Amino acid dipepetide frequency for Paracoccidioides brasiliensis (strain Pb18)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.912AlaAla: 7.912 ± 0.071	0.915AlaCys: 0.915 ± 0.016	3.813AlaAsp: 3.813 ± 0.034	4.768AlaGlu: 4.768 ± 0.047	2.756AlaPhe: 2.756 ± 0.031	5.323AlaGly: 5.323 ± 0.04	1.658AlaHis: 1.658 ± 0.021	3.99AlaIle: 3.99 ± 0.034	3.964AlaLys: 3.964 ± 0.04	6.918AlaLeu: 6.918 ± 0.049	1.703AlaMet: 1.703 ± 0.021	2.971AlaAsn: 2.971 ± 0.029	4.156AlaPro: 4.156 ± 0.04	3.001AlaGln: 3.001 ± 0.037	4.562AlaArg: 4.562 ± 0.034	6.857AlaSer: 6.857 ± 0.054	4.852AlaThr: 4.852 ± 0.04	4.959AlaVal: 4.959 ± 0.041	0.919AlaTrp: 0.919 ± 0.017	1.835AlaTyr: 1.835 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.858CysAla: 0.858 ± 0.014	0.245CysCys: 0.245 ± 0.009	0.61CysAsp: 0.61 ± 0.014	0.61CysGlu: 0.61 ± 0.012	0.509CysPhe: 0.509 ± 0.011	0.92CysGly: 0.92 ± 0.019	0.348CysHis: 0.348 ± 0.01	0.696CysIle: 0.696 ± 0.014	0.544CysLys: 0.544 ± 0.012	1.263CysLeu: 1.263 ± 0.023	0.261CysMet: 0.261 ± 0.008	0.446CysAsn: 0.446 ± 0.011	0.693CysPro: 0.693 ± 0.014	0.491CysGln: 0.491 ± 0.01	0.781CysArg: 0.781 ± 0.015	0.998CysSer: 0.998 ± 0.017	0.645CysThr: 0.645 ± 0.012	0.727CysVal: 0.727 ± 0.013	0.187CysTrp: 0.187 ± 0.007	0.344CysTyr: 0.344 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.126AspAla: 4.126 ± 0.035	0.606AspCys: 0.606 ± 0.014	4.214AspAsp: 4.214 ± 0.055	4.299AspGlu: 4.299 ± 0.046	2.078AspPhe: 2.078 ± 0.027	4.097AspGly: 4.097 ± 0.034	1.185AspHis: 1.185 ± 0.018	3.299AspIle: 3.299 ± 0.026	2.38AspLys: 2.38 ± 0.026	4.801AspLeu: 4.801 ± 0.042	1.26AspMet: 1.26 ± 0.018	2.011AspAsn: 2.011 ± 0.021	3.254AspPro: 3.254 ± 0.034	1.757AspGln: 1.757 ± 0.022	3.124AspArg: 3.124 ± 0.042	4.209AspSer: 4.209 ± 0.038	2.829AspThr: 2.829 ± 0.029	3.571AspVal: 3.571 ± 0.034	0.735AspTrp: 0.735 ± 0.014	1.469AspTyr: 1.469 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.835GluAla: 4.835 ± 0.04	0.654GluCys: 0.654 ± 0.012	4.006GluAsp: 4.006 ± 0.043	5.63GluGlu: 5.63 ± 0.058	1.987GluPhe: 1.987 ± 0.022	3.797GluGly: 3.797 ± 0.038	1.361GluHis: 1.361 ± 0.021	3.282GluIle: 3.282 ± 0.037	3.908GluLys: 3.908 ± 0.042	5.306GluLeu: 5.306 ± 0.049	1.506GluMet: 1.506 ± 0.019	2.661GluAsn: 2.661 ± 0.028	2.683GluPro: 2.683 ± 0.036	2.458GluGln: 2.458 ± 0.028	4.17GluArg: 4.17 ± 0.039	4.474GluSer: 4.474 ± 0.038	3.367GluThr: 3.367 ± 0.032	3.454GluVal: 3.454 ± 0.037	0.836GluTrp: 0.836 ± 0.015	1.647GluTyr: 1.647 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.71PheAla: 2.71 ± 0.031	0.562PheCys: 0.562 ± 0.012	2.178PheAsp: 2.178 ± 0.024	2.162PheGlu: 2.162 ± 0.024	1.477PhePhe: 1.477 ± 0.023	2.626PheGly: 2.626 ± 0.032	0.923PheHis: 0.923 ± 0.017	1.821PheIle: 1.821 ± 0.023	1.562PheLys: 1.562 ± 0.022	3.42PheLeu: 3.42 ± 0.035	0.715PheMet: 0.715 ± 0.014	1.469PheAsn: 1.469 ± 0.02	2.095PhePro: 2.095 ± 0.027	1.402PheGln: 1.402 ± 0.019	2.053PheArg: 2.053 ± 0.026	3.255PheSer: 3.255 ± 0.031	2.032PheThr: 2.032 ± 0.023	2.267PheVal: 2.267 ± 0.026	0.556PheTrp: 0.556 ± 0.013	1.05PheTyr: 1.05 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.726GlyAla: 4.726 ± 0.047	0.837GlyCys: 0.837 ± 0.015	3.756GlyAsp: 3.756 ± 0.037	3.916GlyGlu: 3.916 ± 0.032	2.586GlyPhe: 2.586 ± 0.025	6.013GlyGly: 6.013 ± 0.065	1.598GlyHis: 1.598 ± 0.025	3.584GlyIle: 3.584 ± 0.037	3.655GlyLys: 3.655 ± 0.039	5.503GlyLeu: 5.503 ± 0.043	1.607GlyMet: 1.607 ± 0.022	2.794GlyAsn: 2.794 ± 0.031	3.144GlyPro: 3.144 ± 0.037	2.448GlyGln: 2.448 ± 0.031	4.259GlyArg: 4.259 ± 0.043	5.797GlySer: 5.797 ± 0.05	3.728GlyThr: 3.728 ± 0.034	4.212GlyVal: 4.212 ± 0.035	1.052GlyTrp: 1.052 ± 0.017	1.984GlyTyr: 1.984 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.718HisAla: 1.718 ± 0.022	0.328HisCys: 0.328 ± 0.011	1.274HisAsp: 1.274 ± 0.018	1.287HisGlu: 1.287 ± 0.02	0.94HisPhe: 0.94 ± 0.016	1.672HisGly: 1.672 ± 0.021	0.995HisHis: 0.995 ± 0.023	1.344HisIle: 1.344 ± 0.018	0.977HisLys: 0.977 ± 0.017	2.3HisLeu: 2.3 ± 0.03	0.485HisMet: 0.485 ± 0.012	0.955HisAsn: 0.955 ± 0.017	1.912HisPro: 1.912 ± 0.029	1.159HisGln: 1.159 ± 0.019	1.631HisArg: 1.631 ± 0.024	2.16HisSer: 2.16 ± 0.029	1.32HisThr: 1.32 ± 0.019	1.408HisVal: 1.408 ± 0.02	0.3HisTrp: 0.3 ± 0.009	0.667HisTyr: 0.667 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.928IleAla: 3.928 ± 0.037	0.786IleCys: 0.786 ± 0.015	2.906IleAsp: 2.906 ± 0.028	2.931IleGlu: 2.931 ± 0.035	2.109IlePhe: 2.109 ± 0.028	3.034IleGly: 3.034 ± 0.031	1.322IleHis: 1.322 ± 0.019	2.695IleIle: 2.695 ± 0.03	2.311IleLys: 2.311 ± 0.026	4.84IleLeu: 4.84 ± 0.044	0.983IleMet: 0.983 ± 0.018	1.958IleAsn: 1.958 ± 0.024	3.476IlePro: 3.476 ± 0.035	2.011IleGln: 2.011 ± 0.024	3.045IleArg: 3.045 ± 0.028	4.644IleSer: 4.644 ± 0.03	2.904IleThr: 2.904 ± 0.028	3.079IleVal: 3.079 ± 0.033	0.674IleTrp: 0.674 ± 0.013	1.484IleTyr: 1.484 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.974LysAla: 3.974 ± 0.04	0.556LysCys: 0.556 ± 0.012	2.691LysAsp: 2.691 ± 0.028	3.579LysGlu: 3.579 ± 0.038	1.63LysPhe: 1.63 ± 0.021	3.187LysGly: 3.187 ± 0.034	1.213LysHis: 1.213 ± 0.019	2.534LysIle: 2.534 ± 0.026	3.464LysLys: 3.464 ± 0.056	4.458LysLeu: 4.458 ± 0.039	1.077LysMet: 1.077 ± 0.017	1.931LysAsn: 1.931 ± 0.026	2.947LysPro: 2.947 ± 0.036	2.007LysGln: 2.007 ± 0.026	3.825LysArg: 3.825 ± 0.038	4.027LysSer: 4.027 ± 0.038	2.787LysThr: 2.787 ± 0.029	2.812LysVal: 2.812 ± 0.031	0.657LysTrp: 0.657 ± 0.014	1.433LysTyr: 1.433 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	7.046LeuAla: 7.046 ± 0.053	1.179LeuCys: 1.179 ± 0.018	4.969LeuAsp: 4.969 ± 0.039	5.574LeuGlu: 5.574 ± 0.054	3.279LeuPhe: 3.279 ± 0.037	5.518LeuGly: 5.518 ± 0.044	2.288LeuHis: 2.288 ± 0.025	4.049LeuIle: 4.049 ± 0.035	4.538LeuLys: 4.538 ± 0.037	8.373LeuLeu: 8.373 ± 0.068	1.672LeuMet: 1.672 ± 0.023	3.366LeuAsn: 3.366 ± 0.031	5.657LeuPro: 5.657 ± 0.046	3.896LeuGln: 3.896 ± 0.038	5.893LeuArg: 5.893 ± 0.044	7.932LeuSer: 7.932 ± 0.051	4.754LeuThr: 4.754 ± 0.037	5.101LeuVal: 5.101 ± 0.043	1.071LeuTrp: 1.071 ± 0.018	2.269LeuTyr: 2.269 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.986MetAla: 1.986 ± 0.025	0.227MetCys: 0.227 ± 0.008	1.229MetAsp: 1.229 ± 0.02	1.394MetGlu: 1.394 ± 0.018	0.713MetPhe: 0.713 ± 0.014	1.432MetGly: 1.432 ± 0.021	0.444MetHis: 0.444 ± 0.011	0.977MetIle: 0.977 ± 0.019	1.106MetLys: 1.106 ± 0.019	1.756MetLeu: 1.756 ± 0.022	0.514MetMet: 0.514 ± 0.012	0.827MetAsn: 0.827 ± 0.016	1.185MetPro: 1.185 ± 0.018	0.813MetGln: 0.813 ± 0.014	1.248MetArg: 1.248 ± 0.017	1.845MetSer: 1.845 ± 0.023	1.218MetThr: 1.218 ± 0.017	1.25MetVal: 1.25 ± 0.02	0.244MetTrp: 0.244 ± 0.008	0.459MetTyr: 0.459 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.041AsnAla: 3.041 ± 0.028	0.493AsnCys: 0.493 ± 0.011	2.16AsnAsp: 2.16 ± 0.023	2.214AsnGlu: 2.214 ± 0.028	1.426AsnPhe: 1.426 ± 0.02	3.169AsnGly: 3.169 ± 0.033	1.028AsnHis: 1.028 ± 0.02	2.302AsnIle: 2.302 ± 0.024	1.771AsnLys: 1.771 ± 0.02	3.477AsnLeu: 3.477 ± 0.036	0.848AsnMet: 0.848 ± 0.015	1.965AsnAsn: 1.965 ± 0.03	2.825AsnPro: 2.825 ± 0.03	1.493AsnGln: 1.493 ± 0.02	2.258AsnArg: 2.258 ± 0.028	3.314AsnSer: 3.314 ± 0.03	2.36AsnThr: 2.36 ± 0.025	2.398AsnVal: 2.398 ± 0.025	0.503AsnTrp: 0.503 ± 0.012	1.049AsnTyr: 1.049 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.789ProAla: 4.789 ± 0.045	0.559ProCys: 0.559 ± 0.014	3.111ProAsp: 3.111 ± 0.03	3.663ProGlu: 3.663 ± 0.035	2.128ProPhe: 2.128 ± 0.025	3.771ProGly: 3.771 ± 0.034	1.551ProHis: 1.551 ± 0.022	2.789ProIle: 2.789 ± 0.027	2.821ProLys: 2.821 ± 0.032	5.084ProLeu: 5.084 ± 0.037	1.022ProMet: 1.022 ± 0.019	2.481ProAsn: 2.481 ± 0.026	5.857ProPro: 5.857 ± 0.087	2.742ProGln: 2.742 ± 0.039	3.521ProArg: 3.521 ± 0.038	6.815ProSer: 6.815 ± 0.066	4.23ProThr: 4.23 ± 0.044	3.521ProVal: 3.521 ± 0.032	0.648ProTrp: 0.648 ± 0.013	1.524ProTyr: 1.524 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.011GlnAla: 3.011 ± 0.036	0.446GlnCys: 0.446 ± 0.009	1.919GlnAsp: 1.919 ± 0.026	2.368GlnGlu: 2.368 ± 0.03	1.318GlnPhe: 1.318 ± 0.02	2.312GlnGly: 2.312 ± 0.03	1.222GlnHis: 1.222 ± 0.024	1.995GlnIle: 1.995 ± 0.021	2.122GlnLys: 2.122 ± 0.028	3.536GlnLeu: 3.536 ± 0.033	0.865GlnMet: 0.865 ± 0.017	1.768GlnAsn: 1.768 ± 0.023	2.776GlnPro: 2.776 ± 0.037	3.174GlnGln: 3.174 ± 0.069	2.861GlnArg: 2.861 ± 0.028	3.408GlnSer: 3.408 ± 0.039	2.38GlnThr: 2.38 ± 0.021	2.062GlnVal: 2.062 ± 0.021	0.482GlnTrp: 0.482 ± 0.012	1.098GlnTyr: 1.098 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.497ArgAla: 4.497 ± 0.035	0.783ArgCys: 0.783 ± 0.014	3.427ArgAsp: 3.427 ± 0.04	4.133ArgGlu: 4.133 ± 0.039	2.167ArgPhe: 2.167 ± 0.027	3.999ArgGly: 3.999 ± 0.04	1.647ArgHis: 1.647 ± 0.022	3.195ArgIle: 3.195 ± 0.032	3.853ArgLys: 3.853 ± 0.04	5.472ArgLeu: 5.472 ± 0.042	1.361ArgMet: 1.361 ± 0.02	2.665ArgAsn: 2.665 ± 0.032	3.544ArgPro: 3.544 ± 0.037	2.745ArgGln: 2.745 ± 0.03	5.49ArgArg: 5.49 ± 0.058	5.334ArgSer: 5.334 ± 0.052	3.375ArgThr: 3.375 ± 0.031	3.421ArgVal: 3.421 ± 0.026	0.855ArgTrp: 0.855 ± 0.016	1.661ArgTyr: 1.661 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.437SerAla: 6.437 ± 0.046	0.968SerCys: 0.968 ± 0.017	4.219SerAsp: 4.219 ± 0.038	4.28SerGlu: 4.28 ± 0.042	3.229SerPhe: 3.229 ± 0.033	5.817SerGly: 5.817 ± 0.048	2.295SerHis: 2.295 ± 0.026	4.363SerIle: 4.363 ± 0.035	4.246SerLys: 4.246 ± 0.037	7.754SerLeu: 7.754 ± 0.052	1.74SerMet: 1.74 ± 0.022	3.622SerAsn: 3.622 ± 0.031	6.428SerPro: 6.428 ± 0.071	3.738SerGln: 3.738 ± 0.04	5.701SerArg: 5.701 ± 0.05	10.454SerSer: 10.454 ± 0.101	6.047SerThr: 6.047 ± 0.051	4.642SerVal: 4.642 ± 0.043	1.066SerTrp: 1.066 ± 0.018	2.081SerTyr: 2.081 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.829ThrAla: 4.829 ± 0.041	0.714ThrCys: 0.714 ± 0.016	2.811ThrAsp: 2.811 ± 0.029	3.013ThrGlu: 3.013 ± 0.026	2.113ThrPhe: 2.113 ± 0.026	3.971ThrGly: 3.971 ± 0.039	1.347ThrHis: 1.347 ± 0.02	3.053ThrIle: 3.053 ± 0.027	2.686ThrLys: 2.686 ± 0.026	5.152ThrLeu: 5.152 ± 0.041	1.097ThrMet: 1.097 ± 0.017	2.281ThrAsn: 2.281 ± 0.025	4.507ThrPro: 4.507 ± 0.04	2.05ThrGln: 2.05 ± 0.023	3.2ThrArg: 3.2 ± 0.033	5.848ThrSer: 5.848 ± 0.054	4.485ThrThr: 4.485 ± 0.049	3.479ThrVal: 3.479 ± 0.032	0.681ThrTrp: 0.681 ± 0.015	1.48ThrTyr: 1.48 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	4.605ValAla: 4.605 ± 0.032	0.767ValCys: 0.767 ± 0.014	3.668ValAsp: 3.668 ± 0.034	3.927ValGlu: 3.927 ± 0.036	2.274ValPhe: 2.274 ± 0.025	3.899ValGly: 3.899 ± 0.036	1.343ValHis: 1.343 ± 0.021	2.994ValIle: 2.994 ± 0.031	3.01ValLys: 3.01 ± 0.029	5.271ValLeu: 5.271 ± 0.042	1.263ValMet: 1.263 ± 0.019	2.278ValAsn: 2.278 ± 0.025	3.433ValPro: 3.433 ± 0.032	2.2ValGln: 2.2 ± 0.021	3.451ValArg: 3.451 ± 0.031	4.753ValSer: 4.753 ± 0.034	3.28ValThr: 3.28 ± 0.03	4.016ValVal: 4.016 ± 0.035	0.745ValTrp: 0.745 ± 0.015	1.504ValTyr: 1.504 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.016	0.167TrpCys: 0.167 ± 0.007	0.794TrpAsp: 0.794 ± 0.015	0.804TrpGlu: 0.804 ± 0.016	0.455TrpPhe: 0.455 ± 0.013	0.791TrpGly: 0.791 ± 0.016	0.309TrpHis: 0.309 ± 0.01	0.695TrpIle: 0.695 ± 0.015	0.786TrpLys: 0.786 ± 0.015	1.171TrpLeu: 1.171 ± 0.019	0.336TrpMet: 0.336 ± 0.01	0.587TrpAsn: 0.587 ± 0.012	0.501TrpPro: 0.501 ± 0.013	0.479TrpGln: 0.479 ± 0.01	0.934TrpArg: 0.934 ± 0.016	0.917TrpSer: 0.917 ± 0.018	0.743TrpThr: 0.743 ± 0.016	0.781TrpVal: 0.781 ± 0.014	0.241TrpTrp: 0.241 ± 0.009	0.344TrpTyr: 0.344 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.857TyrAla: 1.857 ± 0.022	0.385TyrCys: 0.385 ± 0.011	1.55TyrAsp: 1.55 ± 0.021	1.467TyrGlu: 1.467 ± 0.02	1.158TyrPhe: 1.158 ± 0.017	1.849TyrGly: 1.849 ± 0.024	0.755TyrHis: 0.755 ± 0.014	1.462TyrIle: 1.462 ± 0.023	1.083TyrLys: 1.083 ± 0.019	2.569TyrLeu: 2.569 ± 0.03	0.55TyrMet: 0.55 ± 0.011	1.057TyrAsn: 1.057 ± 0.016	1.555TyrPro: 1.555 ± 0.026	1.059TyrGln: 1.059 ± 0.018	1.618TyrArg: 1.618 ± 0.02	2.086TyrSer: 2.086 ± 0.023	1.46TyrThr: 1.46 ± 0.018	1.522TyrVal: 1.522 ± 0.022	0.335TyrTrp: 0.335 ± 0.009	0.862TyrTyr: 0.862 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8399 proteins (3885900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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