Amino acid dipepetide frequency for Oceanicola granulosus (strain ATCC BAA-861 / DSM 15982 / KCTC 12143 / HTCC2516)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.032AlaAla: 21.032 ± 0.278	1.06AlaCys: 1.06 ± 0.035	7.981AlaAsp: 7.981 ± 0.144	9.707AlaGlu: 9.707 ± 0.14	4.203AlaPhe: 4.203 ± 0.062	12.366AlaGly: 12.366 ± 0.17	2.455AlaHis: 2.455 ± 0.052	5.511AlaIle: 5.511 ± 0.072	2.557AlaLys: 2.557 ± 0.066	15.544AlaLeu: 15.544 ± 0.184	3.493AlaMet: 3.493 ± 0.073	2.473AlaAsn: 2.473 ± 0.054	7.197AlaPro: 7.197 ± 0.137	3.858AlaGln: 3.858 ± 0.068	11.133AlaArg: 11.133 ± 0.158	5.558AlaSer: 5.558 ± 0.09	6.339AlaThr: 6.339 ± 0.109	9.134AlaVal: 9.134 ± 0.101	1.592AlaTrp: 1.592 ± 0.043	2.523AlaTyr: 2.523 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.045CysAla: 1.045 ± 0.036	0.107CysCys: 0.107 ± 0.01	0.568CysAsp: 0.568 ± 0.024	0.448CysGlu: 0.448 ± 0.022	0.277CysPhe: 0.277 ± 0.016	0.879CysGly: 0.879 ± 0.034	0.253CysHis: 0.253 ± 0.015	0.348CysIle: 0.348 ± 0.018	0.134CysLys: 0.134 ± 0.011	0.779CysLeu: 0.779 ± 0.025	0.127CysMet: 0.127 ± 0.011	0.163CysAsn: 0.163 ± 0.012	0.442CysPro: 0.442 ± 0.022	0.178CysGln: 0.178 ± 0.012	0.554CysArg: 0.554 ± 0.024	0.342CysSer: 0.342 ± 0.022	0.403CysThr: 0.403 ± 0.02	0.534CysVal: 0.534 ± 0.023	0.094CysTrp: 0.094 ± 0.009	0.178CysTyr: 0.178 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.145AspAla: 8.145 ± 0.134	0.45AspCys: 0.45 ± 0.021	4.078AspAsp: 4.078 ± 0.216	3.996AspGlu: 3.996 ± 0.069	2.25AspPhe: 2.25 ± 0.051	6.525AspGly: 6.525 ± 0.205	1.314AspHis: 1.314 ± 0.041	3.001AspIle: 3.001 ± 0.078	1.337AspLys: 1.337 ± 0.043	6.413AspLeu: 6.413 ± 0.107	1.383AspMet: 1.383 ± 0.04	1.247AspAsn: 1.247 ± 0.053	3.862AspPro: 3.862 ± 0.062	1.425AspGln: 1.425 ± 0.031	4.489AspArg: 4.489 ± 0.073	2.348AspSer: 2.348 ± 0.097	2.925AspThr: 2.925 ± 0.12	4.573AspVal: 4.573 ± 0.118	1.178AspTrp: 1.178 ± 0.033	1.497AspTyr: 1.497 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	9.69GluAla: 9.69 ± 0.142	0.322GluCys: 0.322 ± 0.018	3.196GluAsp: 3.196 ± 0.056	3.86GluGlu: 3.86 ± 0.083	1.619GluPhe: 1.619 ± 0.037	5.551GluGly: 5.551 ± 0.086	1.254GluHis: 1.254 ± 0.041	3.554GluIle: 3.554 ± 0.056	1.464GluLys: 1.464 ± 0.044	5.706GluLeu: 5.706 ± 0.079	1.795GluMet: 1.795 ± 0.047	1.361GluAsn: 1.361 ± 0.035	3.039GluPro: 3.039 ± 0.068	1.945GluGln: 1.945 ± 0.043	5.305GluArg: 5.305 ± 0.096	2.49GluSer: 2.49 ± 0.049	4.117GluThr: 4.117 ± 0.059	5.063GluVal: 5.063 ± 0.069	0.71GluTrp: 0.71 ± 0.024	0.962GluTyr: 0.962 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.649PheAla: 4.649 ± 0.068	0.362PheCys: 0.362 ± 0.019	2.754PheAsp: 2.754 ± 0.064	2.243PheGlu: 2.243 ± 0.045	1.279PhePhe: 1.279 ± 0.038	3.554PheGly: 3.554 ± 0.071	0.742PheHis: 0.742 ± 0.026	1.343PheIle: 1.343 ± 0.044	0.594PheLys: 0.594 ± 0.025	3.294PheLeu: 3.294 ± 0.056	0.703PheMet: 0.703 ± 0.025	0.893PheAsn: 0.893 ± 0.03	1.504PhePro: 1.504 ± 0.041	0.853PheGln: 0.853 ± 0.026	2.313PheArg: 2.313 ± 0.049	1.822PheSer: 1.822 ± 0.047	2.042PheThr: 2.042 ± 0.051	2.676PheVal: 2.676 ± 0.049	0.543PheTrp: 0.543 ± 0.025	0.851PheTyr: 0.851 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.438GlyAla: 11.438 ± 0.168	0.863GlyCys: 0.863 ± 0.031	5.476GlyAsp: 5.476 ± 0.272	5.67GlyGlu: 5.67 ± 0.083	3.52GlyPhe: 3.52 ± 0.069	8.734GlyGly: 8.734 ± 0.278	2.056GlyHis: 2.056 ± 0.063	4.194GlyIle: 4.194 ± 0.064	2.36GlyLys: 2.36 ± 0.057	9.832GlyLeu: 9.832 ± 0.111	2.347GlyMet: 2.347 ± 0.055	1.987GlyAsn: 1.987 ± 0.082	4.169GlyPro: 4.169 ± 0.075	2.928GlyGln: 2.928 ± 0.063	7.081GlyArg: 7.081 ± 0.103	4.317GlySer: 4.317 ± 0.135	5.049GlyThr: 5.049 ± 0.146	6.388GlyVal: 6.388 ± 0.074	1.578GlyTrp: 1.578 ± 0.04	2.27GlyTyr: 2.27 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.472HisAla: 2.472 ± 0.051	0.2HisCys: 0.2 ± 0.013	1.396HisAsp: 1.396 ± 0.04	1.184HisGlu: 1.184 ± 0.038	0.79HisPhe: 0.79 ± 0.028	2.145HisGly: 2.145 ± 0.068	0.648HisHis: 0.648 ± 0.076	0.772HisIle: 0.772 ± 0.026	0.387HisLys: 0.387 ± 0.02	2.136HisLeu: 2.136 ± 0.052	0.461HisMet: 0.461 ± 0.022	0.405HisAsn: 0.405 ± 0.02	1.407HisPro: 1.407 ± 0.041	0.517HisGln: 0.517 ± 0.022	1.576HisArg: 1.576 ± 0.064	0.746HisSer: 0.746 ± 0.027	0.771HisThr: 0.771 ± 0.025	1.596HisVal: 1.596 ± 0.035	0.33HisTrp: 0.33 ± 0.02	0.523HisTyr: 0.523 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.545IleAla: 6.545 ± 0.077	0.488IleCys: 0.488 ± 0.021	3.494IleAsp: 3.494 ± 0.077	3.288IleGlu: 3.288 ± 0.056	1.519IlePhe: 1.519 ± 0.044	4.519IleGly: 4.519 ± 0.067	0.829IleHis: 0.829 ± 0.025	1.664IleIle: 1.664 ± 0.043	0.924IleLys: 0.924 ± 0.028	4.206IleLeu: 4.206 ± 0.079	0.817IleMet: 0.817 ± 0.032	1.038IleAsn: 1.038 ± 0.036	2.034IlePro: 2.034 ± 0.048	0.872IleGln: 0.872 ± 0.024	2.94IleArg: 2.94 ± 0.055	2.275IleSer: 2.275 ± 0.055	2.473IleThr: 2.473 ± 0.066	3.867IleVal: 3.867 ± 0.062	0.607IleTrp: 0.607 ± 0.024	1.06IleTyr: 1.06 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.834LysAla: 2.834 ± 0.069	0.112LysCys: 0.112 ± 0.011	1.173LysAsp: 1.173 ± 0.039	1.002LysGlu: 1.002 ± 0.035	0.641LysPhe: 0.641 ± 0.025	1.944LysGly: 1.944 ± 0.054	0.426LysHis: 0.426 ± 0.023	1.088LysIle: 1.088 ± 0.031	0.72LysLys: 0.72 ± 0.032	2.193LysLeu: 2.193 ± 0.061	0.566LysMet: 0.566 ± 0.024	0.542LysAsn: 0.542 ± 0.023	1.267LysPro: 1.267 ± 0.043	0.574LysGln: 0.574 ± 0.023	1.659LysArg: 1.659 ± 0.048	1.237LysSer: 1.237 ± 0.043	1.307LysThr: 1.307 ± 0.04	1.865LysVal: 1.865 ± 0.048	0.266LysTrp: 0.266 ± 0.015	0.41LysTyr: 0.41 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.599LeuAla: 15.599 ± 0.182	0.83LeuCys: 0.83 ± 0.032	6.491LeuAsp: 6.491 ± 0.086	6.156LeuGlu: 6.156 ± 0.082	3.573LeuPhe: 3.573 ± 0.069	9.057LeuGly: 9.057 ± 0.136	1.988LeuHis: 1.988 ± 0.046	4.425LeuIle: 4.425 ± 0.077	2.386LeuLys: 2.386 ± 0.062	9.824LeuLeu: 9.824 ± 0.148	2.305LeuMet: 2.305 ± 0.052	2.184LeuAsn: 2.184 ± 0.051	5.862LeuPro: 5.862 ± 0.097	2.417LeuGln: 2.417 ± 0.052	7.57LeuArg: 7.57 ± 0.097	5.969LeuSer: 5.969 ± 0.075	5.955LeuThr: 5.955 ± 0.091	7.776LeuVal: 7.776 ± 0.084	1.272LeuTrp: 1.272 ± 0.037	2.031LeuTyr: 2.031 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.137MetAla: 3.137 ± 0.058	0.149MetCys: 0.149 ± 0.012	1.223MetAsp: 1.223 ± 0.034	1.258MetGlu: 1.258 ± 0.03	0.742MetPhe: 0.742 ± 0.028	1.828MetGly: 1.828 ± 0.05	0.41MetHis: 0.41 ± 0.021	1.343MetIle: 1.343 ± 0.042	0.74MetLys: 0.74 ± 0.027	2.362MetLeu: 2.362 ± 0.046	0.615MetMet: 0.615 ± 0.026	0.697MetAsn: 0.697 ± 0.028	1.383MetPro: 1.383 ± 0.041	0.749MetGln: 0.749 ± 0.028	1.814MetArg: 1.814 ± 0.045	1.698MetSer: 1.698 ± 0.037	1.789MetThr: 1.789 ± 0.049	1.72MetVal: 1.72 ± 0.043	0.229MetTrp: 0.229 ± 0.016	0.295MetTyr: 0.295 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.647AsnAla: 2.647 ± 0.056	0.207AsnCys: 0.207 ± 0.014	1.308AsnAsp: 1.308 ± 0.09	1.098AsnGlu: 1.098 ± 0.035	0.855AsnPhe: 0.855 ± 0.028	2.045AsnGly: 2.045 ± 0.056	0.432AsnHis: 0.432 ± 0.019	1.041AsnIle: 1.041 ± 0.033	0.424AsnLys: 0.424 ± 0.024	2.183AsnLeu: 2.183 ± 0.049	0.539AsnMet: 0.539 ± 0.022	0.569AsnAsn: 0.569 ± 0.026	1.537AsnPro: 1.537 ± 0.038	0.542AsnGln: 0.542 ± 0.025	1.549AsnArg: 1.549 ± 0.037	1.029AsnSer: 1.029 ± 0.044	1.032AsnThr: 1.032 ± 0.039	1.746AsnVal: 1.746 ± 0.049	0.345AsnTrp: 0.345 ± 0.018	0.556AsnTyr: 0.556 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.983ProAla: 6.983 ± 0.116	0.34ProCys: 0.34 ± 0.019	4.189ProAsp: 4.189 ± 0.067	4.527ProGlu: 4.527 ± 0.081	1.897ProPhe: 1.897 ± 0.048	5.332ProGly: 5.332 ± 0.078	1.086ProHis: 1.086 ± 0.033	1.89ProIle: 1.89 ± 0.043	1.085ProLys: 1.085 ± 0.035	5.178ProLeu: 5.178 ± 0.094	1.229ProMet: 1.229 ± 0.038	1.06ProAsn: 1.06 ± 0.032	2.979ProPro: 2.979 ± 0.074	1.338ProGln: 1.338 ± 0.033	3.38ProArg: 3.38 ± 0.072	2.23ProSer: 2.23 ± 0.047	2.367ProThr: 2.367 ± 0.041	4.519ProVal: 4.519 ± 0.069	0.727ProTrp: 0.727 ± 0.029	1.157ProTyr: 1.157 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.583GlnAla: 3.583 ± 0.057	0.156GlnCys: 0.156 ± 0.013	1.395GlnAsp: 1.395 ± 0.038	1.379GlnGlu: 1.379 ± 0.042	0.904GlnPhe: 0.904 ± 0.028	2.27GlnGly: 2.27 ± 0.048	0.485GlnHis: 0.485 ± 0.022	1.476GlnIle: 1.476 ± 0.038	0.7GlnLys: 0.7 ± 0.028	2.642GlnLeu: 2.642 ± 0.049	0.843GlnMet: 0.843 ± 0.026	0.629GlnAsn: 0.629 ± 0.024	1.452GlnPro: 1.452 ± 0.039	1.006GlnGln: 1.006 ± 0.038	2.088GlnArg: 2.088 ± 0.062	1.476GlnSer: 1.476 ± 0.038	1.473GlnThr: 1.473 ± 0.034	2.278GlnVal: 2.278 ± 0.047	0.338GlnTrp: 0.338 ± 0.016	0.477GlnTyr: 0.477 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.799ArgAla: 9.799 ± 0.128	0.482ArgCys: 0.482 ± 0.021	4.744ArgAsp: 4.744 ± 0.066	4.509ArgGlu: 4.509 ± 0.082	2.813ArgPhe: 2.813 ± 0.049	5.435ArgGly: 5.435 ± 0.097	1.921ArgHis: 1.921 ± 0.064	3.896ArgIle: 3.896 ± 0.055	1.72ArgLys: 1.72 ± 0.05	8.833ArgLeu: 8.833 ± 0.129	1.947ArgMet: 1.947 ± 0.044	1.513ArgAsn: 1.513 ± 0.038	4.126ArgPro: 4.126 ± 0.085	2.38ArgGln: 2.38 ± 0.06	6.437ArgArg: 6.437 ± 0.193	3.114ArgSer: 3.114 ± 0.065	3.468ArgThr: 3.468 ± 0.061	5.164ArgVal: 5.164 ± 0.076	1.046ArgTrp: 1.046 ± 0.035	1.657ArgTyr: 1.657 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.722SerAla: 5.722 ± 0.099	0.357SerCys: 0.357 ± 0.021	3.043SerAsp: 3.043 ± 0.084	2.703SerGlu: 2.703 ± 0.057	2.049SerPhe: 2.049 ± 0.043	5.349SerGly: 5.349 ± 0.154	1.004SerHis: 1.004 ± 0.027	2.104SerIle: 2.104 ± 0.044	0.945SerLys: 0.945 ± 0.032	4.829SerLeu: 4.829 ± 0.084	1.124SerMet: 1.124 ± 0.03	1.104SerAsn: 1.104 ± 0.04	2.417SerPro: 2.417 ± 0.053	1.273SerGln: 1.273 ± 0.034	3.252SerArg: 3.252 ± 0.058	2.217SerSer: 2.217 ± 0.065	2.354SerThr: 2.354 ± 0.067	3.661SerVal: 3.661 ± 0.083	0.69SerTrp: 0.69 ± 0.024	1.167SerTyr: 1.167 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.325ThrAla: 6.325 ± 0.105	0.427ThrCys: 0.427 ± 0.02	3.307ThrAsp: 3.307 ± 0.091	2.967ThrGlu: 2.967 ± 0.057	2.127ThrPhe: 2.127 ± 0.054	5.733ThrGly: 5.733 ± 0.138	0.999ThrHis: 0.999 ± 0.027	2.576ThrIle: 2.576 ± 0.079	0.96ThrLys: 0.96 ± 0.03	6.144ThrLeu: 6.144 ± 0.111	1.214ThrMet: 1.214 ± 0.033	1.106ThrAsn: 1.106 ± 0.038	3.258ThrPro: 3.258 ± 0.056	1.169ThrGln: 1.169 ± 0.033	3.614ThrArg: 3.614 ± 0.056	2.538ThrSer: 2.538 ± 0.063	2.723ThrThr: 2.723 ± 0.078	4.319ThrVal: 4.319 ± 0.094	0.72ThrTrp: 0.72 ± 0.028	1.191ThrTyr: 1.191 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.15ValAla: 10.15 ± 0.098	0.606ValCys: 0.606 ± 0.025	4.301ValAsp: 4.301 ± 0.078	4.938ValGlu: 4.938 ± 0.067	2.645ValPhe: 2.645 ± 0.052	5.921ValGly: 5.921 ± 0.09	1.338ValHis: 1.338 ± 0.037	3.709ValIle: 3.709 ± 0.058	1.62ValLys: 1.62 ± 0.048	7.792ValLeu: 7.792 ± 0.078	1.837ValMet: 1.837 ± 0.048	1.831ValAsn: 1.831 ± 0.046	3.758ValPro: 3.758 ± 0.063	1.871ValGln: 1.871 ± 0.039	5.299ValArg: 5.299 ± 0.081	4.137ValSer: 4.137 ± 0.076	5.039ValThr: 5.039 ± 0.112	5.989ValVal: 5.989 ± 0.087	0.958ValTrp: 0.958 ± 0.029	1.498ValTyr: 1.498 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.377TrpAla: 1.377 ± 0.037	0.128TrpCys: 0.128 ± 0.01	0.763TrpAsp: 0.763 ± 0.03	0.709TrpGlu: 0.709 ± 0.026	0.518TrpPhe: 0.518 ± 0.024	0.976TrpGly: 0.976 ± 0.034	0.355TrpHis: 0.355 ± 0.018	0.697TrpIle: 0.697 ± 0.023	0.33TrpLys: 0.33 ± 0.017	1.696TrpLeu: 1.696 ± 0.047	0.368TrpMet: 0.368 ± 0.018	0.372TrpAsn: 0.372 ± 0.018	0.719TrpPro: 0.719 ± 0.025	0.581TrpGln: 0.581 ± 0.023	1.257TrpArg: 1.257 ± 0.038	0.833TrpSer: 0.833 ± 0.03	0.797TrpThr: 0.797 ± 0.025	0.836TrpVal: 0.836 ± 0.027	0.241TrpTrp: 0.241 ± 0.014	0.253TrpTyr: 0.253 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.044	0.203TyrCys: 0.203 ± 0.013	1.559TyrAsp: 1.559 ± 0.036	1.361TyrGlu: 1.361 ± 0.036	0.792TyrPhe: 0.792 ± 0.03	2.093TyrGly: 2.093 ± 0.048	0.469TyrHis: 0.469 ± 0.019	0.828TyrIle: 0.828 ± 0.03	0.438TyrLys: 0.438 ± 0.022	2.083TyrLeu: 2.083 ± 0.045	0.469TyrMet: 0.469 ± 0.023	0.508TyrAsn: 0.508 ± 0.022	1.082TyrPro: 1.082 ± 0.032	0.576TyrGln: 0.576 ± 0.025	1.693TyrArg: 1.693 ± 0.038	0.99TyrSer: 0.99 ± 0.03	0.997TyrThr: 0.997 ± 0.033	1.533TyrVal: 1.533 ± 0.039	0.34TyrTrp: 0.34 ± 0.017	0.518TyrTyr: 0.518 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3791 proteins (1231118 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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