: 0.58 ± 0.022
3.3GlyAsp: 3.3 ± 0.048
3.101GlyGlu: 3.101 ± 0.041
3.712GlyPhe: 3.712 ± 0.045
4.693GlyGly: 4.693 ± 0.079
1.125GlyHis: 1.125 ± 0.027
5.52GlyIle: 5.52 ± 0.064
5.403GlyLys: 5.403 ± 0.06
6.326GlyLeu: 6.326 ± 0.074
1.688GlyMet: 1.688 ± 0.033
3.794GlyAsn: 3.794 ± 0.064
1.506GlyPro: 1.506 ± 0.029
2.124GlyGln: 2.124 ± 0.038
2.438GlyArg: 2.438 ± 0.047
4.654GlySer: 4.654 ± 0.067
4.338GlyThr: 4.338 ± 0.075
4.152GlyVal: 4.152 ± 0.054
0.897GlyTrp: 0.897 ± 0.028
3.182GlyTyr: 3.182 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.141HisAla: 1.141 ± 0.031
0.155HisCys: 0.155 ± 0.01
0.852HisAsp: 0.852 ± 0.023
0.984HisGlu: 0.984 ± 0.026
1.053HisPhe: 1.053 ± 0.025
1.079HisGly: 1.079 ± 0.025
0.478HisHis: 0.478 ± 0.018
1.315HisIle: 1.315 ± 0.03
1.037HisLys: 1.037 ± 0.028
1.801HisLeu: 1.801 ± 0.033
0.344HisMet: 0.344 ± 0.015
0.872HisAsn: 0.872 ± 0.024
0.914HisPro: 0.914 ± 0.028
0.744HisGln: 0.744 ± 0.024
0.698HisArg: 0.698 ± 0.022
0.994HisSer: 0.994 ± 0.028
1.007HisThr: 1.007 ± 0.024
0.968HisVal: 0.968 ± 0.027
0.229HisTrp: 0.229 ± 0.012
0.803HisTyr: 0.803 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.871IleAla: 5.871 ± 0.071
0.696IleCys: 0.696 ± 0.022
4.439IleAsp: 4.439 ± 0.054
4.406IleGlu: 4.406 ± 0.055
3.286IlePhe: 3.286 ± 0.05
4.967IleGly: 4.967 ± 0.064
1.36IleHis: 1.36 ± 0.03
5.156IleIle: 5.156 ± 0.064
5.447IleLys: 5.447 ± 0.059
6.794IleLeu: 6.794 ± 0.083
1.387IleMet: 1.387 ± 0.031
4.497IleAsn: 4.497 ± 0.048
3.093IlePro: 3.093 ± 0.04
2.425IleGln: 2.425 ± 0.043
3.164IleArg: 3.164 ± 0.049
5.643IleSer: 5.643 ± 0.071
4.617IleThr: 4.617 ± 0.059
4.243IleVal: 4.243 ± 0.055
0.722IleTrp: 0.722 ± 0.017
2.842IleTyr: 2.842 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
5.11LysAla: 5.11 ± 0.067
0.331LysCys: 0.331 ± 0.015
4.489LysAsp: 4.489 ± 0.054
4.914LysGlu: 4.914 ± 0.073
2.772LysPhe: 2.772 ± 0.039
4.452LysGly: 4.452 ± 0.059
1.224LysHis: 1.224 ± 0.028
5.567LysIle: 5.567 ± 0.067
5.739LysLys: 5.739 ± 0.072
6.362LysLeu: 6.362 ± 0.068
1.947LysMet: 1.947 ± 0.037
4.455LysAsn: 4.455 ± 0.045
2.816LysPro: 2.816 ± 0.051
2.713LysGln: 2.713 ± 0.039
2.827LysArg: 2.827 ± 0.039
4.281LysSer: 4.281 ± 0.046
4.358LysThr: 4.358 ± 0.064
4.404LysVal: 4.404 ± 0.057
0.787LysTrp: 0.787 ± 0.024
2.964LysTyr: 2.964 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.465LeuAla: 6.465 ± 0.064
0.762LeuCys: 0.762 ± 0.023
4.861LeuAsp: 4.861 ± 0.056
5.101LeuGlu: 5.101 ± 0.067
4.78LeuPhe: 4.78 ± 0.067
5.604LeuGly: 5.604 ± 0.066
1.584LeuHis: 1.584 ± 0.034
7.224LeuIle: 7.224 ± 0.085
7.783LeuLys: 7.783 ± 0.084
9.429LeuLeu: 9.429 ± 0.098
2.221LeuMet: 2.221 ± 0.046
6.089LeuAsn: 6.089 ± 0.071
4.021LeuPro: 4.021 ± 0.05
3.38LeuGln: 3.38 ± 0.045
3.506LeuArg: 3.506 ± 0.045
7.529LeuSer: 7.529 ± 0.069
5.682LeuThr: 5.682 ± 0.067
5.463LeuVal: 5.463 ± 0.063
0.899LeuTrp: 0.899 ± 0.026
3.34LeuTyr: 3.34 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.791MetAla: 1.791 ± 0.034
0.124MetCys: 0.124 ± 0.009
1.225MetAsp: 1.225 ± 0.025
1.453MetGlu: 1.453 ± 0.033
0.822MetPhe: 0.822 ± 0.023
1.503MetGly: 1.503 ± 0.033
0.415MetHis: 0.415 ± 0.018
1.636MetIle: 1.636 ± 0.031
1.936MetLys: 1.936 ± 0.032
2.134MetLeu: 2.134 ± 0.041
0.593MetMet: 0.593 ± 0.021
1.325MetAsn: 1.325 ± 0.03
1.031MetPro: 1.031 ± 0.025
0.873MetGln: 0.873 ± 0.024
0.915MetArg: 0.915 ± 0.028
1.401MetSer: 1.401 ± 0.031
1.084MetThr: 1.084 ± 0.026
1.44MetVal: 1.44 ± 0.032
0.166MetTrp: 0.166 ± 0.011
0.722MetTyr: 0.722 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
4.235AsnAla: 4.235 ± 0.056
0.39AsnCys: 0.39 ± 0.017
2.792AsnAsp: 2.792 ± 0.042
3.138AsnGlu: 3.138 ± 0.051
2.762AsnPhe: 2.762 ± 0.046
4.195AsnGly: 4.195 ± 0.059
0.975AsnHis: 0.975 ± 0.026
4.141AsnIle: 4.141 ± 0.056
3.855AsnLys: 3.855 ± 0.048
5.37AsnLeu: 5.37 ± 0.061
1.264AsnMet: 1.264 ± 0.028
3.328AsnAsn: 3.328 ± 0.057
2.771AsnPro: 2.771 ± 0.045
2.041AsnGln: 2.041 ± 0.036
2.332AsnArg: 2.332 ± 0.044
3.543AsnSer: 3.543 ± 0.052
3.55AsnThr: 3.55 ± 0.043
3.298AsnVal: 3.298 ± 0.043
0.751AsnTrp: 0.751 ± 0.022
2.719AsnTyr: 2.719 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.219ProAla: 3.219 ± 0.062
0.218ProCys: 0.218 ± 0.013
2.578ProAsp: 2.578 ± 0.043
2.86ProGlu: 2.86 ± 0.053
1.897ProPhe: 1.897 ± 0.036
2.857ProGly: 2.857 ± 0.04
0.59ProHis: 0.59 ± 0.02
2.365ProIle: 2.365 ± 0.042
2.335ProLys: 2.335 ± 0.041
3.401ProLeu: 3.401 ± 0.044
0.754ProMet: 0.754 ± 0.022
1.95ProAsn: 1.95 ± 0.033
0.89ProPro: 0.89 ± 0.032
1.248ProGln: 1.248 ± 0.024
1.018ProArg: 1.018 ± 0.029
2.169ProSer: 2.169 ± 0.043
1.755ProThr: 1.755 ± 0.035
3.25ProVal: 3.25 ± 0.055
0.352ProTrp: 0.352 ± 0.016
1.483ProTyr: 1.483 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.406GlnAla: 2.406 ± 0.042
0.186GlnCys: 0.186 ± 0.011
1.652GlnAsp: 1.652 ± 0.034
2.077GlnGlu: 2.077 ± 0.043
1.678GlnPhe: 1.678 ± 0.035
1.936GlnGly: 1.936 ± 0.037
0.725GlnHis: 0.725 ± 0.022
2.696GlnIle: 2.696 ± 0.044
2.69GlnLys: 2.69 ± 0.045
3.769GlnLeu: 3.769 ± 0.051
0.881GlnMet: 0.881 ± 0.025
2.039GlnAsn: 2.039 ± 0.042
1.315GlnPro: 1.315 ± 0.032
1.861GlnGln: 1.861 ± 0.042
1.471GlnArg: 1.471 ± 0.032
2.295GlnSer: 2.295 ± 0.039
2.047GlnThr: 2.047 ± 0.04
2.288GlnVal: 2.288 ± 0.036
0.38GlnTrp: 0.38 ± 0.015
1.472GlnTyr: 1.472 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.334ArgAla: 2.334 ± 0.043
0.225ArgCys: 0.225 ± 0.011
1.895ArgAsp: 1.895 ± 0.038
2.154ArgGlu: 2.154 ± 0.039
2.16ArgPhe: 2.16 ± 0.042
2.1ArgGly: 2.1 ± 0.038
0.597ArgHis: 0.597 ± 0.019
3.273ArgIle: 3.273 ± 0.043
2.93ArgLys: 2.93 ± 0.045
3.843ArgLeu: 3.843 ± 0.051
1.043ArgMet: 1.043 ± 0.029
2.315ArgAsn: 2.315 ± 0.041
1.317ArgPro: 1.317 ± 0.031
1.326ArgGln: 1.326 ± 0.032
1.458ArgArg: 1.458 ± 0.031
2.591ArgSer: 2.591 ± 0.038
2.179ArgThr: 2.179 ± 0.044
2.273ArgVal: 2.273 ± 0.038
0.449ArgTrp: 0.449 ± 0.018
1.834ArgTyr: 1.834 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
5.089SerAla: 5.089 ± 0.063
0.549SerCys: 0.549 ± 0.019
3.392SerAsp: 3.392 ± 0.047
3.317SerGlu: 3.317 ± 0.049
3.753SerPhe: 3.753 ± 0.057
5.27SerGly: 5.27 ± 0.074
1.003SerHis: 1.003 ± 0.023
5.175SerIle: 5.175 ± 0.058
4.352SerLys: 4.352 ± 0.052
6.418SerLeu: 6.418 ± 0.064
1.333SerMet: 1.333 ± 0.034
3.518SerAsn: 3.518 ± 0.049
2.39SerPro: 2.39 ± 0.051
1.989SerGln: 1.989 ± 0.04
2.53SerArg: 2.53 ± 0.036
4.557SerSer: 4.557 ± 0.065
3.701SerThr: 3.701 ± 0.055
4.371SerVal: 4.371 ± 0.051
0.793SerTrp: 0.793 ± 0.025
2.965SerTyr: 2.965 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.765ThrAla: 4.765 ± 0.085
0.302ThrCys: 0.302 ± 0.014
3.461ThrAsp: 3.461 ± 0.053
3.232ThrGlu: 3.232 ± 0.058
2.771ThrPhe: 2.771 ± 0.043
4.832ThrGly: 4.832 ± 0.066
0.954ThrHis: 0.954 ± 0.027
4.504ThrIle: 4.504 ± 0.06
3.285ThrLys: 3.285 ± 0.048
5.427ThrLeu: 5.427 ± 0.06
1.006ThrMet: 1.006 ± 0.026
2.923ThrAsn: 2.923 ± 0.048
2.515ThrPro: 2.515 ± 0.058
1.794ThrGln: 1.794 ± 0.034
2.049ThrArg: 2.049 ± 0.035
3.678ThrSer: 3.678 ± 0.057
3.523ThrThr: 3.523 ± 0.084
3.912ThrVal: 3.912 ± 0.08
0.654ThrTrp: 0.654 ± 0.022
2.472ThrTyr: 2.472 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.228ValAla: 4.228 ± 0.05
0.495ValCys: 0.495 ± 0.02
3.204ValAsp: 3.204 ± 0.042
3.29ValGlu: 3.29 ± 0.053
3.186ValPhe: 3.186 ± 0.052
3.367ValGly: 3.367 ± 0.054
0.998ValHis: 0.998 ± 0.028
4.829ValIle: 4.829 ± 0.055
4.765ValLys: 4.765 ± 0.062
6.058ValLeu: 6.058 ± 0.074
1.438ValMet: 1.438 ± 0.029
3.757ValAsn: 3.757 ± 0.05
2.452ValPro: 2.452 ± 0.045
2.07ValGln: 2.07 ± 0.032
2.27ValArg: 2.27 ± 0.043
4.515ValSer: 4.515 ± 0.055
3.912ValThr: 3.912 ± 0.076
4.078ValVal: 4.078 ± 0.068
0.63ValTrp: 0.63 ± 0.017
2.536ValTyr: 2.536 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.738TrpAla: 0.738 ± 0.025
0.109TrpCys: 0.109 ± 0.009
0.61TrpAsp: 0.61 ± 0.018
0.598TrpGlu: 0.598 ± 0.02
0.556TrpPhe: 0.556 ± 0.021
0.79TrpGly: 0.79 ± 0.025
0.233TrpHis: 0.233 ± 0.012
0.786TrpIle: 0.786 ± 0.023
0.859TrpLys: 0.859 ± 0.024
1.054TrpLeu: 1.054 ± 0.03
0.329TrpMet: 0.329 ± 0.014
0.689TrpAsn: 0.689 ± 0.022
0.34TrpPro: 0.34 ± 0.018
0.456TrpGln: 0.456 ± 0.017
0.448TrpArg: 0.448 ± 0.017
0.632TrpSer: 0.632 ± 0.022
0.599TrpThr: 0.599 ± 0.02
0.66TrpVal: 0.66 ± 0.021
0.179TrpTrp: 0.179 ± 0.011
0.479TrpTyr: 0.479 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.885TyrAla: 2.885 ± 0.044
0.344TyrCys: 0.344 ± 0.015
2.199TyrAsp: 2.199 ± 0.043
2.105TyrGlu: 2.105 ± 0.039
2.316TyrPhe: 2.316 ± 0.042
2.713TyrGly: 2.713 ± 0.039
0.827TyrHis: 0.827 ± 0.021
2.706TyrIle: 2.706 ± 0.046
2.798TyrLys: 2.798 ± 0.051
4.04TyrLeu: 4.04 ± 0.052
0.787TyrMet: 0.787 ± 0.022
2.542TyrAsn: 2.542 ± 0.043
1.695TyrPro: 1.695 ± 0.039
1.689TyrGln: 1.689 ± 0.036
1.919TyrArg: 1.919 ± 0.038
2.908TyrSer: 2.908 ± 0.043
2.684TyrThr: 2.684 ± 0.048
2.135TyrVal: 2.135 ± 0.041
0.515TyrTrp: 0.515 ± 0.021
1.907TyrTyr: 1.907 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4545 proteins (1594471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski