Amino acid dipepetide frequency for bacterium YEK0313

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.726AlaAla: 22.726 ± 0.187
1.146AlaCys: 1.146 ± 0.024
7.385AlaAsp: 7.385 ± 0.068
8.454AlaGlu: 8.454 ± 0.082
5.095AlaPhe: 5.095 ± 0.049
13.851AlaGly: 13.851 ± 0.117
2.341AlaHis: 2.341 ± 0.037
6.905AlaIle: 6.905 ± 0.065
3.383AlaLys: 3.383 ± 0.054
15.056AlaLeu: 15.056 ± 0.108
3.827AlaMet: 3.827 ± 0.048
2.728AlaAsn: 2.728 ± 0.046
6.597AlaPro: 6.597 ± 0.068
3.683AlaGln: 3.683 ± 0.048
11.182AlaArg: 11.182 ± 0.088
6.505AlaSer: 6.505 ± 0.068
6.684AlaThr: 6.684 ± 0.073
10.453AlaVal: 10.453 ± 0.099
1.721AlaTrp: 1.721 ± 0.031
2.665AlaTyr: 2.665 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.924CysAla: 0.924 ± 0.023
0.11CysCys: 0.11 ± 0.008
0.463CysAsp: 0.463 ± 0.016
0.378CysGlu: 0.378 ± 0.015
0.315CysPhe: 0.315 ± 0.012
0.872CysGly: 0.872 ± 0.023
0.227CysHis: 0.227 ± 0.01
0.351CysIle: 0.351 ± 0.013
0.121CysLys: 0.121 ± 0.007
0.76CysLeu: 0.76 ± 0.022
0.144CysMet: 0.144 ± 0.008
0.18CysAsn: 0.18 ± 0.009
0.419CysPro: 0.419 ± 0.015
0.186CysGln: 0.186 ± 0.01
0.718CysArg: 0.718 ± 0.021
0.362CysSer: 0.362 ± 0.013
0.358CysThr: 0.358 ± 0.015
0.54CysVal: 0.54 ± 0.017
0.107CysTrp: 0.107 ± 0.008
0.161CysTyr: 0.161 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.66AspAla: 6.66 ± 0.069
0.42AspCys: 0.42 ± 0.014
2.784AspAsp: 2.784 ± 0.04
3.056AspGlu: 3.056 ± 0.044
1.965AspPhe: 1.965 ± 0.031
5.267AspGly: 5.267 ± 0.051
1.294AspHis: 1.294 ± 0.03
2.862AspIle: 2.862 ± 0.038
1.339AspLys: 1.339 ± 0.028
5.904AspLeu: 5.904 ± 0.056
1.252AspMet: 1.252 ± 0.025
1.062AspAsn: 1.062 ± 0.024
3.531AspPro: 3.531 ± 0.047
1.567AspGln: 1.567 ± 0.029
4.809AspArg: 4.809 ± 0.052
1.678AspSer: 1.678 ± 0.032
2.335AspThr: 2.335 ± 0.04
3.899AspVal: 3.899 ± 0.046
0.888AspTrp: 0.888 ± 0.023
1.356AspTyr: 1.356 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
8.613GluAla: 8.613 ± 0.082
0.287GluCys: 0.287 ± 0.013
2.232GluAsp: 2.232 ± 0.037
2.534GluGlu: 2.534 ± 0.041
1.438GluPhe: 1.438 ± 0.028
3.833GluGly: 3.833 ± 0.045
0.985GluHis: 0.985 ± 0.02
3.081GluIle: 3.081 ± 0.046
1.492GluLys: 1.492 ± 0.033
4.773GluLeu: 4.773 ± 0.055
1.191GluMet: 1.191 ± 0.026
1.148GluAsn: 1.148 ± 0.024
2.85GluPro: 2.85 ± 0.041
1.686GluGln: 1.686 ± 0.032
5.305GluArg: 5.305 ± 0.058
1.707GluSer: 1.707 ± 0.032
3.396GluThr: 3.396 ± 0.044
3.71GluVal: 3.71 ± 0.039
0.596GluTrp: 0.596 ± 0.018
0.71GluTyr: 0.71 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
5.154PheAla: 5.154 ± 0.06
0.364PheCys: 0.364 ± 0.013
2.53PheAsp: 2.53 ± 0.039
1.939PheGlu: 1.939 ± 0.032
1.298PhePhe: 1.298 ± 0.026
4.052PheGly: 4.052 ± 0.057
0.747PheHis: 0.747 ± 0.02
1.544PheIle: 1.544 ± 0.027
0.843PheLys: 0.843 ± 0.024
3.252PheLeu: 3.252 ± 0.043
0.745PheMet: 0.745 ± 0.019
0.923PheAsn: 0.923 ± 0.026
1.607PhePro: 1.607 ± 0.028
1.025PheGln: 1.025 ± 0.023
2.445PheArg: 2.445 ± 0.034
1.999PheSer: 1.999 ± 0.033
1.863PheThr: 1.863 ± 0.033
3.048PheVal: 3.048 ± 0.04
0.523PheTrp: 0.523 ± 0.017
0.799PheTyr: 0.799 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.151GlyAla: 11.151 ± 0.092
0.806GlyCys: 0.806 ± 0.022
4.245GlyAsp: 4.245 ± 0.069
4.854GlyGlu: 4.854 ± 0.055
3.85GlyPhe: 3.85 ± 0.044
8.353GlyGly: 8.353 ± 0.126
2.04GlyHis: 2.04 ± 0.037
4.684GlyIle: 4.684 ± 0.049
2.475GlyLys: 2.475 ± 0.038
10.595GlyLeu: 10.595 ± 0.083
2.343GlyMet: 2.343 ± 0.035
1.936GlyAsn: 1.936 ± 0.047
4.23GlyPro: 4.23 ± 0.054
2.899GlyGln: 2.899 ± 0.045
7.919GlyArg: 7.919 ± 0.063
4.571GlySer: 4.571 ± 0.063
5.091GlyThr: 5.091 ± 0.093
5.987GlyVal: 5.987 ± 0.054
1.477GlyTrp: 1.477 ± 0.028
2.262GlyTyr: 2.262 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.529HisAla: 2.529 ± 0.035
0.197HisCys: 0.197 ± 0.01
1.22HisAsp: 1.22 ± 0.024
0.916HisGlu: 0.916 ± 0.022
0.806HisPhe: 0.806 ± 0.018
2.167HisGly: 2.167 ± 0.036
0.53HisHis: 0.53 ± 0.022
0.822HisIle: 0.822 ± 0.02
0.364HisLys: 0.364 ± 0.013
2.018HisLeu: 2.018 ± 0.037
0.437HisMet: 0.437 ± 0.013
0.375HisAsn: 0.375 ± 0.015
1.323HisPro: 1.323 ± 0.026
0.533HisGln: 0.533 ± 0.016
1.529HisArg: 1.529 ± 0.028
0.761HisSer: 0.761 ± 0.019
0.72HisThr: 0.72 ± 0.02
1.695HisVal: 1.695 ± 0.032
0.338HisTrp: 0.338 ± 0.013
0.469HisTyr: 0.469 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
7.995IleAla: 7.995 ± 0.061
0.445IleCys: 0.445 ± 0.017
3.36IleAsp: 3.36 ± 0.041
3.111IleGlu: 3.111 ± 0.044
1.499IlePhe: 1.499 ± 0.03
5.332IleGly: 5.332 ± 0.051
0.892IleHis: 0.892 ± 0.02
1.918IleIle: 1.918 ± 0.037
1.117IleLys: 1.117 ± 0.027
4.261IleLeu: 4.261 ± 0.052
0.923IleMet: 0.923 ± 0.023
1.208IleAsn: 1.208 ± 0.026
2.069IlePro: 2.069 ± 0.033
1.165IleGln: 1.165 ± 0.025
3.407IleArg: 3.407 ± 0.044
2.238IleSer: 2.238 ± 0.033
2.464IleThr: 2.464 ± 0.039
4.523IleVal: 4.523 ± 0.048
0.545IleTrp: 0.545 ± 0.018
1.013IleTyr: 1.013 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.971LysAla: 3.971 ± 0.054
0.106LysCys: 0.106 ± 0.006
1.273LysAsp: 1.273 ± 0.028
1.053LysGlu: 1.053 ± 0.025
0.622LysPhe: 0.622 ± 0.019
2.047LysGly: 2.047 ± 0.042
0.441LysHis: 0.441 ± 0.015
1.24LysIle: 1.24 ± 0.027
0.732LysLys: 0.732 ± 0.022
2.614LysLeu: 2.614 ± 0.036
0.469LysMet: 0.469 ± 0.015
0.528LysAsn: 0.528 ± 0.019
1.697LysPro: 1.697 ± 0.03
0.668LysGln: 0.668 ± 0.02
2.019LysArg: 2.019 ± 0.041
1.305LysSer: 1.305 ± 0.028
1.476LysThr: 1.476 ± 0.028
2.143LysVal: 2.143 ± 0.037
0.253LysTrp: 0.253 ± 0.012
0.417LysTyr: 0.417 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
16.615LeuAla: 16.615 ± 0.133
0.798LeuCys: 0.798 ± 0.018
6.051LeuAsp: 6.051 ± 0.062
4.391LeuGlu: 4.391 ± 0.049
3.708LeuPhe: 3.708 ± 0.052
9.201LeuGly: 9.201 ± 0.08
1.746LeuHis: 1.746 ± 0.03
5.108LeuIle: 5.108 ± 0.057
3.321LeuLys: 3.321 ± 0.044
8.645LeuLeu: 8.645 ± 0.102
2.435LeuMet: 2.435 ± 0.04
2.262LeuAsn: 2.262 ± 0.03
5.576LeuPro: 5.576 ± 0.058
2.452LeuGln: 2.452 ± 0.035
6.867LeuArg: 6.867 ± 0.066
5.644LeuSer: 5.644 ± 0.059
5.71LeuThr: 5.71 ± 0.059
8.544LeuVal: 8.544 ± 0.081
1.144LeuTrp: 1.144 ± 0.023
1.85LeuTyr: 1.85 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
3.432MetAla: 3.432 ± 0.041
0.141MetCys: 0.141 ± 0.009
0.955MetAsp: 0.955 ± 0.022
0.884MetGlu: 0.884 ± 0.022
0.703MetPhe: 0.703 ± 0.018
1.641MetGly: 1.641 ± 0.029
0.396MetHis: 0.396 ± 0.014
1.281MetIle: 1.281 ± 0.027
0.732MetLys: 0.732 ± 0.019
2.411MetLeu: 2.411 ± 0.039
0.58MetMet: 0.58 ± 0.019
0.628MetAsn: 0.628 ± 0.019
1.58MetPro: 1.58 ± 0.026
0.736MetGln: 0.736 ± 0.019
1.887MetArg: 1.887 ± 0.028
1.476MetSer: 1.476 ± 0.026
2.082MetThr: 2.082 ± 0.03
1.694MetVal: 1.694 ± 0.029
0.191MetTrp: 0.191 ± 0.01
0.268MetTyr: 0.268 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.97AsnAla: 2.97 ± 0.05
0.188AsnCys: 0.188 ± 0.009
1.144AsnAsp: 1.144 ± 0.032
0.969AsnGlu: 0.969 ± 0.023
0.779AsnPhe: 0.779 ± 0.023
2.139AsnGly: 2.139 ± 0.043
0.422AsnHis: 0.422 ± 0.016
1.03AsnIle: 1.03 ± 0.025
0.46AsnLys: 0.46 ± 0.014
2.326AsnLeu: 2.326 ± 0.037
0.477AsnMet: 0.477 ± 0.016
0.584AsnAsn: 0.584 ± 0.021
1.668AsnPro: 1.668 ± 0.026
0.655AsnGln: 0.655 ± 0.022
1.742AsnArg: 1.742 ± 0.034
0.958AsnSer: 0.958 ± 0.033
1.064AsnThr: 1.064 ± 0.03
1.732AsnVal: 1.732 ± 0.031
0.345AsnTrp: 0.345 ± 0.013
0.558AsnTyr: 0.558 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.021ProAla: 8.021 ± 0.088
0.29ProCys: 0.29 ± 0.013
3.679ProAsp: 3.679 ± 0.048
3.19ProGlu: 3.19 ± 0.046
2.054ProPhe: 2.054 ± 0.029
5.138ProGly: 5.138 ± 0.053
1.1ProHis: 1.1 ± 0.025
2.321ProIle: 2.321 ± 0.032
1.414ProLys: 1.414 ± 0.031
5.026ProLeu: 5.026 ± 0.05
1.213ProMet: 1.213 ± 0.026
1.229ProAsn: 1.229 ± 0.028
3.016ProPro: 3.016 ± 0.047
1.63ProGln: 1.63 ± 0.031
3.658ProArg: 3.658 ± 0.056
2.651ProSer: 2.651 ± 0.037
2.553ProThr: 2.553 ± 0.037
4.629ProVal: 4.629 ± 0.051
0.705ProTrp: 0.705 ± 0.018
1.122ProTyr: 1.122 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
4.263GlnAla: 4.263 ± 0.051
0.178GlnCys: 0.178 ± 0.01
1.255GlnAsp: 1.255 ± 0.025
1.152GlnGlu: 1.152 ± 0.024
0.936GlnPhe: 0.936 ± 0.02
2.34GlnGly: 2.34 ± 0.035
0.537GlnHis: 0.537 ± 0.014
1.596GlnIle: 1.596 ± 0.027
0.716GlnLys: 0.716 ± 0.023
2.546GlnLeu: 2.546 ± 0.038
0.745GlnMet: 0.745 ± 0.019
0.715GlnAsn: 0.715 ± 0.019
1.793GlnPro: 1.793 ± 0.035
1.055GlnGln: 1.055 ± 0.032
2.558GlnArg: 2.558 ± 0.038
1.427GlnSer: 1.427 ± 0.023
1.493GlnThr: 1.493 ± 0.026
2.275GlnVal: 2.275 ± 0.04
0.388GlnTrp: 0.388 ± 0.014
0.494GlnTyr: 0.494 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
9.775ArgAla: 9.775 ± 0.078
0.539ArgCys: 0.539 ± 0.017
4.32ArgAsp: 4.32 ± 0.05
4.158ArgGlu: 4.158 ± 0.052
3.348ArgPhe: 3.348 ± 0.039
5.703ArgGly: 5.703 ± 0.062
1.967ArgHis: 1.967 ± 0.032
4.279ArgIle: 4.279 ± 0.051
1.783ArgLys: 1.783 ± 0.034
9.285ArgLeu: 9.285 ± 0.072
1.983ArgMet: 1.983 ± 0.034
1.735ArgAsn: 1.735 ± 0.029
4.699ArgPro: 4.699 ± 0.055
2.761ArgGln: 2.761 ± 0.04
7.294ArgArg: 7.294 ± 0.079
3.944ArgSer: 3.944 ± 0.04
3.659ArgThr: 3.659 ± 0.039
5.139ArgVal: 5.139 ± 0.052
1.094ArgTrp: 1.094 ± 0.025
1.702ArgTyr: 1.702 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
5.96SerAla: 5.96 ± 0.061
0.349SerCys: 0.349 ± 0.013
2.409SerAsp: 2.409 ± 0.034
2.156SerGlu: 2.156 ± 0.037
2.15SerPhe: 2.15 ± 0.036
5.309SerGly: 5.309 ± 0.081
1.02SerHis: 1.02 ± 0.024
2.386SerIle: 2.386 ± 0.033
1.045SerLys: 1.045 ± 0.026
5.124SerLeu: 5.124 ± 0.05
1.111SerMet: 1.111 ± 0.022
1.109SerAsn: 1.109 ± 0.033
2.733SerPro: 2.733 ± 0.039
1.377SerGln: 1.377 ± 0.028
3.569SerArg: 3.569 ± 0.043
2.421SerSer: 2.421 ± 0.043
2.468SerThr: 2.468 ± 0.039
3.441SerVal: 3.441 ± 0.037
0.685SerTrp: 0.685 ± 0.018
1.183SerTyr: 1.183 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.93ThrAla: 6.93 ± 0.07
0.394ThrCys: 0.394 ± 0.015
2.535ThrAsp: 2.535 ± 0.035
2.415ThrGlu: 2.415 ± 0.034
2.025ThrPhe: 2.025 ± 0.041
5.392ThrGly: 5.392 ± 0.089
0.911ThrHis: 0.911 ± 0.02
2.937ThrIle: 2.937 ± 0.043
1.024ThrLys: 1.024 ± 0.022
5.748ThrLeu: 5.748 ± 0.064
1.219ThrMet: 1.219 ± 0.025
1.163ThrAsn: 1.163 ± 0.036
3.183ThrPro: 3.183 ± 0.04
1.242ThrGln: 1.242 ± 0.027
3.664ThrArg: 3.664 ± 0.041
2.58ThrSer: 2.58 ± 0.041
2.862ThrThr: 2.862 ± 0.043
4.732ThrVal: 4.732 ± 0.054
0.672ThrTrp: 0.672 ± 0.017
1.143ThrTyr: 1.143 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
10.826ValAla: 10.826 ± 0.084
0.579ValCys: 0.579 ± 0.017
4.226ValAsp: 4.226 ± 0.054
4.438ValGlu: 4.438 ± 0.047
2.765ValPhe: 2.765 ± 0.039
6.075ValGly: 6.075 ± 0.054
1.431ValHis: 1.431 ± 0.026
3.817ValIle: 3.817 ± 0.043
1.969ValLys: 1.969 ± 0.034
7.939ValLeu: 7.939 ± 0.076
1.922ValMet: 1.922 ± 0.035
1.864ValAsn: 1.864 ± 0.035
4.225ValPro: 4.225 ± 0.05
1.972ValGln: 1.972 ± 0.028
5.4ValArg: 5.4 ± 0.053
4.014ValSer: 4.014 ± 0.051
4.774ValThr: 4.774 ± 0.055
6.732ValVal: 6.732 ± 0.063
0.867ValTrp: 0.867 ± 0.023
1.394ValTyr: 1.394 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.33TrpAla: 1.33 ± 0.025
0.137TrpCys: 0.137 ± 0.009
0.567TrpAsp: 0.567 ± 0.017
0.465TrpGlu: 0.465 ± 0.017
0.551TrpPhe: 0.551 ± 0.016
0.948TrpGly: 0.948 ± 0.024
0.318TrpHis: 0.318 ± 0.012
0.638TrpIle: 0.638 ± 0.021
0.314TrpLys: 0.314 ± 0.012
1.648TrpLeu: 1.648 ± 0.03
0.319TrpMet: 0.319 ± 0.013
0.408TrpAsn: 0.408 ± 0.013
0.78TrpPro: 0.78 ± 0.021
0.548TrpGln: 0.548 ± 0.017
1.292TrpArg: 1.292 ± 0.025
0.761TrpSer: 0.761 ± 0.021
0.81TrpThr: 0.81 ± 0.02
0.782TrpVal: 0.782 ± 0.02
0.23TrpTrp: 0.23 ± 0.012
0.255TrpTyr: 0.255 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.543TyrAla: 2.543 ± 0.047
0.219TyrCys: 0.219 ± 0.011
1.296TyrAsp: 1.296 ± 0.026
1.054TyrGlu: 1.054 ± 0.023
0.796TyrPhe: 0.796 ± 0.019
2.109TyrGly: 2.109 ± 0.033
0.406TyrHis: 0.406 ± 0.013
0.686TyrIle: 0.686 ± 0.018
0.429TyrLys: 0.429 ± 0.017
2.139TyrLeu: 2.139 ± 0.032
0.362TyrMet: 0.362 ± 0.016
0.426TyrAsn: 0.426 ± 0.015
1.063TyrPro: 1.063 ± 0.023
0.623TyrGln: 0.623 ± 0.018
1.899TyrArg: 1.899 ± 0.029
1.002TyrSer: 1.002 ± 0.023
0.907TyrThr: 0.907 ± 0.024
1.531TyrVal: 1.531 ± 0.031
0.33TyrTrp: 0.33 ± 0.012
0.484TyrTyr: 0.484 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6563 proteins (2090780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski