Amino acid dipepetide frequency for Halosimplex carlsbadense 2-9-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.175AlaAla: 15.175 ± 0.168	0.695AlaCys: 0.695 ± 0.024	11.158AlaAsp: 11.158 ± 0.108	9.136AlaGlu: 9.136 ± 0.109	3.828AlaPhe: 3.828 ± 0.053	10.548AlaGly: 10.548 ± 0.118	1.828AlaHis: 1.828 ± 0.038	3.97AlaIle: 3.97 ± 0.058	1.561AlaLys: 1.561 ± 0.035	10.932AlaLeu: 10.932 ± 0.126	2.116AlaMet: 2.116 ± 0.041	2.35AlaAsn: 2.35 ± 0.05	4.343AlaPro: 4.343 ± 0.064	2.169AlaGln: 2.169 ± 0.049	6.588AlaArg: 6.588 ± 0.072	5.632AlaSer: 5.632 ± 0.071	7.862AlaThr: 7.862 ± 0.107	12.608AlaVal: 12.608 ± 0.143	1.153AlaTrp: 1.153 ± 0.029	2.709AlaTyr: 2.709 ± 0.046	0.003AlaXaa: 0.003 ± 0.002
Cys	0.587CysAla: 0.587 ± 0.026	0.083CysCys: 0.083 ± 0.009	0.577CysAsp: 0.577 ± 0.024	0.615CysGlu: 0.615 ± 0.022	0.19CysPhe: 0.19 ± 0.012	0.839CysGly: 0.839 ± 0.031	0.188CysHis: 0.188 ± 0.012	0.208CysIle: 0.208 ± 0.013	0.098CysLys: 0.098 ± 0.009	0.525CysLeu: 0.525 ± 0.02	0.088CysMet: 0.088 ± 0.009	0.175CysAsn: 0.175 ± 0.012	0.492CysPro: 0.492 ± 0.022	0.147CysGln: 0.147 ± 0.01	0.504CysArg: 0.504 ± 0.022	0.415CysSer: 0.415 ± 0.019	0.34CysThr: 0.34 ± 0.018	0.438CysVal: 0.438 ± 0.018	0.1CysTrp: 0.1 ± 0.008	0.222CysTyr: 0.222 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	11.018AspAla: 11.018 ± 0.109	0.688AspCys: 0.688 ± 0.025	8.653AspAsp: 8.653 ± 0.106	8.179AspGlu: 8.179 ± 0.09	2.124AspPhe: 2.124 ± 0.047	9.702AspGly: 9.702 ± 0.149	1.956AspHis: 1.956 ± 0.044	2.953AspIle: 2.953 ± 0.058	0.839AspLys: 0.839 ± 0.027	7.366AspLeu: 7.366 ± 0.09	1.307AspMet: 1.307 ± 0.032	1.303AspAsn: 1.303 ± 0.038	5.418AspPro: 5.418 ± 0.074	1.639AspGln: 1.639 ± 0.039	7.342AspArg: 7.342 ± 0.091	4.006AspSer: 4.006 ± 0.068	4.356AspThr: 4.356 ± 0.068	7.03AspVal: 7.03 ± 0.087	1.114AspTrp: 1.114 ± 0.036	2.127AspTyr: 2.127 ± 0.043	0.002AspXaa: 0.002 ± 0.001
Glu	8.811GluAla: 8.811 ± 0.103	0.501GluCys: 0.501 ± 0.023	5.422GluAsp: 5.422 ± 0.083	5.935GluGlu: 5.935 ± 0.104	2.903GluPhe: 2.903 ± 0.048	5.996GluGly: 5.996 ± 0.072	1.738GluHis: 1.738 ± 0.045	3.39GluIle: 3.39 ± 0.061	1.472GluLys: 1.472 ± 0.038	6.627GluLeu: 6.627 ± 0.083	1.765GluMet: 1.765 ± 0.041	2.03GluAsn: 2.03 ± 0.041	4.047GluPro: 4.047 ± 0.061	2.408GluGln: 2.408 ± 0.053	8.669GluArg: 8.669 ± 0.125	5.32GluSer: 5.32 ± 0.072	6.334GluThr: 6.334 ± 0.089	5.941GluVal: 5.941 ± 0.078	1.314GluTrp: 1.314 ± 0.033	2.569GluTyr: 2.569 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.821PheAla: 3.821 ± 0.062	0.257PheCys: 0.257 ± 0.016	3.509PheAsp: 3.509 ± 0.054	3.13PheGlu: 3.13 ± 0.054	0.967PhePhe: 0.967 ± 0.026	3.239PheGly: 3.239 ± 0.053	0.626PheHis: 0.626 ± 0.019	0.76PheIle: 0.76 ± 0.028	0.385PheLys: 0.385 ± 0.018	2.751PheLeu: 2.751 ± 0.057	0.448PheMet: 0.448 ± 0.02	0.639PheAsn: 0.639 ± 0.024	1.303PhePro: 1.303 ± 0.032	0.72PheGln: 0.72 ± 0.024	1.768PheArg: 1.768 ± 0.041	1.59PheSer: 1.59 ± 0.043	1.698PheThr: 1.698 ± 0.037	3.368PheVal: 3.368 ± 0.054	0.42PheTrp: 0.42 ± 0.017	0.816PheTyr: 0.816 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.482GlyAla: 9.482 ± 0.121	0.715GlyCys: 0.715 ± 0.027	8.07GlyAsp: 8.07 ± 0.114	7.75GlyGlu: 7.75 ± 0.094	3.116GlyPhe: 3.116 ± 0.053	8.693GlyGly: 8.693 ± 0.12	1.692GlyHis: 1.692 ± 0.037	3.609GlyIle: 3.609 ± 0.06	1.577GlyLys: 1.577 ± 0.039	7.413GlyLeu: 7.413 ± 0.098	1.689GlyMet: 1.689 ± 0.039	1.906GlyAsn: 1.906 ± 0.04	3.858GlyPro: 3.858 ± 0.068	2.027GlyGln: 2.027 ± 0.046	5.48GlyArg: 5.48 ± 0.076	5.664GlySer: 5.664 ± 0.086	6.073GlyThr: 6.073 ± 0.08	7.966GlyVal: 7.966 ± 0.097	1.232GlyTrp: 1.232 ± 0.033	2.648GlyTyr: 2.648 ± 0.049	0.002GlyXaa: 0.002 ± 0.001
His	1.924HisAla: 1.924 ± 0.045	0.185HisCys: 0.185 ± 0.013	1.721HisAsp: 1.721 ± 0.042	1.536HisGlu: 1.536 ± 0.036	0.578HisPhe: 0.578 ± 0.02	1.855HisGly: 1.855 ± 0.037	0.486HisHis: 0.486 ± 0.021	0.549HisIle: 0.549 ± 0.019	0.251HisLys: 0.251 ± 0.013	1.65HisLeu: 1.65 ± 0.04	0.269HisMet: 0.269 ± 0.014	0.43HisAsn: 0.43 ± 0.016	1.196HisPro: 1.196 ± 0.032	0.441HisGln: 0.441 ± 0.021	1.309HisArg: 1.309 ± 0.032	0.845HisSer: 0.845 ± 0.028	0.959HisThr: 0.959 ± 0.024	1.852HisVal: 1.852 ± 0.037	0.278HisTrp: 0.278 ± 0.014	0.559HisTyr: 0.559 ± 0.02	0.002HisXaa: 0.002 ± 0.001
Ile	4.057IleAla: 4.057 ± 0.057	0.232IleCys: 0.232 ± 0.014	3.561IleAsp: 3.561 ± 0.06	3.513IleGlu: 3.513 ± 0.066	0.802IlePhe: 0.802 ± 0.023	3.157IleGly: 3.157 ± 0.059	0.684IleHis: 0.684 ± 0.024	0.935IleIle: 0.935 ± 0.031	0.536IleLys: 0.536 ± 0.021	2.394IleLeu: 2.394 ± 0.052	0.408IleMet: 0.408 ± 0.02	0.836IleAsn: 0.836 ± 0.025	1.786IlePro: 1.786 ± 0.04	0.866IleGln: 0.866 ± 0.027	2.223IleArg: 2.223 ± 0.041	1.691IleSer: 1.691 ± 0.043	1.962IleThr: 1.962 ± 0.046	3.07IleVal: 3.07 ± 0.052	0.267IleTrp: 0.267 ± 0.015	0.73IleTyr: 0.73 ± 0.024	0.002IleXaa: 0.002 ± 0.001
Lys	1.449LysAla: 1.449 ± 0.037	0.111LysCys: 0.111 ± 0.01	0.839LysAsp: 0.839 ± 0.028	0.999LysGlu: 0.999 ± 0.036	0.462LysPhe: 0.462 ± 0.019	1.114LysGly: 1.114 ± 0.029	0.387LysHis: 0.387 ± 0.02	0.623LysIle: 0.623 ± 0.024	0.356LysLys: 0.356 ± 0.019	1.403LysLeu: 1.403 ± 0.035	0.311LysMet: 0.311 ± 0.018	0.446LysAsn: 0.446 ± 0.02	0.814LysPro: 0.814 ± 0.028	0.594LysGln: 0.594 ± 0.024	1.331LysArg: 1.331 ± 0.033	0.922LysSer: 0.922 ± 0.025	1.036LysThr: 1.036 ± 0.032	1.061LysVal: 1.061 ± 0.028	0.212LysTrp: 0.212 ± 0.012	0.492LysTyr: 0.492 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	11.626LeuAla: 11.626 ± 0.136	0.511LeuCys: 0.511 ± 0.02	7.836LeuAsp: 7.836 ± 0.082	5.809LeuGlu: 5.809 ± 0.076	2.94LeuPhe: 2.94 ± 0.066	7.674LeuGly: 7.674 ± 0.097	1.34LeuHis: 1.34 ± 0.033	2.292LeuIle: 2.292 ± 0.047	1.255LeuLys: 1.255 ± 0.031	7.87LeuLeu: 7.87 ± 0.125	1.215LeuMet: 1.215 ± 0.031	1.631LeuAsn: 1.631 ± 0.046	4.037LeuPro: 4.037 ± 0.062	1.903LeuGln: 1.903 ± 0.035	5.56LeuArg: 5.56 ± 0.077	5.352LeuSer: 5.352 ± 0.069	5.108LeuThr: 5.108 ± 0.062	8.684LeuVal: 8.684 ± 0.096	0.9LeuTrp: 0.9 ± 0.032	2.095LeuTyr: 2.095 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	1.855MetAla: 1.855 ± 0.041	0.104MetCys: 0.104 ± 0.009	1.328MetAsp: 1.328 ± 0.036	1.037MetGlu: 1.037 ± 0.032	0.472MetPhe: 0.472 ± 0.02	1.445MetGly: 1.445 ± 0.031	0.315MetHis: 0.315 ± 0.013	0.55MetIle: 0.55 ± 0.021	0.331MetLys: 0.331 ± 0.016	1.38MetLeu: 1.38 ± 0.031	0.266MetMet: 0.266 ± 0.017	0.523MetAsn: 0.523 ± 0.018	0.758MetPro: 0.758 ± 0.021	0.453MetGln: 0.453 ± 0.021	1.053MetArg: 1.053 ± 0.028	1.422MetSer: 1.422 ± 0.031	1.358MetThr: 1.358 ± 0.035	1.266MetVal: 1.266 ± 0.034	0.153MetTrp: 0.153 ± 0.012	0.396MetTyr: 0.396 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.395AsnAla: 2.395 ± 0.045	0.208AsnCys: 0.208 ± 0.013	1.632AsnAsp: 1.632 ± 0.042	1.609AsnGlu: 1.609 ± 0.035	0.654AsnPhe: 0.654 ± 0.022	1.985AsnGly: 1.985 ± 0.049	0.454AsnHis: 0.454 ± 0.019	0.749AsnIle: 0.749 ± 0.025	0.354AsnLys: 0.354 ± 0.015	1.798AsnLeu: 1.798 ± 0.038	0.364AsnMet: 0.364 ± 0.018	0.503AsnAsn: 0.503 ± 0.024	1.449AsnPro: 1.449 ± 0.035	0.613AsnGln: 0.613 ± 0.02	1.544AsnArg: 1.544 ± 0.039	0.926AsnSer: 0.926 ± 0.032	1.155AsnThr: 1.155 ± 0.037	2.188AsnVal: 2.188 ± 0.04	0.311AsnTrp: 0.311 ± 0.018	0.611AsnTyr: 0.611 ± 0.023	0.002AsnXaa: 0.002 ± 0.001
Pro	5.293ProAla: 5.293 ± 0.072	0.225ProCys: 0.225 ± 0.013	5.121ProAsp: 5.121 ± 0.06	4.593ProGlu: 4.593 ± 0.063	1.586ProPhe: 1.586 ± 0.039	4.126ProGly: 4.126 ± 0.066	0.849ProHis: 0.849 ± 0.03	1.578ProIle: 1.578 ± 0.034	0.739ProLys: 0.739 ± 0.026	3.689ProLeu: 3.689 ± 0.063	0.802ProMet: 0.802 ± 0.027	1.145ProAsn: 1.145 ± 0.028	2.299ProPro: 2.299 ± 0.049	0.913ProGln: 0.913 ± 0.027	2.363ProArg: 2.363 ± 0.047	2.738ProSer: 2.738 ± 0.046	3.619ProThr: 3.619 ± 0.083	4.49ProVal: 4.49 ± 0.062	0.599ProTrp: 0.599 ± 0.023	1.135ProTyr: 1.135 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.295GlnAla: 2.295 ± 0.037	0.149GlnCys: 0.149 ± 0.012	1.229GlnAsp: 1.229 ± 0.033	1.496GlnGlu: 1.496 ± 0.043	1.008GlnPhe: 1.008 ± 0.028	1.692GlnGly: 1.692 ± 0.036	0.488GlnHis: 0.488 ± 0.02	0.991GlnIle: 0.991 ± 0.03	0.46GlnLys: 0.46 ± 0.02	2.083GlnLeu: 2.083 ± 0.049	0.447GlnMet: 0.447 ± 0.019	0.623GlnAsn: 0.623 ± 0.024	1.09GlnPro: 1.09 ± 0.026	0.895GlnGln: 0.895 ± 0.039	2.072GlnArg: 2.072 ± 0.04	1.513GlnSer: 1.513 ± 0.041	1.503GlnThr: 1.503 ± 0.038	1.86GlnVal: 1.86 ± 0.038	0.384GlnTrp: 0.384 ± 0.019	0.759GlnTyr: 0.759 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.379ArgAla: 7.379 ± 0.087	0.463ArgCys: 0.463 ± 0.022	5.409ArgAsp: 5.409 ± 0.061	7.026ArgGlu: 7.026 ± 0.099	2.44ArgPhe: 2.44 ± 0.04	4.816ArgGly: 4.816 ± 0.071	1.276ArgHis: 1.276 ± 0.036	2.742ArgIle: 2.742 ± 0.046	1.174ArgLys: 1.174 ± 0.034	6.147ArgLeu: 6.147 ± 0.087	1.261ArgMet: 1.261 ± 0.03	1.518ArgAsn: 1.518 ± 0.035	2.875ArgPro: 2.875 ± 0.052	1.775ArgGln: 1.775 ± 0.04	5.315ArgArg: 5.315 ± 0.085	3.869ArgSer: 3.869 ± 0.051	4.109ArgThr: 4.109 ± 0.052	5.94ArgVal: 5.94 ± 0.073	0.894ArgTrp: 0.894 ± 0.03	2.04ArgTyr: 2.04 ± 0.036	0.001ArgXaa: 0.001 ± 0.001
Ser	5.827SerAla: 5.827 ± 0.079	0.274SerCys: 0.274 ± 0.015	4.659SerAsp: 4.659 ± 0.066	4.359SerGlu: 4.359 ± 0.068	1.806SerPhe: 1.806 ± 0.039	5.751SerGly: 5.751 ± 0.073	0.984SerHis: 0.984 ± 0.03	1.989SerIle: 1.989 ± 0.043	0.994SerLys: 0.994 ± 0.028	4.762SerLeu: 4.762 ± 0.07	1.027SerMet: 1.027 ± 0.029	1.226SerAsn: 1.226 ± 0.037	2.685SerPro: 2.685 ± 0.046	1.326SerGln: 1.326 ± 0.038	3.082SerArg: 3.082 ± 0.05	2.847SerSer: 2.847 ± 0.065	3.523SerThr: 3.523 ± 0.062	5.354SerVal: 5.354 ± 0.072	0.645SerTrp: 0.645 ± 0.023	1.364SerTyr: 1.364 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	7.542ThrAla: 7.542 ± 0.099	0.358ThrCys: 0.358 ± 0.016	6.261ThrAsp: 6.261 ± 0.076	4.751ThrGlu: 4.751 ± 0.067	2.046ThrPhe: 2.046 ± 0.042	6.107ThrGly: 6.107 ± 0.074	1.106ThrHis: 1.106 ± 0.033	2.229ThrIle: 2.229 ± 0.043	0.829ThrLys: 0.829 ± 0.026	5.513ThrLeu: 5.513 ± 0.067	0.898ThrMet: 0.898 ± 0.026	1.356ThrAsn: 1.356 ± 0.035	3.439ThrPro: 3.439 ± 0.071	1.239ThrGln: 1.239 ± 0.029	3.256ThrArg: 3.256 ± 0.052	2.587ThrSer: 2.587 ± 0.057	4.044ThrThr: 4.044 ± 0.063	7.569ThrVal: 7.569 ± 0.098	0.699ThrTrp: 0.699 ± 0.027	1.764ThrTyr: 1.764 ± 0.034	0.002ThrXaa: 0.002 ± 0.001
Val	11.909ValAla: 11.909 ± 0.129	0.705ValCys: 0.705 ± 0.024	8.641ValAsp: 8.641 ± 0.091	8.424ValGlu: 8.424 ± 0.098	2.956ValPhe: 2.956 ± 0.053	8.691ValGly: 8.691 ± 0.106	1.619ValHis: 1.619 ± 0.037	2.531ValIle: 2.531 ± 0.055	1.129ValLys: 1.129 ± 0.037	7.69ValLeu: 7.69 ± 0.095	1.209ValMet: 1.209 ± 0.038	1.876ValAsn: 1.876 ± 0.044	4.292ValPro: 4.292 ± 0.05	1.829ValGln: 1.829 ± 0.038	5.924ValArg: 5.924 ± 0.076	5.256ValSer: 5.256 ± 0.068	6.251ValThr: 6.251 ± 0.088	10.057ValVal: 10.057 ± 0.117	0.927ValTrp: 0.927 ± 0.025	2.267ValTyr: 2.267 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.139TrpAla: 1.139 ± 0.031	0.103TrpCys: 0.103 ± 0.009	0.858TrpAsp: 0.858 ± 0.028	0.839TrpGlu: 0.839 ± 0.031	0.511TrpPhe: 0.511 ± 0.018	0.886TrpGly: 0.886 ± 0.03	0.251TrpHis: 0.251 ± 0.014	0.451TrpIle: 0.451 ± 0.019	0.24TrpLys: 0.24 ± 0.014	1.252TrpLeu: 1.252 ± 0.036	0.217TrpMet: 0.217 ± 0.013	0.39TrpAsn: 0.39 ± 0.018	0.488TrpPro: 0.488 ± 0.022	0.372TrpGln: 0.372 ± 0.018	0.95TrpArg: 0.95 ± 0.032	0.707TrpSer: 0.707 ± 0.024	0.913TrpThr: 0.913 ± 0.027	1.015TrpVal: 1.015 ± 0.03	0.233TrpTrp: 0.233 ± 0.016	0.396TrpTyr: 0.396 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.781TyrAla: 2.781 ± 0.052	0.264TyrCys: 0.264 ± 0.014	2.64TyrAsp: 2.64 ± 0.05	2.453TyrGlu: 2.453 ± 0.047	0.826TyrPhe: 0.826 ± 0.028	2.347TyrGly: 2.347 ± 0.043	0.605TyrHis: 0.605 ± 0.021	0.609TyrIle: 0.609 ± 0.023	0.382TyrLys: 0.382 ± 0.017	2.393TyrLeu: 2.393 ± 0.046	0.356TyrMet: 0.356 ± 0.015	0.6TyrAsn: 0.6 ± 0.022	1.231TyrPro: 1.231 ± 0.031	0.705TyrGln: 0.705 ± 0.023	2.135TyrArg: 2.135 ± 0.05	1.181TyrSer: 1.181 ± 0.033	1.39TyrThr: 1.39 ± 0.033	2.427TyrVal: 2.427 ± 0.041	0.375TyrTrp: 0.375 ± 0.019	0.856TyrTyr: 0.856 ± 0.028	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.003XaaHis: 0.003 ± 0.002	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.003

Statistics based on 4458 proteins (1310473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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