Amino acid dipepetide frequency for Circovirus-like genome DHCV-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.912AlaAla: 1.912 ± 1.545
1.912AlaCys: 1.912 ± 1.256
0.0AlaAsp: 0.0 ± 0.0
1.912AlaGlu: 1.912 ± 1.256
0.0AlaPhe: 0.0 ± 0.0
1.912AlaGly: 1.912 ± 1.256
1.912AlaHis: 1.912 ± 1.256
5.736AlaIle: 5.736 ± 3.767
0.0AlaLys: 0.0 ± 0.0
3.824AlaLeu: 3.824 ± 0.289
0.0AlaMet: 0.0 ± 0.0
0.0AlaAsn: 0.0 ± 0.0
1.912AlaPro: 1.912 ± 1.545
5.736AlaGln: 5.736 ± 0.967
5.736AlaArg: 5.736 ± 1.834
3.824AlaSer: 3.824 ± 0.289
5.736AlaThr: 5.736 ± 4.635
3.824AlaVal: 3.824 ± 0.289
0.0AlaTrp: 0.0 ± 0.0
3.824AlaTyr: 3.824 ± 0.289
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
3.824CysAsp: 3.824 ± 2.512
0.0CysGlu: 0.0 ± 0.0
3.824CysPhe: 3.824 ± 2.512
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.912CysLys: 1.912 ± 1.256
1.912CysLeu: 1.912 ± 1.545
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.912CysPro: 1.912 ± 1.256
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
3.824CysSer: 3.824 ± 2.512
0.0CysThr: 0.0 ± 0.0
1.912CysVal: 1.912 ± 1.545
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.912AspAla: 1.912 ± 1.256
0.0AspCys: 0.0 ± 0.0
3.824AspAsp: 3.824 ± 3.09
1.912AspGlu: 1.912 ± 1.256
5.736AspPhe: 5.736 ± 0.967
3.824AspGly: 3.824 ± 2.512
0.0AspHis: 0.0 ± 0.0
1.912AspIle: 1.912 ± 1.256
5.736AspLys: 5.736 ± 0.967
3.824AspLeu: 3.824 ± 2.512
1.912AspMet: 1.912 ± 1.256
0.0AspAsn: 0.0 ± 0.0
1.912AspPro: 1.912 ± 1.545
1.912AspGln: 1.912 ± 1.545
0.0AspArg: 0.0 ± 0.0
11.472AspSer: 11.472 ± 0.868
3.824AspThr: 3.824 ± 0.289
9.56AspVal: 9.56 ± 4.924
0.0AspTrp: 0.0 ± 0.0
1.912AspTyr: 1.912 ± 1.256
0.0AspXaa: 0.0 ± 0.0
Glu
1.912GluAla: 1.912 ± 1.256
0.0GluCys: 0.0 ± 0.0
1.912GluAsp: 1.912 ± 1.256
0.0GluGlu: 0.0 ± 0.0
3.824GluPhe: 3.824 ± 2.512
0.0GluGly: 0.0 ± 0.0
3.824GluHis: 3.824 ± 2.512
3.824GluIle: 3.824 ± 2.512
0.0GluLys: 0.0 ± 0.0
0.0GluLeu: 0.0 ± 0.0
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
1.912GluPro: 1.912 ± 1.256
1.912GluGln: 1.912 ± 1.256
3.824GluArg: 3.824 ± 0.289
0.0GluSer: 0.0 ± 0.0
3.824GluThr: 3.824 ± 0.289
1.912GluVal: 1.912 ± 1.256
0.0GluTrp: 0.0 ± 0.0
1.912GluTyr: 1.912 ± 1.256
0.0GluXaa: 0.0 ± 0.0
Phe
5.736PheAla: 5.736 ± 0.967
3.824PheCys: 3.824 ± 0.289
9.56PheAsp: 9.56 ± 3.478
1.912PheGlu: 1.912 ± 1.256
0.0PhePhe: 0.0 ± 0.0
3.824PheGly: 3.824 ± 2.512
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
3.824PheLys: 3.824 ± 0.289
1.912PheLeu: 1.912 ± 1.545
3.824PheMet: 3.824 ± 3.09
0.0PheAsn: 0.0 ± 0.0
5.736PhePro: 5.736 ± 0.967
3.824PheGln: 3.824 ± 2.512
0.0PheArg: 0.0 ± 0.0
1.912PheSer: 1.912 ± 1.256
9.56PheThr: 9.56 ± 0.677
1.912PheVal: 1.912 ± 1.256
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.736GlyAla: 5.736 ± 1.834
0.0GlyCys: 0.0 ± 0.0
1.912GlyAsp: 1.912 ± 1.256
1.912GlyGlu: 1.912 ± 1.256
1.912GlyPhe: 1.912 ± 1.256
1.912GlyGly: 1.912 ± 1.256
1.912GlyHis: 1.912 ± 1.256
1.912GlyIle: 1.912 ± 1.256
5.736GlyLys: 5.736 ± 0.967
5.736GlyLeu: 5.736 ± 1.834
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
0.0GlyPro: 0.0 ± 0.0
5.736GlyGln: 5.736 ± 0.967
3.824GlyArg: 3.824 ± 0.289
5.736GlySer: 5.736 ± 1.834
7.648GlyThr: 7.648 ± 0.578
5.736GlyVal: 5.736 ± 1.834
0.0GlyTrp: 0.0 ± 0.0
7.648GlyTyr: 7.648 ± 3.379
0.0GlyXaa: 0.0 ± 0.0
His
1.912HisAla: 1.912 ± 1.545
0.0HisCys: 0.0 ± 0.0
1.912HisAsp: 1.912 ± 1.545
0.0HisGlu: 0.0 ± 0.0
5.736HisPhe: 5.736 ± 3.767
1.912HisGly: 1.912 ± 1.256
3.824HisHis: 3.824 ± 2.512
0.0HisIle: 0.0 ± 0.0
1.912HisLys: 1.912 ± 1.256
1.912HisLeu: 1.912 ± 1.256
0.0HisMet: 0.0 ± 0.0
1.912HisAsn: 1.912 ± 1.256
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.912HisArg: 1.912 ± 1.256
0.0HisSer: 0.0 ± 0.0
3.824HisThr: 3.824 ± 2.512
1.912HisVal: 1.912 ± 1.545
0.0HisTrp: 0.0 ± 0.0
5.736HisTyr: 5.736 ± 0.967
0.0HisXaa: 0.0 ± 0.0
Ile
1.912IleAla: 1.912 ± 1.256
0.0IleCys: 0.0 ± 0.0
3.824IleAsp: 3.824 ± 2.512
0.0IleGlu: 0.0 ± 0.0
5.736IlePhe: 5.736 ± 0.967
0.0IleGly: 0.0 ± 0.0
1.912IleHis: 1.912 ± 1.545
5.736IleIle: 5.736 ± 0.967
9.56IleLys: 9.56 ± 3.478
1.912IleLeu: 1.912 ± 1.256
0.0IleMet: 0.0 ± 0.0
5.736IleAsn: 5.736 ± 4.635
0.0IlePro: 0.0 ± 0.0
3.824IleGln: 3.824 ± 2.512
1.912IleArg: 1.912 ± 1.545
1.912IleSer: 1.912 ± 1.256
9.56IleThr: 9.56 ± 0.677
1.912IleVal: 1.912 ± 1.256
1.912IleTrp: 1.912 ± 1.256
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
3.824LysAla: 3.824 ± 2.512
0.0LysCys: 0.0 ± 0.0
0.0LysAsp: 0.0 ± 0.0
0.0LysGlu: 0.0 ± 0.0
7.648LysPhe: 7.648 ± 3.379
9.56LysGly: 9.56 ± 4.924
0.0LysHis: 0.0 ± 0.0
1.912LysIle: 1.912 ± 1.256
0.0LysLys: 0.0 ± 0.0
9.56LysLeu: 9.56 ± 0.677
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
5.736LysPro: 5.736 ± 0.967
1.912LysGln: 1.912 ± 1.256
13.384LysArg: 13.384 ± 0.388
1.912LysSer: 1.912 ± 1.256
5.736LysThr: 5.736 ± 0.967
0.0LysVal: 0.0 ± 0.0
3.824LysTrp: 3.824 ± 2.512
3.824LysTyr: 3.824 ± 3.09
0.0LysXaa: 0.0 ± 0.0
Leu
3.824LeuAla: 3.824 ± 2.512
0.0LeuCys: 0.0 ± 0.0
7.648LeuAsp: 7.648 ± 6.18
5.736LeuGlu: 5.736 ± 3.767
0.0LeuPhe: 0.0 ± 0.0
3.824LeuGly: 3.824 ± 3.09
0.0LeuHis: 0.0 ± 0.0
3.824LeuIle: 3.824 ± 0.289
5.736LeuLys: 5.736 ± 1.834
3.824LeuLeu: 3.824 ± 0.289
0.0LeuMet: 0.0 ± 1.018
0.0LeuAsn: 0.0 ± 0.0
0.0LeuPro: 0.0 ± 0.0
3.824LeuGln: 3.824 ± 2.512
1.912LeuArg: 1.912 ± 1.545
5.736LeuSer: 5.736 ± 0.967
9.56LeuThr: 9.56 ± 0.677
1.912LeuVal: 1.912 ± 1.545
1.912LeuTrp: 1.912 ± 1.545
1.912LeuTyr: 1.912 ± 1.545
0.0LeuXaa: 0.0 ± 0.0
Met
1.912MetAla: 1.912 ± 1.256
0.0MetCys: 0.0 ± 0.0
1.912MetAsp: 1.912 ± 1.256
1.912MetGlu: 1.912 ± 1.545
1.912MetPhe: 1.912 ± 1.545
3.824MetGly: 3.824 ± 0.289
0.0MetHis: 0.0 ± 0.0
3.824MetIle: 3.824 ± 3.09
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
3.824MetSer: 3.824 ± 2.512
3.824MetThr: 3.824 ± 0.289
1.912MetVal: 1.912 ± 1.545
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
1.912AsnGlu: 1.912 ± 1.256
1.912AsnPhe: 1.912 ± 1.256
3.824AsnGly: 3.824 ± 0.289
0.0AsnHis: 0.0 ± 0.0
1.912AsnIle: 1.912 ± 1.545
3.824AsnLys: 3.824 ± 0.289
0.0AsnLeu: 0.0 ± 0.0
0.0AsnMet: 0.0 ± 0.0
1.912AsnAsn: 1.912 ± 1.545
3.824AsnPro: 3.824 ± 3.09
0.0AsnGln: 0.0 ± 0.0
1.912AsnArg: 1.912 ± 1.256
1.912AsnSer: 1.912 ± 1.545
0.0AsnThr: 0.0 ± 0.0
1.912AsnVal: 1.912 ± 1.545
1.912AsnTrp: 1.912 ± 1.545
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.0ProCys: 0.0 ± 0.0
3.824ProAsp: 3.824 ± 0.289
0.0ProGlu: 0.0 ± 0.0
0.0ProPhe: 0.0 ± 0.0
1.912ProGly: 1.912 ± 1.256
3.824ProHis: 3.824 ± 0.289
3.824ProIle: 3.824 ± 0.289
1.912ProLys: 1.912 ± 1.545
1.912ProLeu: 1.912 ± 1.545
1.912ProMet: 1.912 ± 1.256
3.824ProAsn: 3.824 ± 3.09
0.0ProPro: 0.0 ± 0.0
0.0ProGln: 0.0 ± 0.0
7.648ProArg: 7.648 ± 6.18
3.824ProSer: 3.824 ± 0.289
3.824ProThr: 3.824 ± 0.289
1.912ProVal: 1.912 ± 1.256
1.912ProTrp: 1.912 ± 1.256
1.912ProTyr: 1.912 ± 1.256
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
1.912GlnAsp: 1.912 ± 1.256
1.912GlnGlu: 1.912 ± 1.256
3.824GlnPhe: 3.824 ± 0.289
9.56GlnGly: 9.56 ± 0.677
3.824GlnHis: 3.824 ± 2.512
1.912GlnIle: 1.912 ± 1.545
1.912GlnLys: 1.912 ± 1.256
0.0GlnLeu: 0.0 ± 0.0
0.0GlnMet: 0.0 ± 0.0
3.824GlnAsn: 3.824 ± 2.512
1.912GlnPro: 1.912 ± 1.256
0.0GlnGln: 0.0 ± 0.0
3.824GlnArg: 3.824 ± 2.512
1.912GlnSer: 1.912 ± 1.256
3.824GlnThr: 3.824 ± 3.09
0.0GlnVal: 0.0 ± 0.0
0.0GlnTrp: 0.0 ± 0.0
3.824GlnTyr: 3.824 ± 2.512
0.0GlnXaa: 0.0 ± 0.0
Arg
1.912ArgAla: 1.912 ± 1.545
1.912ArgCys: 1.912 ± 1.545
3.824ArgAsp: 3.824 ± 2.512
5.736ArgGlu: 5.736 ± 0.967
5.736ArgPhe: 5.736 ± 3.767
1.912ArgGly: 1.912 ± 1.256
0.0ArgHis: 0.0 ± 0.0
0.0ArgIle: 0.0 ± 0.0
5.736ArgLys: 5.736 ± 4.635
3.824ArgLeu: 3.824 ± 2.512
3.824ArgMet: 3.824 ± 3.09
1.912ArgAsn: 1.912 ± 1.545
7.648ArgPro: 7.648 ± 6.18
3.824ArgGln: 3.824 ± 0.289
7.648ArgArg: 7.648 ± 0.578
1.912ArgSer: 1.912 ± 1.256
5.736ArgThr: 5.736 ± 1.834
0.0ArgVal: 0.0 ± 0.0
1.912ArgTrp: 1.912 ± 1.545
3.824ArgTyr: 3.824 ± 0.289
0.0ArgXaa: 0.0 ± 0.0
Ser
3.824SerAla: 3.824 ± 3.09
1.912SerCys: 1.912 ± 1.256
5.736SerAsp: 5.736 ± 0.967
1.912SerGlu: 1.912 ± 1.256
0.0SerPhe: 0.0 ± 0.0
3.824SerGly: 3.824 ± 0.289
3.824SerHis: 3.824 ± 2.512
7.648SerIle: 7.648 ± 2.222
5.736SerLys: 5.736 ± 0.967
7.648SerLeu: 7.648 ± 0.578
1.912SerMet: 1.912 ± 0.913
1.912SerAsn: 1.912 ± 1.256
1.912SerPro: 1.912 ± 1.256
0.0SerGln: 0.0 ± 0.0
5.736SerArg: 5.736 ± 0.967
5.736SerSer: 5.736 ± 1.834
11.472SerThr: 11.472 ± 6.469
0.0SerVal: 0.0 ± 0.0
0.0SerTrp: 0.0 ± 0.0
1.912SerTyr: 1.912 ± 1.545
0.0SerXaa: 0.0 ± 0.0
Thr
3.824ThrAla: 3.824 ± 0.289
3.824ThrCys: 3.824 ± 2.512
5.736ThrAsp: 5.736 ± 1.834
1.912ThrGlu: 1.912 ± 1.256
1.912ThrPhe: 1.912 ± 1.545
9.56ThrGly: 9.56 ± 4.924
5.736ThrHis: 5.736 ± 1.834
3.824ThrIle: 3.824 ± 2.512
9.56ThrLys: 9.56 ± 3.478
9.56ThrLeu: 9.56 ± 7.725
7.648ThrMet: 7.648 ± 0.578
3.824ThrAsn: 3.824 ± 0.289
3.824ThrPro: 3.824 ± 0.289
5.736ThrGln: 5.736 ± 3.767
1.912ThrArg: 1.912 ± 1.545
9.56ThrSer: 9.56 ± 4.924
3.824ThrThr: 3.824 ± 3.09
5.736ThrVal: 5.736 ± 3.767
1.912ThrTrp: 1.912 ± 1.256
3.824ThrTyr: 3.824 ± 3.09
0.0ThrXaa: 0.0 ± 0.0
Val
3.824ValAla: 3.824 ± 0.289
1.912ValCys: 1.912 ± 1.256
1.912ValAsp: 1.912 ± 1.545
0.0ValGlu: 0.0 ± 0.0
3.824ValPhe: 3.824 ± 0.289
1.912ValGly: 1.912 ± 1.256
0.0ValHis: 0.0 ± 0.0
3.824ValIle: 3.824 ± 3.09
3.824ValLys: 3.824 ± 3.09
1.912ValLeu: 1.912 ± 1.545
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
3.824ValPro: 3.824 ± 0.289
1.912ValGln: 1.912 ± 1.545
3.824ValArg: 3.824 ± 0.289
1.912ValSer: 1.912 ± 1.545
7.648ValThr: 7.648 ± 2.222
1.912ValVal: 1.912 ± 1.256
0.0ValTrp: 0.0 ± 0.0
1.912ValTyr: 1.912 ± 1.256
0.0ValXaa: 0.0 ± 0.0
Trp
1.912TrpAla: 1.912 ± 1.545
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
3.824TrpPhe: 3.824 ± 0.289
0.0TrpGly: 0.0 ± 0.0
1.912TrpHis: 1.912 ± 1.256
1.912TrpIle: 1.912 ± 1.256
0.0TrpLys: 0.0 ± 0.0
1.912TrpLeu: 1.912 ± 1.545
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
3.824TrpSer: 3.824 ± 2.512
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
1.912TrpTrp: 1.912 ± 1.256
1.912TrpTyr: 1.912 ± 1.545
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.824TyrAla: 3.824 ± 0.289
3.824TyrCys: 3.824 ± 2.512
1.912TyrAsp: 1.912 ± 1.545
1.912TyrGlu: 1.912 ± 1.256
0.0TyrPhe: 0.0 ± 0.0
1.912TyrGly: 1.912 ± 1.545
1.912TyrHis: 1.912 ± 1.256
3.824TyrIle: 3.824 ± 2.512
1.912TyrLys: 1.912 ± 1.545
1.912TyrLeu: 1.912 ± 1.256
1.912TyrMet: 1.912 ± 1.256
1.912TyrAsn: 1.912 ± 1.545
1.912TyrPro: 1.912 ± 1.545
3.824TyrGln: 3.824 ± 0.289
3.824TyrArg: 3.824 ± 3.09
1.912TyrSer: 1.912 ± 1.545
3.824TyrThr: 3.824 ± 0.289
1.912TyrVal: 1.912 ± 1.545
1.912TyrTrp: 1.912 ± 1.545
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (524 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski