Amino acid dipepetide frequency for Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.011AlaAla: 3.011 ± 0.142
0.371AlaCys: 0.371 ± 0.042
2.263AlaAsp: 2.263 ± 0.131
2.614AlaGlu: 2.614 ± 0.158
2.761AlaPhe: 2.761 ± 0.27
2.39AlaGly: 2.39 ± 0.141
0.727AlaHis: 0.727 ± 0.065
6.077AlaIle: 6.077 ± 0.191
6.692AlaLys: 6.692 ± 0.295
4.923AlaLeu: 4.923 ± 0.173
1.058AlaMet: 1.058 ± 0.077
4.292AlaAsn: 4.292 ± 0.176
1.165AlaPro: 1.165 ± 0.076
1.602AlaGln: 1.602 ± 0.097
1.938AlaArg: 1.938 ± 0.114
3.504AlaSer: 3.504 ± 0.148
2.802AlaThr: 2.802 ± 0.142
2.319AlaVal: 2.319 ± 0.121
0.427AlaTrp: 0.427 ± 0.052
2.06AlaTyr: 2.06 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.346CysAla: 0.346 ± 0.048
0.107CysCys: 0.107 ± 0.028
0.417CysAsp: 0.417 ± 0.047
0.397CysGlu: 0.397 ± 0.067
0.453CysPhe: 0.453 ± 0.047
0.437CysGly: 0.437 ± 0.046
0.142CysHis: 0.142 ± 0.029
0.575CysIle: 0.575 ± 0.053
0.554CysLys: 0.554 ± 0.062
0.778CysLeu: 0.778 ± 0.056
0.092CysMet: 0.092 ± 0.021
0.61CysAsn: 0.61 ± 0.067
0.254CysPro: 0.254 ± 0.04
0.264CysGln: 0.264 ± 0.04
0.168CysArg: 0.168 ± 0.032
0.539CysSer: 0.539 ± 0.054
0.234CysThr: 0.234 ± 0.034
0.32CysVal: 0.32 ± 0.044
0.071CysTrp: 0.071 ± 0.02
0.229CysTyr: 0.229 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.939AspAla: 2.939 ± 0.221
0.361AspCys: 0.361 ± 0.05
2.695AspAsp: 2.695 ± 0.15
4.409AspGlu: 4.409 ± 0.166
3.885AspPhe: 3.885 ± 0.15
2.553AspGly: 2.553 ± 0.123
0.636AspHis: 0.636 ± 0.052
5.441AspIle: 5.441 ± 0.188
5.563AspLys: 5.563 ± 0.233
5.594AspLeu: 5.594 ± 0.214
0.778AspMet: 0.778 ± 0.069
3.89AspAsn: 3.89 ± 0.147
1.688AspPro: 1.688 ± 0.094
1.729AspGln: 1.729 ± 0.106
1.149AspArg: 1.149 ± 0.068
3.555AspSer: 3.555 ± 0.152
1.882AspThr: 1.882 ± 0.118
3.016AspVal: 3.016 ± 0.114
0.57AspTrp: 0.57 ± 0.05
2.507AspTyr: 2.507 ± 0.126
0.0AspXaa: 0.0 ± 0.0
Glu
3.57GluAla: 3.57 ± 0.166
0.432GluCys: 0.432 ± 0.05
3.397GluAsp: 3.397 ± 0.144
4.902GluGlu: 4.902 ± 0.187
3.621GluPhe: 3.621 ± 0.177
2.695GluGly: 2.695 ± 0.178
0.885GluHis: 0.885 ± 0.071
7.964GluIle: 7.964 ± 0.241
7.277GluLys: 7.277 ± 0.218
7.297GluLeu: 7.297 ± 0.244
1.348GluMet: 1.348 ± 0.084
5.838GluAsn: 5.838 ± 0.165
1.434GluPro: 1.434 ± 0.102
2.482GluGln: 2.482 ± 0.144
1.836GluArg: 1.836 ± 0.1
3.611GluSer: 3.611 ± 0.146
3.331GluThr: 3.331 ± 0.135
3.961GluVal: 3.961 ± 0.166
0.544GluTrp: 0.544 ± 0.058
3.382GluTyr: 3.382 ± 0.145
0.0GluXaa: 0.0 ± 0.0
Phe
2.716PheAla: 2.716 ± 0.139
0.453PheCys: 0.453 ± 0.053
3.565PheAsp: 3.565 ± 0.136
3.636PheGlu: 3.636 ± 0.158
2.39PhePhe: 2.39 ± 0.133
2.538PheGly: 2.538 ± 0.133
0.564PheHis: 0.564 ± 0.056
4.887PheIle: 4.887 ± 0.195
5.396PheLys: 5.396 ± 0.199
4.968PheLeu: 4.968 ± 0.191
0.768PheMet: 0.768 ± 0.069
4.857PheAsn: 4.857 ± 0.196
1.114PhePro: 1.114 ± 0.079
1.246PheGln: 1.246 ± 0.088
1.22PheArg: 1.22 ± 0.077
4.114PheSer: 4.114 ± 0.199
1.897PheThr: 1.897 ± 0.11
2.944PheVal: 2.944 ± 0.151
0.488PheTrp: 0.488 ± 0.059
2.309PheTyr: 2.309 ± 0.141
0.0PheXaa: 0.0 ± 0.0
Gly
2.655GlyAla: 2.655 ± 0.19
0.361GlyCys: 0.361 ± 0.079
2.248GlyAsp: 2.248 ± 0.122
2.502GlyGlu: 2.502 ± 0.148
2.497GlyPhe: 2.497 ± 0.133
2.797GlyGly: 2.797 ± 0.172
0.941GlyHis: 0.941 ± 0.07
4.918GlyIle: 4.918 ± 0.197
4.155GlyLys: 4.155 ± 0.174
4.165GlyLeu: 4.165 ± 0.202
0.87GlyMet: 0.87 ± 0.078
2.731GlyAsn: 2.731 ± 0.133
1.053GlyPro: 1.053 ± 0.075
1.714GlyGln: 1.714 ± 0.097
1.515GlyArg: 1.515 ± 0.11
2.995GlySer: 2.995 ± 0.158
2.36GlyThr: 2.36 ± 0.124
2.39GlyVal: 2.39 ± 0.13
0.376GlyTrp: 0.376 ± 0.046
2.166GlyTyr: 2.166 ± 0.12
0.0GlyXaa: 0.0 ± 0.0
His
0.803HisAla: 0.803 ± 0.078
0.142HisCys: 0.142 ± 0.027
0.641HisAsp: 0.641 ± 0.053
0.905HisGlu: 0.905 ± 0.064
0.773HisPhe: 0.773 ± 0.069
0.844HisGly: 0.844 ± 0.067
0.254HisHis: 0.254 ± 0.037
1.134HisIle: 1.134 ± 0.069
1.139HisLys: 1.139 ± 0.072
1.139HisLeu: 1.139 ± 0.079
0.219HisMet: 0.219 ± 0.035
0.971HisAsn: 0.971 ± 0.078
0.539HisPro: 0.539 ± 0.054
0.351HisGln: 0.351 ± 0.036
0.453HisArg: 0.453 ± 0.056
0.865HisSer: 0.865 ± 0.069
0.575HisThr: 0.575 ± 0.059
0.702HisVal: 0.702 ± 0.063
0.127HisTrp: 0.127 ± 0.025
0.564HisTyr: 0.564 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
5.807IleAla: 5.807 ± 0.174
0.839IleCys: 0.839 ± 0.08
6.499IleAsp: 6.499 ± 0.205
7.694IleGlu: 7.694 ± 0.234
5.258IlePhe: 5.258 ± 0.201
4.399IleGly: 4.399 ± 0.273
1.124IleHis: 1.124 ± 0.086
9.276IleIle: 9.276 ± 0.26
10.42IleLys: 10.42 ± 0.275
9.088IleLeu: 9.088 ± 0.29
1.526IleMet: 1.526 ± 0.086
8.259IleAsn: 8.259 ± 0.221
2.888IlePro: 2.888 ± 0.202
2.919IleGln: 2.919 ± 0.133
2.675IleArg: 2.675 ± 0.145
7.821IleSer: 7.821 ± 0.222
4.714IleThr: 4.714 ± 0.186
5.248IleVal: 5.248 ± 0.178
0.651IleTrp: 0.651 ± 0.066
3.738IleTyr: 3.738 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
4.872LysAla: 4.872 ± 0.197
0.493LysCys: 0.493 ± 0.058
5.879LysAsp: 5.879 ± 0.259
8.803LysGlu: 8.803 ± 0.288
4.689LysPhe: 4.689 ± 0.178
3.392LysGly: 3.392 ± 0.166
1.363LysHis: 1.363 ± 0.073
11.071LysIle: 11.071 ± 0.318
11.279LysLys: 11.279 ± 0.332
9.505LysLeu: 9.505 ± 0.286
2.471LysMet: 2.471 ± 0.118
10.145LysAsn: 10.145 ± 0.304
2.802LysPro: 2.802 ± 0.14
4.551LysGln: 4.551 ± 0.242
3.051LysArg: 3.051 ± 0.135
6.219LysSer: 6.219 ± 0.195
5.38LysThr: 5.38 ± 0.189
4.531LysVal: 4.531 ± 0.146
0.895LysTrp: 0.895 ± 0.066
4.862LysTyr: 4.862 ± 0.169
0.0LysXaa: 0.0 ± 0.0
Leu
5.675LeuAla: 5.675 ± 0.161
0.62LeuCys: 0.62 ± 0.059
5.416LeuAsp: 5.416 ± 0.173
6.108LeuGlu: 6.108 ± 0.236
4.923LeuPhe: 4.923 ± 0.214
4.434LeuGly: 4.434 ± 0.188
1.159LeuHis: 1.159 ± 0.076
9.494LeuIle: 9.494 ± 0.277
10.445LeuLys: 10.445 ± 0.284
8.493LeuLeu: 8.493 ± 0.211
1.521LeuMet: 1.521 ± 0.1
8.808LeuAsn: 8.808 ± 0.285
2.787LeuPro: 2.787 ± 0.128
3.021LeuGln: 3.021 ± 0.165
2.695LeuArg: 2.695 ± 0.131
6.697LeuSer: 6.697 ± 0.18
4.745LeuThr: 4.745 ± 0.141
4.821LeuVal: 4.821 ± 0.173
0.605LeuTrp: 0.605 ± 0.06
2.955LeuTyr: 2.955 ± 0.127
0.0LeuXaa: 0.0 ± 0.0
Met
1.226MetAla: 1.226 ± 0.071
0.112MetCys: 0.112 ± 0.023
0.722MetAsp: 0.722 ± 0.062
0.859MetGlu: 0.859 ± 0.073
0.987MetPhe: 0.987 ± 0.081
0.697MetGly: 0.697 ± 0.062
0.28MetHis: 0.28 ± 0.037
1.485MetIle: 1.485 ± 0.104
1.795MetLys: 1.795 ± 0.09
1.81MetLeu: 1.81 ± 0.11
0.31MetMet: 0.31 ± 0.035
1.271MetAsn: 1.271 ± 0.069
0.748MetPro: 0.748 ± 0.066
0.697MetGln: 0.697 ± 0.064
0.463MetArg: 0.463 ± 0.047
1.337MetSer: 1.337 ± 0.086
0.778MetThr: 0.778 ± 0.074
0.829MetVal: 0.829 ± 0.06
0.122MetTrp: 0.122 ± 0.025
0.575MetTyr: 0.575 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
3.534AsnAla: 3.534 ± 0.158
0.488AsnCys: 0.488 ± 0.046
4.653AsnAsp: 4.653 ± 0.209
6.611AsnGlu: 6.611 ± 0.205
4.038AsnPhe: 4.038 ± 0.166
3.265AsnGly: 3.265 ± 0.136
1.002AsnHis: 1.002 ± 0.074
8.406AsnIle: 8.406 ± 0.265
9.906AsnLys: 9.906 ± 0.289
7.872AsnLeu: 7.872 ± 0.224
1.19AsnMet: 1.19 ± 0.074
7.567AsnAsn: 7.567 ± 0.27
2.466AsnPro: 2.466 ± 0.116
2.904AsnGln: 2.904 ± 0.142
1.876AsnArg: 1.876 ± 0.109
5.716AsnSer: 5.716 ± 0.194
3.087AsnThr: 3.087 ± 0.176
4.236AsnVal: 4.236 ± 0.184
0.783AsnTrp: 0.783 ± 0.065
3.428AsnTyr: 3.428 ± 0.162
0.0AsnXaa: 0.0 ± 0.0
Pro
1.343ProAla: 1.343 ± 0.096
0.178ProCys: 0.178 ± 0.033
1.307ProAsp: 1.307 ± 0.087
2.207ProGlu: 2.207 ± 0.121
1.271ProPhe: 1.271 ± 0.092
1.465ProGly: 1.465 ± 0.123
0.432ProHis: 0.432 ± 0.05
2.629ProIle: 2.629 ± 0.133
2.502ProLys: 2.502 ± 0.139
2.41ProLeu: 2.41 ± 0.105
0.412ProMet: 0.412 ± 0.044
2.014ProAsn: 2.014 ± 0.104
0.407ProPro: 0.407 ± 0.046
1.032ProGln: 1.032 ± 0.067
0.646ProArg: 0.646 ± 0.067
1.658ProSer: 1.658 ± 0.099
1.622ProThr: 1.622 ± 0.1
1.307ProVal: 1.307 ± 0.097
0.31ProTrp: 0.31 ± 0.039
1.109ProTyr: 1.109 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
1.805GlnAla: 1.805 ± 0.139
0.173GlnCys: 0.173 ± 0.026
1.978GlnAsp: 1.978 ± 0.169
2.69GlnGlu: 2.69 ± 0.138
1.368GlnPhe: 1.368 ± 0.08
1.343GlnGly: 1.343 ± 0.084
0.381GlnHis: 0.381 ± 0.044
3.239GlnIle: 3.239 ± 0.143
4.297GlnLys: 4.297 ± 0.207
3.28GlnLeu: 3.28 ± 0.166
0.559GlnMet: 0.559 ± 0.045
2.883GlnAsn: 2.883 ± 0.118
0.595GlnPro: 0.595 ± 0.064
1.165GlnGln: 1.165 ± 0.108
1.129GlnArg: 1.129 ± 0.083
1.841GlnSer: 1.841 ± 0.092
1.551GlnThr: 1.551 ± 0.091
1.449GlnVal: 1.449 ± 0.085
0.28GlnTrp: 0.28 ± 0.043
1.551GlnTyr: 1.551 ± 0.097
0.0GlnXaa: 0.0 ± 0.0
Arg
1.47ArgAla: 1.47 ± 0.109
0.163ArgCys: 0.163 ± 0.031
1.765ArgAsp: 1.765 ± 0.101
1.993ArgGlu: 1.993 ± 0.108
1.327ArgPhe: 1.327 ± 0.074
1.475ArgGly: 1.475 ± 0.098
0.392ArgHis: 0.392 ± 0.047
2.726ArgIle: 2.726 ± 0.128
2.721ArgLys: 2.721 ± 0.121
2.477ArgLeu: 2.477 ± 0.118
0.687ArgMet: 0.687 ± 0.061
2.11ArgAsn: 2.11 ± 0.1
0.773ArgPro: 0.773 ± 0.066
1.109ArgGln: 1.109 ± 0.076
1.053ArgArg: 1.053 ± 0.078
1.617ArgSer: 1.617 ± 0.093
1.256ArgThr: 1.256 ± 0.078
1.531ArgVal: 1.531 ± 0.095
0.219ArgTrp: 0.219 ± 0.038
1.22ArgTyr: 1.22 ± 0.084
0.0ArgXaa: 0.0 ± 0.0
Ser
3.26SerAla: 3.26 ± 0.134
0.641SerCys: 0.641 ± 0.057
3.473SerAsp: 3.473 ± 0.122
4.129SerGlu: 4.129 ± 0.155
3.651SerPhe: 3.651 ± 0.163
3.316SerGly: 3.316 ± 0.159
0.895SerHis: 0.895 ± 0.083
6.982SerIle: 6.982 ± 0.244
7.328SerLys: 7.328 ± 0.222
6.682SerLeu: 6.682 ± 0.198
1.037SerMet: 1.037 ± 0.083
5.523SerAsn: 5.523 ± 0.21
1.597SerPro: 1.597 ± 0.082
2.716SerGln: 2.716 ± 0.135
1.709SerArg: 1.709 ± 0.091
4.755SerSer: 4.755 ± 0.178
3.092SerThr: 3.092 ± 0.123
2.792SerVal: 2.792 ± 0.14
0.641SerTrp: 0.641 ± 0.054
2.731SerTyr: 2.731 ± 0.125
0.0SerXaa: 0.0 ± 0.0
Thr
2.151ThrAla: 2.151 ± 0.118
0.244ThrCys: 0.244 ± 0.042
1.831ThrAsp: 1.831 ± 0.131
2.344ThrGlu: 2.344 ± 0.121
2.594ThrPhe: 2.594 ± 0.122
2.339ThrGly: 2.339 ± 0.128
0.666ThrHis: 0.666 ± 0.063
5.268ThrIle: 5.268 ± 0.198
5.426ThrLys: 5.426 ± 0.162
4.806ThrLeu: 4.806 ± 0.164
0.727ThrMet: 0.727 ± 0.062
3.809ThrAsn: 3.809 ± 0.138
1.378ThrPro: 1.378 ± 0.1
1.2ThrGln: 1.2 ± 0.088
1.515ThrArg: 1.515 ± 0.092
3.163ThrSer: 3.163 ± 0.14
2.787ThrThr: 2.787 ± 0.146
2.171ThrVal: 2.171 ± 0.117
0.381ThrTrp: 0.381 ± 0.046
1.927ThrTyr: 1.927 ± 0.114
0.0ThrXaa: 0.0 ± 0.0
Val
3.346ValAla: 3.346 ± 0.141
0.397ValCys: 0.397 ± 0.049
3.239ValAsp: 3.239 ± 0.141
3.687ValGlu: 3.687 ± 0.15
2.726ValPhe: 2.726 ± 0.12
2.538ValGly: 2.538 ± 0.135
0.625ValHis: 0.625 ± 0.054
4.541ValIle: 4.541 ± 0.175
4.429ValLys: 4.429 ± 0.203
4.862ValLeu: 4.862 ± 0.169
0.671ValMet: 0.671 ± 0.057
3.509ValAsn: 3.509 ± 0.149
1.337ValPro: 1.337 ± 0.092
1.317ValGln: 1.317 ± 0.082
1.383ValArg: 1.383 ± 0.095
3.494ValSer: 3.494 ± 0.135
2.273ValThr: 2.273 ± 0.114
3.087ValVal: 3.087 ± 0.148
0.412ValTrp: 0.412 ± 0.045
2.232ValTyr: 2.232 ± 0.124
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.056
0.071TrpCys: 0.071 ± 0.025
0.437TrpAsp: 0.437 ± 0.044
0.458TrpGlu: 0.458 ± 0.052
0.427TrpPhe: 0.427 ± 0.052
0.366TrpGly: 0.366 ± 0.047
0.122TrpHis: 0.122 ± 0.027
0.92TrpIle: 0.92 ± 0.079
0.9TrpLys: 0.9 ± 0.071
0.681TrpLeu: 0.681 ± 0.063
0.295TrpMet: 0.295 ± 0.044
0.814TrpAsn: 0.814 ± 0.078
0.214TrpPro: 0.214 ± 0.034
0.178TrpGln: 0.178 ± 0.028
0.27TrpArg: 0.27 ± 0.033
0.468TrpSer: 0.468 ± 0.047
0.524TrpThr: 0.524 ± 0.051
0.458TrpVal: 0.458 ± 0.046
0.051TrpTrp: 0.051 ± 0.015
0.412TrpTyr: 0.412 ± 0.053
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.963TyrAla: 1.963 ± 0.107
0.341TyrCys: 0.341 ± 0.044
2.416TyrAsp: 2.416 ± 0.117
2.858TyrGlu: 2.858 ± 0.116
2.431TyrPhe: 2.431 ± 0.141
2.126TyrGly: 2.126 ± 0.126
0.549TyrHis: 0.549 ± 0.059
3.809TyrIle: 3.809 ± 0.138
4.028TyrLys: 4.028 ± 0.141
4.592TyrLeu: 4.592 ± 0.157
0.559TyrMet: 0.559 ± 0.051
3.127TyrAsn: 3.127 ± 0.161
1.022TyrPro: 1.022 ± 0.072
1.363TyrGln: 1.363 ± 0.076
1.337TyrArg: 1.337 ± 0.093
2.98TyrSer: 2.98 ± 0.145
1.841TyrThr: 1.841 ± 0.099
1.999TyrVal: 1.999 ± 0.108
0.615TyrTrp: 0.615 ± 0.07
1.897TyrTyr: 1.897 ± 0.121
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 529 proteins (196644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski