Amino acid dipepetide frequency for Schistosoma haematobium (Blood fluke)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.292AlaAla: 3.292 ± 0.041	1.02AlaCys: 1.02 ± 0.016	2.241AlaAsp: 2.241 ± 0.025	2.503AlaGlu: 2.503 ± 0.028	2.001AlaPhe: 2.001 ± 0.023	2.092AlaGly: 2.092 ± 0.032	1.035AlaHis: 1.035 ± 0.013	2.831AlaIle: 2.831 ± 0.025	2.401AlaLys: 2.401 ± 0.028	4.497AlaLeu: 4.497 ± 0.035	0.934AlaMet: 0.934 ± 0.014	2.47AlaAsn: 2.47 ± 0.024	1.77AlaPro: 1.77 ± 0.021	1.649AlaGln: 1.649 ± 0.02	2.355AlaArg: 2.355 ± 0.024	4.142AlaSer: 4.142 ± 0.033	2.797AlaThr: 2.797 ± 0.027	2.932AlaVal: 2.932 ± 0.029	0.466AlaTrp: 0.466 ± 0.011	1.588AlaTyr: 1.588 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.015	0.565CysCys: 0.565 ± 0.013	1.158CysAsp: 1.158 ± 0.018	1.122CysGlu: 1.122 ± 0.016	0.937CysPhe: 0.937 ± 0.014	1.076CysGly: 1.076 ± 0.015	0.641CysHis: 0.641 ± 0.013	1.572CysIle: 1.572 ± 0.019	1.143CysLys: 1.143 ± 0.019	2.541CysLeu: 2.541 ± 0.028	0.378CysMet: 0.378 ± 0.008	1.196CysAsn: 1.196 ± 0.017	1.078CysPro: 1.078 ± 0.019	0.913CysGln: 0.913 ± 0.015	1.159CysArg: 1.159 ± 0.016	2.175CysSer: 2.175 ± 0.024	1.255CysThr: 1.255 ± 0.017	1.13CysVal: 1.13 ± 0.016	0.265CysTrp: 0.265 ± 0.006	0.649CysTyr: 0.649 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	2.161AspAla: 2.161 ± 0.025	1.075AspCys: 1.075 ± 0.014	3.921AspAsp: 3.921 ± 0.054	3.573AspGlu: 3.573 ± 0.034	2.028AspPhe: 2.028 ± 0.019	2.514AspGly: 2.514 ± 0.057	1.656AspHis: 1.656 ± 0.023	3.584AspIle: 3.584 ± 0.023	2.827AspLys: 2.827 ± 0.025	4.994AspLeu: 4.994 ± 0.031	0.993AspMet: 0.993 ± 0.013	3.676AspAsn: 3.676 ± 0.036	2.194AspPro: 2.194 ± 0.02	2.014AspGln: 2.014 ± 0.019	2.42AspArg: 2.42 ± 0.024	4.682AspSer: 4.682 ± 0.034	2.617AspThr: 2.617 ± 0.02	2.943AspVal: 2.943 ± 0.026	0.654AspTrp: 0.654 ± 0.012	1.87AspTyr: 1.87 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	2.788GluAla: 2.788 ± 0.033	1.076GluCys: 1.076 ± 0.018	2.858GluAsp: 2.858 ± 0.038	3.801GluGlu: 3.801 ± 0.043	2.193GluPhe: 2.193 ± 0.021	1.816GluGly: 1.816 ± 0.023	1.419GluHis: 1.419 ± 0.018	3.666GluIle: 3.666 ± 0.028	3.669GluLys: 3.669 ± 0.042	5.699GluLeu: 5.699 ± 0.047	1.206GluMet: 1.206 ± 0.017	3.815GluAsn: 3.815 ± 0.033	1.721GluPro: 1.721 ± 0.025	2.493GluGln: 2.493 ± 0.025	2.757GluArg: 2.757 ± 0.032	4.525GluSer: 4.525 ± 0.034	3.258GluThr: 3.258 ± 0.025	2.903GluVal: 2.903 ± 0.027	0.569GluTrp: 0.569 ± 0.011	1.826GluTyr: 1.826 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	1.718PheAla: 1.718 ± 0.022	0.872PheCys: 0.872 ± 0.015	2.17PheAsp: 2.17 ± 0.024	1.898PheGlu: 1.898 ± 0.021	1.373PhePhe: 1.373 ± 0.018	2.016PheGly: 2.016 ± 0.024	1.227PheHis: 1.227 ± 0.016	2.909PheIle: 2.909 ± 0.029	1.99PheLys: 1.99 ± 0.019	3.657PheLeu: 3.657 ± 0.029	0.784PheMet: 0.784 ± 0.012	2.651PheAsn: 2.651 ± 0.025	1.747PhePro: 1.747 ± 0.019	1.562PheGln: 1.562 ± 0.017	1.922PheArg: 1.922 ± 0.02	3.706PheSer: 3.706 ± 0.033	2.587PheThr: 2.587 ± 0.022	2.231PheVal: 2.231 ± 0.023	0.419PheTrp: 0.419 ± 0.01	1.373PheTyr: 1.373 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	1.911GlyAla: 1.911 ± 0.027	1.043GlyCys: 1.043 ± 0.017	2.267GlyAsp: 2.267 ± 0.043	2.218GlyGlu: 2.218 ± 0.046	1.909GlyPhe: 1.909 ± 0.024	2.636GlyGly: 2.636 ± 0.038	1.317GlyHis: 1.317 ± 0.016	3.0GlyIle: 3.0 ± 0.039	2.421GlyLys: 2.421 ± 0.028	4.409GlyLeu: 4.409 ± 0.044	0.839GlyMet: 0.839 ± 0.014	2.408GlyAsn: 2.408 ± 0.023	1.893GlyPro: 1.893 ± 0.053	1.77GlyGln: 1.77 ± 0.023	2.521GlyArg: 2.521 ± 0.031	4.188GlySer: 4.188 ± 0.038	2.419GlyThr: 2.419 ± 0.023	2.71GlyVal: 2.71 ± 0.028	0.599GlyTrp: 0.599 ± 0.012	1.568GlyTyr: 1.568 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	0.996HisAla: 0.996 ± 0.013	0.707HisCys: 0.707 ± 0.012	1.319HisAsp: 1.319 ± 0.016	1.425HisGlu: 1.425 ± 0.016	1.177HisPhe: 1.177 ± 0.015	1.227HisGly: 1.227 ± 0.016	1.59HisHis: 1.59 ± 0.032	1.874HisIle: 1.874 ± 0.019	1.512HisLys: 1.512 ± 0.021	3.186HisLeu: 3.186 ± 0.028	0.519HisMet: 0.519 ± 0.009	1.874HisAsn: 1.874 ± 0.025	1.375HisPro: 1.375 ± 0.018	1.473HisGln: 1.473 ± 0.018	1.752HisArg: 1.752 ± 0.024	3.019HisSer: 3.019 ± 0.035	1.595HisThr: 1.595 ± 0.016	1.505HisVal: 1.505 ± 0.017	0.363HisTrp: 0.363 ± 0.009	1.038HisTyr: 1.038 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	2.78IleAla: 2.78 ± 0.024	1.528IleCys: 1.528 ± 0.018	3.84IleAsp: 3.84 ± 0.032	3.514IleGlu: 3.514 ± 0.03	2.445IlePhe: 2.445 ± 0.023	2.968IleGly: 2.968 ± 0.028	2.2IleHis: 2.2 ± 0.022	4.535IleIle: 4.535 ± 0.044	3.76IleLys: 3.76 ± 0.033	5.968IleLeu: 5.968 ± 0.043	1.238IleMet: 1.238 ± 0.014	5.027IleAsn: 5.027 ± 0.05	3.421IlePro: 3.421 ± 0.037	3.097IleGln: 3.097 ± 0.026	3.261IleArg: 3.261 ± 0.026	6.431IleSer: 6.431 ± 0.038	4.261IleThr: 4.261 ± 0.035	3.31IleVal: 3.31 ± 0.028	0.733IleTrp: 0.733 ± 0.013	2.224IleTyr: 2.224 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.703LysAla: 2.703 ± 0.026	1.327LysCys: 1.327 ± 0.019	2.557LysAsp: 2.557 ± 0.022	3.291LysGlu: 3.291 ± 0.033	2.075LysPhe: 2.075 ± 0.019	1.893LysGly: 1.893 ± 0.04	1.772LysHis: 1.772 ± 0.021	3.46LysIle: 3.46 ± 0.029	3.542LysLys: 3.542 ± 0.037	5.988LysLeu: 5.988 ± 0.043	1.192LysMet: 1.192 ± 0.014	3.303LysAsn: 3.303 ± 0.03	2.575LysPro: 2.575 ± 0.028	2.952LysGln: 2.952 ± 0.027	3.426LysArg: 3.426 ± 0.029	5.746LysSer: 5.746 ± 0.038	3.407LysThr: 3.407 ± 0.027	2.691LysVal: 2.691 ± 0.027	0.591LysTrp: 0.591 ± 0.011	2.017LysTyr: 2.017 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	4.793LeuAla: 4.793 ± 0.034	2.17LeuCys: 2.17 ± 0.026	4.786LeuAsp: 4.786 ± 0.027	5.042LeuGlu: 5.042 ± 0.049	4.061LeuPhe: 4.061 ± 0.035	3.944LeuGly: 3.944 ± 0.031	2.746LeuHis: 2.746 ± 0.021	6.475LeuIle: 6.475 ± 0.047	5.878LeuLys: 5.878 ± 0.038	10.176LeuLeu: 10.176 ± 0.059	1.915LeuMet: 1.915 ± 0.019	6.53LeuAsn: 6.53 ± 0.055	5.147LeuPro: 5.147 ± 0.036	4.063LeuGln: 4.063 ± 0.03	5.308LeuArg: 5.308 ± 0.04	10.003LeuSer: 10.003 ± 0.06	6.122LeuThr: 6.122 ± 0.037	4.907LeuVal: 4.907 ± 0.037	1.062LeuTrp: 1.062 ± 0.017	2.944LeuTyr: 2.944 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	0.974MetAla: 0.974 ± 0.015	0.365MetCys: 0.365 ± 0.009	1.101MetAsp: 1.101 ± 0.014	1.194MetGlu: 1.194 ± 0.015	0.763MetPhe: 0.763 ± 0.012	0.774MetGly: 0.774 ± 0.013	0.477MetHis: 0.477 ± 0.01	1.309MetIle: 1.309 ± 0.018	1.506MetLys: 1.506 ± 0.019	1.762MetLeu: 1.762 ± 0.017	0.536MetMet: 0.536 ± 0.017	1.822MetAsn: 1.822 ± 0.024	0.826MetPro: 0.826 ± 0.012	0.723MetGln: 0.723 ± 0.011	0.903MetArg: 0.903 ± 0.013	1.698MetSer: 1.698 ± 0.018	1.156MetThr: 1.156 ± 0.013	0.969MetVal: 0.969 ± 0.015	0.171MetTrp: 0.171 ± 0.005	0.559MetTyr: 0.559 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.514AsnAla: 2.514 ± 0.026	1.353AsnCys: 1.353 ± 0.018	4.175AsnAsp: 4.175 ± 0.039	4.106AsnGlu: 4.106 ± 0.038	2.287AsnPhe: 2.287 ± 0.023	2.839AsnGly: 2.839 ± 0.03	2.292AsnHis: 2.292 ± 0.028	4.566AsnIle: 4.566 ± 0.04	3.91AsnLys: 3.91 ± 0.035	5.97AsnLeu: 5.97 ± 0.042	1.211AsnMet: 1.211 ± 0.019	8.531AsnAsn: 8.531 ± 0.151	2.868AsnPro: 2.868 ± 0.026	3.304AsnGln: 3.304 ± 0.029	2.915AsnArg: 2.915 ± 0.023	7.283AsnSer: 7.283 ± 0.066	4.379AsnThr: 4.379 ± 0.045	3.355AsnVal: 3.355 ± 0.027	0.633AsnTrp: 0.633 ± 0.011	2.384AsnTyr: 2.384 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	1.775ProAla: 1.775 ± 0.02	0.936ProCys: 0.936 ± 0.015	2.293ProAsp: 2.293 ± 0.029	2.406ProGlu: 2.406 ± 0.021	1.745ProPhe: 1.745 ± 0.019	2.319ProGly: 2.319 ± 0.071	1.143ProHis: 1.143 ± 0.014	3.305ProIle: 3.305 ± 0.032	2.314ProLys: 2.314 ± 0.025	4.101ProLeu: 4.101 ± 0.029	0.818ProMet: 0.818 ± 0.013	2.936ProAsn: 2.936 ± 0.027	2.958ProPro: 2.958 ± 0.043	1.637ProGln: 1.637 ± 0.018	2.029ProArg: 2.029 ± 0.021	4.88ProSer: 4.88 ± 0.037	3.207ProThr: 3.207 ± 0.03	2.951ProVal: 2.951 ± 0.028	0.41ProTrp: 0.41 ± 0.01	1.475ProTyr: 1.475 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	1.838GlnAla: 1.838 ± 0.025	0.951GlnCys: 0.951 ± 0.015	1.553GlnAsp: 1.553 ± 0.017	1.921GlnGlu: 1.921 ± 0.023	1.714GlnPhe: 1.714 ± 0.018	1.298GlnGly: 1.298 ± 0.023	1.355GlnHis: 1.355 ± 0.018	2.898GlnIle: 2.898 ± 0.022	2.307GlnLys: 2.307 ± 0.023	5.101GlnLeu: 5.101 ± 0.041	0.957GlnMet: 0.957 ± 0.015	2.743GlnAsn: 2.743 ± 0.027	1.957GlnPro: 1.957 ± 0.026	2.904GlnGln: 2.904 ± 0.05	2.186GlnArg: 2.186 ± 0.02	4.4GlnSer: 4.4 ± 0.034	2.637GlnThr: 2.637 ± 0.023	1.929GlnVal: 1.929 ± 0.018	0.534GlnTrp: 0.534 ± 0.01	1.421GlnTyr: 1.421 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	2.28ArgAla: 2.28 ± 0.024	1.123ArgCys: 1.123 ± 0.02	2.166ArgAsp: 2.166 ± 0.026	2.542ArgGlu: 2.542 ± 0.027	2.125ArgPhe: 2.125 ± 0.021	2.116ArgGly: 2.116 ± 0.031	1.55ArgHis: 1.55 ± 0.02	3.476ArgIle: 3.476 ± 0.027	3.349ArgLys: 3.349 ± 0.033	5.87ArgLeu: 5.87 ± 0.041	1.047ArgMet: 1.047 ± 0.015	2.969ArgAsn: 2.969 ± 0.026	2.201ArgPro: 2.201 ± 0.023	2.283ArgGln: 2.283 ± 0.022	3.931ArgArg: 3.931 ± 0.042	4.494ArgSer: 4.494 ± 0.039	2.751ArgThr: 2.751 ± 0.027	2.628ArgVal: 2.628 ± 0.032	0.666ArgTrp: 0.666 ± 0.012	1.633ArgTyr: 1.633 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	4.079SerAla: 4.079 ± 0.03	2.083SerCys: 2.083 ± 0.025	5.15SerAsp: 5.15 ± 0.037	4.931SerGlu: 4.931 ± 0.034	3.577SerPhe: 3.577 ± 0.028	4.752SerGly: 4.752 ± 0.041	2.683SerHis: 2.683 ± 0.028	6.536SerIle: 6.536 ± 0.043	5.234SerLys: 5.234 ± 0.037	9.163SerLeu: 9.163 ± 0.049	1.948SerMet: 1.948 ± 0.021	7.612SerAsn: 7.612 ± 0.074	4.615SerPro: 4.615 ± 0.041	3.817SerGln: 3.817 ± 0.033	4.524SerArg: 4.524 ± 0.04	14.724SerSer: 14.724 ± 0.409	7.162SerThr: 7.162 ± 0.058	5.792SerVal: 5.792 ± 0.044	0.909SerTrp: 0.909 ± 0.013	2.757SerTyr: 2.757 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	2.892ThrAla: 2.892 ± 0.024	1.303ThrCys: 1.303 ± 0.017	3.375ThrAsp: 3.375 ± 0.028	3.294ThrGlu: 3.294 ± 0.026	2.233ThrPhe: 2.233 ± 0.023	2.996ThrGly: 2.996 ± 0.032	1.501ThrHis: 1.501 ± 0.02	4.242ThrIle: 4.242 ± 0.033	3.273ThrLys: 3.273 ± 0.022	5.407ThrLeu: 5.407 ± 0.032	1.242ThrMet: 1.242 ± 0.015	4.972ThrAsn: 4.972 ± 0.044	2.899ThrPro: 2.899 ± 0.025	2.081ThrGln: 2.081 ± 0.021	2.604ThrArg: 2.604 ± 0.024	6.956ThrSer: 6.956 ± 0.058	6.566ThrThr: 6.566 ± 0.122	3.623ThrVal: 3.623 ± 0.03	0.668ThrTrp: 0.668 ± 0.011	1.823ThrTyr: 1.823 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	2.674ValAla: 2.674 ± 0.027	1.323ValCys: 1.323 ± 0.018	3.175ValAsp: 3.175 ± 0.026	2.955ValGlu: 2.955 ± 0.03	2.193ValPhe: 2.193 ± 0.02	2.679ValGly: 2.679 ± 0.029	1.523ValHis: 1.523 ± 0.018	3.366ValIle: 3.366 ± 0.025	3.117ValLys: 3.117 ± 0.028	4.95ValLeu: 4.95 ± 0.035	0.997ValMet: 0.997 ± 0.013	3.63ValAsn: 3.63 ± 0.027	2.34ValPro: 2.34 ± 0.027	2.104ValGln: 2.104 ± 0.021	2.767ValArg: 2.767 ± 0.03	4.959ValSer: 4.959 ± 0.039	3.341ValThr: 3.341 ± 0.025	3.338ValVal: 3.338 ± 0.036	0.574ValTrp: 0.574 ± 0.01	1.842ValTyr: 1.842 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.437TrpAla: 0.437 ± 0.01	0.27TrpCys: 0.27 ± 0.007	0.559TrpAsp: 0.559 ± 0.01	0.5TrpGlu: 0.5 ± 0.011	0.508TrpPhe: 0.508 ± 0.011	0.387TrpGly: 0.387 ± 0.009	0.289TrpHis: 0.289 ± 0.007	0.88TrpIle: 0.88 ± 0.015	0.737TrpLys: 0.737 ± 0.012	1.212TrpLeu: 1.212 ± 0.017	0.225TrpMet: 0.225 ± 0.007	0.724TrpAsn: 0.724 ± 0.013	0.534TrpPro: 0.534 ± 0.009	0.377TrpGln: 0.377 ± 0.009	0.686TrpArg: 0.686 ± 0.012	1.002TrpSer: 1.002 ± 0.016	0.581TrpThr: 0.581 ± 0.011	0.425TrpVal: 0.425 ± 0.011	0.155TrpTrp: 0.155 ± 0.005	0.337TrpTyr: 0.337 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.476TyrAla: 1.476 ± 0.017	0.796TyrCys: 0.796 ± 0.012	1.733TyrAsp: 1.733 ± 0.02	1.822TyrGlu: 1.822 ± 0.022	1.468TyrPhe: 1.468 ± 0.019	1.705TyrGly: 1.705 ± 0.022	1.11TyrHis: 1.11 ± 0.015	2.056TyrIle: 2.056 ± 0.026	1.62TyrLys: 1.62 ± 0.019	3.422TyrLeu: 3.422 ± 0.032	0.605TyrMet: 0.605 ± 0.013	1.99TyrAsn: 1.99 ± 0.024	1.518TyrPro: 1.518 ± 0.018	1.388TyrGln: 1.388 ± 0.016	1.773TyrArg: 1.773 ± 0.019	3.032TyrSer: 3.032 ± 0.027	1.855TyrThr: 1.855 ± 0.019	1.576TyrVal: 1.576 ± 0.019	0.384TyrTrp: 0.384 ± 0.008	1.233TyrTyr: 1.233 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 8963 proteins (5861687 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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