Amino acid dipepetide frequency for Herrania umbratica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.379AlaAla: 6.379 ± 0.04	1.338AlaCys: 1.338 ± 0.012	3.187AlaAsp: 3.187 ± 0.019	4.283AlaGlu: 4.283 ± 0.022	2.822AlaPhe: 2.822 ± 0.018	4.117AlaGly: 4.117 ± 0.025	1.311AlaHis: 1.311 ± 0.011	3.82AlaIle: 3.82 ± 0.02	3.958AlaLys: 3.958 ± 0.022	6.865AlaLeu: 6.865 ± 0.034	1.793AlaMet: 1.793 ± 0.012	2.66AlaAsn: 2.66 ± 0.018	2.765AlaPro: 2.765 ± 0.02	2.161AlaGln: 2.161 ± 0.016	3.411AlaArg: 3.411 ± 0.02	6.186AlaSer: 6.186 ± 0.03	3.574AlaThr: 3.574 ± 0.02	4.907AlaVal: 4.907 ± 0.023	0.778AlaTrp: 0.778 ± 0.009	1.859AlaTyr: 1.859 ± 0.016	0.016AlaXaa: 0.016 ± 0.001
Cys	1.014CysAla: 1.014 ± 0.01	0.549CysCys: 0.549 ± 0.009	0.87CysAsp: 0.87 ± 0.009	0.923CysGlu: 0.923 ± 0.011	0.926CysPhe: 0.926 ± 0.01	1.4CysGly: 1.4 ± 0.013	0.496CysHis: 0.496 ± 0.007	1.041CysIle: 1.041 ± 0.01	1.201CysLys: 1.201 ± 0.012	2.002CysLeu: 2.002 ± 0.014	0.45CysMet: 0.45 ± 0.007	0.896CysAsn: 0.896 ± 0.008	0.955CysPro: 0.955 ± 0.012	0.665CysGln: 0.665 ± 0.008	1.053CysArg: 1.053 ± 0.011	1.924CysSer: 1.924 ± 0.015	0.87CysThr: 0.87 ± 0.009	1.028CysVal: 1.028 ± 0.009	0.254CysTrp: 0.254 ± 0.004	0.563CysTyr: 0.563 ± 0.008	0.006CysXaa: 0.006 ± 0.001
Asp	3.515AspAla: 3.515 ± 0.019	1.003AspCys: 1.003 ± 0.009	3.464AspAsp: 3.464 ± 0.024	3.889AspGlu: 3.889 ± 0.024	2.347AspPhe: 2.347 ± 0.015	3.762AspGly: 3.762 ± 0.021	1.192AspHis: 1.192 ± 0.011	3.041AspIle: 3.041 ± 0.016	2.698AspLys: 2.698 ± 0.017	5.117AspLeu: 5.117 ± 0.025	1.323AspMet: 1.323 ± 0.011	2.07AspAsn: 2.07 ± 0.014	2.549AspPro: 2.549 ± 0.016	1.796AspGln: 1.796 ± 0.011	2.379AspArg: 2.379 ± 0.016	4.274AspSer: 4.274 ± 0.024	2.127AspThr: 2.127 ± 0.016	3.582AspVal: 3.582 ± 0.019	0.698AspTrp: 0.698 ± 0.008	1.528AspTyr: 1.528 ± 0.011	0.014AspXaa: 0.014 ± 0.001
Glu	4.802GluAla: 4.802 ± 0.023	0.923GluCys: 0.923 ± 0.01	3.906GluAsp: 3.906 ± 0.023	6.227GluGlu: 6.227 ± 0.044	2.378GluPhe: 2.378 ± 0.014	3.755GluGly: 3.755 ± 0.021	1.268GluHis: 1.268 ± 0.011	3.794GluIle: 3.794 ± 0.024	4.84GluLys: 4.84 ± 0.03	6.116GluLeu: 6.116 ± 0.029	1.838GluMet: 1.838 ± 0.013	3.243GluAsn: 3.243 ± 0.02	2.158GluPro: 2.158 ± 0.016	2.273GluGln: 2.273 ± 0.015	3.456GluArg: 3.456 ± 0.02	4.652GluSer: 4.652 ± 0.022	3.09GluThr: 3.09 ± 0.021	4.162GluVal: 4.162 ± 0.024	0.735GluTrp: 0.735 ± 0.008	1.604GluTyr: 1.604 ± 0.015	0.016GluXaa: 0.016 ± 0.001
Phe	2.552PheAla: 2.552 ± 0.018	0.948PheCys: 0.948 ± 0.011	2.341PheAsp: 2.341 ± 0.016	2.308PheGlu: 2.308 ± 0.013	1.984PhePhe: 1.984 ± 0.017	3.018PheGly: 3.018 ± 0.017	1.133PheHis: 1.133 ± 0.011	2.077PheIle: 2.077 ± 0.016	2.135PheLys: 2.135 ± 0.016	4.488PheLeu: 4.488 ± 0.025	0.961PheMet: 0.961 ± 0.009	1.773PheAsn: 1.773 ± 0.012	2.131PhePro: 2.131 ± 0.015	1.601PheGln: 1.601 ± 0.011	2.036PheArg: 2.036 ± 0.016	4.204PheSer: 4.204 ± 0.021	1.98PheThr: 1.98 ± 0.014	2.713PheVal: 2.713 ± 0.017	0.598PheTrp: 0.598 ± 0.008	1.3PheTyr: 1.3 ± 0.013	0.012PheXaa: 0.012 ± 0.001
Gly	3.871GlyAla: 3.871 ± 0.023	1.331GlyCys: 1.331 ± 0.013	3.295GlyAsp: 3.295 ± 0.019	3.665GlyGlu: 3.665 ± 0.023	3.151GlyPhe: 3.151 ± 0.017	4.904GlyGly: 4.904 ± 0.038	1.522GlyHis: 1.522 ± 0.012	3.644GlyIle: 3.644 ± 0.02	4.148GlyLys: 4.148 ± 0.022	6.073GlyLeu: 6.073 ± 0.029	1.509GlyMet: 1.509 ± 0.013	3.171GlyAsn: 3.171 ± 0.021	2.462GlyPro: 2.462 ± 0.019	2.192GlyGln: 2.192 ± 0.015	3.584GlyArg: 3.584 ± 0.023	6.09GlySer: 6.09 ± 0.03	3.172GlyThr: 3.172 ± 0.017	4.139GlyVal: 4.139 ± 0.022	0.895GlyTrp: 0.895 ± 0.009	2.07GlyTyr: 2.07 ± 0.017	0.029GlyXaa: 0.029 ± 0.002
His	1.435HisAla: 1.435 ± 0.011	0.531HisCys: 0.531 ± 0.007	1.168HisAsp: 1.168 ± 0.01	1.266HisGlu: 1.266 ± 0.013	1.083HisPhe: 1.083 ± 0.01	1.737HisGly: 1.737 ± 0.014	0.887HisHis: 0.887 ± 0.014	1.166HisIle: 1.166 ± 0.012	1.158HisLys: 1.158 ± 0.009	2.431HisLeu: 2.431 ± 0.016	0.543HisMet: 0.543 ± 0.008	0.926HisAsn: 0.926 ± 0.01	1.374HisPro: 1.374 ± 0.014	1.044HisGln: 1.044 ± 0.011	1.346HisArg: 1.346 ± 0.011	1.95HisSer: 1.95 ± 0.014	0.894HisThr: 0.894 ± 0.009	1.539HisVal: 1.539 ± 0.012	0.301HisTrp: 0.301 ± 0.006	0.702HisTyr: 0.702 ± 0.009	0.007HisXaa: 0.007 ± 0.001
Ile	3.623IleAla: 3.623 ± 0.021	1.145IleCys: 1.145 ± 0.01	2.858IleAsp: 2.858 ± 0.016	3.236IleGlu: 3.236 ± 0.017	2.308IlePhe: 2.308 ± 0.015	3.365IleGly: 3.365 ± 0.019	1.283IleHis: 1.283 ± 0.011	2.793IleIle: 2.793 ± 0.018	2.961IleLys: 2.961 ± 0.018	5.319IleLeu: 5.319 ± 0.025	1.109IleMet: 1.109 ± 0.01	2.187IleAsn: 2.187 ± 0.013	2.973IlePro: 2.973 ± 0.02	1.99IleGln: 1.99 ± 0.014	2.62IleArg: 2.62 ± 0.015	4.942IleSer: 4.942 ± 0.02	2.512IleThr: 2.512 ± 0.016	3.388IleVal: 3.388 ± 0.017	0.705IleTrp: 0.705 ± 0.009	1.488IleTyr: 1.488 ± 0.013	0.012IleXaa: 0.012 ± 0.001
Lys	4.143LysAla: 4.143 ± 0.022	1.019LysCys: 1.019 ± 0.012	3.241LysAsp: 3.241 ± 0.02	4.781LysGlu: 4.781 ± 0.03	2.221LysPhe: 2.221 ± 0.016	3.678LysGly: 3.678 ± 0.021	1.351LysHis: 1.351 ± 0.012	3.208LysIle: 3.208 ± 0.019	4.561LysLys: 4.561 ± 0.029	6.121LysLeu: 6.121 ± 0.03	1.497LysMet: 1.497 ± 0.011	2.66LysAsn: 2.66 ± 0.014	2.773LysPro: 2.773 ± 0.019	2.386LysGln: 2.386 ± 0.016	3.625LysArg: 3.625 ± 0.022	4.665LysSer: 4.665 ± 0.023	2.843LysThr: 2.843 ± 0.018	3.89LysVal: 3.89 ± 0.021	0.785LysTrp: 0.785 ± 0.009	1.601LysTyr: 1.601 ± 0.013	0.018LysXaa: 0.018 ± 0.001
Leu	6.709LeuAla: 6.709 ± 0.031	1.923LeuCys: 1.923 ± 0.015	5.17LeuAsp: 5.17 ± 0.026	6.608LeuGlu: 6.608 ± 0.037	3.965LeuPhe: 3.965 ± 0.023	5.877LeuGly: 5.877 ± 0.027	2.637LeuHis: 2.637 ± 0.016	4.688LeuIle: 4.688 ± 0.027	6.332LeuLys: 6.332 ± 0.029	10.191LeuLeu: 10.191 ± 0.047	2.162LeuMet: 2.162 ± 0.014	4.068LeuAsn: 4.068 ± 0.023	5.277LeuPro: 5.277 ± 0.021	4.552LeuGln: 4.552 ± 0.026	5.435LeuArg: 5.435 ± 0.026	9.007LeuSer: 9.007 ± 0.047	4.475LeuThr: 4.475 ± 0.027	6.403LeuVal: 6.403 ± 0.026	1.161LeuTrp: 1.161 ± 0.012	2.544LeuTyr: 2.544 ± 0.017	0.027LeuXaa: 0.027 ± 0.002
Met	2.113MetAla: 2.113 ± 0.015	0.32MetCys: 0.32 ± 0.005	1.42MetAsp: 1.42 ± 0.011	2.036MetGlu: 2.036 ± 0.015	0.813MetPhe: 0.813 ± 0.008	1.608MetGly: 1.608 ± 0.013	0.536MetHis: 0.536 ± 0.007	1.19MetIle: 1.19 ± 0.01	1.638MetLys: 1.638 ± 0.013	2.235MetLeu: 2.235 ± 0.014	0.639MetMet: 0.639 ± 0.008	0.988MetAsn: 0.988 ± 0.01	1.083MetPro: 1.083 ± 0.012	0.99MetGln: 0.99 ± 0.01	1.161MetArg: 1.161 ± 0.009	1.741MetSer: 1.741 ± 0.014	1.027MetThr: 1.027 ± 0.009	1.646MetVal: 1.646 ± 0.012	0.256MetTrp: 0.256 ± 0.005	0.57MetTyr: 0.57 ± 0.008	0.006MetXaa: 0.006 ± 0.001
Asn	2.791AsnAla: 2.791 ± 0.016	0.901AsnCys: 0.901 ± 0.01	2.089AsnAsp: 2.089 ± 0.014	2.618AsnGlu: 2.618 ± 0.018	1.977AsnPhe: 1.977 ± 0.014	3.362AsnGly: 3.362 ± 0.022	1.081AsnHis: 1.081 ± 0.009	2.443AsnIle: 2.443 ± 0.014	2.358AsnLys: 2.358 ± 0.015	4.795AsnLeu: 4.795 ± 0.033	1.094AsnMet: 1.094 ± 0.011	2.261AsnAsn: 2.261 ± 0.02	2.339AsnPro: 2.339 ± 0.014	1.772AsnGln: 1.772 ± 0.014	1.989AsnArg: 1.989 ± 0.015	4.019AsnSer: 4.019 ± 0.023	1.827AsnThr: 1.827 ± 0.012	2.757AsnVal: 2.757 ± 0.015	0.577AsnTrp: 0.577 ± 0.008	1.296AsnTyr: 1.296 ± 0.011	0.013AsnXaa: 0.013 ± 0.001
Pro	3.047ProAla: 3.047 ± 0.019	0.807ProCys: 0.807 ± 0.01	2.524ProAsp: 2.524 ± 0.016	3.157ProGlu: 3.157 ± 0.018	2.055ProPhe: 2.055 ± 0.015	2.764ProGly: 2.764 ± 0.016	1.071ProHis: 1.071 ± 0.01	2.274ProIle: 2.274 ± 0.016	2.722ProLys: 2.722 ± 0.017	4.37ProLeu: 4.37 ± 0.022	0.965ProMet: 0.965 ± 0.009	2.259ProAsn: 2.259 ± 0.014	3.596ProPro: 3.596 ± 0.04	1.856ProGln: 1.856 ± 0.016	2.358ProArg: 2.358 ± 0.019	5.173ProSer: 5.173 ± 0.029	2.531ProThr: 2.531 ± 0.018	3.109ProVal: 3.109 ± 0.019	0.593ProTrp: 0.593 ± 0.007	1.318ProTyr: 1.318 ± 0.012	0.022ProXaa: 0.022 ± 0.002
Gln	2.534GlnAla: 2.534 ± 0.017	0.617GlnCys: 0.617 ± 0.008	1.715GlnAsp: 1.715 ± 0.013	2.51GlnGlu: 2.51 ± 0.019	1.426GlnPhe: 1.426 ± 0.012	2.232GlnGly: 2.232 ± 0.015	0.945GlnHis: 0.945 ± 0.01	2.036GlnIle: 2.036 ± 0.014	2.427GlnLys: 2.427 ± 0.016	3.799GlnLeu: 3.799 ± 0.022	1.01GlnMet: 1.01 ± 0.01	1.905GlnAsn: 1.905 ± 0.013	1.796GlnPro: 1.796 ± 0.017	2.206GlnGln: 2.206 ± 0.034	2.191GlnArg: 2.191 ± 0.014	3.031GlnSer: 3.031 ± 0.017	1.736GlnThr: 1.736 ± 0.014	2.438GlnVal: 2.438 ± 0.014	0.467GlnTrp: 0.467 ± 0.007	0.946GlnTyr: 0.946 ± 0.01	0.011GlnXaa: 0.011 ± 0.001
Arg	3.272ArgAla: 3.272 ± 0.023	0.968ArgCys: 0.968 ± 0.01	2.612ArgAsp: 2.612 ± 0.02	3.336ArgGlu: 3.336 ± 0.021	2.2ArgPhe: 2.2 ± 0.014	3.139ArgGly: 3.139 ± 0.019	1.253ArgHis: 1.253 ± 0.012	2.835ArgIle: 2.835 ± 0.017	3.893ArgLys: 3.893 ± 0.02	5.091ArgLeu: 5.091 ± 0.022	1.329ArgMet: 1.329 ± 0.011	2.501ArgAsn: 2.501 ± 0.014	2.313ArgPro: 2.313 ± 0.017	1.91ArgGln: 1.91 ± 0.015	3.822ArgArg: 3.822 ± 0.029	4.322ArgSer: 4.322 ± 0.028	2.433ArgThr: 2.433 ± 0.015	3.236ArgVal: 3.236 ± 0.017	0.727ArgTrp: 0.727 ± 0.008	1.433ArgTyr: 1.433 ± 0.013	0.015ArgXaa: 0.015 ± 0.001
Ser	5.52SerAla: 5.52 ± 0.026	1.818SerCys: 1.818 ± 0.013	4.393SerAsp: 4.393 ± 0.024	4.907SerGlu: 4.907 ± 0.026	4.098SerPhe: 4.098 ± 0.023	5.948SerGly: 5.948 ± 0.03	2.012SerHis: 2.012 ± 0.014	4.585SerIle: 4.585 ± 0.019	5.093SerLys: 5.093 ± 0.024	9.121SerLeu: 9.121 ± 0.038	2.131SerMet: 2.131 ± 0.013	4.158SerAsn: 4.158 ± 0.023	4.529SerPro: 4.529 ± 0.03	3.204SerGln: 3.204 ± 0.02	4.51SerArg: 4.51 ± 0.025	11.08SerSer: 11.08 ± 0.056	4.634SerThr: 4.634 ± 0.024	5.286SerVal: 5.286 ± 0.026	1.201SerTrp: 1.201 ± 0.012	2.343SerTyr: 2.343 ± 0.015	0.024SerXaa: 0.024 ± 0.002
Thr	3.495ThrAla: 3.495 ± 0.019	0.922ThrCys: 0.922 ± 0.01	2.248ThrAsp: 2.248 ± 0.014	2.764ThrGlu: 2.764 ± 0.018	2.034ThrPhe: 2.034 ± 0.014	3.259ThrGly: 3.259 ± 0.019	0.976ThrHis: 0.976 ± 0.009	2.643ThrIle: 2.643 ± 0.017	2.576ThrLys: 2.576 ± 0.016	4.631ThrLeu: 4.631 ± 0.021	1.13ThrMet: 1.13 ± 0.011	1.982ThrAsn: 1.982 ± 0.014	2.5ThrPro: 2.5 ± 0.018	1.525ThrGln: 1.525 ± 0.011	2.293ThrArg: 2.293 ± 0.014	4.533ThrSer: 4.533 ± 0.024	2.732ThrThr: 2.732 ± 0.02	3.281ThrVal: 3.281 ± 0.02	0.613ThrTrp: 0.613 ± 0.008	1.369ThrTyr: 1.369 ± 0.012	0.016ThrXaa: 0.016 ± 0.001
Val	4.812ValAla: 4.812 ± 0.023	1.144ValCys: 1.144 ± 0.012	3.663ValAsp: 3.663 ± 0.015	4.373ValGlu: 4.373 ± 0.022	2.661ValPhe: 2.661 ± 0.017	4.138ValGly: 4.138 ± 0.021	1.522ValHis: 1.522 ± 0.013	3.353ValIle: 3.353 ± 0.019	3.906ValLys: 3.906 ± 0.018	6.408ValLeu: 6.408 ± 0.031	1.473ValMet: 1.473 ± 0.012	2.633ValAsn: 2.633 ± 0.017	3.218ValPro: 3.218 ± 0.018	2.367ValGln: 2.367 ± 0.014	3.069ValArg: 3.069 ± 0.019	5.475ValSer: 5.475 ± 0.026	3.181ValThr: 3.181 ± 0.017	4.711ValVal: 4.711 ± 0.024	0.758ValTrp: 0.758 ± 0.009	1.895ValTyr: 1.895 ± 0.016	0.017ValXaa: 0.017 ± 0.001
Trp	0.761TrpAla: 0.761 ± 0.009	0.232TrpCys: 0.232 ± 0.005	0.698TrpAsp: 0.698 ± 0.009	0.77TrpGlu: 0.77 ± 0.009	0.546TrpPhe: 0.546 ± 0.008	0.717TrpGly: 0.717 ± 0.01	0.299TrpHis: 0.299 ± 0.006	0.718TrpIle: 0.718 ± 0.008	0.939TrpLys: 0.939 ± 0.01	1.233TrpLeu: 1.233 ± 0.012	0.334TrpMet: 0.334 ± 0.005	0.708TrpAsn: 0.708 ± 0.008	0.5TrpPro: 0.5 ± 0.006	0.484TrpGln: 0.484 ± 0.007	0.817TrpArg: 0.817 ± 0.007	0.975TrpSer: 0.975 ± 0.011	0.637TrpThr: 0.637 ± 0.008	0.803TrpVal: 0.803 ± 0.008	0.234TrpTrp: 0.234 ± 0.005	0.338TrpTyr: 0.338 ± 0.005	0.005TrpXaa: 0.005 ± 0.001
Tyr	1.787TyrAla: 1.787 ± 0.013	0.643TyrCys: 0.643 ± 0.008	1.49TyrAsp: 1.49 ± 0.013	1.562TyrGlu: 1.562 ± 0.014	1.285TyrPhe: 1.285 ± 0.011	2.109TyrGly: 2.109 ± 0.016	0.704TyrHis: 0.704 ± 0.008	1.457TyrIle: 1.457 ± 0.013	1.5TyrLys: 1.5 ± 0.013	2.773TyrLeu: 2.773 ± 0.018	0.724TyrMet: 0.724 ± 0.008	1.298TyrAsn: 1.298 ± 0.014	1.258TyrPro: 1.258 ± 0.012	0.992TyrGln: 0.992 ± 0.009	1.469TyrArg: 1.469 ± 0.011	2.327TyrSer: 2.327 ± 0.018	1.234TyrThr: 1.234 ± 0.012	1.745TyrVal: 1.745 ± 0.013	0.41TyrTrp: 0.41 ± 0.006	0.934TyrTyr: 0.934 ± 0.01	0.007TyrXaa: 0.007 ± 0.001
Xaa	0.015XaaAla: 0.015 ± 0.001	0.005XaaCys: 0.005 ± 0.001	0.016XaaAsp: 0.016 ± 0.001	0.018XaaGlu: 0.018 ± 0.001	0.014XaaPhe: 0.014 ± 0.001	0.025XaaGly: 0.025 ± 0.002	0.008XaaHis: 0.008 ± 0.001	0.013XaaIle: 0.013 ± 0.001	0.02XaaLys: 0.02 ± 0.001	0.03XaaLeu: 0.03 ± 0.002	0.005XaaMet: 0.005 ± 0.001	0.012XaaAsn: 0.012 ± 0.001	0.021XaaPro: 0.021 ± 0.002	0.009XaaGln: 0.009 ± 0.001	0.017XaaArg: 0.017 ± 0.001	0.026XaaSer: 0.026 ± 0.002	0.013XaaThr: 0.013 ± 0.001	0.017XaaVal: 0.017 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.008XaaTyr: 0.008 ± 0.001	0.11XaaXaa: 0.11 ± 0.011

Statistics based on 23848 proteins (11398064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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