Amino acid dipepetide frequency for Candidatus Synechococcus spongiarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.714AlaAla: 13.714 ± 0.256
1.412AlaCys: 1.412 ± 0.061
5.056AlaAsp: 5.056 ± 0.115
5.273AlaGlu: 5.273 ± 0.127
2.859AlaPhe: 2.859 ± 0.093
8.269AlaGly: 8.269 ± 0.162
2.248AlaHis: 2.248 ± 0.078
4.047AlaIle: 4.047 ± 0.09
2.661AlaLys: 2.661 ± 0.096
13.54AlaLeu: 13.54 ± 0.209
3.285AlaMet: 3.285 ± 0.084
2.323AlaAsn: 2.323 ± 0.079
5.026AlaPro: 5.026 ± 0.116
4.867AlaGln: 4.867 ± 0.127
6.911AlaArg: 6.911 ± 0.136
5.671AlaSer: 5.671 ± 0.135
5.697AlaThr: 5.697 ± 0.13
9.059AlaVal: 9.059 ± 0.155
1.596AlaTrp: 1.596 ± 0.062
1.908AlaTyr: 1.908 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.932CysAla: 0.932 ± 0.049
0.389CysCys: 0.389 ± 0.03
0.657CysAsp: 0.657 ± 0.038
0.524CysGlu: 0.524 ± 0.033
0.562CysPhe: 0.562 ± 0.036
1.48CysGly: 1.48 ± 0.068
0.443CysHis: 0.443 ± 0.034
0.527CysIle: 0.527 ± 0.037
0.352CysLys: 0.352 ± 0.026
1.685CysLeu: 1.685 ± 0.064
0.24CysMet: 0.24 ± 0.027
0.363CysAsn: 0.363 ± 0.03
0.932CysPro: 0.932 ± 0.045
0.627CysGln: 0.627 ± 0.04
1.284CysArg: 1.284 ± 0.06
0.846CysSer: 0.846 ± 0.044
0.666CysThr: 0.666 ± 0.033
0.713CysVal: 0.713 ± 0.045
0.377CysTrp: 0.377 ± 0.028
0.291CysTyr: 0.291 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.59AspAla: 4.59 ± 0.12
0.673AspCys: 0.673 ± 0.039
2.288AspAsp: 2.288 ± 0.074
2.53AspGlu: 2.53 ± 0.088
1.647AspPhe: 1.647 ± 0.069
4.504AspGly: 4.504 ± 0.105
1.715AspHis: 1.715 ± 0.063
1.605AspIle: 1.605 ± 0.071
1.205AspLys: 1.205 ± 0.074
6.631AspLeu: 6.631 ± 0.134
0.918AspMet: 0.918 ± 0.051
1.312AspAsn: 1.312 ± 0.058
3.623AspPro: 3.623 ± 0.086
2.705AspGln: 2.705 ± 0.068
3.535AspArg: 3.535 ± 0.097
2.391AspSer: 2.391 ± 0.077
2.244AspThr: 2.244 ± 0.083
3.612AspVal: 3.612 ± 0.102
0.969AspTrp: 0.969 ± 0.054
1.191AspTyr: 1.191 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
6.592GluAla: 6.592 ± 0.138
0.417GluCys: 0.417 ± 0.029
2.996GluAsp: 2.996 ± 0.09
3.346GluGlu: 3.346 ± 0.1
1.279GluPhe: 1.279 ± 0.065
3.705GluGly: 3.705 ± 0.092
1.279GluHis: 1.279 ± 0.064
2.106GluIle: 2.106 ± 0.083
1.624GluLys: 1.624 ± 0.08
6.356GluLeu: 6.356 ± 0.148
1.037GluMet: 1.037 ± 0.042
1.104GluAsn: 1.104 ± 0.041
2.808GluPro: 2.808 ± 0.081
3.386GluGln: 3.386 ± 0.101
4.784GluArg: 4.784 ± 0.103
2.286GluSer: 2.286 ± 0.077
2.784GluThr: 2.784 ± 0.09
3.53GluVal: 3.53 ± 0.102
0.55GluTrp: 0.55 ± 0.038
0.65GluTyr: 0.65 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.034PheAla: 3.034 ± 0.091
0.624PheCys: 0.624 ± 0.037
1.794PheAsp: 1.794 ± 0.071
1.244PheGlu: 1.244 ± 0.054
1.016PhePhe: 1.016 ± 0.059
2.584PheGly: 2.584 ± 0.092
0.804PheHis: 0.804 ± 0.044
1.172PheIle: 1.172 ± 0.053
0.778PheLys: 0.778 ± 0.043
3.285PheLeu: 3.285 ± 0.099
0.578PheMet: 0.578 ± 0.044
0.969PheAsn: 0.969 ± 0.049
1.533PhePro: 1.533 ± 0.053
1.335PheGln: 1.335 ± 0.059
2.004PheArg: 2.004 ± 0.078
2.123PheSer: 2.123 ± 0.065
1.755PheThr: 1.755 ± 0.066
1.922PheVal: 1.922 ± 0.073
0.531PheTrp: 0.531 ± 0.038
0.785PheTyr: 0.785 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.538GlyAla: 7.538 ± 0.153
1.463GlyCys: 1.463 ± 0.066
4.105GlyAsp: 4.105 ± 0.101
4.467GlyGlu: 4.467 ± 0.109
3.125GlyPhe: 3.125 ± 0.097
6.603GlyGly: 6.603 ± 0.169
2.272GlyHis: 2.272 ± 0.083
3.695GlyIle: 3.695 ± 0.097
2.554GlyLys: 2.554 ± 0.084
10.557GlyLeu: 10.557 ± 0.194
2.036GlyMet: 2.036 ± 0.079
2.069GlyAsn: 2.069 ± 0.072
3.893GlyPro: 3.893 ± 0.105
4.387GlyGln: 4.387 ± 0.101
6.107GlyArg: 6.107 ± 0.124
4.867GlySer: 4.867 ± 0.097
3.886GlyThr: 3.886 ± 0.092
6.079GlyVal: 6.079 ± 0.106
1.68GlyTrp: 1.68 ± 0.074
1.904GlyTyr: 1.904 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.836HisAla: 1.836 ± 0.065
0.557HisCys: 0.557 ± 0.04
1.053HisAsp: 1.053 ± 0.049
0.857HisGlu: 0.857 ± 0.042
0.829HisPhe: 0.829 ± 0.048
3.008HisGly: 3.008 ± 0.098
1.279HisHis: 1.279 ± 0.059
0.797HisIle: 0.797 ± 0.05
0.517HisLys: 0.517 ± 0.037
3.507HisLeu: 3.507 ± 0.095
0.45HisMet: 0.45 ± 0.035
0.69HisAsn: 0.69 ± 0.042
1.946HisPro: 1.946 ± 0.065
1.54HisGln: 1.54 ± 0.059
2.144HisArg: 2.144 ± 0.072
1.261HisSer: 1.261 ± 0.054
1.116HisThr: 1.116 ± 0.057
1.685HisVal: 1.685 ± 0.064
0.694HisTrp: 0.694 ± 0.048
0.58HisTyr: 0.58 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
3.828IleAla: 3.828 ± 0.097
0.624IleCys: 0.624 ± 0.039
1.994IleAsp: 1.994 ± 0.075
1.929IleGlu: 1.929 ± 0.074
1.13IlePhe: 1.13 ± 0.059
3.271IleGly: 3.271 ± 0.096
1.2IleHis: 1.2 ± 0.06
1.354IleIle: 1.354 ± 0.064
1.111IleLys: 1.111 ± 0.053
3.854IleLeu: 3.854 ± 0.108
0.522IleMet: 0.522 ± 0.037
1.496IleAsn: 1.496 ± 0.065
2.509IlePro: 2.509 ± 0.099
1.654IleGln: 1.654 ± 0.062
2.966IleArg: 2.966 ± 0.084
2.474IleSer: 2.474 ± 0.081
2.388IleThr: 2.388 ± 0.073
2.365IleVal: 2.365 ± 0.081
0.552IleTrp: 0.552 ± 0.038
0.906IleTyr: 0.906 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.248LysAla: 3.248 ± 0.092
0.179LysCys: 0.179 ± 0.019
1.473LysAsp: 1.473 ± 0.071
1.459LysGlu: 1.459 ± 0.064
0.557LysPhe: 0.557 ± 0.038
1.957LysGly: 1.957 ± 0.074
0.594LysHis: 0.594 ± 0.036
0.997LysIle: 0.997 ± 0.063
0.829LysLys: 0.829 ± 0.053
3.05LysLeu: 3.05 ± 0.099
0.422LysMet: 0.422 ± 0.033
0.671LysAsn: 0.671 ± 0.042
1.566LysPro: 1.566 ± 0.068
1.193LysGln: 1.193 ± 0.054
2.064LysArg: 2.064 ± 0.074
1.372LysSer: 1.372 ± 0.062
1.741LysThr: 1.741 ± 0.07
1.988LysVal: 1.988 ± 0.087
0.193LysTrp: 0.193 ± 0.02
0.424LysTyr: 0.424 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
14.714LeuAla: 14.714 ± 0.243
1.487LeuCys: 1.487 ± 0.059
6.158LeuAsp: 6.158 ± 0.138
7.677LeuGlu: 7.677 ± 0.145
3.157LeuPhe: 3.157 ± 0.107
9.863LeuGly: 9.863 ± 0.173
3.155LeuHis: 3.155 ± 0.095
4.099LeuIle: 4.099 ± 0.104
3.49LeuLys: 3.49 ± 0.099
15.746LeuLeu: 15.746 ± 0.282
2.491LeuMet: 2.491 ± 0.087
3.166LeuAsn: 3.166 ± 0.084
7.221LeuPro: 7.221 ± 0.152
6.505LeuGln: 6.505 ± 0.154
9.204LeuArg: 9.204 ± 0.155
6.957LeuSer: 6.957 ± 0.124
5.872LeuThr: 5.872 ± 0.114
9.576LeuVal: 9.576 ± 0.18
1.899LeuTrp: 1.899 ± 0.086
1.796LeuTyr: 1.796 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
3.863MetAla: 3.863 ± 0.092
0.144MetCys: 0.144 ± 0.019
1.4MetAsp: 1.4 ± 0.062
1.484MetGlu: 1.484 ± 0.061
0.454MetPhe: 0.454 ± 0.034
2.391MetGly: 2.391 ± 0.077
0.37MetHis: 0.37 ± 0.035
0.832MetIle: 0.832 ± 0.049
0.617MetLys: 0.617 ± 0.04
1.876MetLeu: 1.876 ± 0.071
0.361MetMet: 0.361 ± 0.03
0.538MetAsn: 0.538 ± 0.038
1.23MetPro: 1.23 ± 0.054
0.629MetGln: 0.629 ± 0.037
1.086MetArg: 1.086 ± 0.055
1.025MetSer: 1.025 ± 0.049
1.3MetThr: 1.3 ± 0.058
2.211MetVal: 2.211 ± 0.075
0.105MetTrp: 0.105 ± 0.018
0.189MetTyr: 0.189 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.09AsnAla: 2.09 ± 0.073
0.366AsnCys: 0.366 ± 0.029
1.109AsnAsp: 1.109 ± 0.056
0.932AsnGlu: 0.932 ± 0.05
0.755AsnPhe: 0.755 ± 0.044
2.181AsnGly: 2.181 ± 0.073
0.725AsnHis: 0.725 ± 0.04
0.906AsnIle: 0.906 ± 0.05
0.662AsnLys: 0.662 ± 0.048
3.164AsnLeu: 3.164 ± 0.09
0.475AsnMet: 0.475 ± 0.034
0.792AsnAsn: 0.792 ± 0.047
2.046AsnPro: 2.046 ± 0.082
1.214AsnGln: 1.214 ± 0.057
2.062AsnArg: 2.062 ± 0.085
1.449AsnSer: 1.449 ± 0.055
1.307AsnThr: 1.307 ± 0.059
1.582AsnVal: 1.582 ± 0.06
0.468AsnTrp: 0.468 ± 0.035
0.508AsnTyr: 0.508 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
5.524ProAla: 5.524 ± 0.13
0.79ProCys: 0.79 ± 0.045
3.243ProAsp: 3.243 ± 0.081
3.749ProGlu: 3.749 ± 0.097
1.71ProPhe: 1.71 ± 0.065
5.236ProGly: 5.236 ± 0.099
1.675ProHis: 1.675 ± 0.063
1.878ProIle: 1.878 ± 0.067
1.228ProLys: 1.228 ± 0.055
7.09ProLeu: 7.09 ± 0.156
1.591ProMet: 1.591 ± 0.063
1.219ProAsn: 1.219 ± 0.051
3.754ProPro: 3.754 ± 0.101
3.129ProGln: 3.129 ± 0.09
3.702ProArg: 3.702 ± 0.105
3.416ProSer: 3.416 ± 0.093
2.992ProThr: 2.992 ± 0.074
4.359ProVal: 4.359 ± 0.1
1.335ProTrp: 1.335 ± 0.057
1.142ProTyr: 1.142 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
6.121GlnAla: 6.121 ± 0.137
0.454GlnCys: 0.454 ± 0.033
2.498GlnAsp: 2.498 ± 0.072
3.106GlnGlu: 3.106 ± 0.087
1.17GlnPhe: 1.17 ± 0.047
4.119GlnGly: 4.119 ± 0.101
1.172GlnHis: 1.172 ± 0.058
1.494GlnIle: 1.494 ± 0.058
1.23GlnLys: 1.23 ± 0.051
6.797GlnLeu: 6.797 ± 0.158
0.848GlnMet: 0.848 ± 0.038
0.881GlnAsn: 0.881 ± 0.048
3.56GlnPro: 3.56 ± 0.098
4.024GlnGln: 4.024 ± 0.125
5.091GlnArg: 5.091 ± 0.115
2.176GlnSer: 2.176 ± 0.072
1.992GlnThr: 1.992 ± 0.067
4.38GlnVal: 4.38 ± 0.104
0.846GlnTrp: 0.846 ± 0.044
0.538GlnTyr: 0.538 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
5.592ArgAla: 5.592 ± 0.128
1.358ArgCys: 1.358 ± 0.063
3.448ArgAsp: 3.448 ± 0.092
3.584ArgGlu: 3.584 ± 0.092
2.689ArgPhe: 2.689 ± 0.078
5.007ArgGly: 5.007 ± 0.115
2.495ArgHis: 2.495 ± 0.088
3.334ArgIle: 3.334 ± 0.099
1.925ArgLys: 1.925 ± 0.075
10.506ArgLeu: 10.506 ± 0.175
1.538ArgMet: 1.538 ± 0.064
1.906ArgAsn: 1.906 ± 0.069
3.928ArgPro: 3.928 ± 0.094
5.734ArgGln: 5.734 ± 0.126
7.046ArgArg: 7.046 ± 0.146
4.383ArgSer: 4.383 ± 0.106
3.346ArgThr: 3.346 ± 0.09
4.297ArgVal: 4.297 ± 0.116
1.748ArgTrp: 1.748 ± 0.069
1.738ArgTyr: 1.738 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.846SerAla: 4.846 ± 0.105
0.741SerCys: 0.741 ± 0.045
2.449SerAsp: 2.449 ± 0.068
2.307SerGlu: 2.307 ± 0.075
1.883SerPhe: 1.883 ± 0.067
5.368SerGly: 5.368 ± 0.11
1.435SerHis: 1.435 ± 0.062
2.181SerIle: 2.181 ± 0.078
1.326SerLys: 1.326 ± 0.062
6.871SerLeu: 6.871 ± 0.152
1.286SerMet: 1.286 ± 0.054
1.393SerAsn: 1.393 ± 0.065
3.817SerPro: 3.817 ± 0.105
2.684SerGln: 2.684 ± 0.088
4.539SerArg: 4.539 ± 0.101
3.728SerSer: 3.728 ± 0.119
3.034SerThr: 3.034 ± 0.083
3.404SerVal: 3.404 ± 0.104
1.03SerTrp: 1.03 ± 0.059
1.114SerTyr: 1.114 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.067ThrAla: 6.067 ± 0.132
0.659ThrCys: 0.659 ± 0.037
2.36ThrAsp: 2.36 ± 0.074
2.16ThrGlu: 2.16 ± 0.077
1.466ThrPhe: 1.466 ± 0.049
4.585ThrGly: 4.585 ± 0.104
1.074ThrHis: 1.074 ± 0.054
2.405ThrIle: 2.405 ± 0.072
1.0ThrLys: 1.0 ± 0.051
5.545ThrLeu: 5.545 ± 0.123
1.689ThrMet: 1.689 ± 0.062
1.114ThrAsn: 1.114 ± 0.049
3.663ThrPro: 3.663 ± 0.096
1.682ThrGln: 1.682 ± 0.064
2.968ThrArg: 2.968 ± 0.093
2.973ThrSer: 2.973 ± 0.09
3.446ThrThr: 3.446 ± 0.104
4.378ThrVal: 4.378 ± 0.103
0.769ThrTrp: 0.769 ± 0.047
1.03ThrTyr: 1.03 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
8.474ValAla: 8.474 ± 0.158
0.909ValCys: 0.909 ± 0.046
4.031ValAsp: 4.031 ± 0.113
4.387ValGlu: 4.387 ± 0.103
2.442ValPhe: 2.442 ± 0.08
5.678ValGly: 5.678 ± 0.119
1.573ValHis: 1.573 ± 0.047
3.218ValIle: 3.218 ± 0.095
2.043ValLys: 2.043 ± 0.087
9.462ValLeu: 9.462 ± 0.185
1.666ValMet: 1.666 ± 0.061
1.892ValAsn: 1.892 ± 0.073
3.726ValPro: 3.726 ± 0.1
3.194ValGln: 3.194 ± 0.094
4.688ValArg: 4.688 ± 0.106
3.982ValSer: 3.982 ± 0.103
3.884ValThr: 3.884 ± 0.103
7.277ValVal: 7.277 ± 0.142
0.869ValTrp: 0.869 ± 0.05
1.16ValTyr: 1.16 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.184TrpAla: 1.184 ± 0.054
0.305TrpCys: 0.305 ± 0.027
0.722TrpAsp: 0.722 ± 0.047
0.68TrpGlu: 0.68 ± 0.038
0.566TrpPhe: 0.566 ± 0.035
1.2TrpGly: 1.2 ± 0.057
0.41TrpHis: 0.41 ± 0.032
0.757TrpIle: 0.757 ± 0.043
0.331TrpLys: 0.331 ± 0.027
2.794TrpLeu: 2.794 ± 0.105
0.329TrpMet: 0.329 ± 0.027
0.384TrpAsn: 0.384 ± 0.032
0.988TrpPro: 0.988 ± 0.057
1.167TrpGln: 1.167 ± 0.055
1.703TrpArg: 1.703 ± 0.089
1.06TrpSer: 1.06 ± 0.048
0.769TrpThr: 0.769 ± 0.048
0.955TrpVal: 0.955 ± 0.048
0.37TrpTrp: 0.37 ± 0.038
0.266TrpTyr: 0.266 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.636TyrAla: 1.636 ± 0.059
0.336TyrCys: 0.336 ± 0.03
1.051TyrAsp: 1.051 ± 0.051
0.923TyrGlu: 0.923 ± 0.05
0.576TyrPhe: 0.576 ± 0.038
2.279TyrGly: 2.279 ± 0.072
0.426TyrHis: 0.426 ± 0.03
0.727TyrIle: 0.727 ± 0.044
0.494TyrLys: 0.494 ± 0.039
1.92TyrLeu: 1.92 ± 0.07
0.343TyrMet: 0.343 ± 0.031
0.51TyrAsn: 0.51 ± 0.037
0.995TyrPro: 0.995 ± 0.046
0.839TyrGln: 0.839 ± 0.045
1.715TyrArg: 1.715 ± 0.073
0.995TyrSer: 0.995 ± 0.052
0.816TyrThr: 0.816 ± 0.043
1.184TyrVal: 1.184 ± 0.058
0.359TyrTrp: 0.359 ± 0.031
0.48TyrTyr: 0.48 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1661 proteins (429182 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski