Amino acid dipepetide frequency for Kaistia algarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.346AlaAla: 17.346 ± 0.164	0.884AlaCys: 0.884 ± 0.022	6.815AlaAsp: 6.815 ± 0.071	7.742AlaGlu: 7.742 ± 0.074	4.728AlaPhe: 4.728 ± 0.051	10.944AlaGly: 10.944 ± 0.103	2.067AlaHis: 2.067 ± 0.035	7.464AlaIle: 7.464 ± 0.074	4.249AlaLys: 4.249 ± 0.058	13.178AlaLeu: 13.178 ± 0.105	3.371AlaMet: 3.371 ± 0.046	2.945AlaAsn: 2.945 ± 0.048	5.37AlaPro: 5.37 ± 0.079	3.24AlaGln: 3.24 ± 0.045	7.834AlaArg: 7.834 ± 0.081	6.91AlaSer: 6.91 ± 0.076	6.059AlaThr: 6.059 ± 0.066	8.738AlaVal: 8.738 ± 0.076	1.425AlaTrp: 1.425 ± 0.029	2.637AlaTyr: 2.637 ± 0.035	0.003AlaXaa: 0.003 ± 0.001
Cys	0.775CysAla: 0.775 ± 0.019	0.112CysCys: 0.112 ± 0.008	0.467CysAsp: 0.467 ± 0.018	0.381CysGlu: 0.381 ± 0.012	0.3CysPhe: 0.3 ± 0.013	0.79CysGly: 0.79 ± 0.024	0.226CysHis: 0.226 ± 0.012	0.369CysIle: 0.369 ± 0.015	0.173CysLys: 0.173 ± 0.009	0.746CysLeu: 0.746 ± 0.021	0.13CysMet: 0.13 ± 0.008	0.195CysAsn: 0.195 ± 0.011	0.383CysPro: 0.383 ± 0.017	0.212CysGln: 0.212 ± 0.011	0.544CysArg: 0.544 ± 0.018	0.414CysSer: 0.414 ± 0.014	0.357CysThr: 0.357 ± 0.014	0.562CysVal: 0.562 ± 0.022	0.096CysTrp: 0.096 ± 0.008	0.182CysTyr: 0.182 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.647AspAla: 6.647 ± 0.064	0.427AspCys: 0.427 ± 0.018	2.901AspAsp: 2.901 ± 0.043	3.481AspGlu: 3.481 ± 0.048	2.269AspPhe: 2.269 ± 0.037	5.142AspGly: 5.142 ± 0.06	1.213AspHis: 1.213 ± 0.027	3.249AspIle: 3.249 ± 0.049	1.763AspLys: 1.763 ± 0.035	5.89AspLeu: 5.89 ± 0.052	1.236AspMet: 1.236 ± 0.025	1.326AspAsn: 1.326 ± 0.031	3.62AspPro: 3.62 ± 0.049	1.734AspGln: 1.734 ± 0.035	4.16AspArg: 4.16 ± 0.052	2.301AspSer: 2.301 ± 0.038	2.388AspThr: 2.388 ± 0.037	4.088AspVal: 4.088 ± 0.049	0.952AspTrp: 0.952 ± 0.023	1.566AspTyr: 1.566 ± 0.033	0.002AspXaa: 0.002 ± 0.001
Glu	7.803GluAla: 7.803 ± 0.083	0.318GluCys: 0.318 ± 0.014	2.575GluAsp: 2.575 ± 0.04	2.838GluGlu: 2.838 ± 0.054	1.86GluPhe: 1.86 ± 0.036	4.181GluGly: 4.181 ± 0.053	1.164GluHis: 1.164 ± 0.032	3.878GluIle: 3.878 ± 0.05	2.249GluLys: 2.249 ± 0.04	5.227GluLeu: 5.227 ± 0.058	1.353GluMet: 1.353 ± 0.031	1.543GluAsn: 1.543 ± 0.036	2.877GluPro: 2.877 ± 0.048	1.972GluGln: 1.972 ± 0.038	4.608GluArg: 4.608 ± 0.071	2.424GluSer: 2.424 ± 0.037	3.444GluThr: 3.444 ± 0.045	3.627GluVal: 3.627 ± 0.051	0.729GluTrp: 0.729 ± 0.02	0.982GluTyr: 0.982 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	4.759PheAla: 4.759 ± 0.052	0.38PheCys: 0.38 ± 0.014	2.714PheAsp: 2.714 ± 0.036	2.206PheGlu: 2.206 ± 0.042	1.625PhePhe: 1.625 ± 0.03	3.946PheGly: 3.946 ± 0.053	0.767PheHis: 0.767 ± 0.024	1.926PheIle: 1.926 ± 0.032	1.18PheLys: 1.18 ± 0.03	3.663PheLeu: 3.663 ± 0.045	0.774PheMet: 0.774 ± 0.021	1.19PheAsn: 1.19 ± 0.025	1.674PhePro: 1.674 ± 0.034	1.112PheGln: 1.112 ± 0.026	2.242PheArg: 2.242 ± 0.035	2.315PheSer: 2.315 ± 0.039	1.902PheThr: 1.902 ± 0.029	3.041PheVal: 3.041 ± 0.047	0.572PheTrp: 0.572 ± 0.019	0.997PheTyr: 0.997 ± 0.027	0.002PheXaa: 0.002 ± 0.001
Gly	9.171GlyAla: 9.171 ± 0.095	0.728GlyCys: 0.728 ± 0.022	4.352GlyAsp: 4.352 ± 0.051	4.794GlyGlu: 4.794 ± 0.054	3.651GlyPhe: 3.651 ± 0.048	7.529GlyGly: 7.529 ± 0.114	1.814GlyHis: 1.814 ± 0.036	5.131GlyIle: 5.131 ± 0.064	3.35GlyLys: 3.35 ± 0.052	9.137GlyLeu: 9.137 ± 0.084	2.118GlyMet: 2.118 ± 0.038	2.219GlyAsn: 2.219 ± 0.041	3.461GlyPro: 3.461 ± 0.048	2.616GlyGln: 2.616 ± 0.042	6.234GlyArg: 6.234 ± 0.066	5.048GlySer: 5.048 ± 0.078	4.794GlyThr: 4.794 ± 0.08	6.233GlyVal: 6.233 ± 0.06	1.437GlyTrp: 1.437 ± 0.029	2.357GlyTyr: 2.357 ± 0.036	0.003GlyXaa: 0.003 ± 0.001
His	2.154HisAla: 2.154 ± 0.038	0.195HisCys: 0.195 ± 0.012	1.168HisAsp: 1.168 ± 0.03	1.015HisGlu: 1.015 ± 0.028	0.917HisPhe: 0.917 ± 0.022	1.84HisGly: 1.84 ± 0.034	0.562HisHis: 0.562 ± 0.021	1.013HisIle: 1.013 ± 0.027	0.494HisLys: 0.494 ± 0.018	2.089HisLeu: 2.089 ± 0.04	0.426HisMet: 0.426 ± 0.015	0.458HisAsn: 0.458 ± 0.017	1.294HisPro: 1.294 ± 0.028	0.63HisGln: 0.63 ± 0.019	1.385HisArg: 1.385 ± 0.03	0.965HisSer: 0.965 ± 0.024	0.731HisThr: 0.731 ± 0.022	1.477HisVal: 1.477 ± 0.032	0.309HisTrp: 0.309 ± 0.013	0.584HisTyr: 0.584 ± 0.021	0.001HisXaa: 0.001 ± 0.001
Ile	8.061IleAla: 8.061 ± 0.075	0.492IleCys: 0.492 ± 0.018	4.04IleAsp: 4.04 ± 0.046	4.06IleGlu: 4.06 ± 0.046	1.95IlePhe: 1.95 ± 0.038	5.736IleGly: 5.736 ± 0.062	1.04IleHis: 1.04 ± 0.027	2.54IleIle: 2.54 ± 0.039	1.578IleLys: 1.578 ± 0.037	5.31IleLeu: 5.31 ± 0.066	0.934IleMet: 0.934 ± 0.026	1.484IleAsn: 1.484 ± 0.034	2.492IlePro: 2.492 ± 0.038	1.541IleGln: 1.541 ± 0.033	3.54IleArg: 3.54 ± 0.047	3.045IleSer: 3.045 ± 0.044	2.622IleThr: 2.622 ± 0.044	4.967IleVal: 4.967 ± 0.062	0.675IleTrp: 0.675 ± 0.021	1.296IleTyr: 1.296 ± 0.031	0.002IleXaa: 0.002 ± 0.001
Lys	4.376LysAla: 4.376 ± 0.061	0.146LysCys: 0.146 ± 0.009	1.781LysAsp: 1.781 ± 0.036	1.574LysGlu: 1.574 ± 0.033	0.967LysPhe: 0.967 ± 0.024	2.653LysGly: 2.653 ± 0.043	0.578LysHis: 0.578 ± 0.019	1.99LysIle: 1.99 ± 0.039	1.481LysLys: 1.481 ± 0.039	3.447LysLeu: 3.447 ± 0.048	0.808LysMet: 0.808 ± 0.024	1.097LysAsn: 1.097 ± 0.031	2.055LysPro: 2.055 ± 0.034	1.155LysGln: 1.155 ± 0.029	2.296LysArg: 2.296 ± 0.039	2.026LysSer: 2.026 ± 0.042	2.029LysThr: 2.029 ± 0.034	2.527LysVal: 2.527 ± 0.043	0.392LysTrp: 0.392 ± 0.015	0.71LysTyr: 0.71 ± 0.024	0.001LysXaa: 0.001 ± 0.001
Leu	14.07LeuAla: 14.07 ± 0.112	0.805LeuCys: 0.805 ± 0.021	6.171LeuAsp: 6.171 ± 0.059	4.917LeuGlu: 4.917 ± 0.06	3.887LeuPhe: 3.887 ± 0.055	8.589LeuGly: 8.589 ± 0.085	1.815LeuHis: 1.815 ± 0.033	5.349LeuIle: 5.349 ± 0.066	3.844LeuLys: 3.844 ± 0.055	9.481LeuLeu: 9.481 ± 0.101	2.269LeuMet: 2.269 ± 0.041	2.652LeuAsn: 2.652 ± 0.042	5.617LeuPro: 5.617 ± 0.061	2.763LeuGln: 2.763 ± 0.039	6.198LeuArg: 6.198 ± 0.064	6.717LeuSer: 6.717 ± 0.064	5.444LeuThr: 5.444 ± 0.061	7.95LeuVal: 7.95 ± 0.066	1.139LeuTrp: 1.139 ± 0.026	2.219LeuTyr: 2.219 ± 0.035	0.002LeuXaa: 0.002 ± 0.001
Met	2.927MetAla: 2.927 ± 0.046	0.122MetCys: 0.122 ± 0.009	1.038MetAsp: 1.038 ± 0.026	0.966MetGlu: 0.966 ± 0.021	0.653MetPhe: 0.653 ± 0.019	1.604MetGly: 1.604 ± 0.03	0.385MetHis: 0.385 ± 0.015	1.43MetIle: 1.43 ± 0.027	0.97MetLys: 0.97 ± 0.027	2.35MetLeu: 2.35 ± 0.037	0.631MetMet: 0.631 ± 0.021	0.754MetAsn: 0.754 ± 0.021	1.406MetPro: 1.406 ± 0.027	0.839MetGln: 0.839 ± 0.023	1.652MetArg: 1.652 ± 0.03	1.626MetSer: 1.626 ± 0.03	1.745MetThr: 1.745 ± 0.029	1.692MetVal: 1.692 ± 0.03	0.179MetTrp: 0.179 ± 0.011	0.299MetTyr: 0.299 ± 0.012	0.002MetXaa: 0.002 ± 0.001
Asn	2.981AsnAla: 2.981 ± 0.045	0.245AsnCys: 0.245 ± 0.013	1.424AsnAsp: 1.424 ± 0.033	1.322AsnGlu: 1.322 ± 0.029	1.091AsnPhe: 1.091 ± 0.026	2.399AsnGly: 2.399 ± 0.048	0.553AsnHis: 0.553 ± 0.018	1.582AsnIle: 1.582 ± 0.034	0.842AsnLys: 0.842 ± 0.025	2.717AsnLeu: 2.717 ± 0.038	0.581AsnMet: 0.581 ± 0.02	0.804AsnAsn: 0.804 ± 0.026	1.808AsnPro: 1.808 ± 0.033	0.931AsnGln: 0.931 ± 0.024	1.738AsnArg: 1.738 ± 0.033	1.416AsnSer: 1.416 ± 0.034	1.248AsnThr: 1.248 ± 0.029	1.968AsnVal: 1.968 ± 0.041	0.465AsnTrp: 0.465 ± 0.015	0.757AsnTyr: 0.757 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	6.4ProAla: 6.4 ± 0.084	0.281ProCys: 0.281 ± 0.013	3.435ProAsp: 3.435 ± 0.045	3.487ProGlu: 3.487 ± 0.054	2.062ProPhe: 2.062 ± 0.039	4.241ProGly: 4.241 ± 0.045	1.039ProHis: 1.039 ± 0.023	2.83ProIle: 2.83 ± 0.039	1.824ProLys: 1.824 ± 0.034	4.782ProLeu: 4.782 ± 0.059	1.195ProMet: 1.195 ± 0.021	1.488ProAsn: 1.488 ± 0.027	2.543ProPro: 2.543 ± 0.057	1.423ProGln: 1.423 ± 0.028	2.781ProArg: 2.781 ± 0.046	2.977ProSer: 2.977 ± 0.04	2.695ProThr: 2.695 ± 0.034	4.006ProVal: 4.006 ± 0.056	0.648ProTrp: 0.648 ± 0.02	1.228ProTyr: 1.228 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.625GlnAla: 3.625 ± 0.054	0.18GlnCys: 0.18 ± 0.011	1.427GlnAsp: 1.427 ± 0.028	1.381GlnGlu: 1.381 ± 0.031	1.095GlnPhe: 1.095 ± 0.027	2.266GlnGly: 2.266 ± 0.036	0.683GlnHis: 0.683 ± 0.021	2.001GlnIle: 2.001 ± 0.032	1.238GlnLys: 1.238 ± 0.023	2.906GlnLeu: 2.906 ± 0.047	0.793GlnMet: 0.793 ± 0.025	0.954GlnAsn: 0.954 ± 0.023	1.717GlnPro: 1.717 ± 0.035	1.406GlnGln: 1.406 ± 0.038	2.242GlnArg: 2.242 ± 0.041	1.826GlnSer: 1.826 ± 0.035	1.604GlnThr: 1.604 ± 0.036	2.045GlnVal: 2.045 ± 0.036	0.398GlnTrp: 0.398 ± 0.017	0.718GlnTyr: 0.718 ± 0.022	0.004GlnXaa: 0.004 ± 0.002
Arg	7.195ArgAla: 7.195 ± 0.079	0.431ArgCys: 0.431 ± 0.018	3.681ArgAsp: 3.681 ± 0.046	3.746ArgGlu: 3.746 ± 0.048	2.971ArgPhe: 2.971 ± 0.042	4.622ArgGly: 4.622 ± 0.054	1.585ArgHis: 1.585 ± 0.031	4.24ArgIle: 4.24 ± 0.054	1.996ArgLys: 1.996 ± 0.032	7.785ArgLeu: 7.785 ± 0.082	1.627ArgMet: 1.627 ± 0.03	1.674ArgAsn: 1.674 ± 0.032	3.49ArgPro: 3.49 ± 0.053	2.414ArgGln: 2.414 ± 0.042	5.482ArgArg: 5.482 ± 0.077	3.826ArgSer: 3.826 ± 0.05	3.106ArgThr: 3.106 ± 0.043	4.341ArgVal: 4.341 ± 0.055	0.947ArgTrp: 0.947 ± 0.022	1.636ArgTyr: 1.636 ± 0.033	0.003ArgXaa: 0.003 ± 0.001
Ser	6.459SerAla: 6.459 ± 0.068	0.396SerCys: 0.396 ± 0.016	3.041SerAsp: 3.041 ± 0.047	2.896SerGlu: 2.896 ± 0.044	2.554SerPhe: 2.554 ± 0.034	5.767SerGly: 5.767 ± 0.073	1.076SerHis: 1.076 ± 0.027	3.277SerIle: 3.277 ± 0.051	1.75SerLys: 1.75 ± 0.035	5.839SerLeu: 5.839 ± 0.061	1.316SerMet: 1.316 ± 0.029	1.529SerAsn: 1.529 ± 0.036	2.875SerPro: 2.875 ± 0.04	1.663SerGln: 1.663 ± 0.033	3.617SerArg: 3.617 ± 0.052	3.241SerSer: 3.241 ± 0.051	2.842SerThr: 2.842 ± 0.047	4.256SerVal: 4.256 ± 0.055	0.771SerTrp: 0.771 ± 0.02	1.354SerTyr: 1.354 ± 0.031	0.002SerXaa: 0.002 ± 0.001
Thr	6.045ThrAla: 6.045 ± 0.065	0.345ThrCys: 0.345 ± 0.013	2.747ThrAsp: 2.747 ± 0.045	2.63ThrGlu: 2.63 ± 0.043	1.986ThrPhe: 1.986 ± 0.035	4.933ThrGly: 4.933 ± 0.073	0.973ThrHis: 0.973 ± 0.024	3.344ThrIle: 3.344 ± 0.052	1.527ThrLys: 1.527 ± 0.033	5.793ThrLeu: 5.793 ± 0.069	1.187ThrMet: 1.187 ± 0.025	1.367ThrAsn: 1.367 ± 0.031	3.015ThrPro: 3.015 ± 0.034	1.389ThrGln: 1.389 ± 0.028	2.968ThrArg: 2.968 ± 0.045	2.823ThrSer: 2.823 ± 0.041	2.914ThrThr: 2.914 ± 0.049	4.245ThrVal: 4.245 ± 0.056	0.611ThrTrp: 0.611 ± 0.018	1.202ThrTyr: 1.202 ± 0.027	0.003ThrXaa: 0.003 ± 0.001
Val	9.489ValAla: 9.489 ± 0.077	0.572ValCys: 0.572 ± 0.02	4.473ValAsp: 4.473 ± 0.05	4.473ValGlu: 4.473 ± 0.05	2.789ValPhe: 2.789 ± 0.043	5.958ValGly: 5.958 ± 0.073	1.36ValHis: 1.36 ± 0.028	4.056ValIle: 4.056 ± 0.05	2.372ValLys: 2.372 ± 0.038	7.559ValLeu: 7.559 ± 0.071	1.738ValMet: 1.738 ± 0.028	1.992ValAsn: 1.992 ± 0.041	3.857ValPro: 3.857 ± 0.051	2.016ValGln: 2.016 ± 0.037	4.476ValArg: 4.476 ± 0.057	4.417ValSer: 4.417 ± 0.049	4.319ValThr: 4.319 ± 0.058	6.185ValVal: 6.185 ± 0.067	0.882ValTrp: 0.882 ± 0.022	1.545ValTyr: 1.545 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.026	0.118TrpCys: 0.118 ± 0.007	0.628TrpAsp: 0.628 ± 0.02	0.493TrpGlu: 0.493 ± 0.018	0.567TrpPhe: 0.567 ± 0.016	0.89TrpGly: 0.89 ± 0.021	0.317TrpHis: 0.317 ± 0.015	0.755TrpIle: 0.755 ± 0.021	0.499TrpLys: 0.499 ± 0.018	1.607TrpLeu: 1.607 ± 0.032	0.348TrpMet: 0.348 ± 0.014	0.516TrpAsn: 0.516 ± 0.016	0.684TrpPro: 0.684 ± 0.02	0.61TrpGln: 0.61 ± 0.019	1.09TrpArg: 1.09 ± 0.027	0.855TrpSer: 0.855 ± 0.023	0.771TrpThr: 0.771 ± 0.022	0.814TrpVal: 0.814 ± 0.02	0.22TrpTrp: 0.22 ± 0.012	0.314TrpTyr: 0.314 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.532TyrAla: 2.532 ± 0.045	0.237TyrCys: 0.237 ± 0.014	1.476TyrAsp: 1.476 ± 0.032	1.243TyrGlu: 1.243 ± 0.029	1.06TyrPhe: 1.06 ± 0.024	2.146TyrGly: 2.146 ± 0.039	0.49TyrHis: 0.49 ± 0.016	0.978TyrIle: 0.978 ± 0.023	0.708TyrLys: 0.708 ± 0.024	2.39TyrLeu: 2.39 ± 0.038	0.434TyrMet: 0.434 ± 0.015	0.686TyrAsn: 0.686 ± 0.02	1.128TyrPro: 1.128 ± 0.026	0.84TyrGln: 0.84 ± 0.027	1.711TyrArg: 1.711 ± 0.034	1.346TyrSer: 1.346 ± 0.032	1.032TyrThr: 1.032 ± 0.024	1.766TyrVal: 1.766 ± 0.03	0.38TyrTrp: 0.38 ± 0.013	0.62TyrTyr: 0.62 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.003XaaIle: 0.003 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6004 proteins (1794267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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