Amino acid dipepetide frequency for Micromonospora fluostatini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.11AlaAla: 21.11 ± 0.219
0.924AlaCys: 0.924 ± 0.03
8.821AlaAsp: 8.821 ± 0.109
8.307AlaGlu: 8.307 ± 0.12
3.215AlaPhe: 3.215 ± 0.062
14.39AlaGly: 14.39 ± 0.15
2.716AlaHis: 2.716 ± 0.056
3.633AlaIle: 3.633 ± 0.069
2.187AlaLys: 2.187 ± 0.056
14.067AlaLeu: 14.067 ± 0.163
2.373AlaMet: 2.373 ± 0.047
2.138AlaAsn: 2.138 ± 0.051
6.468AlaPro: 6.468 ± 0.094
3.579AlaGln: 3.579 ± 0.065
10.508AlaArg: 10.508 ± 0.128
4.97AlaSer: 4.97 ± 0.083
8.047AlaThr: 8.047 ± 0.085
12.756AlaVal: 12.756 ± 0.143
1.975AlaTrp: 1.975 ± 0.051
2.874AlaTyr: 2.874 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.984CysAla: 0.984 ± 0.031
0.101CysCys: 0.101 ± 0.008
0.502CysAsp: 0.502 ± 0.02
0.355CysGlu: 0.355 ± 0.021
0.203CysPhe: 0.203 ± 0.016
0.9CysGly: 0.9 ± 0.035
0.215CysHis: 0.215 ± 0.014
0.161CysIle: 0.161 ± 0.013
0.089CysLys: 0.089 ± 0.01
0.695CysLeu: 0.695 ± 0.028
0.089CysMet: 0.089 ± 0.008
0.129CysAsn: 0.129 ± 0.011
0.525CysPro: 0.525 ± 0.025
0.214CysGln: 0.214 ± 0.015
0.633CysArg: 0.633 ± 0.026
0.358CysSer: 0.358 ± 0.018
0.449CysThr: 0.449 ± 0.019
0.635CysVal: 0.635 ± 0.025
0.161CysTrp: 0.161 ± 0.014
0.164CysTyr: 0.164 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.356AspAla: 7.356 ± 0.088
0.407AspCys: 0.407 ± 0.018
3.883AspAsp: 3.883 ± 0.062
3.778AspGlu: 3.778 ± 0.065
1.541AspPhe: 1.541 ± 0.047
6.328AspGly: 6.328 ± 0.084
1.464AspHis: 1.464 ± 0.042
1.631AspIle: 1.631 ± 0.042
0.922AspLys: 0.922 ± 0.037
7.299AspLeu: 7.299 ± 0.091
0.724AspMet: 0.724 ± 0.028
1.013AspAsn: 1.013 ± 0.037
4.98AspPro: 4.98 ± 0.073
1.742AspGln: 1.742 ± 0.037
5.933AspArg: 5.933 ± 0.084
2.24AspSer: 2.24 ± 0.046
3.044AspThr: 3.044 ± 0.048
5.12AspVal: 5.12 ± 0.065
1.016AspTrp: 1.016 ± 0.033
1.196AspTyr: 1.196 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.503GluAla: 6.503 ± 0.105
0.361GluCys: 0.361 ± 0.02
2.118GluAsp: 2.118 ± 0.051
2.733GluGlu: 2.733 ± 0.065
1.51GluPhe: 1.51 ± 0.043
3.307GluGly: 3.307 ± 0.063
1.432GluHis: 1.432 ± 0.039
2.273GluIle: 2.273 ± 0.053
1.032GluLys: 1.032 ± 0.036
6.203GluLeu: 6.203 ± 0.08
0.899GluMet: 0.899 ± 0.03
0.93GluAsn: 0.93 ± 0.028
3.343GluPro: 3.343 ± 0.059
2.289GluGln: 2.289 ± 0.054
5.099GluArg: 5.099 ± 0.084
2.215GluSer: 2.215 ± 0.048
2.557GluThr: 2.557 ± 0.05
5.112GluVal: 5.112 ± 0.082
0.738GluTrp: 0.738 ± 0.025
1.236GluTyr: 1.236 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.597PheAla: 3.597 ± 0.069
0.247PheCys: 0.247 ± 0.015
2.009PheAsp: 2.009 ± 0.048
1.3PheGlu: 1.3 ± 0.041
0.934PhePhe: 0.934 ± 0.029
3.035PheGly: 3.035 ± 0.063
0.573PheHis: 0.573 ± 0.023
0.672PheIle: 0.672 ± 0.025
0.402PheLys: 0.402 ± 0.023
2.524PheLeu: 2.524 ± 0.059
0.361PheMet: 0.361 ± 0.019
0.567PheAsn: 0.567 ± 0.024
1.366PhePro: 1.366 ± 0.034
0.636PheGln: 0.636 ± 0.026
1.871PheArg: 1.871 ± 0.044
1.289PheSer: 1.289 ± 0.04
2.029PheThr: 2.029 ± 0.052
2.475PheVal: 2.475 ± 0.053
0.432PheTrp: 0.432 ± 0.021
0.614PheTyr: 0.614 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.441GlyAla: 10.441 ± 0.118
0.822GlyCys: 0.822 ± 0.025
5.486GlyAsp: 5.486 ± 0.077
4.782GlyGlu: 4.782 ± 0.069
2.717GlyPhe: 2.717 ± 0.057
8.534GlyGly: 8.534 ± 0.127
2.249GlyHis: 2.249 ± 0.048
3.145GlyIle: 3.145 ± 0.059
1.872GlyLys: 1.872 ± 0.047
9.393GlyLeu: 9.393 ± 0.113
1.831GlyMet: 1.831 ± 0.038
1.741GlyAsn: 1.741 ± 0.048
5.292GlyPro: 5.292 ± 0.087
2.938GlyGln: 2.938 ± 0.06
8.09GlyArg: 8.09 ± 0.102
4.713GlySer: 4.713 ± 0.075
6.172GlyThr: 6.172 ± 0.085
8.062GlyVal: 8.062 ± 0.096
1.905GlyTrp: 1.905 ± 0.047
2.569GlyTyr: 2.569 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.545HisAla: 2.545 ± 0.05
0.227HisCys: 0.227 ± 0.013
1.472HisAsp: 1.472 ± 0.043
1.067HisGlu: 1.067 ± 0.034
0.591HisPhe: 0.591 ± 0.023
2.154HisGly: 2.154 ± 0.046
0.705HisHis: 0.705 ± 0.03
0.545HisIle: 0.545 ± 0.024
0.286HisLys: 0.286 ± 0.018
2.817HisLeu: 2.817 ± 0.058
0.304HisMet: 0.304 ± 0.017
0.378HisAsn: 0.378 ± 0.018
1.816HisPro: 1.816 ± 0.043
0.721HisGln: 0.721 ± 0.027
2.345HisArg: 2.345 ± 0.055
0.894HisSer: 0.894 ± 0.029
1.203HisThr: 1.203 ± 0.035
1.721HisVal: 1.721 ± 0.043
0.365HisTrp: 0.365 ± 0.021
0.456HisTyr: 0.456 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.318IleAla: 4.318 ± 0.075
0.3IleCys: 0.3 ± 0.017
2.281IleAsp: 2.281 ± 0.054
2.04IleGlu: 2.04 ± 0.046
0.867IlePhe: 0.867 ± 0.032
3.354IleGly: 3.354 ± 0.057
0.576IleHis: 0.576 ± 0.024
0.94IleIle: 0.94 ± 0.038
0.636IleLys: 0.636 ± 0.025
2.536IleLeu: 2.536 ± 0.059
0.432IleMet: 0.432 ± 0.022
0.734IleAsn: 0.734 ± 0.03
1.599IlePro: 1.599 ± 0.044
0.741IleGln: 0.741 ± 0.03
2.591IleArg: 2.591 ± 0.051
1.602IleSer: 1.602 ± 0.042
2.066IleThr: 2.066 ± 0.045
2.82IleVal: 2.82 ± 0.06
0.385IleTrp: 0.385 ± 0.021
0.611IleTyr: 0.611 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.087LysAla: 2.087 ± 0.053
0.112LysCys: 0.112 ± 0.011
0.789LysAsp: 0.789 ± 0.032
0.819LysGlu: 0.819 ± 0.031
0.407LysPhe: 0.407 ± 0.021
1.317LysGly: 1.317 ± 0.042
0.313LysHis: 0.313 ± 0.017
0.823LysIle: 0.823 ± 0.033
0.507LysLys: 0.507 ± 0.029
1.814LysLeu: 1.814 ± 0.044
0.308LysMet: 0.308 ± 0.015
0.355LysAsn: 0.355 ± 0.02
1.026LysPro: 1.026 ± 0.037
0.603LysGln: 0.603 ± 0.027
1.251LysArg: 1.251 ± 0.038
0.877LysSer: 0.877 ± 0.034
1.001LysThr: 1.001 ± 0.035
1.587LysVal: 1.587 ± 0.046
0.221LysTrp: 0.221 ± 0.014
0.364LysTyr: 0.364 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
16.396LeuAla: 16.396 ± 0.182
0.751LeuCys: 0.751 ± 0.029
7.296LeuAsp: 7.296 ± 0.089
3.95LeuGlu: 3.95 ± 0.06
2.633LeuPhe: 2.633 ± 0.056
9.075LeuGly: 9.075 ± 0.122
2.456LeuHis: 2.456 ± 0.052
3.068LeuIle: 3.068 ± 0.06
1.506LeuLys: 1.506 ± 0.047
11.573LeuLeu: 11.573 ± 0.16
1.424LeuMet: 1.424 ± 0.033
1.654LeuAsn: 1.654 ± 0.044
6.268LeuPro: 6.268 ± 0.082
1.966LeuGln: 1.966 ± 0.046
9.572LeuArg: 9.572 ± 0.103
4.794LeuSer: 4.794 ± 0.07
7.334LeuThr: 7.334 ± 0.079
10.172LeuVal: 10.172 ± 0.125
1.279LeuTrp: 1.279 ± 0.037
1.852LeuTyr: 1.852 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.061MetAla: 2.061 ± 0.042
0.111MetCys: 0.111 ± 0.012
0.742MetAsp: 0.742 ± 0.029
0.612MetGlu: 0.612 ± 0.028
0.469MetPhe: 0.469 ± 0.02
1.16MetGly: 1.16 ± 0.037
0.279MetHis: 0.279 ± 0.015
0.632MetIle: 0.632 ± 0.026
0.317MetLys: 0.317 ± 0.019
1.707MetLeu: 1.707 ± 0.042
0.267MetMet: 0.267 ± 0.015
0.342MetAsn: 0.342 ± 0.017
1.032MetPro: 1.032 ± 0.033
0.469MetGln: 0.469 ± 0.019
1.447MetArg: 1.447 ± 0.039
1.178MetSer: 1.178 ± 0.034
1.56MetThr: 1.56 ± 0.04
1.352MetVal: 1.352 ± 0.041
0.213MetTrp: 0.213 ± 0.014
0.311MetTyr: 0.311 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.068AsnAla: 2.068 ± 0.051
0.183AsnCys: 0.183 ± 0.015
0.973AsnAsp: 0.973 ± 0.033
0.751AsnGlu: 0.751 ± 0.029
0.521AsnPhe: 0.521 ± 0.022
1.83AsnGly: 1.83 ± 0.051
0.391AsnHis: 0.391 ± 0.02
0.595AsnIle: 0.595 ± 0.028
0.388AsnLys: 0.388 ± 0.02
1.944AsnLeu: 1.944 ± 0.05
0.266AsnMet: 0.266 ± 0.016
0.478AsnAsn: 0.478 ± 0.026
1.518AsnPro: 1.518 ± 0.041
0.61AsnGln: 0.61 ± 0.026
1.443AsnArg: 1.443 ± 0.04
0.911AsnSer: 0.911 ± 0.034
1.119AsnThr: 1.119 ± 0.038
1.403AsnVal: 1.403 ± 0.035
0.313AsnTrp: 0.313 ± 0.021
0.437AsnTyr: 0.437 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
9.436ProAla: 9.436 ± 0.118
0.309ProCys: 0.309 ± 0.02
4.697ProAsp: 4.697 ± 0.083
3.798ProGlu: 3.798 ± 0.059
1.412ProPhe: 1.412 ± 0.038
6.407ProGly: 6.407 ± 0.08
1.221ProHis: 1.221 ± 0.035
1.524ProIle: 1.524 ± 0.031
0.918ProLys: 0.918 ± 0.034
5.186ProLeu: 5.186 ± 0.088
0.917ProMet: 0.917 ± 0.033
1.006ProAsn: 1.006 ± 0.032
3.665ProPro: 3.665 ± 0.079
1.636ProGln: 1.636 ± 0.039
3.931ProArg: 3.931 ± 0.066
2.69ProSer: 2.69 ± 0.053
3.945ProThr: 3.945 ± 0.055
5.91ProVal: 5.91 ± 0.076
0.951ProTrp: 0.951 ± 0.029
1.338ProTyr: 1.338 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.945GlnAla: 3.945 ± 0.068
0.164GlnCys: 0.164 ± 0.011
1.148GlnAsp: 1.148 ± 0.032
1.285GlnGlu: 1.285 ± 0.036
0.748GlnPhe: 0.748 ± 0.024
1.984GlnGly: 1.984 ± 0.045
0.684GlnHis: 0.684 ± 0.027
1.093GlnIle: 1.093 ± 0.036
0.426GlnLys: 0.426 ± 0.02
3.091GlnLeu: 3.091 ± 0.068
0.494GlnMet: 0.494 ± 0.022
0.538GlnAsn: 0.538 ± 0.028
1.874GlnPro: 1.874 ± 0.048
1.273GlnGln: 1.273 ± 0.045
2.914GlnArg: 2.914 ± 0.048
1.128GlnSer: 1.128 ± 0.03
1.338GlnThr: 1.338 ± 0.039
3.078GlnVal: 3.078 ± 0.068
0.543GlnTrp: 0.543 ± 0.024
0.585GlnTyr: 0.585 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
10.487ArgAla: 10.487 ± 0.121
0.668ArgCys: 0.668 ± 0.025
4.769ArgAsp: 4.769 ± 0.069
4.43ArgGlu: 4.43 ± 0.086
2.535ArgPhe: 2.535 ± 0.052
5.859ArgGly: 5.859 ± 0.077
2.404ArgHis: 2.404 ± 0.057
3.334ArgIle: 3.334 ± 0.058
1.386ArgLys: 1.386 ± 0.048
9.536ArgLeu: 9.536 ± 0.119
1.894ArgMet: 1.894 ± 0.041
1.561ArgAsn: 1.561 ± 0.04
5.451ArgPro: 5.451 ± 0.08
2.806ArgGln: 2.806 ± 0.054
8.97ArgArg: 8.97 ± 0.141
4.201ArgSer: 4.201 ± 0.07
5.204ArgThr: 5.204 ± 0.088
6.744ArgVal: 6.744 ± 0.079
1.724ArgTrp: 1.724 ± 0.041
2.239ArgTyr: 2.239 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.816SerAla: 5.816 ± 0.082
0.381SerCys: 0.381 ± 0.02
2.281SerAsp: 2.281 ± 0.05
1.92SerGlu: 1.92 ± 0.05
1.441SerPhe: 1.441 ± 0.037
5.29SerGly: 5.29 ± 0.076
0.918SerHis: 0.918 ± 0.028
1.497SerIle: 1.497 ± 0.043
0.807SerLys: 0.807 ± 0.029
4.186SerLeu: 4.186 ± 0.068
0.923SerMet: 0.923 ± 0.029
0.835SerAsn: 0.835 ± 0.027
2.871SerPro: 2.871 ± 0.056
1.158SerGln: 1.158 ± 0.034
3.701SerArg: 3.701 ± 0.068
2.33SerSer: 2.33 ± 0.068
3.186SerThr: 3.186 ± 0.057
3.99SerVal: 3.99 ± 0.058
0.844SerTrp: 0.844 ± 0.03
1.165SerTyr: 1.165 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
8.733ThrAla: 8.733 ± 0.106
0.454ThrCys: 0.454 ± 0.023
3.751ThrAsp: 3.751 ± 0.058
3.113ThrGlu: 3.113 ± 0.045
1.707ThrPhe: 1.707 ± 0.041
7.116ThrGly: 7.116 ± 0.08
1.097ThrHis: 1.097 ± 0.036
2.06ThrIle: 2.06 ± 0.044
0.903ThrLys: 0.903 ± 0.03
6.054ThrLeu: 6.054 ± 0.073
1.051ThrMet: 1.051 ± 0.032
1.175ThrAsn: 1.175 ± 0.039
4.066ThrPro: 4.066 ± 0.064
1.383ThrGln: 1.383 ± 0.041
4.404ThrArg: 4.404 ± 0.063
2.966ThrSer: 2.966 ± 0.065
3.945ThrThr: 3.945 ± 0.074
6.794ThrVal: 6.794 ± 0.083
1.047ThrTrp: 1.047 ± 0.039
1.366ThrTyr: 1.366 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
12.679ValAla: 12.679 ± 0.138
0.704ValCys: 0.704 ± 0.028
6.289ValAsp: 6.289 ± 0.081
5.077ValGlu: 5.077 ± 0.089
2.4ValPhe: 2.4 ± 0.05
7.599ValGly: 7.599 ± 0.096
1.948ValHis: 1.948 ± 0.047
2.78ValIle: 2.78 ± 0.06
1.411ValLys: 1.411 ± 0.044
9.883ValLeu: 9.883 ± 0.139
1.209ValMet: 1.209 ± 0.034
1.745ValAsn: 1.745 ± 0.045
5.51ValPro: 5.51 ± 0.073
2.175ValGln: 2.175 ± 0.051
7.563ValArg: 7.563 ± 0.088
4.242ValSer: 4.242 ± 0.066
6.706ValThr: 6.706 ± 0.077
9.362ValVal: 9.362 ± 0.124
1.16ValTrp: 1.16 ± 0.036
1.63ValTyr: 1.63 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.712TrpAla: 1.712 ± 0.041
0.157TrpCys: 0.157 ± 0.014
0.789TrpAsp: 0.789 ± 0.029
0.667TrpGlu: 0.667 ± 0.027
0.476TrpPhe: 0.476 ± 0.022
0.969TrpGly: 0.969 ± 0.035
0.439TrpHis: 0.439 ± 0.021
0.587TrpIle: 0.587 ± 0.025
0.296TrpLys: 0.296 ± 0.019
2.004TrpLeu: 2.004 ± 0.054
0.279TrpMet: 0.279 ± 0.016
0.407TrpAsn: 0.407 ± 0.025
0.915TrpPro: 0.915 ± 0.031
0.654TrpGln: 0.654 ± 0.026
1.738TrpArg: 1.738 ± 0.041
1.038TrpSer: 1.038 ± 0.04
1.033TrpThr: 1.033 ± 0.039
1.063TrpVal: 1.063 ± 0.033
0.392TrpTrp: 0.392 ± 0.021
0.419TrpTyr: 0.419 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.047
0.176TyrCys: 0.176 ± 0.014
1.52TyrAsp: 1.52 ± 0.035
1.107TyrGlu: 1.107 ± 0.036
0.604TyrPhe: 0.604 ± 0.028
2.146TyrGly: 2.146 ± 0.045
0.535TyrHis: 0.535 ± 0.021
0.435TyrIle: 0.435 ± 0.022
0.29TyrLys: 0.29 ± 0.017
2.507TyrLeu: 2.507 ± 0.044
0.216TyrMet: 0.216 ± 0.014
0.42TyrAsn: 0.42 ± 0.02
1.312TyrPro: 1.312 ± 0.043
0.741TyrGln: 0.741 ± 0.029
2.199TyrArg: 2.199 ± 0.046
0.905TyrSer: 0.905 ± 0.034
1.244TyrThr: 1.244 ± 0.037
1.916TyrVal: 1.916 ± 0.045
0.371TyrTrp: 0.371 ± 0.025
0.452TyrTyr: 0.452 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3712 proteins (1024851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski