Amino acid dipepetide frequency for Litorimicrobium taeanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.931AlaAla: 15.931 ± 0.177	1.055AlaCys: 1.055 ± 0.034	6.919AlaAsp: 6.919 ± 0.083	7.722AlaGlu: 7.722 ± 0.084	4.195AlaPhe: 4.195 ± 0.065	10.009AlaGly: 10.009 ± 0.101	2.398AlaHis: 2.398 ± 0.044	5.764AlaIle: 5.764 ± 0.075	4.021AlaLys: 4.021 ± 0.075	13.7AlaLeu: 13.7 ± 0.15	3.707AlaMet: 3.707 ± 0.061	2.736AlaAsn: 2.736 ± 0.046	5.663AlaPro: 5.663 ± 0.096	4.879AlaGln: 4.879 ± 0.062	8.526AlaArg: 8.526 ± 0.108	5.371AlaSer: 5.371 ± 0.073	6.071AlaThr: 6.071 ± 0.072	8.2AlaVal: 8.2 ± 0.099	1.303AlaTrp: 1.303 ± 0.038	2.486AlaTyr: 2.486 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.031	0.108CysCys: 0.108 ± 0.011	0.627CysAsp: 0.627 ± 0.023	0.409CysGlu: 0.409 ± 0.023	0.352CysPhe: 0.352 ± 0.018	0.909CysGly: 0.909 ± 0.03	0.291CysHis: 0.291 ± 0.019	0.449CysIle: 0.449 ± 0.02	0.227CysLys: 0.227 ± 0.013	0.86CysLeu: 0.86 ± 0.029	0.153CysMet: 0.153 ± 0.011	0.235CysAsn: 0.235 ± 0.013	0.54CysPro: 0.54 ± 0.023	0.232CysGln: 0.232 ± 0.012	0.523CysArg: 0.523 ± 0.02	0.451CysSer: 0.451 ± 0.02	0.454CysThr: 0.454 ± 0.023	0.633CysVal: 0.633 ± 0.024	0.116CysTrp: 0.116 ± 0.011	0.21CysTyr: 0.21 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.76AspAla: 6.76 ± 0.085	0.536AspCys: 0.536 ± 0.023	3.467AspAsp: 3.467 ± 0.085	3.574AspGlu: 3.574 ± 0.058	2.299AspPhe: 2.299 ± 0.053	5.437AspGly: 5.437 ± 0.099	1.357AspHis: 1.357 ± 0.035	3.068AspIle: 3.068 ± 0.053	1.839AspLys: 1.839 ± 0.042	6.506AspLeu: 6.506 ± 0.077	1.758AspMet: 1.758 ± 0.037	1.297AspAsn: 1.297 ± 0.039	3.451AspPro: 3.451 ± 0.052	2.163AspGln: 2.163 ± 0.047	4.16AspArg: 4.16 ± 0.054	2.309AspSer: 2.309 ± 0.048	3.381AspThr: 3.381 ± 0.093	4.368AspVal: 4.368 ± 0.075	1.177AspTrp: 1.177 ± 0.037	1.533AspTyr: 1.533 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.715GluAla: 7.715 ± 0.1	0.376GluCys: 0.376 ± 0.018	3.249GluAsp: 3.249 ± 0.058	3.148GluGlu: 3.148 ± 0.059	1.852GluPhe: 1.852 ± 0.038	4.555GluGly: 4.555 ± 0.075	1.173GluHis: 1.173 ± 0.031	3.468GluIle: 3.468 ± 0.057	2.312GluLys: 2.312 ± 0.054	5.168GluLeu: 5.168 ± 0.064	1.825GluMet: 1.825 ± 0.04	1.797GluAsn: 1.797 ± 0.04	2.329GluPro: 2.329 ± 0.056	2.163GluGln: 2.163 ± 0.045	4.088GluArg: 4.088 ± 0.078	2.073GluSer: 2.073 ± 0.046	3.743GluThr: 3.743 ± 0.055	4.35GluVal: 4.35 ± 0.061	0.691GluTrp: 0.691 ± 0.022	1.148GluTyr: 1.148 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.28PheAla: 4.28 ± 0.061	0.431PheCys: 0.431 ± 0.02	2.841PheAsp: 2.841 ± 0.048	2.246PheGlu: 2.246 ± 0.047	1.392PhePhe: 1.392 ± 0.039	3.768PheGly: 3.768 ± 0.054	0.778PheHis: 0.778 ± 0.026	1.588PheIle: 1.588 ± 0.039	0.98PheLys: 0.98 ± 0.03	3.444PheLeu: 3.444 ± 0.056	0.865PheMet: 0.865 ± 0.03	1.036PheAsn: 1.036 ± 0.031	1.573PhePro: 1.573 ± 0.037	1.069PheGln: 1.069 ± 0.033	2.169PheArg: 2.169 ± 0.043	2.242PheSer: 2.242 ± 0.046	2.096PheThr: 2.096 ± 0.044	2.746PheVal: 2.746 ± 0.049	0.537PheTrp: 0.537 ± 0.022	0.938PheTyr: 0.938 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.761GlyAla: 9.761 ± 0.102	0.844GlyCys: 0.844 ± 0.025	4.804GlyAsp: 4.804 ± 0.11	4.386GlyGlu: 4.386 ± 0.062	3.624GlyPhe: 3.624 ± 0.053	7.41GlyGly: 7.41 ± 0.167	1.944GlyHis: 1.944 ± 0.039	4.354GlyIle: 4.354 ± 0.069	3.394GlyLys: 3.394 ± 0.064	9.125GlyLeu: 9.125 ± 0.101	2.669GlyMet: 2.669 ± 0.048	2.279GlyAsn: 2.279 ± 0.095	3.502GlyPro: 3.502 ± 0.055	3.316GlyGln: 3.316 ± 0.055	5.445GlyArg: 5.445 ± 0.076	4.059GlySer: 4.059 ± 0.07	4.745GlyThr: 4.745 ± 0.072	6.495GlyVal: 6.495 ± 0.071	1.467GlyTrp: 1.467 ± 0.039	2.356GlyTyr: 2.356 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.351HisAla: 2.351 ± 0.046	0.238HisCys: 0.238 ± 0.014	1.295HisAsp: 1.295 ± 0.033	1.041HisGlu: 1.041 ± 0.027	0.863HisPhe: 0.863 ± 0.027	1.979HisGly: 1.979 ± 0.049	0.624HisHis: 0.624 ± 0.029	1.057HisIle: 1.057 ± 0.031	0.583HisLys: 0.583 ± 0.022	2.222HisLeu: 2.222 ± 0.044	0.563HisMet: 0.563 ± 0.024	0.526HisAsn: 0.526 ± 0.023	1.449HisPro: 1.449 ± 0.037	0.616HisGln: 0.616 ± 0.024	1.358HisArg: 1.358 ± 0.035	1.03HisSer: 1.03 ± 0.03	0.92HisThr: 0.92 ± 0.031	1.495HisVal: 1.495 ± 0.038	0.344HisTrp: 0.344 ± 0.021	0.551HisTyr: 0.551 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.672IleAla: 6.672 ± 0.08	0.613IleCys: 0.613 ± 0.022	3.399IleAsp: 3.399 ± 0.054	3.659IleGlu: 3.659 ± 0.054	1.751IlePhe: 1.751 ± 0.04	4.869IleGly: 4.869 ± 0.062	0.939IleHis: 0.939 ± 0.026	2.309IleIle: 2.309 ± 0.054	1.53IleLys: 1.53 ± 0.037	4.785IleLeu: 4.785 ± 0.071	1.144IleMet: 1.144 ± 0.034	1.47IleAsn: 1.47 ± 0.04	2.349IlePro: 2.349 ± 0.042	1.311IleGln: 1.311 ± 0.029	3.197IleArg: 3.197 ± 0.053	3.184IleSer: 3.184 ± 0.051	3.098IleThr: 3.098 ± 0.051	3.711IleVal: 3.711 ± 0.057	0.735IleTrp: 0.735 ± 0.021	1.219IleTyr: 1.219 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.134LysAla: 4.134 ± 0.066	0.216LysCys: 0.216 ± 0.013	1.809LysAsp: 1.809 ± 0.041	1.559LysGlu: 1.559 ± 0.04	1.016LysPhe: 1.016 ± 0.033	2.766LysGly: 2.766 ± 0.053	0.692LysHis: 0.692 ± 0.027	1.836LysIle: 1.836 ± 0.042	1.318LysLys: 1.318 ± 0.04	3.216LysLeu: 3.216 ± 0.057	0.937LysMet: 0.937 ± 0.03	0.866LysAsn: 0.866 ± 0.029	1.881LysPro: 1.881 ± 0.048	1.071LysGln: 1.071 ± 0.035	2.41LysArg: 2.41 ± 0.055	1.939LysSer: 1.939 ± 0.042	2.252LysThr: 2.252 ± 0.047	2.382LysVal: 2.382 ± 0.054	0.436LysTrp: 0.436 ± 0.024	0.742LysTyr: 0.742 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.467LeuAla: 12.467 ± 0.133	0.951LeuCys: 0.951 ± 0.027	6.016LeuAsp: 6.016 ± 0.079	5.528LeuGlu: 5.528 ± 0.067	3.559LeuPhe: 3.559 ± 0.061	8.332LeuGly: 8.332 ± 0.088	2.027LeuHis: 2.027 ± 0.041	5.476LeuIle: 5.476 ± 0.07	3.4LeuLys: 3.4 ± 0.059	9.094LeuLeu: 9.094 ± 0.121	2.698LeuMet: 2.698 ± 0.048	2.89LeuAsn: 2.89 ± 0.05	5.532LeuPro: 5.532 ± 0.08	2.819LeuGln: 2.819 ± 0.05	7.032LeuArg: 7.032 ± 0.089	7.267LeuSer: 7.267 ± 0.098	6.356LeuThr: 6.356 ± 0.078	6.586LeuVal: 6.586 ± 0.084	1.307LeuTrp: 1.307 ± 0.04	1.974LeuTyr: 1.974 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.451MetAla: 3.451 ± 0.055	0.197MetCys: 0.197 ± 0.013	1.435MetAsp: 1.435 ± 0.038	1.323MetGlu: 1.323 ± 0.034	0.881MetPhe: 0.881 ± 0.026	2.394MetGly: 2.394 ± 0.056	0.476MetHis: 0.476 ± 0.02	1.592MetIle: 1.592 ± 0.034	1.105MetLys: 1.105 ± 0.029	2.687MetLeu: 2.687 ± 0.048	0.874MetMet: 0.874 ± 0.029	0.861MetAsn: 0.861 ± 0.028	1.541MetPro: 1.541 ± 0.036	1.12MetGln: 1.12 ± 0.031	1.893MetArg: 1.893 ± 0.035	1.776MetSer: 1.776 ± 0.037	2.123MetThr: 2.123 ± 0.048	1.889MetVal: 1.889 ± 0.038	0.249MetTrp: 0.249 ± 0.017	0.363MetTyr: 0.363 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.263AsnAla: 3.263 ± 0.047	0.261AsnCys: 0.261 ± 0.015	1.664AsnAsp: 1.664 ± 0.093	1.234AsnGlu: 1.234 ± 0.033	0.964AsnPhe: 0.964 ± 0.03	2.477AsnGly: 2.477 ± 0.057	0.542AsnHis: 0.542 ± 0.025	1.453AsnIle: 1.453 ± 0.034	0.777AsnLys: 0.777 ± 0.026	2.588AsnLeu: 2.588 ± 0.048	0.719AsnMet: 0.719 ± 0.025	0.713AsnAsn: 0.713 ± 0.029	1.815AsnPro: 1.815 ± 0.038	0.747AsnGln: 0.747 ± 0.026	1.724AsnArg: 1.724 ± 0.045	1.263AsnSer: 1.263 ± 0.033	1.491AsnThr: 1.491 ± 0.038	1.804AsnVal: 1.804 ± 0.046	0.431AsnTrp: 0.431 ± 0.019	0.662AsnTyr: 0.662 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.539ProAla: 5.539 ± 0.092	0.365ProCys: 0.365 ± 0.017	3.893ProAsp: 3.893 ± 0.058	3.944ProGlu: 3.944 ± 0.065	1.89ProPhe: 1.89 ± 0.04	4.17ProGly: 4.17 ± 0.058	1.091ProHis: 1.091 ± 0.033	2.274ProIle: 2.274 ± 0.045	1.774ProLys: 1.774 ± 0.038	4.721ProLeu: 4.721 ± 0.066	1.307ProMet: 1.307 ± 0.03	1.327ProAsn: 1.327 ± 0.037	2.195ProPro: 2.195 ± 0.059	1.822ProGln: 1.822 ± 0.045	2.785ProArg: 2.785 ± 0.049	2.473ProSer: 2.473 ± 0.044	2.604ProThr: 2.604 ± 0.042	4.281ProVal: 4.281 ± 0.06	0.578ProTrp: 0.578 ± 0.021	1.124ProTyr: 1.124 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.495GlnAla: 4.495 ± 0.065	0.206GlnCys: 0.206 ± 0.014	1.789GlnAsp: 1.789 ± 0.042	1.598GlnGlu: 1.598 ± 0.044	1.191GlnPhe: 1.191 ± 0.036	2.729GlnGly: 2.729 ± 0.051	0.657GlnHis: 0.657 ± 0.022	2.23GlnIle: 2.23 ± 0.038	1.149GlnLys: 1.149 ± 0.033	3.098GlnLeu: 3.098 ± 0.058	1.206GlnMet: 1.206 ± 0.032	1.037GlnAsn: 1.037 ± 0.025	1.65GlnPro: 1.65 ± 0.041	1.193GlnGln: 1.193 ± 0.034	2.247GlnArg: 2.247 ± 0.053	1.857GlnSer: 1.857 ± 0.041	1.977GlnThr: 1.977 ± 0.043	2.597GlnVal: 2.597 ± 0.041	0.425GlnTrp: 0.425 ± 0.018	0.623GlnTyr: 0.623 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.985ArgAla: 7.985 ± 0.1	0.461ArgCys: 0.461 ± 0.021	4.109ArgAsp: 4.109 ± 0.06	3.632ArgGlu: 3.632 ± 0.061	2.591ArgPhe: 2.591 ± 0.05	4.484ArgGly: 4.484 ± 0.058	1.491ArgHis: 1.491 ± 0.032	3.737ArgIle: 3.737 ± 0.058	2.428ArgLys: 2.428 ± 0.052	7.197ArgLeu: 7.197 ± 0.091	1.985ArgMet: 1.985 ± 0.042	1.788ArgAsn: 1.788 ± 0.038	3.251ArgPro: 3.251 ± 0.052	2.284ArgGln: 2.284 ± 0.044	4.789ArgArg: 4.789 ± 0.083	3.285ArgSer: 3.285 ± 0.055	3.03ArgThr: 3.03 ± 0.054	4.8ArgVal: 4.8 ± 0.066	0.925ArgTrp: 0.925 ± 0.032	1.583ArgTyr: 1.583 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.953SerAla: 5.953 ± 0.068	0.482SerCys: 0.482 ± 0.022	3.481SerAsp: 3.481 ± 0.054	2.942SerGlu: 2.942 ± 0.056	2.25SerPhe: 2.25 ± 0.046	5.45SerGly: 5.45 ± 0.084	1.109SerHis: 1.109 ± 0.031	2.544SerIle: 2.544 ± 0.053	1.652SerLys: 1.652 ± 0.043	5.039SerLeu: 5.039 ± 0.074	1.375SerMet: 1.375 ± 0.034	1.428SerAsn: 1.428 ± 0.037	2.528SerPro: 2.528 ± 0.052	1.664SerGln: 1.664 ± 0.037	3.152SerArg: 3.152 ± 0.052	2.691SerSer: 2.691 ± 0.054	2.571SerThr: 2.571 ± 0.043	3.914SerVal: 3.914 ± 0.054	0.683SerTrp: 0.683 ± 0.023	1.361SerTyr: 1.361 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.297ThrAla: 6.297 ± 0.083	0.501ThrCys: 0.501 ± 0.023	3.287ThrAsp: 3.287 ± 0.054	3.1ThrGlu: 3.1 ± 0.05	1.971ThrPhe: 1.971 ± 0.04	5.628ThrGly: 5.628 ± 0.081	1.229ThrHis: 1.229 ± 0.036	2.766ThrIle: 2.766 ± 0.051	1.656ThrLys: 1.656 ± 0.041	6.209ThrLeu: 6.209 ± 0.072	1.38ThrMet: 1.38 ± 0.038	1.333ThrAsn: 1.333 ± 0.038	3.55ThrPro: 3.55 ± 0.059	1.864ThrGln: 1.864 ± 0.04	3.589ThrArg: 3.589 ± 0.058	2.833ThrSer: 2.833 ± 0.054	3.058ThrThr: 3.058 ± 0.059	4.116ThrVal: 4.116 ± 0.069	0.642ThrTrp: 0.642 ± 0.024	1.336ThrTyr: 1.336 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.568ValAla: 8.568 ± 0.114	0.626ValCys: 0.626 ± 0.024	3.981ValAsp: 3.981 ± 0.052	4.367ValGlu: 4.367 ± 0.072	2.879ValPhe: 2.879 ± 0.049	5.447ValGly: 5.447 ± 0.072	1.379ValHis: 1.379 ± 0.033	4.351ValIle: 4.351 ± 0.064	2.245ValLys: 2.245 ± 0.052	7.713ValLeu: 7.713 ± 0.088	2.109ValMet: 2.109 ± 0.049	1.957ValAsn: 1.957 ± 0.04	3.63ValPro: 3.63 ± 0.058	2.319ValGln: 2.319 ± 0.04	4.17ValArg: 4.17 ± 0.053	4.229ValSer: 4.229 ± 0.061	4.532ValThr: 4.532 ± 0.072	5.718ValVal: 5.718 ± 0.083	0.942ValTrp: 0.942 ± 0.029	1.431ValTyr: 1.431 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.362TrpAla: 1.362 ± 0.031	0.128TrpCys: 0.128 ± 0.01	0.755TrpAsp: 0.755 ± 0.026	0.599TrpGlu: 0.599 ± 0.022	0.535TrpPhe: 0.535 ± 0.024	0.989TrpGly: 0.989 ± 0.029	0.361TrpHis: 0.361 ± 0.019	0.697TrpIle: 0.697 ± 0.025	0.457TrpLys: 0.457 ± 0.022	1.591TrpLeu: 1.591 ± 0.045	0.438TrpMet: 0.438 ± 0.02	0.406TrpAsn: 0.406 ± 0.019	0.68TrpPro: 0.68 ± 0.029	0.596TrpGln: 0.596 ± 0.023	1.074TrpArg: 1.074 ± 0.033	0.758TrpSer: 0.758 ± 0.025	0.757TrpThr: 0.757 ± 0.024	0.911TrpVal: 0.911 ± 0.028	0.184TrpTrp: 0.184 ± 0.013	0.26TrpTyr: 0.26 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.615TyrAla: 2.615 ± 0.047	0.241TyrCys: 0.241 ± 0.013	1.62TyrAsp: 1.62 ± 0.039	1.212TyrGlu: 1.212 ± 0.032	0.964TyrPhe: 0.964 ± 0.033	2.177TyrGly: 2.177 ± 0.043	0.546TyrHis: 0.546 ± 0.022	0.928TyrIle: 0.928 ± 0.03	0.632TyrLys: 0.632 ± 0.023	2.344TyrLeu: 2.344 ± 0.042	0.518TyrMet: 0.518 ± 0.022	0.612TyrAsn: 0.612 ± 0.023	1.049TyrPro: 1.049 ± 0.028	0.707TyrGln: 0.707 ± 0.026	1.504TyrArg: 1.504 ± 0.037	1.18TyrSer: 1.18 ± 0.029	1.087TyrThr: 1.087 ± 0.032	1.595TyrVal: 1.595 ± 0.039	0.367TyrTrp: 0.367 ± 0.018	0.598TyrTyr: 0.598 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3839 proteins (1201575 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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