Amino acid dipepetide frequency for Candidatus Tachikawaea gelatinosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.818AlaAla: 2.818 ± 0.174
0.662AlaCys: 0.662 ± 0.058
1.834AlaAsp: 1.834 ± 0.094
2.374AlaGlu: 2.374 ± 0.121
2.002AlaPhe: 2.002 ± 0.117
2.986AlaGly: 2.986 ± 0.153
1.034AlaHis: 1.034 ± 0.073
5.946AlaIle: 5.946 ± 0.197
4.443AlaLys: 4.443 ± 0.155
4.718AlaLeu: 4.718 ± 0.169
1.172AlaMet: 1.172 ± 0.077
2.39AlaAsn: 2.39 ± 0.115
1.07AlaPro: 1.07 ± 0.08
1.391AlaGln: 1.391 ± 0.082
1.982AlaArg: 1.982 ± 0.103
2.731AlaSer: 2.731 ± 0.112
2.283AlaThr: 2.283 ± 0.123
2.277AlaVal: 2.277 ± 0.127
0.423AlaTrp: 0.423 ± 0.043
1.595AlaTyr: 1.595 ± 0.091
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.056
0.173CysCys: 0.173 ± 0.035
0.55CysAsp: 0.55 ± 0.042
0.555CysGlu: 0.555 ± 0.052
0.769CysPhe: 0.769 ± 0.057
0.866CysGly: 0.866 ± 0.061
0.29CysHis: 0.29 ± 0.043
1.34CysIle: 1.34 ± 0.074
1.004CysLys: 1.004 ± 0.074
1.197CysLeu: 1.197 ± 0.073
0.214CysMet: 0.214 ± 0.029
0.759CysAsn: 0.759 ± 0.055
0.428CysPro: 0.428 ± 0.049
0.448CysGln: 0.448 ± 0.045
0.469CysArg: 0.469 ± 0.044
0.953CysSer: 0.953 ± 0.067
0.515CysThr: 0.515 ± 0.054
0.616CysVal: 0.616 ± 0.05
0.143CysTrp: 0.143 ± 0.029
0.525CysTyr: 0.525 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
1.916AspAla: 1.916 ± 0.103
0.571AspCys: 0.571 ± 0.052
1.564AspAsp: 1.564 ± 0.096
2.063AspGlu: 2.063 ± 0.108
2.639AspPhe: 2.639 ± 0.105
2.028AspGly: 2.028 ± 0.113
0.836AspHis: 0.836 ± 0.067
5.808AspIle: 5.808 ± 0.172
3.388AspLys: 3.388 ± 0.135
4.708AspLeu: 4.708 ± 0.158
0.866AspMet: 0.866 ± 0.086
2.4AspAsn: 2.4 ± 0.099
1.238AspPro: 1.238 ± 0.083
1.549AspGln: 1.549 ± 0.088
1.498AspArg: 1.498 ± 0.09
2.298AspSer: 2.298 ± 0.11
1.804AspThr: 1.804 ± 0.091
2.517AspVal: 2.517 ± 0.12
0.362AspTrp: 0.362 ± 0.041
1.885AspTyr: 1.885 ± 0.11
0.0AspXaa: 0.0 ± 0.0
Glu
2.283GluAla: 2.283 ± 0.116
0.535GluCys: 0.535 ± 0.057
2.018GluAsp: 2.018 ± 0.115
3.235GluGlu: 3.235 ± 0.146
1.717GluPhe: 1.717 ± 0.095
2.155GluGly: 2.155 ± 0.113
0.978GluHis: 0.978 ± 0.07
6.583GluIle: 6.583 ± 0.215
7.755GluLys: 7.755 ± 0.225
4.616GluLeu: 4.616 ± 0.163
1.223GluMet: 1.223 ± 0.072
3.775GluAsn: 3.775 ± 0.158
1.126GluPro: 1.126 ± 0.075
1.539GluGln: 1.539 ± 0.092
1.926GluArg: 1.926 ± 0.128
3.093GluSer: 3.093 ± 0.14
2.308GluThr: 2.308 ± 0.103
2.425GluVal: 2.425 ± 0.13
0.433GluTrp: 0.433 ± 0.05
1.702GluTyr: 1.702 ± 0.106
0.0GluXaa: 0.0 ± 0.0
Phe
1.676PheAla: 1.676 ± 0.101
0.983PheCys: 0.983 ± 0.076
2.405PheAsp: 2.405 ± 0.097
2.308PheGlu: 2.308 ± 0.111
4.422PhePhe: 4.422 ± 0.21
2.945PheGly: 2.945 ± 0.127
1.223PheHis: 1.223 ± 0.089
5.554PheIle: 5.554 ± 0.192
4.015PheLys: 4.015 ± 0.158
6.506PheLeu: 6.506 ± 0.226
1.111PheMet: 1.111 ± 0.084
3.398PheAsn: 3.398 ± 0.144
1.692PhePro: 1.692 ± 0.095
1.559PheGln: 1.559 ± 0.095
1.498PheArg: 1.498 ± 0.093
4.693PheSer: 4.693 ± 0.168
1.911PheThr: 1.911 ± 0.099
2.16PheVal: 2.16 ± 0.104
0.657PheTrp: 0.657 ± 0.067
2.502PheTyr: 2.502 ± 0.121
0.0PheXaa: 0.0 ± 0.0
Gly
2.899GlyAla: 2.899 ± 0.148
0.856GlyCys: 0.856 ± 0.067
2.293GlyAsp: 2.293 ± 0.119
2.583GlyGlu: 2.583 ± 0.132
2.721GlyPhe: 2.721 ± 0.12
3.653GlyGly: 3.653 ± 0.17
1.284GlyHis: 1.284 ± 0.094
6.894GlyIle: 6.894 ± 0.219
5.166GlyLys: 5.166 ± 0.152
5.044GlyLeu: 5.044 ± 0.171
1.355GlyMet: 1.355 ± 0.093
2.899GlyAsn: 2.899 ± 0.139
1.345GlyPro: 1.345 ± 0.079
1.534GlyGln: 1.534 ± 0.081
2.216GlyArg: 2.216 ± 0.115
3.353GlySer: 3.353 ± 0.157
2.853GlyThr: 2.853 ± 0.116
2.807GlyVal: 2.807 ± 0.115
0.53GlyTrp: 0.53 ± 0.059
2.15GlyTyr: 2.15 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
1.07HisAla: 1.07 ± 0.073
0.306HisCys: 0.306 ± 0.043
0.769HisAsp: 0.769 ± 0.064
0.881HisGlu: 0.881 ± 0.073
1.075HisPhe: 1.075 ± 0.071
1.32HisGly: 1.32 ± 0.09
0.484HisHis: 0.484 ± 0.054
2.435HisIle: 2.435 ± 0.111
1.641HisLys: 1.641 ± 0.104
2.079HisLeu: 2.079 ± 0.116
0.464HisMet: 0.464 ± 0.051
1.33HisAsn: 1.33 ± 0.076
1.009HisPro: 1.009 ± 0.078
0.8HisGln: 0.8 ± 0.068
0.968HisArg: 0.968 ± 0.068
1.192HisSer: 1.192 ± 0.082
0.902HisThr: 0.902 ± 0.07
1.131HisVal: 1.131 ± 0.082
0.189HisTrp: 0.189 ± 0.033
0.729HisTyr: 0.729 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
6.348IleAla: 6.348 ± 0.186
1.615IleCys: 1.615 ± 0.082
5.859IleAsp: 5.859 ± 0.171
6.058IleGlu: 6.058 ± 0.19
6.425IlePhe: 6.425 ± 0.255
7.133IleGly: 7.133 ± 0.25
2.221IleHis: 2.221 ± 0.119
12.773IleIle: 12.773 ± 0.336
12.004IleLys: 12.004 ± 0.278
11.056IleLeu: 11.056 ± 0.294
2.267IleMet: 2.267 ± 0.109
9.945IleAsn: 9.945 ± 0.265
3.786IlePro: 3.786 ± 0.146
3.607IleGln: 3.607 ± 0.138
4.045IleArg: 4.045 ± 0.131
8.259IleSer: 8.259 ± 0.177
5.477IleThr: 5.477 ± 0.164
5.655IleVal: 5.655 ± 0.175
0.912IleTrp: 0.912 ± 0.091
4.27IleTyr: 4.27 ± 0.172
0.0IleXaa: 0.0 ± 0.0
Lys
3.098LysAla: 3.098 ± 0.134
0.693LysCys: 0.693 ± 0.057
3.913LysAsp: 3.913 ± 0.145
6.145LysGlu: 6.145 ± 0.193
4.147LysPhe: 4.147 ± 0.181
3.765LysGly: 3.765 ± 0.165
1.595LysHis: 1.595 ± 0.102
14.113LysIle: 14.113 ± 0.346
18.811LysLys: 18.811 ± 0.494
7.78LysLeu: 7.78 ± 0.215
2.272LysMet: 2.272 ± 0.106
12.529LysAsn: 12.529 ± 0.331
2.16LysPro: 2.16 ± 0.095
2.568LysGln: 2.568 ± 0.115
3.47LysArg: 3.47 ± 0.126
5.559LysSer: 5.559 ± 0.197
4.642LysThr: 4.642 ± 0.151
3.888LysVal: 3.888 ± 0.154
0.881LysTrp: 0.881 ± 0.067
3.709LysTyr: 3.709 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
4.611LeuAla: 4.611 ± 0.172
1.034LeuCys: 1.034 ± 0.071
3.913LeuAsp: 3.913 ± 0.159
5.258LeuGlu: 5.258 ± 0.181
4.626LeuPhe: 4.626 ± 0.175
5.217LeuGly: 5.217 ± 0.163
2.155LeuHis: 2.155 ± 0.096
10.684LeuIle: 10.684 ± 0.263
10.71LeuLys: 10.71 ± 0.284
9.492LeuLeu: 9.492 ± 0.277
2.14LeuMet: 2.14 ± 0.122
6.766LeuAsn: 6.766 ± 0.166
3.556LeuPro: 3.556 ± 0.154
3.21LeuGln: 3.21 ± 0.128
3.826LeuArg: 3.826 ± 0.141
7.281LeuSer: 7.281 ± 0.204
4.55LeuThr: 4.55 ± 0.157
4.127LeuVal: 4.127 ± 0.142
0.79LeuTrp: 0.79 ± 0.068
3.424LeuTyr: 3.424 ± 0.122
0.0LeuXaa: 0.0 ± 0.0
Met
1.019MetAla: 1.019 ± 0.068
0.27MetCys: 0.27 ± 0.034
0.8MetAsp: 0.8 ± 0.052
0.958MetGlu: 0.958 ± 0.061
1.024MetPhe: 1.024 ± 0.068
1.264MetGly: 1.264 ± 0.091
0.499MetHis: 0.499 ± 0.054
2.4MetIle: 2.4 ± 0.11
2.023MetLys: 2.023 ± 0.099
2.339MetLeu: 2.339 ± 0.098
0.474MetMet: 0.474 ± 0.054
1.753MetAsn: 1.753 ± 0.089
0.759MetPro: 0.759 ± 0.066
0.871MetGln: 0.871 ± 0.064
0.958MetArg: 0.958 ± 0.066
1.518MetSer: 1.518 ± 0.09
1.004MetThr: 1.004 ± 0.074
0.917MetVal: 0.917 ± 0.067
0.112MetTrp: 0.112 ± 0.025
0.647MetTyr: 0.647 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
2.792AsnAla: 2.792 ± 0.13
0.876AsnCys: 0.876 ± 0.073
2.914AsnAsp: 2.914 ± 0.101
3.403AsnGlu: 3.403 ± 0.116
5.177AsnPhe: 5.177 ± 0.188
3.149AsnGly: 3.149 ± 0.132
1.513AsnHis: 1.513 ± 0.093
9.859AsnIle: 9.859 ± 0.27
7.464AsnLys: 7.464 ± 0.231
6.624AsnLeu: 6.624 ± 0.183
1.406AsnMet: 1.406 ± 0.079
6.471AsnAsn: 6.471 ± 0.186
2.069AsnPro: 2.069 ± 0.105
2.792AsnGln: 2.792 ± 0.117
2.451AsnArg: 2.451 ± 0.122
4.142AsnSer: 4.142 ± 0.134
3.195AsnThr: 3.195 ± 0.147
3.403AsnVal: 3.403 ± 0.138
0.81AsnTrp: 0.81 ± 0.064
2.945AsnTyr: 2.945 ± 0.132
0.0AsnXaa: 0.0 ± 0.0
Pro
1.172ProAla: 1.172 ± 0.077
0.387ProCys: 0.387 ± 0.04
1.248ProAsp: 1.248 ± 0.082
1.692ProGlu: 1.692 ± 0.087
1.712ProPhe: 1.712 ± 0.092
1.783ProGly: 1.783 ± 0.114
0.739ProHis: 0.739 ± 0.066
3.77ProIle: 3.77 ± 0.14
2.568ProLys: 2.568 ± 0.105
2.935ProLeu: 2.935 ± 0.123
0.586ProMet: 0.586 ± 0.052
1.834ProAsn: 1.834 ± 0.102
0.718ProPro: 0.718 ± 0.063
0.876ProGln: 0.876 ± 0.07
0.83ProArg: 0.83 ± 0.068
1.997ProSer: 1.997 ± 0.105
1.518ProThr: 1.518 ± 0.094
1.758ProVal: 1.758 ± 0.108
0.326ProTrp: 0.326 ± 0.049
1.386ProTyr: 1.386 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
1.62GlnAla: 1.62 ± 0.09
0.275GlnCys: 0.275 ± 0.038
1.299GlnAsp: 1.299 ± 0.081
2.007GlnGlu: 2.007 ± 0.108
1.299GlnPhe: 1.299 ± 0.092
1.59GlnGly: 1.59 ± 0.093
0.601GlnHis: 0.601 ± 0.057
3.521GlnIle: 3.521 ± 0.13
3.994GlnLys: 3.994 ± 0.141
3.312GlnLeu: 3.312 ± 0.133
0.698GlnMet: 0.698 ± 0.053
2.023GlnAsn: 2.023 ± 0.089
0.963GlnPro: 0.963 ± 0.071
1.029GlnGln: 1.029 ± 0.065
1.106GlnArg: 1.106 ± 0.084
1.946GlnSer: 1.946 ± 0.097
1.299GlnThr: 1.299 ± 0.079
1.401GlnVal: 1.401 ± 0.081
0.362GlnTrp: 0.362 ± 0.041
1.391GlnTyr: 1.391 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
1.799ArgAla: 1.799 ± 0.099
0.464ArgCys: 0.464 ± 0.048
1.59ArgAsp: 1.59 ± 0.1
2.048ArgGlu: 2.048 ± 0.101
2.023ArgPhe: 2.023 ± 0.092
1.855ArgGly: 1.855 ± 0.097
0.744ArgHis: 0.744 ± 0.068
4.183ArgIle: 4.183 ± 0.141
3.327ArgLys: 3.327 ± 0.134
3.526ArgLeu: 3.526 ± 0.147
0.856ArgMet: 0.856 ± 0.07
2.232ArgAsn: 2.232 ± 0.106
1.146ArgPro: 1.146 ± 0.072
1.289ArgGln: 1.289 ± 0.088
1.605ArgArg: 1.605 ± 0.093
2.186ArgSer: 2.186 ± 0.108
1.488ArgThr: 1.488 ± 0.076
1.793ArgVal: 1.793 ± 0.12
0.336ArgTrp: 0.336 ± 0.042
1.676ArgTyr: 1.676 ± 0.095
0.0ArgXaa: 0.0 ± 0.0
Ser
3.363SerAla: 3.363 ± 0.135
0.82SerCys: 0.82 ± 0.072
2.711SerAsp: 2.711 ± 0.111
2.894SerGlu: 2.894 ± 0.14
3.888SerPhe: 3.888 ± 0.155
4.03SerGly: 4.03 ± 0.137
1.325SerHis: 1.325 ± 0.083
7.928SerIle: 7.928 ± 0.196
5.477SerLys: 5.477 ± 0.195
6.863SerLeu: 6.863 ± 0.212
1.636SerMet: 1.636 ± 0.098
3.933SerAsn: 3.933 ± 0.133
1.758SerPro: 1.758 ± 0.108
1.814SerGln: 1.814 ± 0.07
2.288SerArg: 2.288 ± 0.107
4.463SerSer: 4.463 ± 0.159
3.021SerThr: 3.021 ± 0.133
3.23SerVal: 3.23 ± 0.125
0.566SerTrp: 0.566 ± 0.059
2.532SerTyr: 2.532 ± 0.106
0.0SerXaa: 0.0 ± 0.0
Thr
2.491ThrAla: 2.491 ± 0.123
0.586ThrCys: 0.586 ± 0.051
1.972ThrAsp: 1.972 ± 0.093
2.145ThrGlu: 2.145 ± 0.104
2.344ThrPhe: 2.344 ± 0.114
3.144ThrGly: 3.144 ± 0.14
0.917ThrHis: 0.917 ± 0.075
5.35ThrIle: 5.35 ± 0.174
3.801ThrLys: 3.801 ± 0.133
4.85ThrLeu: 4.85 ± 0.161
0.836ThrMet: 0.836 ± 0.067
2.762ThrAsn: 2.762 ± 0.126
1.554ThrPro: 1.554 ± 0.095
1.396ThrGln: 1.396 ± 0.083
1.508ThrArg: 1.508 ± 0.098
2.767ThrSer: 2.767 ± 0.123
2.227ThrThr: 2.227 ± 0.115
2.461ThrVal: 2.461 ± 0.106
0.413ThrTrp: 0.413 ± 0.047
1.559ThrTyr: 1.559 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
2.395ValAla: 2.395 ± 0.13
0.616ValCys: 0.616 ± 0.057
2.155ValAsp: 2.155 ± 0.111
2.466ValGlu: 2.466 ± 0.133
2.502ValPhe: 2.502 ± 0.102
2.925ValGly: 2.925 ± 0.131
1.08ValHis: 1.08 ± 0.065
5.538ValIle: 5.538 ± 0.181
3.801ValLys: 3.801 ± 0.142
4.845ValLeu: 4.845 ± 0.148
1.065ValMet: 1.065 ± 0.075
2.94ValAsn: 2.94 ± 0.125
1.839ValPro: 1.839 ± 0.084
1.406ValGln: 1.406 ± 0.09
1.712ValArg: 1.712 ± 0.109
3.047ValSer: 3.047 ± 0.132
2.288ValThr: 2.288 ± 0.123
2.7ValVal: 2.7 ± 0.137
0.382ValTrp: 0.382 ± 0.043
1.534ValTyr: 1.534 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.392TrpAla: 0.392 ± 0.039
0.163TrpCys: 0.163 ± 0.033
0.331TrpAsp: 0.331 ± 0.041
0.428TrpGlu: 0.428 ± 0.046
0.489TrpPhe: 0.489 ± 0.055
0.372TrpGly: 0.372 ± 0.042
0.209TrpHis: 0.209 ± 0.033
1.289TrpIle: 1.289 ± 0.102
0.932TrpLys: 0.932 ± 0.064
0.963TrpLeu: 0.963 ± 0.08
0.301TrpMet: 0.301 ± 0.04
0.606TrpAsn: 0.606 ± 0.062
0.26TrpPro: 0.26 ± 0.033
0.357TrpGln: 0.357 ± 0.048
0.362TrpArg: 0.362 ± 0.044
0.474TrpSer: 0.474 ± 0.048
0.372TrpThr: 0.372 ± 0.043
0.357TrpVal: 0.357 ± 0.045
0.061TrpTrp: 0.061 ± 0.017
0.403TrpTyr: 0.403 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.707TyrAla: 1.707 ± 0.084
0.591TyrCys: 0.591 ± 0.05
1.799TyrAsp: 1.799 ± 0.087
1.921TyrGlu: 1.921 ± 0.118
2.216TyrPhe: 2.216 ± 0.113
2.257TyrGly: 2.257 ± 0.121
1.044TyrHis: 1.044 ± 0.071
3.75TyrIle: 3.75 ± 0.138
3.414TyrLys: 3.414 ± 0.168
3.923TyrLeu: 3.923 ± 0.143
0.662TyrMet: 0.662 ± 0.064
2.711TyrAsn: 2.711 ± 0.107
1.36TyrPro: 1.36 ± 0.089
1.702TyrGln: 1.702 ± 0.082
1.447TyrArg: 1.447 ± 0.096
2.588TyrSer: 2.588 ± 0.122
1.427TyrThr: 1.427 ± 0.081
1.61TyrVal: 1.61 ± 0.086
0.433TyrTrp: 0.433 ± 0.046
1.442TyrTyr: 1.442 ± 0.098
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 613 proteins (196271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski