Amino acid dipepetide frequency for Buchnera aphidicola (Stegophylla sp.)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.819AlaAla: 1.819 ± 0.172
0.606AlaCys: 0.606 ± 0.081
1.114AlaAsp: 1.114 ± 0.108
1.319AlaGlu: 1.319 ± 0.123
1.462AlaPhe: 1.462 ± 0.136
1.783AlaGly: 1.783 ± 0.136
0.945AlaHis: 0.945 ± 0.089
4.761AlaIle: 4.761 ± 0.247
2.844AlaLys: 2.844 ± 0.174
4.092AlaLeu: 4.092 ± 0.191
0.927AlaMet: 0.927 ± 0.127
1.935AlaAsn: 1.935 ± 0.129
0.945AlaPro: 0.945 ± 0.1
1.489AlaGln: 1.489 ± 0.125
1.649AlaArg: 1.649 ± 0.124
2.327AlaSer: 2.327 ± 0.148
1.739AlaThr: 1.739 ± 0.124
1.694AlaVal: 1.694 ± 0.139
0.285AlaTrp: 0.285 ± 0.046
1.516AlaTyr: 1.516 ± 0.118
0.0AlaXaa: 0.0 ± 0.0
Cys
0.437CysAla: 0.437 ± 0.06
0.187CysCys: 0.187 ± 0.046
0.776CysAsp: 0.776 ± 0.089
0.455CysGlu: 0.455 ± 0.074
0.793CysPhe: 0.793 ± 0.099
1.007CysGly: 1.007 ± 0.101
0.49CysHis: 0.49 ± 0.069
1.721CysIle: 1.721 ± 0.136
0.9CysLys: 0.9 ± 0.099
1.248CysLeu: 1.248 ± 0.098
0.312CysMet: 0.312 ± 0.054
0.972CysAsn: 0.972 ± 0.09
0.49CysPro: 0.49 ± 0.067
0.633CysGln: 0.633 ± 0.063
0.357CysArg: 0.357 ± 0.048
1.177CysSer: 1.177 ± 0.105
0.66CysThr: 0.66 ± 0.087
0.669CysVal: 0.669 ± 0.082
0.187CysTrp: 0.187 ± 0.044
0.749CysTyr: 0.749 ± 0.075
0.0CysXaa: 0.0 ± 0.0
Asp
1.854AspAla: 1.854 ± 0.149
0.553AspCys: 0.553 ± 0.072
1.328AspAsp: 1.328 ± 0.117
1.525AspGlu: 1.525 ± 0.118
2.247AspPhe: 2.247 ± 0.154
1.961AspGly: 1.961 ± 0.154
1.097AspHis: 1.097 ± 0.083
5.991AspIle: 5.991 ± 0.266
3.058AspLys: 3.058 ± 0.166
3.958AspLeu: 3.958 ± 0.196
1.016AspMet: 1.016 ± 0.101
2.354AspAsn: 2.354 ± 0.144
1.016AspPro: 1.016 ± 0.102
1.444AspGln: 1.444 ± 0.122
1.462AspArg: 1.462 ± 0.12
2.22AspSer: 2.22 ± 0.162
1.935AspThr: 1.935 ± 0.136
2.282AspVal: 2.282 ± 0.163
0.419AspTrp: 0.419 ± 0.069
1.658AspTyr: 1.658 ± 0.128
0.0AspXaa: 0.0 ± 0.0
Glu
1.48GluAla: 1.48 ± 0.12
0.446GluCys: 0.446 ± 0.069
1.4GluAsp: 1.4 ± 0.107
1.881GluGlu: 1.881 ± 0.141
1.667GluPhe: 1.667 ± 0.093
1.73GluGly: 1.73 ± 0.118
0.918GluHis: 0.918 ± 0.096
5.474GluIle: 5.474 ± 0.235
4.761GluLys: 4.761 ± 0.228
4.181GluLeu: 4.181 ± 0.201
1.061GluMet: 1.061 ± 0.111
2.978GluAsn: 2.978 ± 0.177
1.07GluPro: 1.07 ± 0.107
1.364GluGln: 1.364 ± 0.116
1.649GluArg: 1.649 ± 0.118
2.532GluSer: 2.532 ± 0.153
1.908GluThr: 1.908 ± 0.116
2.158GluVal: 2.158 ± 0.162
0.321GluTrp: 0.321 ± 0.05
1.926GluTyr: 1.926 ± 0.137
0.0GluXaa: 0.0 ± 0.0
Phe
1.284PheAla: 1.284 ± 0.124
0.936PheCys: 0.936 ± 0.108
2.051PheAsp: 2.051 ± 0.176
1.569PheGlu: 1.569 ± 0.114
3.263PhePhe: 3.263 ± 0.268
2.773PheGly: 2.773 ± 0.165
1.302PheHis: 1.302 ± 0.122
5.224PheIle: 5.224 ± 0.272
3.852PheLys: 3.852 ± 0.184
5.171PheLeu: 5.171 ± 0.328
0.945PheMet: 0.945 ± 0.1
3.629PheAsn: 3.629 ± 0.177
1.694PhePro: 1.694 ± 0.123
1.872PheGln: 1.872 ± 0.139
1.578PheArg: 1.578 ± 0.141
4.279PheSer: 4.279 ± 0.226
2.068PheThr: 2.068 ± 0.135
1.988PheVal: 1.988 ± 0.158
0.499PheTrp: 0.499 ± 0.073
2.657PheTyr: 2.657 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
2.256GlyAla: 2.256 ± 0.142
1.123GlyCys: 1.123 ± 0.114
2.149GlyAsp: 2.149 ± 0.167
2.131GlyGlu: 2.131 ± 0.155
2.389GlyPhe: 2.389 ± 0.152
3.486GlyGly: 3.486 ± 0.254
1.239GlyHis: 1.239 ± 0.122
7.311GlyIle: 7.311 ± 0.241
4.342GlyLys: 4.342 ± 0.241
4.618GlyLeu: 4.618 ± 0.211
1.542GlyMet: 1.542 ± 0.111
2.639GlyAsn: 2.639 ± 0.178
1.391GlyPro: 1.391 ± 0.128
1.774GlyGln: 1.774 ± 0.136
2.184GlyArg: 2.184 ± 0.182
3.397GlySer: 3.397 ± 0.183
2.906GlyThr: 2.906 ± 0.172
2.773GlyVal: 2.773 ± 0.177
0.58GlyTrp: 0.58 ± 0.084
2.22GlyTyr: 2.22 ± 0.151
0.0GlyXaa: 0.0 ± 0.0
His
1.4HisAla: 1.4 ± 0.108
0.366HisCys: 0.366 ± 0.055
1.168HisAsp: 1.168 ± 0.085
1.043HisGlu: 1.043 ± 0.096
1.079HisPhe: 1.079 ± 0.097
1.739HisGly: 1.739 ± 0.128
0.811HisHis: 0.811 ± 0.093
3.165HisIle: 3.165 ± 0.175
1.988HisLys: 1.988 ± 0.15
2.095HisLeu: 2.095 ± 0.14
0.562HisMet: 0.562 ± 0.064
2.077HisAsn: 2.077 ± 0.145
1.123HisPro: 1.123 ± 0.103
1.088HisGln: 1.088 ± 0.092
0.9HisArg: 0.9 ± 0.099
1.453HisSer: 1.453 ± 0.116
1.426HisThr: 1.426 ± 0.117
1.516HisVal: 1.516 ± 0.118
0.223HisTrp: 0.223 ± 0.045
0.918HisTyr: 0.918 ± 0.082
0.0HisXaa: 0.0 ± 0.0
Ile
4.957IleAla: 4.957 ± 0.216
1.819IleCys: 1.819 ± 0.139
5.929IleAsp: 5.929 ± 0.256
5.153IleGlu: 5.153 ± 0.198
6.571IlePhe: 6.571 ± 0.342
6.553IleGly: 6.553 ± 0.273
3.548IleHis: 3.548 ± 0.187
16.244IleIle: 16.244 ± 0.549
11.982IleLys: 11.982 ± 0.44
13.32IleLeu: 13.32 ± 0.473
2.906IleMet: 2.906 ± 0.17
10.271IleAsn: 10.271 ± 0.365
4.681IlePro: 4.681 ± 0.196
6.17IleGln: 6.17 ± 0.256
4.395IleArg: 4.395 ± 0.182
9.094IleSer: 9.094 ± 0.308
6.134IleThr: 6.134 ± 0.275
5.875IleVal: 5.875 ± 0.272
0.927IleTrp: 0.927 ± 0.107
4.975IleTyr: 4.975 ± 0.273
0.0IleXaa: 0.0 ± 0.0
Lys
1.756LysAla: 1.756 ± 0.148
0.909LysCys: 0.909 ± 0.083
2.746LysAsp: 2.746 ± 0.162
3.566LysGlu: 3.566 ± 0.229
4.012LysPhe: 4.012 ± 0.194
3.085LysGly: 3.085 ± 0.203
2.042LysHis: 2.042 ± 0.131
15.228LysIle: 15.228 ± 0.59
16.36LysLys: 16.36 ± 0.655
7.89LysLeu: 7.89 ± 0.29
2.594LysMet: 2.594 ± 0.161
11.216LysAsn: 11.216 ± 0.419
2.086LysPro: 2.086 ± 0.139
3.646LysGln: 3.646 ± 0.212
2.782LysArg: 2.782 ± 0.169
4.779LysSer: 4.779 ± 0.212
4.297LysThr: 4.297 ± 0.211
3.29LysVal: 3.29 ± 0.212
0.767LysTrp: 0.767 ± 0.078
6.071LysTyr: 6.071 ± 0.292
0.0LysXaa: 0.0 ± 0.0
Leu
3.138LeuAla: 3.138 ± 0.19
1.364LeuCys: 1.364 ± 0.115
3.825LeuAsp: 3.825 ± 0.183
4.458LeuGlu: 4.458 ± 0.19
4.609LeuPhe: 4.609 ± 0.307
5.537LeuGly: 5.537 ± 0.271
2.389LeuHis: 2.389 ± 0.136
9.647LeuIle: 9.647 ± 0.4
10.012LeuLys: 10.012 ± 0.286
9.45LeuLeu: 9.45 ± 0.409
1.979LeuMet: 1.979 ± 0.133
7.658LeuAsn: 7.658 ± 0.289
3.04LeuPro: 3.04 ± 0.149
3.611LeuGln: 3.611 ± 0.178
3.379LeuArg: 3.379 ± 0.183
8.086LeuSer: 8.086 ± 0.319
3.976LeuThr: 3.976 ± 0.215
3.673LeuVal: 3.673 ± 0.183
0.918LeuTrp: 0.918 ± 0.115
4.369LeuTyr: 4.369 ± 0.211
0.0LeuXaa: 0.0 ± 0.0
Met
0.99MetAla: 0.99 ± 0.091
0.25MetCys: 0.25 ± 0.043
0.838MetAsp: 0.838 ± 0.086
0.954MetGlu: 0.954 ± 0.098
1.079MetPhe: 1.079 ± 0.072
1.275MetGly: 1.275 ± 0.106
0.651MetHis: 0.651 ± 0.079
2.853MetIle: 2.853 ± 0.18
2.684MetLys: 2.684 ± 0.157
2.38MetLeu: 2.38 ± 0.142
0.66MetMet: 0.66 ± 0.084
1.89MetAsn: 1.89 ± 0.128
0.74MetPro: 0.74 ± 0.092
0.981MetGln: 0.981 ± 0.093
0.785MetArg: 0.785 ± 0.086
1.542MetSer: 1.542 ± 0.134
0.892MetThr: 0.892 ± 0.088
1.284MetVal: 1.284 ± 0.121
0.16MetTrp: 0.16 ± 0.043
1.088MetTyr: 1.088 ± 0.101
0.0MetXaa: 0.0 ± 0.0
Asn
2.059AsnAla: 2.059 ± 0.134
0.918AsnCys: 0.918 ± 0.091
2.657AsnAsp: 2.657 ± 0.162
2.505AsnGlu: 2.505 ± 0.152
4.164AsnPhe: 4.164 ± 0.22
2.345AsnGly: 2.345 ± 0.178
2.211AsnHis: 2.211 ± 0.158
14.087AsnIle: 14.087 ± 0.496
8.407AsnLys: 8.407 ± 0.308
6.17AsnLeu: 6.17 ± 0.211
2.202AsnMet: 2.202 ± 0.132
7.106AsnAsn: 7.106 ± 0.296
2.149AsnPro: 2.149 ± 0.154
3.361AsnGln: 3.361 ± 0.19
2.38AsnArg: 2.38 ± 0.151
3.468AsnSer: 3.468 ± 0.182
4.092AsnThr: 4.092 ± 0.229
3.263AsnVal: 3.263 ± 0.187
0.606AsnTrp: 0.606 ± 0.078
3.183AsnTyr: 3.183 ± 0.164
0.0AsnXaa: 0.0 ± 0.0
Pro
0.9ProAla: 0.9 ± 0.109
0.481ProCys: 0.481 ± 0.07
1.168ProAsp: 1.168 ± 0.094
1.426ProGlu: 1.426 ± 0.119
1.195ProPhe: 1.195 ± 0.108
1.935ProGly: 1.935 ± 0.146
0.838ProHis: 0.838 ± 0.091
4.012ProIle: 4.012 ± 0.179
2.764ProLys: 2.764 ± 0.149
2.3ProLeu: 2.3 ± 0.143
0.695ProMet: 0.695 ± 0.078
2.47ProAsn: 2.47 ± 0.174
0.793ProPro: 0.793 ± 0.092
0.883ProGln: 0.883 ± 0.109
0.936ProArg: 0.936 ± 0.1
1.721ProSer: 1.721 ± 0.139
1.409ProThr: 1.409 ± 0.112
1.596ProVal: 1.596 ± 0.132
0.303ProTrp: 0.303 ± 0.055
1.498ProTyr: 1.498 ± 0.134
0.0ProXaa: 0.0 ± 0.0
Gln
1.409GlnAla: 1.409 ± 0.137
0.535GlnCys: 0.535 ± 0.061
1.649GlnAsp: 1.649 ± 0.111
2.354GlnGlu: 2.354 ± 0.167
1.712GlnPhe: 1.712 ± 0.134
2.095GlnGly: 2.095 ± 0.165
1.034GlnHis: 1.034 ± 0.095
4.672GlnIle: 4.672 ± 0.214
4.333GlnLys: 4.333 ± 0.228
4.039GlnLeu: 4.039 ± 0.204
0.597GlnMet: 0.597 ± 0.067
2.987GlnAsn: 2.987 ± 0.184
0.918GlnPro: 0.918 ± 0.08
1.48GlnGln: 1.48 ± 0.143
1.079GlnArg: 1.079 ± 0.099
2.71GlnSer: 2.71 ± 0.136
1.596GlnThr: 1.596 ± 0.135
1.721GlnVal: 1.721 ± 0.133
0.446GlnTrp: 0.446 ± 0.082
2.336GlnTyr: 2.336 ± 0.146
0.0GlnXaa: 0.0 ± 0.0
Arg
1.409ArgAla: 1.409 ± 0.127
0.508ArgCys: 0.508 ± 0.071
1.364ArgAsp: 1.364 ± 0.105
1.685ArgGlu: 1.685 ± 0.132
1.81ArgPhe: 1.81 ± 0.127
1.739ArgGly: 1.739 ± 0.131
0.883ArgHis: 0.883 ± 0.083
4.333ArgIle: 4.333 ± 0.199
3.031ArgLys: 3.031 ± 0.158
3.424ArgLeu: 3.424 ± 0.211
0.963ArgMet: 0.963 ± 0.1
2.309ArgAsn: 2.309 ± 0.164
0.972ArgPro: 0.972 ± 0.103
1.257ArgGln: 1.257 ± 0.121
1.418ArgArg: 1.418 ± 0.142
2.47ArgSer: 2.47 ± 0.163
1.632ArgThr: 1.632 ± 0.109
1.756ArgVal: 1.756 ± 0.171
0.339ArgTrp: 0.339 ± 0.055
1.525ArgTyr: 1.525 ± 0.122
0.0ArgXaa: 0.0 ± 0.0
Ser
2.648SerAla: 2.648 ± 0.174
0.99SerCys: 0.99 ± 0.113
2.826SerAsp: 2.826 ± 0.155
3.04SerGlu: 3.04 ± 0.167
3.308SerPhe: 3.308 ± 0.196
4.823SerGly: 4.823 ± 0.221
1.623SerHis: 1.623 ± 0.134
8.372SerIle: 8.372 ± 0.325
5.679SerLys: 5.679 ± 0.212
5.911SerLeu: 5.911 ± 0.299
1.596SerMet: 1.596 ± 0.098
4.422SerAsn: 4.422 ± 0.222
1.498SerPro: 1.498 ± 0.101
2.211SerGln: 2.211 ± 0.125
2.755SerArg: 2.755 ± 0.146
4.574SerSer: 4.574 ± 0.247
2.898SerThr: 2.898 ± 0.164
3.415SerVal: 3.415 ± 0.186
0.713SerTrp: 0.713 ± 0.097
2.799SerTyr: 2.799 ± 0.17
0.0SerXaa: 0.0 ± 0.0
Thr
1.854ThrAla: 1.854 ± 0.123
0.553ThrCys: 0.553 ± 0.059
1.56ThrAsp: 1.56 ± 0.114
1.649ThrGlu: 1.649 ± 0.128
2.184ThrPhe: 2.184 ± 0.139
3.29ThrGly: 3.29 ± 0.185
1.088ThrHis: 1.088 ± 0.103
6.526ThrIle: 6.526 ± 0.287
3.593ThrLys: 3.593 ± 0.205
4.984ThrLeu: 4.984 ± 0.208
0.99ThrMet: 0.99 ± 0.097
2.817ThrAsn: 2.817 ± 0.158
1.828ThrPro: 1.828 ± 0.128
1.837ThrGln: 1.837 ± 0.127
1.596ThrArg: 1.596 ± 0.116
3.254ThrSer: 3.254 ± 0.173
2.3ThrThr: 2.3 ± 0.152
2.22ThrVal: 2.22 ± 0.146
0.455ThrTrp: 0.455 ± 0.067
1.525ThrTyr: 1.525 ± 0.103
0.0ThrXaa: 0.0 ± 0.0
Val
1.801ValAla: 1.801 ± 0.176
0.758ValCys: 0.758 ± 0.076
2.229ValAsp: 2.229 ± 0.177
2.113ValGlu: 2.113 ± 0.137
2.122ValPhe: 2.122 ± 0.172
2.666ValGly: 2.666 ± 0.196
1.328ValHis: 1.328 ± 0.105
5.367ValIle: 5.367 ± 0.198
3.736ValLys: 3.736 ± 0.195
4.85ValLeu: 4.85 ± 0.225
1.114ValMet: 1.114 ± 0.12
2.906ValAsn: 2.906 ± 0.191
1.409ValPro: 1.409 ± 0.12
1.997ValGln: 1.997 ± 0.148
1.774ValArg: 1.774 ± 0.132
3.201ValSer: 3.201 ± 0.197
1.988ValThr: 1.988 ± 0.125
2.175ValVal: 2.175 ± 0.192
0.339ValTrp: 0.339 ± 0.053
1.694ValTyr: 1.694 ± 0.129
0.0ValXaa: 0.0 ± 0.0
Trp
0.232TrpAla: 0.232 ± 0.039
0.152TrpCys: 0.152 ± 0.042
0.312TrpAsp: 0.312 ± 0.06
0.357TrpGlu: 0.357 ± 0.058
0.49TrpPhe: 0.49 ± 0.069
0.401TrpGly: 0.401 ± 0.066
0.214TrpHis: 0.214 ± 0.043
1.337TrpIle: 1.337 ± 0.14
1.007TrpLys: 1.007 ± 0.114
0.847TrpLeu: 0.847 ± 0.085
0.339TrpMet: 0.339 ± 0.056
0.883TrpAsn: 0.883 ± 0.098
0.241TrpPro: 0.241 ± 0.047
0.241TrpGln: 0.241 ± 0.04
0.312TrpArg: 0.312 ± 0.05
0.597TrpSer: 0.597 ± 0.072
0.25TrpThr: 0.25 ± 0.05
0.312TrpVal: 0.312 ± 0.049
0.08TrpTrp: 0.08 ± 0.025
0.481TrpTyr: 0.481 ± 0.075
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.569TyrAla: 1.569 ± 0.116
0.767TyrCys: 0.767 ± 0.094
2.291TyrAsp: 2.291 ± 0.134
1.721TyrGlu: 1.721 ± 0.12
2.479TyrPhe: 2.479 ± 0.172
2.229TyrGly: 2.229 ± 0.153
1.489TyrHis: 1.489 ± 0.112
5.18TyrIle: 5.18 ± 0.225
3.789TyrLys: 3.789 ± 0.206
4.19TyrLeu: 4.19 ± 0.179
0.963TyrMet: 0.963 ± 0.099
3.816TyrAsn: 3.816 ± 0.189
1.239TyrPro: 1.239 ± 0.102
2.363TyrGln: 2.363 ± 0.173
1.453TyrArg: 1.453 ± 0.128
3.219TyrSer: 3.219 ± 0.195
1.997TyrThr: 1.997 ± 0.131
1.908TyrVal: 1.908 ± 0.153
0.517TyrTrp: 0.517 ± 0.076
2.086TyrTyr: 2.086 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 354 proteins (112165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski