Amino acid dipepetide frequency for Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.314AlaAla: 5.314 ± 0.133
0.858AlaCys: 0.858 ± 0.046
4.234AlaAsp: 4.234 ± 0.092
4.508AlaGlu: 4.508 ± 0.1
2.488AlaPhe: 2.488 ± 0.065
5.8AlaGly: 5.8 ± 0.118
1.278AlaHis: 1.278 ± 0.048
5.687AlaIle: 5.687 ± 0.119
3.332AlaLys: 3.332 ± 0.086
5.833AlaLeu: 5.833 ± 0.114
1.786AlaMet: 1.786 ± 0.058
2.221AlaAsn: 2.221 ± 0.064
1.933AlaPro: 1.933 ± 0.06
1.636AlaGln: 1.636 ± 0.057
3.217AlaArg: 3.217 ± 0.085
4.246AlaSer: 4.246 ± 0.088
3.22AlaThr: 3.22 ± 0.08
5.15AlaVal: 5.15 ± 0.112
0.449AlaTrp: 0.449 ± 0.031
1.944AlaTyr: 1.944 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.039
0.211CysCys: 0.211 ± 0.023
0.734CysAsp: 0.734 ± 0.037
0.763CysGlu: 0.763 ± 0.039
0.357CysPhe: 0.357 ± 0.024
1.294CysGly: 1.294 ± 0.054
0.306CysHis: 0.306 ± 0.029
1.019CysIle: 1.019 ± 0.043
0.668CysLys: 0.668 ± 0.033
0.801CysLeu: 0.801 ± 0.039
0.352CysMet: 0.352 ± 0.024
0.59CysAsn: 0.59 ± 0.031
0.775CysPro: 0.775 ± 0.044
0.321CysGln: 0.321 ± 0.023
0.693CysArg: 0.693 ± 0.033
0.899CysSer: 0.899 ± 0.038
0.68CysThr: 0.68 ± 0.037
0.716CysVal: 0.716 ± 0.037
0.066CysTrp: 0.066 ± 0.011
0.369CysTyr: 0.369 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.845AspAla: 3.845 ± 0.078
0.672AspCys: 0.672 ± 0.032
3.479AspAsp: 3.479 ± 0.091
4.988AspGlu: 4.988 ± 0.1
2.636AspPhe: 2.636 ± 0.07
3.774AspGly: 3.774 ± 0.108
1.351AspHis: 1.351 ± 0.048
6.741AspIle: 6.741 ± 0.105
3.222AspLys: 3.222 ± 0.073
5.429AspLeu: 5.429 ± 0.091
1.93AspMet: 1.93 ± 0.058
2.711AspAsn: 2.711 ± 0.068
2.904AspPro: 2.904 ± 0.072
1.586AspGln: 1.586 ± 0.045
3.107AspArg: 3.107 ± 0.079
4.169AspSer: 4.169 ± 0.09
3.243AspThr: 3.243 ± 0.076
4.683AspVal: 4.683 ± 0.1
0.565AspTrp: 0.565 ± 0.03
2.159AspTyr: 2.159 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.058GluAla: 4.058 ± 0.09
0.891GluCys: 0.891 ± 0.041
4.626GluAsp: 4.626 ± 0.083
5.389GluGlu: 5.389 ± 0.107
2.742GluPhe: 2.742 ± 0.07
4.321GluGly: 4.321 ± 0.091
1.528GluHis: 1.528 ± 0.051
7.126GluIle: 7.126 ± 0.117
5.932GluLys: 5.932 ± 0.126
6.561GluLeu: 6.561 ± 0.111
2.67GluMet: 2.67 ± 0.063
4.377GluAsn: 4.377 ± 0.081
2.269GluPro: 2.269 ± 0.067
2.021GluGln: 2.021 ± 0.06
3.301GluArg: 3.301 ± 0.091
4.549GluSer: 4.549 ± 0.099
3.315GluThr: 3.315 ± 0.07
4.533GluVal: 4.533 ± 0.094
0.734GluTrp: 0.734 ± 0.034
2.96GluTyr: 2.96 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.514PheAla: 2.514 ± 0.075
0.446PheCys: 0.446 ± 0.028
2.731PheAsp: 2.731 ± 0.061
2.968PheGlu: 2.968 ± 0.073
1.559PhePhe: 1.559 ± 0.055
2.896PheGly: 2.896 ± 0.069
0.639PheHis: 0.639 ± 0.033
3.142PheIle: 3.142 ± 0.093
2.002PheLys: 2.002 ± 0.06
3.297PheLeu: 3.297 ± 0.098
0.999PheMet: 0.999 ± 0.042
1.672PheAsn: 1.672 ± 0.052
1.278PhePro: 1.278 ± 0.041
0.947PheGln: 0.947 ± 0.041
1.751PheArg: 1.751 ± 0.057
3.104PheSer: 3.104 ± 0.08
2.141PheThr: 2.141 ± 0.064
2.605PheVal: 2.605 ± 0.068
0.396PheTrp: 0.396 ± 0.028
1.309PheTyr: 1.309 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.577GlyAla: 4.577 ± 0.112
1.007GlyCys: 1.007 ± 0.045
3.99GlyAsp: 3.99 ± 0.121
4.32GlyGlu: 4.32 ± 0.106
2.962GlyPhe: 2.962 ± 0.071
4.634GlyGly: 4.634 ± 0.132
1.455GlyHis: 1.455 ± 0.046
7.072GlyIle: 7.072 ± 0.123
4.538GlyLys: 4.538 ± 0.092
5.719GlyLeu: 5.719 ± 0.109
2.18GlyMet: 2.18 ± 0.061
3.181GlyAsn: 3.181 ± 0.087
2.059GlyPro: 2.059 ± 0.069
1.689GlyGln: 1.689 ± 0.052
3.027GlyArg: 3.027 ± 0.085
4.673GlySer: 4.673 ± 0.092
4.1GlyThr: 4.1 ± 0.09
4.737GlyVal: 4.737 ± 0.094
0.714GlyTrp: 0.714 ± 0.041
2.858GlyTyr: 2.858 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.286HisAla: 1.286 ± 0.051
0.316HisCys: 0.316 ± 0.026
1.261HisAsp: 1.261 ± 0.05
1.366HisGlu: 1.366 ± 0.044
0.796HisPhe: 0.796 ± 0.037
1.417HisGly: 1.417 ± 0.051
0.478HisHis: 0.478 ± 0.031
1.735HisIle: 1.735 ± 0.054
0.978HisLys: 0.978 ± 0.039
1.84HisLeu: 1.84 ± 0.056
0.532HisMet: 0.532 ± 0.034
0.801HisAsn: 0.801 ± 0.035
1.093HisPro: 1.093 ± 0.04
0.529HisGln: 0.529 ± 0.029
1.101HisArg: 1.101 ± 0.043
1.361HisSer: 1.361 ± 0.048
1.027HisThr: 1.027 ± 0.033
1.392HisVal: 1.392 ± 0.046
0.169HisTrp: 0.169 ± 0.017
0.688HisTyr: 0.688 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.425IleAla: 6.425 ± 0.126
1.117IleCys: 1.117 ± 0.043
6.218IleAsp: 6.218 ± 0.096
7.234IleGlu: 7.234 ± 0.12
3.471IlePhe: 3.471 ± 0.106
6.256IleGly: 6.256 ± 0.105
1.817IleHis: 1.817 ± 0.057
7.247IleIle: 7.247 ± 0.136
5.126IleLys: 5.126 ± 0.112
7.714IleLeu: 7.714 ± 0.142
2.272IleMet: 2.272 ± 0.061
3.945IleAsn: 3.945 ± 0.096
3.882IlePro: 3.882 ± 0.072
2.215IleGln: 2.215 ± 0.063
4.303IleArg: 4.303 ± 0.1
6.98IleSer: 6.98 ± 0.114
4.716IleThr: 4.716 ± 0.095
5.855IleVal: 5.855 ± 0.1
0.595IleTrp: 0.595 ± 0.036
2.816IleTyr: 2.816 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 0.095
0.775LysCys: 0.775 ± 0.043
3.524LysAsp: 3.524 ± 0.084
4.952LysGlu: 4.952 ± 0.102
1.861LysPhe: 1.861 ± 0.061
3.733LysGly: 3.733 ± 0.086
1.261LysHis: 1.261 ± 0.049
5.632LysIle: 5.632 ± 0.118
5.61LysLys: 5.61 ± 0.13
4.965LysLeu: 4.965 ± 0.111
2.062LysMet: 2.062 ± 0.062
3.643LysAsn: 3.643 ± 0.086
2.036LysPro: 2.036 ± 0.064
1.677LysGln: 1.677 ± 0.054
2.898LysArg: 2.898 ± 0.075
3.904LysSer: 3.904 ± 0.102
2.788LysThr: 2.788 ± 0.075
3.866LysVal: 3.866 ± 0.092
0.567LysTrp: 0.567 ± 0.031
2.578LysTyr: 2.578 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.013LeuAla: 6.013 ± 0.117
0.906LeuCys: 0.906 ± 0.042
5.514LeuAsp: 5.514 ± 0.087
6.575LeuGlu: 6.575 ± 0.098
3.391LeuPhe: 3.391 ± 0.089
5.447LeuGly: 5.447 ± 0.101
1.579LeuHis: 1.579 ± 0.055
7.584LeuIle: 7.584 ± 0.144
6.181LeuLys: 6.181 ± 0.114
7.629LeuLeu: 7.629 ± 0.166
2.514LeuMet: 2.514 ± 0.064
4.177LeuAsn: 4.177 ± 0.089
3.211LeuPro: 3.211 ± 0.086
2.331LeuGln: 2.331 ± 0.066
3.756LeuArg: 3.756 ± 0.085
6.099LeuSer: 6.099 ± 0.103
4.153LeuThr: 4.153 ± 0.093
5.463LeuVal: 5.463 ± 0.104
0.677LeuTrp: 0.677 ± 0.038
2.554LeuTyr: 2.554 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.962MetAla: 1.962 ± 0.055
0.364MetCys: 0.364 ± 0.027
2.182MetAsp: 2.182 ± 0.055
2.08MetGlu: 2.08 ± 0.057
1.007MetPhe: 1.007 ± 0.045
2.111MetGly: 2.111 ± 0.065
0.568MetHis: 0.568 ± 0.029
2.46MetIle: 2.46 ± 0.061
2.143MetLys: 2.143 ± 0.067
2.441MetLeu: 2.441 ± 0.079
0.835MetMet: 0.835 ± 0.036
1.519MetAsn: 1.519 ± 0.05
0.937MetPro: 0.937 ± 0.041
0.896MetGln: 0.896 ± 0.038
1.248MetArg: 1.248 ± 0.043
1.833MetSer: 1.833 ± 0.05
1.522MetThr: 1.522 ± 0.049
2.071MetVal: 2.071 ± 0.059
0.218MetTrp: 0.218 ± 0.017
0.84MetTyr: 0.84 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
2.624AsnAla: 2.624 ± 0.062
0.495AsnCys: 0.495 ± 0.03
2.392AsnAsp: 2.392 ± 0.075
3.391AsnGlu: 3.391 ± 0.077
1.692AsnPhe: 1.692 ± 0.058
2.819AsnGly: 2.819 ± 0.08
0.778AsnHis: 0.778 ± 0.041
4.909AsnIle: 4.909 ± 0.109
2.637AsnLys: 2.637 ± 0.077
3.94AsnLeu: 3.94 ± 0.083
1.374AsnMet: 1.374 ± 0.047
2.28AsnAsn: 2.28 ± 0.09
2.161AsnPro: 2.161 ± 0.054
1.168AsnGln: 1.168 ± 0.043
2.351AsnArg: 2.351 ± 0.068
3.053AsnSer: 3.053 ± 0.079
2.446AsnThr: 2.446 ± 0.077
3.304AsnVal: 3.304 ± 0.092
0.426AsnTrp: 0.426 ± 0.028
1.638AsnTyr: 1.638 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.482ProAla: 2.482 ± 0.064
0.462ProCys: 0.462 ± 0.029
3.037ProAsp: 3.037 ± 0.067
4.008ProGlu: 4.008 ± 0.089
1.563ProPhe: 1.563 ± 0.053
2.935ProGly: 2.935 ± 0.079
0.875ProHis: 0.875 ± 0.042
2.439ProIle: 2.439 ± 0.062
1.707ProLys: 1.707 ± 0.058
3.263ProLeu: 3.263 ± 0.08
0.881ProMet: 0.881 ± 0.043
1.063ProAsn: 1.063 ± 0.049
1.325ProPro: 1.325 ± 0.053
1.098ProGln: 1.098 ± 0.042
1.358ProArg: 1.358 ± 0.047
2.523ProSer: 2.523 ± 0.062
1.65ProThr: 1.65 ± 0.054
3.563ProVal: 3.563 ± 0.09
0.339ProTrp: 0.339 ± 0.024
1.322ProTyr: 1.322 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.749GlnAla: 1.749 ± 0.053
0.354GlnCys: 0.354 ± 0.026
1.427GlnAsp: 1.427 ± 0.05
1.998GlnGlu: 1.998 ± 0.059
0.88GlnPhe: 0.88 ± 0.041
1.384GlnGly: 1.384 ± 0.051
0.521GlnHis: 0.521 ± 0.028
2.637GlnIle: 2.637 ± 0.069
2.261GlnLys: 2.261 ± 0.067
2.424GlnLeu: 2.424 ± 0.065
0.935GlnMet: 0.935 ± 0.038
1.433GlnAsn: 1.433 ± 0.05
0.791GlnPro: 0.791 ± 0.036
0.881GlnGln: 0.881 ± 0.047
1.314GlnArg: 1.314 ± 0.045
1.628GlnSer: 1.628 ± 0.054
1.189GlnThr: 1.189 ± 0.046
1.712GlnVal: 1.712 ± 0.05
0.28GlnTrp: 0.28 ± 0.019
0.937GlnTyr: 0.937 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.875ArgAla: 2.875 ± 0.079
0.66ArgCys: 0.66 ± 0.031
3.003ArgAsp: 3.003 ± 0.076
3.36ArgGlu: 3.36 ± 0.086
1.825ArgPhe: 1.825 ± 0.049
2.849ArgGly: 2.849 ± 0.077
0.822ArgHis: 0.822 ± 0.036
4.556ArgIle: 4.556 ± 0.105
3.51ArgLys: 3.51 ± 0.087
3.854ArgLeu: 3.854 ± 0.103
1.409ArgMet: 1.409 ± 0.049
2.446ArgAsn: 2.446 ± 0.069
1.622ArgPro: 1.622 ± 0.053
1.309ArgGln: 1.309 ± 0.049
2.259ArgArg: 2.259 ± 0.077
3.245ArgSer: 3.245 ± 0.076
2.455ArgThr: 2.455 ± 0.061
2.937ArgVal: 2.937 ± 0.073
0.459ArgTrp: 0.459 ± 0.031
1.884ArgTyr: 1.884 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.21SerAla: 4.21 ± 0.093
0.796SerCys: 0.796 ± 0.043
4.212SerAsp: 4.212 ± 0.095
4.893SerGlu: 4.893 ± 0.094
2.701SerPhe: 2.701 ± 0.075
5.435SerGly: 5.435 ± 0.102
1.443SerHis: 1.443 ± 0.056
6.126SerIle: 6.126 ± 0.114
3.904SerLys: 3.904 ± 0.095
5.866SerLeu: 5.866 ± 0.095
2.13SerMet: 2.13 ± 0.059
2.857SerAsn: 2.857 ± 0.084
2.56SerPro: 2.56 ± 0.069
2.107SerGln: 2.107 ± 0.06
3.881SerArg: 3.881 ± 0.076
5.198SerSer: 5.198 ± 0.115
3.476SerThr: 3.476 ± 0.081
4.611SerVal: 4.611 ± 0.095
0.593SerTrp: 0.593 ± 0.032
2.265SerTyr: 2.265 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.461ThrAla: 3.461 ± 0.09
0.593ThrCys: 0.593 ± 0.031
3.406ThrAsp: 3.406 ± 0.074
3.378ThrGlu: 3.378 ± 0.067
1.943ThrPhe: 1.943 ± 0.065
4.922ThrGly: 4.922 ± 0.105
0.999ThrHis: 0.999 ± 0.037
4.316ThrIle: 4.316 ± 0.097
2.288ThrLys: 2.288 ± 0.065
4.321ThrLeu: 4.321 ± 0.096
1.265ThrMet: 1.265 ± 0.043
1.876ThrAsn: 1.876 ± 0.062
2.262ThrPro: 2.262 ± 0.059
1.261ThrGln: 1.261 ± 0.045
2.282ThrArg: 2.282 ± 0.059
3.43ThrSer: 3.43 ± 0.076
2.711ThrThr: 2.711 ± 0.074
3.923ThrVal: 3.923 ± 0.096
0.39ThrTrp: 0.39 ± 0.027
1.776ThrTyr: 1.776 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.696ValAla: 4.696 ± 0.097
0.926ValCys: 0.926 ± 0.042
4.521ValAsp: 4.521 ± 0.093
4.836ValGlu: 4.836 ± 0.108
2.623ValPhe: 2.623 ± 0.064
4.456ValGly: 4.456 ± 0.115
1.546ValHis: 1.546 ± 0.055
6.148ValIle: 6.148 ± 0.109
3.892ValLys: 3.892 ± 0.074
5.913ValLeu: 5.913 ± 0.111
1.91ValMet: 1.91 ± 0.058
3.004ValAsn: 3.004 ± 0.073
2.862ValPro: 2.862 ± 0.074
1.751ValGln: 1.751 ± 0.047
3.165ValArg: 3.165 ± 0.095
5.073ValSer: 5.073 ± 0.097
3.633ValThr: 3.633 ± 0.107
4.87ValVal: 4.87 ± 0.113
0.582ValTrp: 0.582 ± 0.035
2.221ValTyr: 2.221 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.478TrpAla: 0.478 ± 0.032
0.11TrpCys: 0.11 ± 0.014
0.536TrpAsp: 0.536 ± 0.03
0.539TrpGlu: 0.539 ± 0.032
0.341TrpPhe: 0.341 ± 0.02
0.562TrpGly: 0.562 ± 0.03
0.159TrpHis: 0.159 ± 0.015
0.898TrpIle: 0.898 ± 0.039
0.624TrpLys: 0.624 ± 0.031
0.775TrpLeu: 0.775 ± 0.038
0.27TrpMet: 0.27 ± 0.024
0.527TrpAsn: 0.527 ± 0.031
0.234TrpPro: 0.234 ± 0.02
0.3TrpGln: 0.3 ± 0.024
0.336TrpArg: 0.336 ± 0.024
0.509TrpSer: 0.509 ± 0.03
0.514TrpThr: 0.514 ± 0.029
0.488TrpVal: 0.488 ± 0.032
0.133TrpTrp: 0.133 ± 0.016
0.369TrpTyr: 0.369 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.09TyrAla: 2.09 ± 0.064
0.432TyrCys: 0.432 ± 0.027
2.169TyrAsp: 2.169 ± 0.059
2.354TyrGlu: 2.354 ± 0.065
1.561TyrPhe: 1.561 ± 0.044
2.442TyrGly: 2.442 ± 0.063
0.762TyrHis: 0.762 ± 0.034
2.731TyrIle: 2.731 ± 0.07
1.481TyrLys: 1.481 ± 0.061
3.168TyrLeu: 3.168 ± 0.087
0.929TyrMet: 0.929 ± 0.037
1.555TyrAsn: 1.555 ± 0.054
1.699TyrPro: 1.699 ± 0.052
1.014TyrGln: 1.014 ± 0.033
1.99TyrArg: 1.99 ± 0.065
2.786TyrSer: 2.786 ± 0.066
1.823TyrThr: 1.823 ± 0.058
2.149TyrVal: 2.149 ± 0.058
0.352TyrTrp: 0.352 ± 0.024
1.355TyrTyr: 1.355 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1972 proteins (610469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski