Amino acid dipepetide frequency for Frankia sp. Cc1.17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.834AlaAla: 23.834 ± 0.187	1.093AlaCys: 1.093 ± 0.024	9.087AlaAsp: 9.087 ± 0.079	7.977AlaGlu: 7.977 ± 0.082	3.542AlaPhe: 3.542 ± 0.04	15.961AlaGly: 15.961 ± 0.113	2.624AlaHis: 2.624 ± 0.041	3.802AlaIle: 3.802 ± 0.048	1.631AlaLys: 1.631 ± 0.033	13.946AlaLeu: 13.946 ± 0.114	2.397AlaMet: 2.397 ± 0.032	1.893AlaAsn: 1.893 ± 0.031	7.768AlaPro: 7.768 ± 0.087	3.526AlaGln: 3.526 ± 0.04	11.57AlaArg: 11.57 ± 0.093	6.568AlaSer: 6.568 ± 0.062	7.835AlaThr: 7.835 ± 0.061	12.741AlaVal: 12.741 ± 0.093	1.771AlaTrp: 1.771 ± 0.032	2.286AlaTyr: 2.286 ± 0.036	0.112AlaXaa: 0.112 ± 0.009
Cys	1.009CysAla: 1.009 ± 0.022	0.09CysCys: 0.09 ± 0.007	0.465CysAsp: 0.465 ± 0.015	0.373CysGlu: 0.373 ± 0.012	0.215CysPhe: 0.215 ± 0.01	0.886CysGly: 0.886 ± 0.023	0.186CysHis: 0.186 ± 0.008	0.176CysIle: 0.176 ± 0.01	0.07CysLys: 0.07 ± 0.006	0.781CysLeu: 0.781 ± 0.019	0.109CysMet: 0.109 ± 0.007	0.117CysAsn: 0.117 ± 0.007	0.489CysPro: 0.489 ± 0.018	0.188CysGln: 0.188 ± 0.009	0.605CysArg: 0.605 ± 0.015	0.45CysSer: 0.45 ± 0.015	0.404CysThr: 0.404 ± 0.015	0.626CysVal: 0.626 ± 0.018	0.135CysTrp: 0.135 ± 0.009	0.155CysTyr: 0.155 ± 0.01	0.004CysXaa: 0.004 ± 0.001
Asp	7.62AspAla: 7.62 ± 0.076	0.394AspCys: 0.394 ± 0.013	3.926AspAsp: 3.926 ± 0.051	3.76AspGlu: 3.76 ± 0.046	1.441AspPhe: 1.441 ± 0.027	6.648AspGly: 6.648 ± 0.065	1.48AspHis: 1.48 ± 0.027	2.08AspIle: 2.08 ± 0.031	0.65AspLys: 0.65 ± 0.022	7.102AspLeu: 7.102 ± 0.064	0.736AspMet: 0.736 ± 0.02	0.891AspAsn: 0.891 ± 0.022	4.991AspPro: 4.991 ± 0.056	1.764AspGln: 1.764 ± 0.026	5.193AspArg: 5.193 ± 0.052	2.497AspSer: 2.497 ± 0.039	2.979AspThr: 2.979 ± 0.041	5.296AspVal: 5.296 ± 0.054	0.885AspTrp: 0.885 ± 0.021	1.128AspTyr: 1.128 ± 0.024	0.048AspXaa: 0.048 ± 0.005
Glu	6.589GluAla: 6.589 ± 0.064	0.32GluCys: 0.32 ± 0.012	2.269GluAsp: 2.269 ± 0.036	2.579GluGlu: 2.579 ± 0.045	1.385GluPhe: 1.385 ± 0.026	3.348GluGly: 3.348 ± 0.036	1.431GluHis: 1.431 ± 0.023	2.545GluIle: 2.545 ± 0.036	1.016GluLys: 1.016 ± 0.026	6.199GluLeu: 6.199 ± 0.066	0.789GluMet: 0.789 ± 0.021	0.962GluAsn: 0.962 ± 0.023	3.396GluPro: 3.396 ± 0.042	2.042GluGln: 2.042 ± 0.032	5.061GluArg: 5.061 ± 0.056	2.286GluSer: 2.286 ± 0.036	2.751GluThr: 2.751 ± 0.036	4.392GluVal: 4.392 ± 0.049	0.677GluTrp: 0.677 ± 0.018	0.914GluTyr: 0.914 ± 0.024	0.045GluXaa: 0.045 ± 0.005
Phe	3.629PheAla: 3.629 ± 0.047	0.265PheCys: 0.265 ± 0.011	2.078PheAsp: 2.078 ± 0.034	1.36PheGlu: 1.36 ± 0.025	0.791PhePhe: 0.791 ± 0.022	3.092PheGly: 3.092 ± 0.044	0.593PheHis: 0.593 ± 0.018	0.686PheIle: 0.686 ± 0.019	0.266PheLys: 0.266 ± 0.012	2.487PheLeu: 2.487 ± 0.032	0.331PheMet: 0.331 ± 0.013	0.46PheAsn: 0.46 ± 0.015	1.443PhePro: 1.443 ± 0.025	0.635PheGln: 0.635 ± 0.016	1.839PheArg: 1.839 ± 0.029	1.376PheSer: 1.376 ± 0.03	1.901PheThr: 1.901 ± 0.034	2.403PheVal: 2.403 ± 0.035	0.39PheTrp: 0.39 ± 0.014	0.551PheTyr: 0.551 ± 0.019	0.024PheXaa: 0.024 ± 0.003
Gly	12.044GlyAla: 12.044 ± 0.097	0.764GlyCys: 0.764 ± 0.023	5.292GlyAsp: 5.292 ± 0.051	4.733GlyGlu: 4.733 ± 0.045	2.785GlyPhe: 2.785 ± 0.042	10.033GlyGly: 10.033 ± 0.114	2.261GlyHis: 2.261 ± 0.038	3.427GlyIle: 3.427 ± 0.044	1.459GlyLys: 1.459 ± 0.03	9.742GlyLeu: 9.742 ± 0.077	1.832GlyMet: 1.832 ± 0.029	1.517GlyAsn: 1.517 ± 0.032	6.458GlyPro: 6.458 ± 0.072	3.057GlyGln: 3.057 ± 0.039	8.778GlyArg: 8.778 ± 0.069	5.885GlySer: 5.885 ± 0.061	6.354GlyThr: 6.354 ± 0.074	7.792GlyVal: 7.792 ± 0.072	1.817GlyTrp: 1.817 ± 0.035	2.19GlyTyr: 2.19 ± 0.038	0.074GlyXaa: 0.074 ± 0.006
His	2.563HisAla: 2.563 ± 0.032	0.171HisCys: 0.171 ± 0.01	1.331HisAsp: 1.331 ± 0.024	1.033HisGlu: 1.033 ± 0.022	0.54HisPhe: 0.54 ± 0.018	2.34HisGly: 2.34 ± 0.037	0.696HisHis: 0.696 ± 0.018	0.614HisIle: 0.614 ± 0.017	0.188HisLys: 0.188 ± 0.01	2.426HisLeu: 2.426 ± 0.039	0.262HisMet: 0.262 ± 0.011	0.33HisAsn: 0.33 ± 0.013	1.889HisPro: 1.889 ± 0.032	0.637HisGln: 0.637 ± 0.018	2.132HisArg: 2.132 ± 0.031	0.991HisSer: 0.991 ± 0.025	1.246HisThr: 1.246 ± 0.023	1.633HisVal: 1.633 ± 0.032	0.304HisTrp: 0.304 ± 0.011	0.41HisTyr: 0.41 ± 0.012	0.012HisXaa: 0.012 ± 0.002
Ile	4.917IleAla: 4.917 ± 0.053	0.309IleCys: 0.309 ± 0.013	2.499IleAsp: 2.499 ± 0.033	2.016IleGlu: 2.016 ± 0.035	0.753IlePhe: 0.753 ± 0.02	3.549IleGly: 3.549 ± 0.043	0.651IleHis: 0.651 ± 0.017	1.068IleIle: 1.068 ± 0.026	0.454IleLys: 0.454 ± 0.016	2.741IleLeu: 2.741 ± 0.036	0.499IleMet: 0.499 ± 0.017	0.66IleAsn: 0.66 ± 0.019	1.909IlePro: 1.909 ± 0.035	0.732IleGln: 0.732 ± 0.021	2.667IleArg: 2.667 ± 0.036	1.899IleSer: 1.899 ± 0.035	2.246IleThr: 2.246 ± 0.036	3.033IleVal: 3.033 ± 0.045	0.362IleTrp: 0.362 ± 0.013	0.583IleTyr: 0.583 ± 0.017	0.025IleXaa: 0.025 ± 0.004
Lys	1.702LysAla: 1.702 ± 0.037	0.069LysCys: 0.069 ± 0.006	0.678LysAsp: 0.678 ± 0.022	0.665LysGlu: 0.665 ± 0.024	0.299LysPhe: 0.299 ± 0.012	0.984LysGly: 0.984 ± 0.023	0.273LysHis: 0.273 ± 0.011	0.718LysIle: 0.718 ± 0.023	0.349LysLys: 0.349 ± 0.016	1.228LysLeu: 1.228 ± 0.027	0.235LysMet: 0.235 ± 0.011	0.288LysAsn: 0.288 ± 0.012	0.788LysPro: 0.788 ± 0.022	0.347LysGln: 0.347 ± 0.014	0.907LysArg: 0.907 ± 0.022	0.658LysSer: 0.658 ± 0.018	0.755LysThr: 0.755 ± 0.02	1.291LysVal: 1.291 ± 0.026	0.135LysTrp: 0.135 ± 0.008	0.246LysTyr: 0.246 ± 0.012	0.012LysXaa: 0.012 ± 0.002
Leu	16.477LeuAla: 16.477 ± 0.116	0.779LeuCys: 0.779 ± 0.02	6.943LeuAsp: 6.943 ± 0.065	4.343LeuGlu: 4.343 ± 0.053	2.59LeuPhe: 2.59 ± 0.037	9.271LeuGly: 9.271 ± 0.072	2.115LeuHis: 2.115 ± 0.034	3.19LeuIle: 3.19 ± 0.04	1.068LeuLys: 1.068 ± 0.025	10.887LeuLeu: 10.887 ± 0.084	1.312LeuMet: 1.312 ± 0.028	1.541LeuAsn: 1.541 ± 0.025	6.516LeuPro: 6.516 ± 0.058	1.869LeuGln: 1.869 ± 0.03	9.303LeuArg: 9.303 ± 0.084	5.083LeuSer: 5.083 ± 0.049	6.656LeuThr: 6.656 ± 0.06	9.375LeuVal: 9.375 ± 0.073	1.214LeuTrp: 1.214 ± 0.028	1.572LeuTyr: 1.572 ± 0.031	0.1LeuXaa: 0.1 ± 0.007
Met	2.061MetAla: 2.061 ± 0.031	0.118MetCys: 0.118 ± 0.007	0.768MetAsp: 0.768 ± 0.017	0.592MetGlu: 0.592 ± 0.017	0.48MetPhe: 0.48 ± 0.017	1.104MetGly: 1.104 ± 0.023	0.307MetHis: 0.307 ± 0.013	0.79MetIle: 0.79 ± 0.021	0.276MetLys: 0.276 ± 0.011	1.671MetLeu: 1.671 ± 0.028	0.28MetMet: 0.28 ± 0.012	0.368MetAsn: 0.368 ± 0.013	1.071MetPro: 1.071 ± 0.021	0.363MetGln: 0.363 ± 0.013	1.327MetArg: 1.327 ± 0.025	1.155MetSer: 1.155 ± 0.025	1.467MetThr: 1.467 ± 0.028	1.275MetVal: 1.275 ± 0.022	0.174MetTrp: 0.174 ± 0.011	0.24MetTyr: 0.24 ± 0.01	0.032MetXaa: 0.032 ± 0.004
Asn	2.102AsnAla: 2.102 ± 0.032	0.137AsnCys: 0.137 ± 0.008	0.87AsnAsp: 0.87 ± 0.021	0.716AsnGlu: 0.716 ± 0.017	0.437AsnPhe: 0.437 ± 0.015	1.725AsnGly: 1.725 ± 0.037	0.34AsnHis: 0.34 ± 0.012	0.675AsnIle: 0.675 ± 0.019	0.211AsnLys: 0.211 ± 0.01	1.666AsnLeu: 1.666 ± 0.033	0.243AsnMet: 0.243 ± 0.011	0.359AsnAsn: 0.359 ± 0.014	1.332AsnPro: 1.332 ± 0.023	0.454AsnGln: 0.454 ± 0.013	1.299AsnArg: 1.299 ± 0.028	0.798AsnSer: 0.798 ± 0.021	0.975AsnThr: 0.975 ± 0.024	1.282AsnVal: 1.282 ± 0.026	0.251AsnTrp: 0.251 ± 0.011	0.342AsnTyr: 0.342 ± 0.013	0.012AsnXaa: 0.012 ± 0.002
Pro	10.809ProAla: 10.809 ± 0.11	0.324ProCys: 0.324 ± 0.013	4.946ProAsp: 4.946 ± 0.056	3.675ProGlu: 3.675 ± 0.045	1.615ProPhe: 1.615 ± 0.027	7.749ProGly: 7.749 ± 0.082	1.278ProHis: 1.278 ± 0.027	1.53ProIle: 1.53 ± 0.028	0.776ProLys: 0.776 ± 0.022	5.308ProLeu: 5.308 ± 0.049	0.958ProMet: 0.958 ± 0.02	0.914ProAsn: 0.914 ± 0.021	4.9ProPro: 4.9 ± 0.089	1.478ProGln: 1.478 ± 0.028	4.512ProArg: 4.512 ± 0.054	3.562ProSer: 3.562 ± 0.05	4.012ProThr: 4.012 ± 0.053	5.725ProVal: 5.725 ± 0.057	0.87ProTrp: 0.87 ± 0.022	1.096ProTyr: 1.096 ± 0.024	0.048ProXaa: 0.048 ± 0.005
Gln	3.838GlnAla: 3.838 ± 0.044	0.168GlnCys: 0.168 ± 0.008	1.177GlnAsp: 1.177 ± 0.022	1.191GlnGlu: 1.191 ± 0.026	0.673GlnPhe: 0.673 ± 0.02	1.892GlnGly: 1.892 ± 0.033	0.573GlnHis: 0.573 ± 0.019	1.208GlnIle: 1.208 ± 0.023	0.358GlnLys: 0.358 ± 0.014	2.889GlnLeu: 2.889 ± 0.042	0.452GlnMet: 0.452 ± 0.014	0.463GlnAsn: 0.463 ± 0.016	1.86GlnPro: 1.86 ± 0.039	0.965GlnGln: 0.965 ± 0.028	2.352GlnArg: 2.352 ± 0.037	1.122GlnSer: 1.122 ± 0.025	1.431GlnThr: 1.431 ± 0.028	2.556GlnVal: 2.556 ± 0.038	0.386GlnTrp: 0.386 ± 0.012	0.476GlnTyr: 0.476 ± 0.016	0.024GlnXaa: 0.024 ± 0.003
Arg	10.966ArgAla: 10.966 ± 0.086	0.631ArgCys: 0.631 ± 0.018	4.763ArgAsp: 4.763 ± 0.051	4.33ArgGlu: 4.33 ± 0.052	2.484ArgPhe: 2.484 ± 0.031	6.558ArgGly: 6.558 ± 0.064	2.177ArgHis: 2.177 ± 0.032	3.221ArgIle: 3.221 ± 0.04	0.982ArgLys: 0.982 ± 0.022	9.4ArgLeu: 9.4 ± 0.08	1.709ArgMet: 1.709 ± 0.025	1.358ArgAsn: 1.358 ± 0.027	5.93ArgPro: 5.93 ± 0.067	2.489ArgGln: 2.489 ± 0.039	9.035ArgArg: 9.035 ± 0.08	4.576ArgSer: 4.576 ± 0.048	4.998ArgThr: 4.998 ± 0.05	6.387ArgVal: 6.387 ± 0.053	1.468ArgTrp: 1.468 ± 0.029	1.842ArgTyr: 1.842 ± 0.029	0.062ArgXaa: 0.062 ± 0.005
Ser	7.086SerAla: 7.086 ± 0.059	0.4SerCys: 0.4 ± 0.014	2.923SerAsp: 2.923 ± 0.036	2.296SerGlu: 2.296 ± 0.033	1.54SerPhe: 1.54 ± 0.028	6.186SerGly: 6.186 ± 0.066	0.969SerHis: 0.969 ± 0.021	1.602SerIle: 1.602 ± 0.036	0.657SerLys: 0.657 ± 0.02	4.704SerLeu: 4.704 ± 0.053	1.037SerMet: 1.037 ± 0.024	0.768SerAsn: 0.768 ± 0.02	3.676SerPro: 3.676 ± 0.05	1.255SerGln: 1.255 ± 0.024	4.168SerArg: 4.168 ± 0.04	3.138SerSer: 3.138 ± 0.04	3.317SerThr: 3.317 ± 0.039	4.226SerVal: 4.226 ± 0.045	0.892SerTrp: 0.892 ± 0.023	1.132SerTyr: 1.132 ± 0.023	0.038SerXaa: 0.038 ± 0.004
Thr	8.919ThrAla: 8.919 ± 0.068	0.456ThrCys: 0.456 ± 0.013	3.605ThrAsp: 3.605 ± 0.042	2.887ThrGlu: 2.887 ± 0.037	1.706ThrPhe: 1.706 ± 0.029	6.811ThrGly: 6.811 ± 0.069	1.129ThrHis: 1.129 ± 0.023	2.045ThrIle: 2.045 ± 0.033	0.729ThrLys: 0.729 ± 0.022	5.562ThrLeu: 5.562 ± 0.055	0.981ThrMet: 0.981 ± 0.021	0.979ThrAsn: 0.979 ± 0.023	4.183ThrPro: 4.183 ± 0.045	1.229ThrGln: 1.229 ± 0.025	4.309ThrArg: 4.309 ± 0.047	3.563ThrSer: 3.563 ± 0.041	3.922ThrThr: 3.922 ± 0.047	5.877ThrVal: 5.877 ± 0.054	0.87ThrTrp: 0.87 ± 0.02	1.139ThrTyr: 1.139 ± 0.03	0.046ThrXaa: 0.046 ± 0.005
Val	11.85ValAla: 11.85 ± 0.083	0.715ValCys: 0.715 ± 0.021	5.772ValAsp: 5.772 ± 0.058	4.701ValGlu: 4.701 ± 0.048	2.292ValPhe: 2.292 ± 0.031	7.344ValGly: 7.344 ± 0.065	1.877ValHis: 1.877 ± 0.03	3.156ValIle: 3.156 ± 0.045	0.971ValLys: 0.971 ± 0.023	9.525ValLeu: 9.525 ± 0.083	1.252ValMet: 1.252 ± 0.022	1.635ValAsn: 1.635 ± 0.032	5.469ValPro: 5.469 ± 0.059	1.878ValGln: 1.878 ± 0.032	7.056ValArg: 7.056 ± 0.053	4.528ValSer: 4.528 ± 0.041	5.724ValThr: 5.724 ± 0.057	8.482ValVal: 8.482 ± 0.078	1.078ValTrp: 1.078 ± 0.021	1.376ValTyr: 1.376 ± 0.026	0.099ValXaa: 0.099 ± 0.007
Trp	1.621TrpAla: 1.621 ± 0.028	0.152TrpCys: 0.152 ± 0.009	0.838TrpAsp: 0.838 ± 0.023	0.719TrpGlu: 0.719 ± 0.02	0.427TrpPhe: 0.427 ± 0.015	0.944TrpGly: 0.944 ± 0.022	0.359TrpHis: 0.359 ± 0.013	0.511TrpIle: 0.511 ± 0.017	0.264TrpLys: 0.264 ± 0.011	1.706TrpLeu: 1.706 ± 0.026	0.276TrpMet: 0.276 ± 0.013	0.35TrpAsn: 0.35 ± 0.013	0.847TrpPro: 0.847 ± 0.021	0.505TrpGln: 0.505 ± 0.014	1.341TrpArg: 1.341 ± 0.026	0.935TrpSer: 0.935 ± 0.021	0.908TrpThr: 0.908 ± 0.021	0.983TrpVal: 0.983 ± 0.021	0.315TrpTrp: 0.315 ± 0.013	0.289TrpTyr: 0.289 ± 0.01	0.017TrpXaa: 0.017 ± 0.003
Tyr	2.222TyrAla: 2.222 ± 0.037	0.172TyrCys: 0.172 ± 0.008	1.226TyrAsp: 1.226 ± 0.029	1.01TyrGlu: 1.01 ± 0.022	0.582TyrPhe: 0.582 ± 0.016	1.805TyrGly: 1.805 ± 0.032	0.407TyrHis: 0.407 ± 0.013	0.478TyrIle: 0.478 ± 0.018	0.229TyrLys: 0.229 ± 0.011	2.166TyrLeu: 2.166 ± 0.036	0.211TyrMet: 0.211 ± 0.011	0.35TyrAsn: 0.35 ± 0.014	1.112TyrPro: 1.112 ± 0.024	0.622TyrGln: 0.622 ± 0.017	1.835TyrArg: 1.835 ± 0.032	0.899TyrSer: 0.899 ± 0.02	0.989TyrThr: 0.989 ± 0.022	1.344TyrVal: 1.344 ± 0.024	0.305TyrTrp: 0.305 ± 0.013	0.41TyrTyr: 0.41 ± 0.014	0.02TyrXaa: 0.02 ± 0.003
Xaa	0.104XaaAla: 0.104 ± 0.007	0.008XaaCys: 0.008 ± 0.002	0.053XaaAsp: 0.053 ± 0.005	0.042XaaGlu: 0.042 ± 0.004	0.021XaaPhe: 0.021 ± 0.003	0.064XaaGly: 0.064 ± 0.005	0.021XaaHis: 0.021 ± 0.003	0.051XaaIle: 0.051 ± 0.005	0.019XaaLys: 0.019 ± 0.003	0.073XaaLeu: 0.073 ± 0.006	0.019XaaMet: 0.019 ± 0.003	0.021XaaAsn: 0.021 ± 0.003	0.058XaaPro: 0.058 ± 0.005	0.021XaaGln: 0.021 ± 0.003	0.077XaaArg: 0.077 ± 0.005	0.043XaaSer: 0.043 ± 0.004	0.075XaaThr: 0.075 ± 0.006	0.062XaaVal: 0.062 ± 0.006	0.011XaaTrp: 0.011 ± 0.002	0.014XaaTyr: 0.014 ± 0.002	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 6324 proteins (2187273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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