Paragonimus westermani

Taxonomy: cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; Digenea; Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus

Average proteome isoelectric point is 6.91

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 12535 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A5J4N9F8|A0A5J4N9F8_9TREM Exocyst complex component 8 OS=Paragonimus westermani OX=34504 GN=DEA37_0009394 PE=3 SV=1
MM1 pKa = 7.85AFTFGWSDD9 pKa = 3.51YY10 pKa = 11.3LIFALLLVVYY20 pKa = 9.47ALIGIYY26 pKa = 9.63QRR28 pKa = 11.84FHH30 pKa = 7.2DD31 pKa = 4.99PIVRR35 pKa = 11.84KK36 pKa = 10.03LNRR39 pKa = 11.84LCCNEE44 pKa = 3.25KK45 pKa = 10.04WKK47 pKa = 10.96LKK49 pKa = 9.4EE50 pKa = 4.3HH51 pKa = 6.19SLSDD55 pKa = 3.52NTAEE59 pKa = 5.55ALTLGNRR66 pKa = 11.84RR67 pKa = 11.84LTLFPIMSSVMASFLSAVSLMGTASEE93 pKa = 4.39AYY95 pKa = 10.01LYY97 pKa = 10.4GFQFILMIVAYY108 pKa = 8.84FIAFSVAAEE117 pKa = 4.07VYY119 pKa = 9.38MPVFYY124 pKa = 10.78KK125 pKa = 10.64LHH127 pKa = 6.25LVSAHH132 pKa = 5.66EE133 pKa = 4.35TDD135 pKa = 4.88DD136 pKa = 4.6DD137 pKa = 4.2HH138 pKa = 9.17AXDD141 pKa = 5.58AGDD144 pKa = 3.95DD145 pKa = 3.8HH146 pKa = 8.21DD147 pKa = 6.51DD148 pKa = 3.68GDD150 pKa = 4.64EE151 pKa = 4.18YY152 pKa = 11.81GHH154 pKa = 7.6DD155 pKa = 4.02DD156 pKa = 3.93DD157 pKa = 7.27DD158 pKa = 5.14YY159 pKa = 12.15GEE161 pKa = 5.78DD162 pKa = 4.62YY163 pKa = 11.45DD164 pKa = 6.49DD165 pKa = 6.28DD166 pKa = 5.18DD167 pKa = 5.71HH168 pKa = 8.92DD169 pKa = 5.0HH170 pKa = 7.67DD171 pKa = 6.08GDD173 pKa = 3.94LHH175 pKa = 7.34HH176 pKa = 7.81DD177 pKa = 3.67SDD179 pKa = 6.07DD180 pKa = 3.9FGNDD184 pKa = 3.89DD185 pKa = 4.1GGADD189 pKa = 4.6AGDD192 pKa = 3.91DD193 pKa = 3.61HH194 pKa = 8.38DD195 pKa = 5.76DD196 pKa = 4.15GNDD199 pKa = 3.35YY200 pKa = 11.44GHH202 pKa = 7.85DD203 pKa = 4.06DD204 pKa = 3.85NADD207 pKa = 3.68GYY209 pKa = 11.6DD210 pKa = 5.67DD211 pKa = 6.0GDD213 pKa = 4.96DD214 pKa = 5.27DD215 pKa = 6.35NGDD218 pKa = 4.4DD219 pKa = 6.14DD220 pKa = 7.01DD221 pKa = 7.74DD222 pKa = 6.29DD223 pKa = 5.19DD224 pKa = 6.78HH225 pKa = 9.07DD226 pKa = 6.6DD227 pKa = 4.83GDD229 pKa = 5.95DD230 pKa = 5.41DD231 pKa = 5.82VDD233 pKa = 4.05DD234 pKa = 5.9DD235 pKa = 5.3KK236 pKa = 11.95DD237 pKa = 4.18AGDD240 pKa = 4.08DD241 pKa = 3.74HH242 pKa = 8.17DD243 pKa = 6.35DD244 pKa = 3.68GDD246 pKa = 4.64EE247 pKa = 4.18YY248 pKa = 11.81GHH250 pKa = 7.6DD251 pKa = 4.02DD252 pKa = 3.93DD253 pKa = 7.27DD254 pKa = 5.14YY255 pKa = 12.15GEE257 pKa = 5.78DD258 pKa = 4.62YY259 pKa = 11.45DD260 pKa = 6.49DD261 pKa = 6.28DD262 pKa = 5.18DD263 pKa = 5.71HH264 pKa = 8.92DD265 pKa = 5.0HH266 pKa = 7.67DD267 pKa = 6.08GDD269 pKa = 3.94LHH271 pKa = 7.34HH272 pKa = 7.81DD273 pKa = 3.67SDD275 pKa = 6.07DD276 pKa = 3.9FGNDD280 pKa = 3.89DD281 pKa = 4.1GGADD285 pKa = 4.6AGDD288 pKa = 3.91DD289 pKa = 3.61HH290 pKa = 8.38DD291 pKa = 5.76DD292 pKa = 4.15GNDD295 pKa = 3.35YY296 pKa = 11.44GHH298 pKa = 7.85DD299 pKa = 4.06DD300 pKa = 3.85NADD303 pKa = 3.68GYY305 pKa = 11.6DD306 pKa = 5.67DD307 pKa = 6.0GDD309 pKa = 5.2DD310 pKa = 5.62DD311 pKa = 6.15NGDD314 pKa = 4.14DD315 pKa = 4.41NDD317 pKa = 5.06DD318 pKa = 3.84GVGDD322 pKa = 4.16VDD324 pKa = 6.34DD325 pKa = 6.19DD326 pKa = 5.67GNDD329 pKa = 3.47DD330 pKa = 5.22DD331 pKa = 6.76AGDD334 pKa = 4.51DD335 pKa = 5.07HH336 pKa = 8.89DD337 pKa = 7.08DD338 pKa = 5.24DD339 pKa = 7.47DD340 pKa = 7.53DD341 pKa = 6.49DD342 pKa = 6.61DD343 pKa = 4.66EE344 pKa = 4.96EE345 pKa = 4.68EE346 pKa = 4.38EE347 pKa = 4.27EE348 pKa = 5.6EE349 pKa = 4.1EE350 pKa = 5.81DD351 pKa = 3.77EE352 pKa = 6.14DD353 pKa = 4.39EE354 pKa = 5.32GAGDD358 pKa = 3.59DD359 pKa = 4.0HH360 pKa = 9.21DD361 pKa = 5.34GEE363 pKa = 4.42EE364 pKa = 4.34HH365 pKa = 6.36VNLVGDD371 pKa = 3.97HH372 pKa = 7.65DD373 pKa = 5.55DD374 pKa = 4.2YY375 pKa = 12.19DD376 pKa = 4.69DD377 pKa = 5.93AGDD380 pKa = 4.11DD381 pKa = 4.92HH382 pKa = 8.19DD383 pKa = 6.79DD384 pKa = 3.98GDD386 pKa = 5.75DD387 pKa = 4.43GDD389 pKa = 4.56GHH391 pKa = 7.75DD392 pKa = 5.87DD393 pKa = 4.17DD394 pKa = 6.12DD395 pKa = 6.25HH396 pKa = 8.95DD397 pKa = 5.21GMIIFMKK404 pKa = 10.31MMTTSVDD411 pKa = 2.97EE412 pKa = 4.74RR413 pKa = 11.84IITFAYY419 pKa = 10.33GNEE422 pKa = 4.17CVFNDD427 pKa = 3.5RR428 pKa = 11.84QNRR431 pKa = 11.84NMTSGFEE438 pKa = 4.3HH439 pKa = 8.11DD440 pKa = 3.91YY441 pKa = 10.58QLKK444 pKa = 10.43NGHH447 pKa = 6.4LVKK450 pKa = 10.62QPANIAPLRR459 pKa = 11.84VINPMPIVTSFEE471 pKa = 3.79IGRR474 pKa = 3.93

Molecular weight: 52.59 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A5J4NCY9|A0A5J4NCY9_9TREM Fibronectin type-III domain-containing protein (Fragment) OS=Paragonimus westermani OX=34504 GN=DEA37_0002973 PE=4 SV=1
MM1 pKa = 7.66GSHH4 pKa = 5.53KK5 pKa = 8.56TLRR8 pKa = 11.84IKK10 pKa = 9.89TKK12 pKa = 10.32LGKK15 pKa = 9.54KK16 pKa = 8.96QKK18 pKa = 9.03QNRR21 pKa = 11.84TLPHH25 pKa = 5.31WTRR28 pKa = 11.84LRR30 pKa = 11.84TGNKK34 pKa = 8.34IRR36 pKa = 11.84YY37 pKa = 5.83NAKK40 pKa = 8.24RR41 pKa = 11.84RR42 pKa = 11.84HH43 pKa = 4.1WRR45 pKa = 11.84RR46 pKa = 11.84TKK48 pKa = 10.89LKK50 pKa = 10.55LL51 pKa = 3.39

Molecular weight: 6.32 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

12535

0

12535

5687671

30

9743

453.7

50.67

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.79 ± 0.019

2.179 ± 0.012

5.252 ± 0.017

5.559 ± 0.025

3.828 ± 0.015

5.348 ± 0.023

2.851 ± 0.012

4.734 ± 0.017

4.368 ± 0.019

10.233 ± 0.028

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.04 ± 0.008

4.197 ± 0.011

5.72 ± 0.023

4.297 ± 0.016

6.405 ± 0.017

9.334 ± 0.031

6.412 ± 0.016

6.63 ± 0.015

1.147 ± 0.006

2.676 ± 0.012
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski